I-Dimaril isidakamizwa esilwa nesifo sikashukela. Kubekelwe ukwelashwa kwe-mellitus engavikelekile nge-insulin.
Igama Lezwe elingafanele
I-Glimeperide
I-Dimaril isidakamizwa esilwa nesifo sikashukela. Kubekelwe ukwelashwa kwe-mellitus engavikelekile nge-insulin.
Ath
A10BB12 - Glimepiride
Khipha amafomu nokwakheka
Isakhi esisebenzayo somuthi yi-glimepiride. Ithebhulethi elilodwa liqukethe i-2, 3 mg noma i-4 mg yale nto. Izakhi ezisizayo: i-lactose monohydrate, i-indigo carmine aluminium varnish, i-microcrystalline cellulose, i-sodium starch glycolate, i-magnesium stearate, i-povidone, i-polysorbate 80, i-iron oxide ephuzi.
Isenzo se-Pharmacological
Ukufinyelela ku-lesion, glimepiride (into esebenzayo), kunemiphumela eminingana yekhemikhali:
- ivuselela ukukhiqizwa nokukhululwa kwe-insulin ye-hormone ngamaseli we-beta wamanyikwe;
- yenza izicubu zepherishi zizwele kakhulu i-insulin;
- iguqula i-postprandial insulin / C-peptide metabolism.
Ngenxa yemiphumela engenhla, izinga loshukela wegazi lesiguli libuyela kokujwayelekile.
I-Pharmacokinetics
Izinga likashukela lehla emahoreni angama-2-3 ngemuva kokuthatha umkhiqizo, lihlala isikhathi esingaphezu kosuku futhi lizinze amasonto amabili. Kwezinye iziguli ezinamazinga aphezulu kashukela, okungenani izidakamizwa ezi-6 g kumele zithathwe ukufeza umphumela wokwelapha.
Izinga likashukela lincipha amahora angama-2-3 ngemuva kokuthatha i-Dimaril, ihlala isikhathi esingaphezu kosuku futhi izinza amasonto ama-2.
Izinkomba zokusetshenziswa
Thayipha isifo sikashukela sohlobo 2, ukumelana ne-insulin.
Contraindication
Contraindication ukusetshenziselwa kufaka: uhlobo 1 isifo sikashukela mellitus (sincike ku-insulin), isifo sikashukela sikashukela, i-thoroma ne-coma, ukuphazamiseka kokusebenza kwezinso nezinso. Umuthi akufanele unikezwe iziguli ezine-hypersensitivity to glimepiride, izingxenye ezisizayo zomuthi, okuphuma ku-sulfonylurea kanye nezinye izidakamizwa ze-sulfonamide.
Ngokunakekela
Umuthi ubekwa ngokuqapha ezigulini ezidinga ukudluliselwa ekwelashweni kwe-insulin. Lesi simo senzeka esimweni sokulimala okuningi kanzima, ukusha okukhulu nokungenelela kokuhlinzwa. Ngaphezu kwalokho, imingcele ekusetshenzisweni kwesidakamizwa yilena: ukuphuza utshwala, ukungasebenzi kahle kokudla nezidakamizwa, i-fever syndrome, ukungasebenzi kahle kwe-adrenal, i-thyroid pathology, ukukhuphuka noma ukuncipha kokukhiqizwa kwama-hormone egilo.
Izinkomba ze-Dimaril - Uhlobo 2 sikashukela i-mellitus, ukumelana ne-insulin.
Ungayithatha kanjani iDimaril
Uhlobo lomthamo lungahluka ngokuya esigabeni se-pathology.
Ngoshukela
Ngaphambi kokuqala ukwelashwa, iziguli zinikeza igazi nomchamo wokuhlaziywa. Ngenxa yocwaningo, odokotela bathola amazinga kashukela. Ngokuya izinkomba ezitholakele, odokotela banquma inani elifunekayo:
- Umthamo wokuqala ngu-1 mg we-glimepiride ngosuku. Lawa amaphilisi ½ we-2 mg. Ngemuva kokwamukelwa, udokotela uqapha ngokucophelela ukusabela kwesiguli. Uma uchwepheshe eqonda ukuthi umthamo onjalo usiza ukulawula lesi sifo, khona-ke usibeka njengokwelashwa kokulondolozwa.
