Umuthi Diosmin: imiyalo esetshenzisiwe

I-Diosmin umuthi onomphumela we-venoprotective. Umuthi usetshenziselwa ukwelashwa nokuvimbela imithambo ye-varicose yamaphethelo aphansi, ama-hemorrhoids. Umuthi usiza ukuqeda ubukhulu kanye nokukhathala emilenzeni, ukufihla inqwaba yemithambo, kunika ukumelana kwezindonga zemithambo emiphumeleni yezimpawu ezingezinhle. Lapho uthatha i-Diosmin, isifo sezinhlungu siyakhululeka.

Igama

NgesiLatin - Diosmin.

I-Diosmin umuthi onomphumela we-venoprotective.

I-ATX

C05CA03.

Khipha amafomu nokwakheka

Umuthi uyatholakala ngesimo sethebulethi. Amathebulethi anomumo oyindilinga we-biconvex futhi ahlanganiswa nge-membrane yefilimu. Ithebhulethi eyi-1 iqukethe u-500 mg wento esebenzayo - diosmin. Njengoba kusetshenziswa izakhi ezisizayo ekwakheni umuthi:

• isitashi se-sodium carboxymethyl;
• i-magnesium stearate;
• dihydrogenated calcium hydrogen phosphate;
• i-hydroxypropyl cellulose;
• i-microcrystalline cellulose.

I-membrane yefilimu iqukethe i-hypromellose, i-titanium dioxide, i-macrogol 6000. Umbala ophuzi wamathebulethi kungenxa yobukhona bedayi ophuzi obususelwa ku-iron oxide.

Lapho uthatha i-Diosmin, isifo sezinhlungu siyakhululeka.

Umuthi uyatholakala emaphaketheni amakhadibhodi aqukethe kusuka ku-1 kuya ku-6 maleyili, ahambisana nemiyalo yokusetshenziswa. Kumaphakethe okulimaza kukhona amaphilisi ayi-10 noma ayi-15.

Isenzo se-Pharmacological

Umuthi unemiphumela eminingana yekhemikhali:

• i-venotonic;
• i-angioprotective;
• ukuvikela nokumelana okwandayo kwe-endothelium yama-veins ezintweni zangaphandle, ukulimala komzimba kanye nokwenziwa.

Umphumela wokwelapha utholakala ngokubonga kumakhemikhali e-diosmin, okusho izinto ezisebenzayo. Ukwakheka kwalo muthi kufaka ama-flavonoid (hesperidin) njengezakhi ezisizayo. Le nhlanganisela yamakhompiyutha asebenzayo inyusa ukukhululeka kwe-norepinephrine, ihomoni ye-adrenal cortex, edingekayo ekunciphiseni kwemikhumbi e-venous. Ngenxa yalokhu, ithoni ye-vascular iyanda, kuya ngethamo elithathiwe.

Ngenxa yesenzo se-angioprotective, i-venous hypertension iyancishiswa.

Ngaphansi kwesenzo sezakhi zamakhemikhali ezisebenzayo, lokhu kusabela okuhle okulandelayo kwenzeka:

• ngokuya ngenani lamathebulethi athathwe, ukuqina kwama-capillaries kuyanda lapho kugcwaliswa ngegazi (ingozi yokuqothuka kwezindonga ze-vascular iyancishiswa);
• ukuvunywa kwemithambo yegazi kuyancipha;
• ukugwinya emithanjeni kuyeka ngenxa yokwehla kwethamo legazi eligcwele i-carbon dioxide;
• i-microcirculation kuma-capillaries amancane ayathuthuka.

Ngenxa yomphumela we-angioprotective, i-venous hypertension iyancipha, futhi ukuphuma kwegazi emithanjeni emikhulu kuyanda. Kukhona ukwanda kokumelana nemisipha. Esikhathini sokusebenza, umuthi unyusa ingcindezi esikhathini se-systole ne-diastole.

