Ukwelashwa kwesifo sikashukela i-mellitus, kusetshenziswa izidakamizwa ezahlukahlukene, ezibandakanya i-Diagnizide. Ngaphambi kokusebenzisa, udinga ukutadisha imiyalo, ngoba umuthi une-contraindication nemiphumela emibi.
Igama Lezwe elingafanele
Igama lomhlaba wonke elingahambisani ne-Glyclazide.
Igama lomhlaba jikelele elingewona ophathelene nalo muthi yi-Gliclazide.
I-ATX
Umkhiqizo unekhodi elandelayo ye-ATX: A10BB09.
Khipha amafomu nokwakheka
I-Gliclazide isebenza njengengxenye esebenzayo. Izingxenye ezingeziwe yi-hypromellose, Copovidone, magnesium stearate ne-silicon anhydrous colloidal dioxide. Umuthi ukhishwa ngesimo samaphilisi angama-30 mg, afakwe enqubeni yama-pcs ayi-10. Inqola iqukethe ama-3 noma ama-6 amabhliki.
Ungayisebenzisa kanjani isidakamizwa iGlyclazide?
I-Victoza yezidakamizwa isetshenziswa ngabanesifo sikashukela neziguli ezifuna ukunciphisa umzimba.
Ngesifo sikashukela, umuthi iMetamin usiza kahle. Funda kabanzi ngayo esihlokweni.
Isenzo se-Pharmacological
Umenzeli we-hypoglycemic ubizwa ngokuthi yi-sulfanylurea derivatives. Kuyasiza ekwehliseni ukuqina kwamalunithi e-beta-cell ama-ion e-calcium, adilize ulwelwesi, akhuphule ukuthuthwa kwama-ion e-calcium ngemigudu futhi andise okuqukethwe kwe-calcium ions ngaphakathi kwamaseli. Ngenxa yalokhu, i-insulin ishiya amaphilisi we-cytoplasmic.
Umuthi osebenzayo uthuthukisa ukusebenza kwe-insulin, unciphise ukumelana ne-insulin, okwenzeka ngokusetshenziswa okuningana, wehlise ukwakheka kwe-glucose esibindini nokuqunjelwa kwayo kwezicubu zemisipha. Ukuthatha umuthi kusiza ukuvikela ukuvela kwezilonda ze-vascular phambi kwesifo sikashukela, kunciphisa ukuhlangana kweplatelet nokunamathela, kuvuse umsebenzi we-fibronolytic vascular kanye nokulawula imetabolism ye-prostaglandin.
Ukuthatha umuthi kusiza ukuvikela ukuvela kwezilonda zemithambo lapho kukhona isifo sikashukela.
Ngaphezu kwalokho, umuthi ubhekwa njengemukeli wama-radicals wamahhala futhi uthinta kancane i-lipid metabolism. I-Glyclazide yehlisa inani le-cholesterol ku-plasma, inciphisa ukugcwala kwama-asidi wamahhala nama-triglycerides. Lezi zinqubo zisiza ukwehlisa isisindo salezi ziguli ezikhuluphele.
I-Pharmacokinetics
Ngemuva kokuphuza iphilisi, ligxilwa ngokushesha emgudwini wesisu. Izinga nezinga lokutholwa lizimele ekudleni kokudla. Iqoqo eliphezulu lomuthi osegazini libonwa ngemuva kwamahora ayi-6 futhi lizoqhubeka amahora angama-6 kuya kwayi-6.
I-Gliclazide metabolism iyenzeka esibindini. AmaMetabolites aqhamuka nomchamo.
Izinkomba zokusetshenziswa
Leli thuluzi lenzelwa ukwelashwa kwe-mellitus yesifo sikashukela engaxhomekeki ku-insulin ezigulini ezindala, lapho izinga le-glucose egazini lingenakulawulwa ngokuzivocavoca, ukunciphisa isisindo nokudla.
Contraindication
Kuyadingeka ukwenqaba ukwelashwa uma:
- hypersensitivity kuzakhi;
- i-mellitus;
- i-ketoacidosis enzima;
- isifo sikashukela entsheni nasezinganeni;
- isifo sikashukela;
- isimo esizithandayo;
- ukwehluleka okukhulu kwe-hepatic noma kwe-renal.
Umuthi uphambaniswe nabesifazane abakhulelwe nababolekayo, nasezigulini ezithatha iMiconazole ngasikhathi sinye.
Ungayithatha kanjani i-Diagnizide
Umuthi uphuzwa ngomlomo isigamu sehora ngaphambi kokudla izikhathi ezi-2 kabili ngosuku. Iziguli ezinefomu elincane lesifo zibekelwa umthamo wansuku zonke we-80 mg, futhi ezigulini ezinenkambo enzima yesifo, inani lomuthi ngosuku liyi-240 mg. Akuvamile ukuthi udokotela anqume iziguli ezingama-320 mg ngosuku.