- Umthamo owengeziwe ngu-2, 3 noma 4 mg wesidakamizwa ngosuku. Kunqunywe uma i-2 mg inganele. Isikhathi senkambo yokwelapha sibekwa ngawodwana.
- Umthamo omkhulu yi-4-6 mg yomuthi. Le ndlela yesilinganiso ibekelwa iziguli ezinamazinga aphezulu kashukela (uma ukuqina okuqinile kwento kubhekwa ngisho nasesiswini esingenalutho).
Ukwelapha okuhlanganayo kufanele kwenziwe ngaphansi kokuqashwa ngokuqinile kodokotela. Ngaphezu kwalokho, kubalulekile ukuqapha indlela yokuphila: ukunciphisa umkhawulo wokuzivocavoca, gwema ukusetshenziswa kwezinto ze-hypoglycemic (okubangela ukwehla okukhulu kwamazinga kashukela) bese ulandela ukudla.
Imiphumela emibi yeDimaril
Ukusabela okungalungile kungenzeka.
Engxenyeni yesitho sombono
Ekuqaleni noma maphakathi nokwelashwa, isiguli singase sibhebhethekise okwesikhashana umbono. Lo mphumela wecala uhambisana noshintsho olubi ekugxileni kwe-glucose glucose.
Amapheshana wesisu
Ezinye iziguli zihlangabezana nokuqunjelwa, ngenxa yokuthi zihlushwa yizinhlungu esifundeni se-epigastric, izinguquko zesitulo, isicanucanu kanye nokuhlanza. Izimpawu zivame ukuhambisana nobunzima esiswini. Ezimweni ezingavamile, umsebenzi wama-enzyme wesibindi uyanda. Ezimweni ezinzima, izifo ezinjenge-hepatitis, cholestasis ne-jaundice ziyahlakulelwa. Ama-Pathologies angaholela enkingeni entsha - ukwehluleka kwesibindi.
Izitho zeHematopoietic
Ngesikhathi sokuhlolwa kwelebhu, kutholakala ushintsho ekuhlolweni kwamaplatelet, ama-leukocytes, amangqamuzana egazi abomvu, ama-granulocytes, ama-agranulocytes. Kwezinye izimo, ukwehla okubukhali kuzo zonke izakhi zegazi kungenzeka, kanye ne-hemolytic noma i-aplastic anemia.
Isistimu yezinzwa ephakathi
Ukwephulwa kohlelo lwezinzwa kuboniswa ngesimo sekhanda ne-asthenia - isimo sobuthakathaka nokungabi namandla.
Kusuka ohlelweni lokuphefumula
Izinguquko ohlelweni lokuphefumula zingenzeka uma isiguli sithuthuka i-dyspnea - umuzwa wokuntuleka komoya okunamandla. Ngaphezu kwalokho, imiphumela emibi ingenzeka ngenxa yokusabela okukhulu komzimba, okuvame ukuhambisana nokwanela.
Engxenyeni yesikhumba
Ngokungakwazi ukubekezelela izakhi noma ukuthambekela kokungezwani komzimba, isimo sesikhumba sivame ukuguquka ezigulini. Ububomvu nokugquma okuhlukahlukene kuyabonakala, okuhambisana nokushiswa nokulunywa kanzima. Ukusabela okuvame kakhulu komzimba yi-urticaria. Leli yiqembu lezifo elihlanganisa uphawu olujwayelekile - ukubonakala kwamakhanda abomvu esikhunjeni, okufana nokuqhuma njengokushiswa kwe-nettle.
Kusuka ohlelweni lwezinhliziyo
Kwezinye izimo, ukwanda okubukhali kwengcindezi yegazi kungenzeka.