Isakhiwo esisebenzayo se-diosmin sithuthukisa ukudonsa kwe-lymphatic, ngenxa yalokho imvamisa yezinkontileka zama-lymph node ikhuphuka. Isilinganiso esilinganayo somphumela kanye nomthamo ubonwa lapho uthatha umuthi ongu-1000 mg.

I-Pharmacokinetics

Lapho ihanjiswa ngomlomo, umuthi udonswa ngokushesha emathunjini amancane ngemuva kwamahora ama-2 emva kokuphatha. Into esebenzayo ifinyelela amazinga aphezulu we-plasma kungakapheli amahora angama-5. Kulokhu, kukhona ukunqwabelana kwe-diosmin emithanjeni nasemgodini oshubile, imithambo ye-venous yamaphethelo aphansi. Ngenxa yokubopha amaprotheni e-plasma, umuthi usatshalaliswa ngokukhethekile kwizitho nezicubu. Ukusabalalisa okukhethiwe kuqala ngemuva kwamahora we-9 ngemuva kokuthatha umuthi futhi kuthathe amahora angama-90.

Lapho ihanjiswa ngomlomo, umuthi udonswa ngokushesha amathumbu amancane.

Ukuqedwa kwesigamu sempilo kufinyelela emahoreni ayi-11. Akukho ukungena kwe-diosmin ngomgoqo we-hematoplacental kuyabonwa. Umuthi ushiya umzimba ikakhulukazi ohlelweni lokuchama ngo-78%, ukhululwe ngo-11% ngamalongwe, u-2.4% ukhishwe ku-bile.

Izinkomba zokusetshenziswa

Umuthi usetshenziselwa ukwelapha nokuvikela isithombe somtholampilo sama-varicose veins asemaphethelweni aphansi. Kusetshenziselwa ama-hemorrhoid ngesikhathi sokuqhuma, ngenxa yokuphazamiseka kwe-capillary microcirculation kanye nokwelashwa kokungapheleli kwe-lymphovenous insuffence yemikhawulo ephansi yokwenza ngcono ukuphuma kwe-lymph.

Contraindication

Umuthi awunconywa noma awenqatshelwe ukusetshenziswa uma kukhona ukuthikamezeka okuthe xaxa kwezicubu ezihlanganisweni zokwakheka zomuthi nasezinganeni ezingaphansi kweminyaka engu-16 ubudala.

Ungayithatha kanjani

Umuthi wenzelwe ukuphathwa ngomlomo. Kunconywa ukuthatha umuthi ngesikhathi sokudla ukuze ukhuphule izinga lokufakwa. Umthamo kanye nesikhathi sokwelashwa kunqunywa uchwepheshe wezokwelapha osuselwa kudatha evela ocwaningweni lwezinsizakalo kanye nelabhorethri, izici ngazinye zomzimba wesiguli. Indima ebalulekile ekunqumeni uhlobo lonyango idlalwa ngobunzima kanye nohlobo lwenqubo ye-pathological.

Ngokwesilinganiso, ukwelashwa kuthatha izinyanga ezimbili kuya kweziyi-6.

Ngo-mellitus ongaxhomekeli ku-insulin futhi ongathembela ku-insulin, ukulungiswa kokungezelelwa komthamo akudingeki.

Ngoshukela

Uma kwenzeka kunenkinga yesifo sikashukela esingaxakisi ku-insulin futhi engatheni i-insulin, ukulungiswa kwemithamo eyengeziwe akudingekile, ngoba umuthi awuthinti ukuhlangana kwe-glucose egazini futhi akuwuthinti umsebenzi wokusebenza kwamanyikwe.

Imiphumela emibi

Kwesinye isikhathi ngemuva kokuthatha i-Diosmin, kungahle kube nesiyezi.

Kwesinye isikhathi ngemuva kokuthatha i-Diosmin, kungahle kube ne-nausea.

Ngesinye isikhathi ngemuva kokuthatha i-Diosmin, kungahle kube ne-edema kaQuincke.

