Namuhla emakhemisi kukhethwa izinhlobo eziningi zezidakamizwa ezinciphisa ushukela, eziningi zazo ezinomphumela obuthakathaka we-hypoglycemic. Lokhu kuyiqiniso ikakhulukazi ngemithi esephelelwe yisikhathi engenazakhi ezingamelana ngempumelelo noshukela ophezulu wegazi.
Ngenhlanhla, isayensi ayimile futhi eminyakeni yamuva nje kuye kwenziwa isizukulwane esisha semithi ye-hypoglycemic esingashesha ukwehlisa izinga likashukela emzimbeni futhi siligcine emazingeni evamile isikhathi eside.
Umuthi owodwa onjalo ikhambi lika-Forsig lesifo sikashukela, ukusebenza kahle okuphezulu okufakazelwe ezifundweni eziningi. Yisidakamizwa lesi esiba ngokuya sinqunywa ngabaphethwe yi-endocrinologists kwiziguli zabo ukwelashwa kwesifo sikashukela sohlobo 2.
Kepha yini eyenza ukuthi umuthi weForsig uphumelele kangaka futhi yimiphi imiphumela emibi ongahlangabezana nayo lapho uyithatha? Le mibuzo ivame ukubuzwa kakhulu yiziguli ezinesifo sikashukela eziya kodokotela abakhona. Ukuze uziqonde, kufanele ufunde okuningi ngangokunokwenzeka ngokwakhiwa kwesidakamizwa, umphumela waso emzimbeni womuntu kanye nemiphumela emibi engaba khona yokuthatha i-Forsig.
Ukwakheka kanye nenqubo yokusebenza
Isithako esikhulu esisebenzayo esiyingxenye yomuthi weForigi yi-dapagliflozin. Kuyasiza ukwehlisa ngempumelelo ushukela wegazi ngokuvimbela ukumuncwa kwe-glucose ngama-reubu tubules futhi uwukhiphe ngomchamo.
Njengoba wazi, izinso izihlungi zomzimba ezisiza ekuhlanzeni igazi lezinto eziningi ngokweqile, ezibe zidedelwa kanye nomchamo. Ngesikhathi sokuhlunga, igazi lifakwa emabangeni athile okuhlanza, lidlula emithanjeni enamasayizi ahlukahlukene.
Ngokuhamba kwalokhu, kwakheka izinhlobo ezimbili zomchamo emzimbeni - eyokuqala neyesekondari. Umchamo oyinhloko i-serum yegazi elihlanzwa esidonswa yizinso bese ebuyela egazini. Okwesibili umchamo, ugcwele zonke izinto ezingadingekile emzimbeni, osuswa ngokwemvelo emzimbeni.
Ososayensi sekuyisikhathi eside bezama ukusebenzisa le mpahla yezinso ukuhlanza noma yiliphi igazi eleqile ukwelapha isifo sikashukela sohlobo 2. Kodwa-ke, amathuba ezinso awanamkhawulo, ngakho-ke awakwazi ukususa ngokuphelele ushukela omningi emzimbeni futhi ngaleyo ndlela asuse isiguli se-hyperglycemia.
Ukuze wenze lokhu, badinga umsizi ongavimbela ukumuncwa kwe-glucose ngama-rebu tubules futhi athuthukise ukuphuma kwawo kanye nomchamo wesibili. Yilezi zakhiwo ezinazo i-dapagliflozin, edlulisa inani elikhulu loshukela kusuka kumchamo oyinhloko uye kwesinye.
Lokhu kungenxa yokwanda okukhulu komsebenzi wamaphrotheni ama-transporter, abamba ngokoqobo ama-molecule woshukela, okuwavimbela ukuba angangenwa yizicubu zezinso abuyele egazini.
Kumele kuqashelwe ukuthi ukususa ushukela omningi, umuthi ukwandisa kakhulu ukuchama, ngenxa yokuthi isiguli siqala ukuya endlini yangasese kaningi. Ngakho-ke, ukuze ulondoloze ibhalansi ejwayelekile yamanzi emzimbeni, isiguli sinconyelwa ukwandisa inani lamanzi asetshenziswa kumalitha angama-2,5-3 ngosuku.
Lesi sidakamizwa singathathwa ngisho neziguli ezinesifo sikashukela sohlobo 2 ezilashwa nge-insulin therapy.
Izinga laleli hormone egazini alithinti umphumela we-Forsig, elenza libe ithuluzi lokwelapha emhlabeni wonke.
Izici eziwusizo
Enye yezinzuzo ezinkulu zesidakamizwa iForsig ukuthi ibonisa umphumela wayo we-hypoglycemic noma ngabe isiguli sinomonakalo kuma-pancreas, okuholela ekufeni kwamanye ama-cells-cell noma ukuthuthukiswa kokuqina kwezicubu ze-insulin.