Kusuka emasosheni omzimba
Mhlawumbe ukuthuthukiswa kokusabela kwe-hypersensitivity, okuboniswa ngesimo sokugoqa, i-edema, i-allergic discocation kanye ne-photosensitivity. Ezimweni ezinzima, ukusabela komzimba kohlobo olusheshayo kukhula - i-edema kaQuincke kanye ne-anaphylactic shock.
Ukwemukelwa kweDimaril kuholela ekunakekelweni kokunaka kokunaka, futhi ijubane lokuphendula kwe-psychomotor liyancipha.
Umthelela ekhonweni lokulawula izindlela
Ekuqaleni kokwelashwa, izinga likashukela wegazi lesiguli alizinzile. Maphakathi nenkambo yokwelapha, ukugxilwa koshukela kungakhuphuka noma kuncishiswe, okuhambisana nokudla ngokungafanele kwesidakamizwa noma amanye amaphutha enziwa yisiguli. Lokhu kuholela ekuphulweni kokuhlushwa, futhi ijubane lokuphendula kwe-psychomotor liyancipha.
Imiyalo ekhethekile
Kwezinye izimo, ukuthatha umuthi ngokuqapha.
Sebenzisa ebudaleni
I-assimilation kanye ne-excretion yesidakamizwa ayihlukile neze kumingcelezi efanayo kwiziguli ezisencane. Ngalesi sizathu, ukulungiswa komthamo akudingeki.
Isabelo sezingane
Ukulungiswa kwedosi akudingeki.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngesikhathi sokukhulelwa, udinga ukubheka njalo izinga le-glucose egazini nomchamo. Noma yikuphi ukungahambi kahle kungaholela ekukhuleni kwezinkinga zokuzala, ukuphuphuma kwesisu noma ukufa kwengane esanda kuzalwa. Njengoba umuthi ungadala i-hypoglycemia, akunakwenzeka ngokuphelele ukuthatha lesi sidakamizwa ngesikhathi sokuzala kwengane. Owesifazane okhulelwe udinga ukudluliselwa ekwelashweni kwe-insulin.
I-Glimepiride idlulela obisini lwebele, ngakho-ke, ngesikhathi sokwelashwa, owesifazane kufanele adlulisele ukuxubana okufakwayo enganeni.
I-Glimepiride iyakwazi ukungena kubisi lwebele futhi ingaba nomthelela ongemuhle ku-fetus. Uma ungakwazi ukwenqaba ukwelashwa, lona wesifazane kufanele ashintshe ekwelashweni kwe-insulin futhi asebenzise izingxube zokwenziwa ukondla ingane.
Isicelo sokusebenza kokulimala kwezinso
Uma kwenzeka ukungasebenzi kahle kwe-renal, ukuthatha i-Dimaril kuyaphulwa. Isiguli kufanele sidluliselwe ekwelashweni kwe-insulin.
Sebenzisa umsebenzi wesibindi okhubazekile
Uma kwenzeka ukwephulwa okuthe xaxa, umthamo ulungiswa ngawodwana, futhi ngesikhathi sokuvuma, kuyadingeka ukubheka njalo ukusebenza kwalo mzimba. Ekukhubazekeni okukhulu, ukwelashwa nge-Dimaril kufakwe contraindication.
Ukweqiwa kweDimaril
Uma isiguli sithathe umthamo omningi womuthi, ushukela wegazi lakhe uzokwehla kakhulu. Lesi simo sihlala kusuka emahoreni ayi-12 kuye kwezinsuku ezintathu futhi singaphinde sihlangane ngemuva kokukhululeka. I-Hypoglycemia ihambisana nalezi zimpawu ezilandelayo:
- Ubuhlungu be-epigastric;
- isicanucanu nokuhlanza
- umbono ongahambisani nokuxhumana;
- ukukhathazeka okukhulayo;
- ukuxhawula isandla;
- coma
- iminyakazo.