Imiyalo ekhethekile

Ngokwelashwa kwezidakamizwa, i-Diosmin iyanconywa ukuhola indlela yokuphila enempilo, ukulinganisela kokudla okunempilo ukunciphisa isisindo somzimba nokuhamba nsuku zonke kumasokisi akhethekile. Lezi zinyathelo zifaka isandla ekuthuthukiseni ukuhamba kwegazi esiteshini se-venous. Umphumela omkhulu wokwelapha izidakamizwa ungatholwa uma uhlanganiswa nomsebenzi womzimba.

Iziguli zithambekele ekubonakalisweni kokuphendula kwe-anaphylactic, ngaphambi kokuqala ukwelashwa, kunconywa ukwenza izivivinyo zokungezwani nokubekezelela izidakamizwa.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Umuthi uvunyelwe ukuthathwa ngesikhathi sokuthuthukiswa kwe-embryonic, ngoba amakhemikhali e-diosmin awanawo amandla okufaka isithiyo se-placental. Umuthi awunawo umphumela we-teratogenic kwi-fetus; isetshenziswa abesifazane abakhulelwe ukudambisa ukuvuvukala nobunzima emilenzeni. Ngaphezu kwalokho, ku-trimester ye-III yokukhulelwa, kunconywa ukuthi uyeke ukuthatha lo muthi emavikini amabili ngaphambi kosuku lokulinganisa oluzelwe.

Ngesikhathi sokulashwa kwezidakamizwa, ukuncelisa kuyanconywa ukuthi kumiswe, ngoba akukho datha evela ezifundweni zomtholampilo ekuqongeleleni i-diosmin emahlanjeni ama-mammary.

Umuthi uvunyelwe ukuthathwa ngesikhathi sokukhula kombungu.

Ukuhambisana notshwala

Ekuqhubekeni kwezifundo zemitholampilo, akukho ukuthintana kokuxubana kwe-diosmin ne-ethyl utshwala obekutholakele, kepha kunconyelwa ukwenqaba ukuphuza utshwala ngenkathi ulashwa nomuthi.

Kubalulekile ukukhumbula ukuthi i-ethanol ithinta kabi amaseli wesibindi futhi inyusa ubuthi bezidakamizwa ezilwa nama-hepatocytes. Ngaphansi kwezimo zokunyuswa komthwalo, amangqamuzana e-hepatic ayafa, kuyilapho izindawo ze-necrotic zithathelwa indawo izicubu ezithintekayo. Ukwehla kwamafutha kwesibindi kukhuphula impilo yengxenye yesidakamizwa, engathathi hlangothi ku-hepatocytes.

Ngaphezu kwalokho, i-ethanol ibangela ukuhlangana kwamangqamuzana abomvu egazi. Lapho kunamathela ndawonye, ​​amayunithi egazi akha iziqeshana ezigcwalisa i-lumen ye-vascular. Ngenxa yalokho, ingcindezi esegazini iphakama, kuvela i-venous stasis. Lokhu kuthinta kabi lonke uhlelo lwenhliziyo, olunciphisa umphumela wokwelapha umuthi.

Uma isiguli sigula ngemuva kokuthatha i-Diosmin, futhi sekudlule amahora angama-4 seliphuze ipilisi, lowo ohlukumezekile kudingeka ahlukunyezwe esiswini.

Ukweqisa

Ngenkathi uthatha umthamo omkhulu, akukho ukudakwa komzimba. Akunazimo zokusebenzisa ngokweqile. Ngokuhlukunyezwa ngomuthi, amathuba emiphumela emibi ayanda. Ukwanda kwemiphumela emibi kungenzeka.

Uma isiguli sigula ngemuva kokuthatha i-Diosmin, futhi sekudlule amahora angama-4 seliphuze ipilisi, lowo ohlukumezekile kudingeka ahlukunyezwe esiswini, ahlanzeke, futhi anikeze i-adsorbent. Asikho i-antidote ethile, ngakho-ke, ezimeni zokuma, ukwelashwa kuhloselwe ukuqeda isithombe esinezimpawu.

Ukuxhumana nezinye izidakamizwa

Ngokusebenzisa kanyekanye i-Diosmin ne-Epinephrine, iSerotonin, i-Norepinephrine, ukwanda komphumela wokwelapha (ukuncipha kwemithambo yegazi) kwalesi sikhathi sokugcina kuyabonakala. Ukungaphenduki kokungafani akubonakali phakathi nezifundo.