Kulokhu, umphumela wokwehlisa ushukela we-Forsig wenzeka ngemuva kokuthatha isibhebhe sokuqala somuthi, futhi ukuqina kwaso kuncike ekujuleni kwesifo sikashukela kanye nezinga loshukela egazini lesiguli. Kepha ezigulini eziningi, kusukela ekuqaleni kwekhambi lokwelashwa nokusetshenziswa kwalesi sidakamizwa, kuyehla ukwehla kokuxineka koshukela kufinyelela ezingeni elijwayelekile.
Okunye okubalulekile ukuthi isidakamizwa iForigs kufanelekile ekwelapheni iziguli ezisanda kuthola ukuthi zitholakele yini, futhi nasezigulini ezinokuhlangenwe nakho kweminyaka engaphezu kwe-10. Le mpahla yalo muthi iwunikeza ithuba elihle kakhulu kunezinye izidakamizwa ezinciphisa ushukela, ezithinta kakhulu isikhathi nobunzima besifo.
Izinga likashukela wegazi elijwayelekile, elitholakala ngemuva kokuthatha amaphilisi weForig, lihlala isikhathi eside impela. Kodwa-ke, kubalulekile ukugcizelela ukuthi umphumela owaziwa kakhulu we-hypoglycemic uzibonakalisa ukusebenza kahle kohlelo lobuchwephesha. Noma yisiphi isifo sezinso singanciphisa kakhulu ukusebenza komuthi.
Amaphilisi kashukela ka-Forsig asiza ukwehla kwegazi, esiza ukuvikela ukukhula kwezifo zenhliziyo ezivame ukwenzeka kubantu abanesifo sikashukela. Ngaphezu kwalokho, lesi sidakamizwa singathathwa ngasikhathi sinye namanye ama-hypoglycemic agents, ngokwesibonelo, njengeGlucofage noma i-insulin.
Umuthi i-Forsig ungahlanganiswa nezidakamizwa ezikhiqizwa ngesisekelo sezithako ezisebenzayo ezilandelayo:
- ISulfonylurea;
- UGlyptin;
- I-Thiazolidinedione;
- I-Metformin.
Ngaphezu kwalokho, i-Forsig inezinye izindawo ezimbili ezengeziwe, kepha ezibaluleke kakhulu ezigulini ezinesifo sikashukela sohlobo 2 - kungukususa uketshezi oludlulele emzimbeni kanye nokulwa nokukhuluphala.
Njengoba umuthi i-Forsig ukhulisa kakhulu ukuchama ukwehlisa amazinga kashukela wegazi, kuyasiza ukususa wonke uketshezi olwedlulele emzimbeni. Lokhu kuvumela isiguli ukuthi sehlise kuze kufike kumakhilogremu ayi-7 wesisindo esingeqile emavikini ambalwa nje wokuphuza lo muthi.
Ngaphezu kwalokho, ngokuvimbela ukumuncwa kwe-glucose futhi kuthuthukiswe ukuphuma kwayo kanye nomchamo, i-Forsig inciphisa ukutholwa kokudla kwansuku zonke kwesifo sikashukela cishe ngo-400 Kcal. Ngenxa yalokhu, isiguli sithatha nje la maphilisi singalwa ngempumelelo nokukhuluphala, sisheshe sithole isibalo esithambile.
Ukuthuthukisa umphumela wokunciphisa umzimba, odokotela batusa ukuthi isiguli silandele imithetho yokudla okunempilo, sikuqede ngokuphelele ukudla kwe-carbohydrate, okunamafutha kanye nama-calorie aphezulu ekudleni.
Kepha kufanele kugcizelelwe ukuthi lesi sidakamizwa akufanele sisetshenziselwe kuphela ukunciphisa isisindo, ngoba umsebenzi waso oyinhloko ukwehlisa ushukela wegazi.
Imiyalo yokusebenzisa amaphilisi
Umuthi iForig kufanele uthathwe kuphela ngaphakathi. Lezi zibhebhe zingadakwa kokubili ngaphambi nangemva kokudla, ngoba lokhu akuwuthinti umthelela wazo emzimbeni. Umthamo wansuku zonke we-Forsigi ngu-10 mg, okufanele uthathwe kanye - ekuseni, ntambama noma kusihlwa.
Lapho welapha isifo sikashukela i-mellitus ne-Forsigoy ngokuhlanganiswa neGlucofage, umthamo wezidakamizwa kufanele ube ngale ndlela elandelayo: Forsig - 10 mg, Glucofage - 500 mg. Uma ungekho umphumela owufunayo, uvunyelwe ukwandisa umthamo we-Glucofage yezidakamizwa.