Ngoshukela
Indlela yokwelashwa lapho kunesifo sikashukela kunqunywa uchwepheshe, kucatshangelwa izici ezithile zesiguli kanye nemiphumela yokuhlolwa.
Imiphumela Emibi Yokuxilonga
Kwezinye izimo, ukusabela okubi komzimba kungenzeka. Mhlawumbe ukuphazamiseka kwe-metabolic ngesimo se-hyponatremia.
Engxenyeni yesitho sombono
Esigabeni sokuqala sokwelashwa, kungavela izinkinga zokubona. Le nto kungenxa yoshintsho kushukela wegazi futhi lidlule ngemuva kwesikhashana.
Amapheshana wesisu
Ukusuka emiphumeleni yesistimu yokugaya ukudla ibonakala ngendlela yesicanucanu, ukugabha, ubuhlungu besisu, isisu sohudo, i-dyspepsia kanye nokuqunjelwa. Izimpawu ezingemnandi zingagwenywa noma zinciphiswe uma ulandela izincomo zikadokotela futhi uphuza umuthi kanye ngesikhathi sokudla kwasekuseni.
Izitho zeHematopoietic
Ukusabela okungalungile kungenzeka engxenyeni yesistimu yegazi nohlelo lwe-lymphatic. Kuboniswa ngokuvela kwe-thrombocytopenia, i-anemia, i-granulocytopenia ne-leukopenia.
Isistimu yezinzwa ephakathi
Ngesikhathi sokulashwa, ukozela, isiyezi, ukudideka, ukudangala, kanye nokukhubazeka kwenkulumo kungavela.
Engxenyeni yesibindi ne-biliary
Ukuthatha umuthi kungadala umsebenzi owengeziwe wama-enzyme wesibindi, i-hepatitis kanye ne-cholestatic jaundice.
Allergies
Ukuvela kokusabela okungekuhle ngendlela ye-urticaria, ukuqubuka kwesikhumba, i-edema kaQuincke, ukulunywa, ukubonakaliswa kwezinkunzi, kanye nokuqhuma kwe-maculopapullous akubandakanywa.
Ngesikhathi sokwelashwa, ukuvela kokungaphenduki okuhle ngendlela ye-urticaria kanye nokuqhuma kwesikhumba akukhishwa.
Umthelela ekhonweni lokulawula izindlela
Isiguli kufanele siqaphele izimpawu ze-hypoglycemia futhi sikwazi ukuzibona lapho sishayela futhi senza izinto ezidinga ukunakwa okwandisiwe kokuphendula kanye nokusabela okusheshayo kwe-psychomotor, ikakhulukazi esigabeni sokuqala sokwelashwa.
Imiyalo ekhethekile
Kunconywa amaphilisi ezigulini ezilandela ukudla. Ubungozi besimo se-hypoglycemic bukhuphuka uma inani elanele lama-carbohydrate livela ekudleni noma uma lingathathwanga ngohlelo. Ukuqapha isimo sesiguli, kuyadingeka ukusebenzisa izivivinyo zaselebhu ukuthola amazinga kashukela egazini.
Sebenzisa ebudaleni
Ukusetshenziswa kwomuthi okwenziwa iziguli esezikhulile kufanele kwenziwe ngaphansi kokuqashwa kukachwepheshe wezempilo ngenxa yengozi enkulu ye-hypoglycemia.
Isabelo sezingane
Kwenqatshelwe ukusebenzisa umuthi ukwelapha izingane ngenxa yokushoda kolwazi ngokuphepha kwayo kwaleli qembu leziguli.
Ukusetshenziswa kwezimali zeziguli esezikhulile kufanele kwenziwe ngaphansi kokuqashwa kukachwepheshe wezokwelapha.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi onciphisa ushukela awusetshenziswa ngesikhathi sokukhulelwa. Uma ukukhulelwa kutholakele ngesikhathi sokwelashwa, khona-ke umuthi we-hypoglycemic uyamiswa bese kuthathwa i-insulin. Uma kudingekile ukwenza izindlela zokwelapha nge-Diagiside, ukuncelisa ibele kuyaphazamiseka, ngoba isakhi esisebenzayo sidlulela ebisini lobisi futhi singadala i-hypoglycemia enganeni.
Isicelo sokusebenza kokulimala kwezinso
Ekuhlulekeni okukhulu kwe-renal, ukwelashwa kufanele kube ngaphansi kokuqondisa kukadokotela.
Sebenzisa umsebenzi wesibindi okhubazekile
Ekuhlulekeni kwesibindi okunzima, ukwelashwa nge-diaglizide kwenziwa ngokuqapha.
Ukweqisa Kwe-Diagnizide
Uma usebenzisa kabi isilinganiso esinconyiwe somuthi, kungavela i-overdose, njengoba kufakazelwa yizimpawu ze-hypoglycemia. Ngefomu elithambile, kuzodingeka kuthathwe umthamo kanye nezinguquko zomsoco. Ngokukhula kwe-hypoglycemia enzima, isiguli sidinga ukunakekelwa kwezokwelashwa, ngakho-ke silaliswa esibhedlela futhi nekhambi le-glucose liphathwa ngaphakathi.