Ukuphepha kokuphepha

Kumele kukhunjulwe ukuthi ngesikhathi sokuqhuma kwama-hemorrhoids, amaphilisi e-Diosmin adinga ukusetshenziswa isikhashana. Ukwelashwa kwezidakamizwa akufanele kuthathe indawo yokwelashwa okuyisisekelo neminye imithi ukuqeda izifo ze-anal. Uma isithombe esinophawu lapho uthatha i-Diosmin singashabalali kungakapheli izinsuku ezingama-3-5, khona-ke kuyadingeka ukwenza uhlolo lwe-proctological lwezicubu ezithambile nemikhumbi ye-rectum. Kulokhu, ukubonisana nodokotela oholayo esikhundleni sokulashwa kuyadingeka.

Kumele kukhunjulwe ukuthi ngesikhathi sokuqhuma kwama-hemorrhoids, amaphilisi e-Diosmin adinga ukusetshenziswa isikhashana.

Ngesikhathi sokulashwa kwezidakamizwa ngeDiosmin, kuyadingeka ukugwema ukuhamba elangeni eliqondile futhi ungahambisani nemisebe ye-ultraviolet, ngoba kunengozi yokuthola izithombe - ukuzwela ukukhanya, kanye nokwenyuka kwengcindezi yegazi. I-Hypertension izosithinta kabi isimo semithambo yegazi.

Umkhiqizi

ICJSC Canonfarm Production, eRussia.

Ama-analog kaDiosmin

Ama-analogs wesakhiwo kanye nezinto esikhundleni sokwenza okufana kwesenzo kufaka phakathi i-venotonics elandelayo ne-angioprotectors:

• Phlebodia 600 mg;
• IVenus;
• IVenosmin;
• IVenozol

I-Detralex, equkethe ama-450 mg we-diosmin ne-50 mg ye-hesperidin, ingeyamalungiselelo ahlanganisiwe afanayo entweni esebenzayo.

Ngesikhathi sokulashwa kwezidakamizwa ngeDiosmin, ukuhamba elangeni eliqondile kufanele kugwenywe.

Ukushintshela komunye umuthi wodwa akunconywa. Ngaphambi kokubuyisela esikhundleni kuyadingeka ukubonisana nodokotela wakho. Kulokhu, ukukhetha umuthi osebenzayo futhi ophephile, ukubekelwa phansi kwesiguli umuthi kuyabhekelelwa.

Imibandela yekhefu lekhemisi

Umuthi uthengiswa ngumbhalo kuphela.

Intengo

Izindleko ezijwayelekile zethebhulethi le-Diosmin ziyahlukahluka kububanzi bezintengo ukusuka kuma-ruble angama-400 kuye kwangama-700, ngokuya ngenani lamathebulethi amaphakethe.

Izimo zesitoreji se-Diosmin

Kunconywa ukugcina umuthi endaweni eyomile, ukhawulelwe ukungena kokukhanya kwelanga, emazingeni okushisa afinyelela ku + 25 ° C. Ungavumeli umuthi uwele ezandleni zezingane.

Isikhathi sokuphelelwa yisikhathi

Impilo yeshalofu kusuka ngosuku okukhishwe ngalo kwiphakethe yiminyaka emi-2. Kwenqatshelwe ngokuphelele ukusebenzisa umuthi ngemuva kosuku lokuphelelwa yisikhathi.

Ukubuyekezwa kodokotela neziguli mayelana neDiosmin

U-Alexander Ilyasov, udokotela wezokwelapha, uRostov-on-Don

I-phlebotonic okuwukuphela kwayo engiyinquma ezigulini ezisebenzayo emitholampilo yama-varicose veins asemaphethelweni aphansi, ama-hemorrhoid kanye nokuphazamiseka kwemithambo yegazi ngenxa yezifo zesistimu yenhliziyo. Uma ngiqhathanisa ama-analogues, okungenani ngigcina ngibona umphumela omuhle wokwelapha. Umuthi uyatholakala ngesimo samathebulethi angama-500 mg, yingakho kulula ukulungisa umthamo, isiguli akufanele sivakashele udokotela njalo. Okuwukuphela kokudonsayo intengo, ngenxa yayo okudingekayo ukuphikisana neziguli ezifuna ukuthenga intela eshibhile.