Ezimpawu zokuqala ze-hypoglycemia, isiguli kufanele sibonane nodokotela ngokushesha.
Ukusuka kwe-overdose ye-Dimaril, izinga likashukela lehla kakhulu. Ezimpawu zokuqala ze-hypoglycemia, isiguli kufanele sibonane nodokotela ngokushesha.
Ukuxhumana nezinye izidakamizwa
Ngaphambi kokuqala ukwelashwa, ukunakwa kufanele kukhokhwe ekuxhumaneni kweDimaril nezinye izidakamizwa. Ukwanda kwamazinga kashukela kungenzeka lapho kuhlanganiswa namaqembu alandelayo emithi:
- ama-estrogens nama-progestogens;
- i-thiazide diuretics;
- ama-saluretics;
- imishanguzo eyenza umsebenzi we-thyroid ube ngokwejwayelekile;
- glucocorticoids;
- i-sympathomimetics;
- adrenaline
- i-nicotinic acid;
- ama-laxatives;
- phenytoin;
- diazoxide;
- i-glucagon;
- ama-barbiturates kanye ne-rifampicin;
- acetozolamide.
Uma isiguli sithatha i-Dimaril kanye nezinye izidakamizwa (ngokwesibonelo, okuphuma ku-coumarin) ngasikhathi sinye, lokhu kuhlanganiswa kungakhuphula futhi kunciphise ukugxila kwe-glucose, ngakho-ke kungcono ukuxhumanisa ukusetshenziswa kwezidakamizwa nodokotela wakho.
Ukuhambisana notshwala
I-Ethanol ingaphakamisa noma yehlise amazinga kashukela, kepha le nqubo ayilindelekile. Ngalesi sizathu, kunconywa ukuthi uyeke ukuphuza utshwala noma uthintane nodokotela ngokuthatha utshwala.
Ama-Analog
Uma ungasibekezeleli lesi sidakamizwa noma ufuna umuthi ngentengo ephansi, kufanele uzijwayeze ngenombolo yama-analogues:
- I-Glimepiride - kusuka kuma-ruble ayi-129;
- I-Amaril - kusuka kuma-ruble angama-354 .;
- I-Diamerid - kusuka kuma-ruble angama-226.
Ngaphambi kokuqala isifundo sokuthatha ngokucophelela imiyalo noma uthinte uchwepheshe obambe iqhaza ekwelashweni kwakho.
Imibandela yekhefu lekhemisi
Kudingeka umuthi ukuthenga umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
I-Dimaril isatshalaliswa emakhemisi ngomuthi.
Intengo ye-Dimaril
Izindleko ezijwayelekile zomuthi zingama-ruble ayi-1000.
Izimo zokugcina zomuthi
Umuthi kufanele ugcinwe endaweni eyomile, uvikeleke elangeni eliqondile futhi ungatholakali ezinganeni. Ukushisa kwesitoreji - kuze kufike ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
I-PJSC "i-Kievmedpreparat", e-Ukraine.
Kunconywa ukuthi uyeke ukuphuza utshwala noma ubonane nodokotela ngokuphuza utshwala.
Ukubuyekezwa mayelana ne-Dimaril
U-Irina, oneminyaka engama-29, Kharkov
Umuthi wanqunywa yi-endocrinologist ukuze kugcinwe amazinga ashukela ajwayelekile. Njengayo yonke eminye imithi, le khambi libangele i-hypoglycemia neminye imiphumela emibi. Ngosuku lwesibili lokwelashwa, izinhlungu zesisu, isicanucanu kwavela. Ngenxa yalokhu, kwadingeka ngishintshele ekwelashweni kwe-insulin, ngoba cishe kwakunzima ukubekezelela.
U-Alexander, oneminyaka engama-41 ubudala, eKiev
Udokotela ukunqume lokhu kwelashwa isifo sikashukela sohlobo 2. Wasebenzise umuthi uhlangana ne-metformin. Ngizwe umphumela usevele ngosuku 2, akukho miphumela emibi.