Iziguli ezinesifo sikashukela sohlobo 2 ezinokwehluleka kwezinso okuncane noma ezilinganiselayo, asikho isidingo sokushintsha umthamo womuthi. Futhi iziguli ezinokungasebenzi kahle kwezinso kunconywa ukwehlisa umthamo weForig kuya ku-5 mg. Ngokuhamba kwesikhathi, uma umzimba wesiguli ubekezelela imiphumela yomuthi, umthamo wawo unganyuselwa ku-10 mg.
Ukwelashwa kweziguli ezihlobene nobudala, kusetshenziswa umthamo ojwayelekile we-10 mg.
Kodwa-ke, kufanele kuqondwe ukuthi ezigulini zalo mkhakha wobudala, izifo zohlelo lomchamo zivame kakhulu, ezingadinga ukwehla komthamo weForig.
Intengo
Umuthi iForig ungathengwa ekhemisi kunoma yisiphi isifunda sezwe. Inezindleko eziphakeme impela, okuthi ngokwesilinganiso eRussia cishe ama-ruble angama-2450. Ungawuthenga lo muthi ngentengo ebiza kakhulu edolobheni laseSaratov, lapho kubiza khona ama-ruble angama-2361. Intengo ephezulu kakhulu yesidakamizwa i-Forsig ibhalwe eTomsk, lapho acelwa ukuthi anikeze ama-ruble angama-2695.
EMoscow, i-Forsiga ngokwesilinganiso ithengiswa ngentengo yama-ruble angama-2500. Okushibhile ngandlela thize, leli thuluzi lizobiza izakhamizi zaseSt. Petersburg, lapho libiza khona ama-ruble angama-2,474.
ECazan, iForig ibiza ama-ruble angama-2451, eChelyabinsk - ama-ruble angama-2512, eSamara - kuma-ruble angama-2416, ePre - kuma-ruble angama-2427, eRostov-on-Don - kuma-ruble angama-2434.
Ukubuyekezwa
Ukubuyekezwa komuthi Forsig muhle kakhulu zombili ezigulini nakwabasebenza ngama-endocrinologists. Njengoba izinzuzo zalo muthi, ukwehla okusheshayo nokuzinzile kwamazinga kashukela wegazi kuyaphawulwa, lapho kudlula khona okuningi kwama-analogues awo.
Ngaphezu kwalokho, iziguli zincome ikhono le-Forsigi lokusebenzelana ngempumelelo nokukhuluphala ngokweqile, okusiza ukuqeda esinye sezimbangela eziphambili zokuthuthuka kwalesi sifo, ngoba ukukhuluphala nesifo sikashukela kuhlobene kakhulu. Futhi, iziguli eziningi zithande ukuthi lesi sidakamizwa akufanele sithathwe yihora, kodwa kufanele sithathwe kanye ngosuku nganoma yisiphi isikhathi esikahle.
Ukujwayeza amazinga kashukela egazini ngenkathi uthatha iForigi kusiza ukuqeda izimpawu ezingathandeki zesifo sikashukela ezinjengobuthakathaka nokukhathala okungapheli. Futhi ngaphandle kokuncipha kokudla kwe-caloric, iziguli eziningi zibika ukwanda kwamandla namandla.
Phakathi kokubi kokulashwa ngalo muthi, iziguli nodokotela baphawula ukwanda kokuthambekela kokukhula kwezifo zohlelo lwezitho zofuzo. Lokhu kuyiqiniso ikakhulukazi kwabesifazane abasengozini yokuthola izifo ezifanayo.
Umphumela omubi onjalo wesidakamizwa i-Forsig uchazwa ngokwanda kokuxineka kwe-glucose kumchamo, okudala izimo ezinhle zokuthuthuka kwe-microflora ehlukahlukene ye-pathogenic. Lokhu kungahle kudale inqubo yokuvuvukala ezinso, ebeleni noma ku-urethra.
Ngenxa yokususwa kwenani elikhulu loketshezi emzimbeni, ezinye iziguli zihlangabezana nenkinga efana nokoma okukhulu nokuqunjelwa. Ukuziqeda, odokotela balule ukwandisa ukusetshenziswa kwamanzi amaminerali amsulwa. Ezimweni ezingavamile, iziguli zikhononda ukuthi zithola i-hypoglycemia ku-mellitus yesifo sikashukela, evame ukuvela lapho kudliswa umthamo onconyelwayo.
Ama-Analog
Njengoba iForigs isidakamizwa sesizukulwane esisha, ayinayo inombolo enkulu yama-analogues. Lokhu kungenxa yokuthi amalungiselelo anomphumela ofanayo we-pharmacological athuthukisiwe kuze kube manje. Njengomthetho, lapho kukhulunywa nge-Forsigi analogues, le mithi elandelayo iyaphawulwa: Bayeta, Onglisa, Combogliz Prolong.
Ividiyo ekulesi sihloko ikhuluma ngomgomo wokusebenza kweForigo.