Anatoly Lukashevich, udokotela ohlinzayo jikelele, i-Arkhangelsk

Ngizama ukunquma i-drug izidakamizwa i-Diosmin ezigulini ezine-varicose veins ngoba umuthi usuziqinisile emakethe yamakhemikhali ngenxa yomphumela omuhle emikhunjini yezindawo eziphansi ne-rectum. Ngokuphikisana nesizinda sokusebenzisa umuthi, ukusebenza kwe-microcirculatory kwama-capillaries kuyathuthuka. Ngincoma ukuyisebenzisa nokudla ukugwema imiphumela emibi ohlelweni lokugaya ukudla. Ikakhulu kubantu abane-peptic ulcer.

UMarina Khoroshevskaya, udokotela ohlinzeka ngemithambo, eMoscow

Ngenkathi ngiphuza umuthi, ngibona iziguli ukuthuthuka hhayi kokujikeleza kwe-microcirculatory kuphela, kepha futhi nokwanda kwethoni yemithambo maqondana nemithambo yomzimba engenalutho. Ngibheka umuthi njengesixazululo esisebenzayo hhayi kuphela ngenxa yomphumela onamandla wokwelapha, kodwa futhi nangenxa yokuthola okungatheni kwemiphumela emibi. Kokwephulwa, i-hypersensitivity kuphela ekhemeleni lamakhemikhali le-diosmin lihlukaniswa, okuthi ezimweni ezingavamile kuholele ekuqhekekeni kwe-anaphylactic.

UNatya Koroleva, oneminyaka engama-37, eSt

Udokotela ohlinzayo unquma ukuphuza amaphilisi e-Diosmin amahlandla ama-2 ngosuku kusuka emithanjeni ye-varicose emilenzeni. Saw 1 isiqephu ekuseni izinyanga ezimbili. Amaviki okuqala ayi-2,5 awukho umphumela, imilenze yayidiniwe, imithambo yayibuhlungu kakhulu, izinyawo zazivuvukala ebusuku. Wacabanga ukuyeka ukuphuza, kepha wanquma ukuphuza elinye futhi isonto. Kwakukhona ukuphumula, izinhlungu emilenzeni yami zazingasekho. Ngakwazi ukulala kahle. Ngisho nokugcotshwa kwamafutha no ayisikhilimu bekungafanele ukuthi kusetshenziswe, kepha umphumela uhlala isikhathi eside. Angibonanga imiphumela emibi, amaphilisi awazange athinte ukugaya nesisu, okwakungu-plus enkulu. Ngigculisekile ngomphumela.

UKonstantin Voronovsky, oneminyaka engama-44 ubudala, eYekaterinburg

Ukugcina umphumela, kufanele uphuze okungenani izinyanga ezi-2. Yemukelwa kusuka kuma-hemorrhoid asebusweni njengoba kuchazwe yi-proctologist. Ngiphuze izidakamizwa eziningi, ngisebenzisa ukhilimu, kepha angizuzanga ngomphumela. Lapho uthatha amaphilisi, ukulunywa, izinhlungu nokulimala ku-anus kwaqala ukunyamalala phakathi nesonto lokuqala. Njengesilinganiso sokuvimbela, ngiphuza amaphilisi ngendlela yezifundo izikhathi ezi-2 ngonyaka. Angiqaphelanga okunye ukusabela okwenziwa yi-allergic, uhudo noma eminye imiphumela emibi, kodwa inani lentengo liphezulu uma uthola ukwelashwa okuhlala isikhathi eside. Ikakhulu uma unqunyelwe ukuphuza amaphilisi ama-4-6 ngosuku. Futhi, hhayi yonke indawo ethengiswayo.