Izimpawu ze-hypoglycemia zibonisa okweqisa komuthi.
Ukwelashwa okuqhubekayo kunqunywa udokotela ngokuya ngesimo sesiguli. Ukusetshenziswa kwe-dialysis kuleli cala ngeke kuveze imiphumela, ngoba i-gliclazide ibopha amaprotheni e-plasma egazi. Ngaphezu kwalokho, ama-sweeteners ngeke abe nomphumela owufunayo, ngakho-ke akufanele asetshenziswe.
Ukuxhumana nezinye izidakamizwa
Ngokuphathwa kanyekanye kwezidakamizwa eziningana, ukusabela okungahle kwenzeke, ngakho-ke, ngaphambi kokuqala ukwelashwa, kufanele uvakashele uchwepheshe ukuze ukhiphe ubungozi bezinkinga.
Inhlanganisela ehlanganisiwe
Kuphikisiwe ukuhlanganisa iMiconazole ne-Diagnizide, ngoba isimo se-hypoglycemic singakhula sifinyelele ku-coma.
Ukuhambisana notshwala
Kwenqatshelwe ukusebenzisa iziphuzo ezidakayo nemithi equkethe utshwala ngesikhathi sokwelashwa. Lapho kuhlanganiswa ne-ethanol, ubungozi be-hypoglycemia ne-coma luyakhula.
Kwenqatshelwe ukusebenzisa iziphuzo ezidakayo nemithi equkethe utshwala ngesikhathi sokwelashwa.
Inhlanganisela edinga ukuqashelwa
Ngokuqapha, phatha ukwelashwa kanyekanye noDiabetesin nezinto ezilandelayo:
- insulin;
- i-acarbose;
- ama-bioganides;
- metformin;
- ama-anticoagulants;
- i-fluconazole;
- ama-beta blockers;
- Mao inhibitors;
- ama-sulfonamides;
- ukucaciswa;
- izidakamizwa ezingezona ze-steroidal ezilwa nokuvuvukala;
- i-dipeptidyl peptidase-4 inhibitors;
- i-glucagon-like peptide-1 receptor agonists;
- Ama-inhibitors e-ACE.
Lezi zinto zingaqhakambisa umphumela we-hypoglycemic.
Akuhlanganisiwe ukuhlanganisa
Ukuxhumana kwento esebenzayo ngotshwala ne-phenylbutazone kungadala ukusabela okungekuhle komzimba ngesimo sokwanda kwe-hypoglycemic effect. Uma kunesidingo, umthamo we-hypoglycemic uguqulwa ngesikhathi nangemva kokulashwa kwe-phenylbutazone.
Ama-Analog
Amakhambi afanayo yile:
- UGlidiab;
- I-Glucosostable;
- Insuton;
- Phindisela emuva;
- I-Diatics;
- Predian.
I-analogue ikhethwa uchwepheshe ngemuva kokuhlolwa kweziguli ngokuphelele.
Imibandela yekhefu lekhemisi
Ukuthenga umuthi, udinga ukunikezwa kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ngaphandle kwencwadi kadokotela, awukwazi ukuthenga lesi sidakamizwa ekhemisi.
Intengo
Izindleko zalo muthi zincike kwinqubomgomo yamanani ekhemisi nezilinganiso ezingama-90 UAH e-Ukraine.
Izimo zokugcina zomuthi
Ukuhlanganiswa ngamathebhulethi kufanele kubekwe endaweni eyomile, emnyama futhi engenakutholwa yizingane ezinamazinga okushisa angeqi ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Umkhiqizo ugcina izakhiwo zawo iminyaka emi-3 kusukela ngosuku lokukhiqizwa, ngokuya ngemibandela yokubekelela. Ngemuva kosuku lokuphelelwa yisikhathi, umuthi ulahlwa.
Umkhiqizi
Ukwenziwa kwe-Diagliside kwenziwa nguPulaziak OJSC.
Ukuthenga umuthi, udinga ukunikezwa kadokotela.
Ukubuyekezwa
U-Antonina, oneminyaka engama-47 ubudala, uKrasnoyarsk: "Bengiphuza lesi sidakamizwa esiswini esingenalutho ku-60 mg ngosuku amasonto ambalwa. Wazizwa engcono, yize isiyezi nokujuluka kukhathazekile ezinsukwini zokuqala. Ayikho eminye imiphumela emibi."
UVladimir, oneminyaka engama-36, eMoscow: "Sekuphele iminyaka nginesifo sikashukela. Umuthi usize ukwehlisa i-glucose egazini futhi uthuthukise isimo sami, kepha ngokuhambisana nokudla kanye nokuzivocavoca umzimba. Uma ungadli isidlo sasekuseni noma isidlo sasekuseni ngesikhathi, kuba mnyama emehlweni ami nesiyezi. "
