I-Aprovel 150 isidakamizwa esinomphumela we-hypotensive (ukwehlisa ingcindezi). Isetshenziselwa kabanzi ukwelapha izinhlobo ezahlukahlukene ze-arterial hypertension.
Igama Lezwe elingafanele
I-INN yesidakamizwa yi-Irbesartan.
I-Aprovel 150 isidakamizwa esinomphumela we-hypotensive (ukwehlisa ingcindezi).
I-ATX
Ikhodi ye-ATX: C09CA04.
Khipha amafomu nokwakheka
Umuthi usesimweni samathebhulethi amhlophe ahlanganiswa namafilimu. Ekhadini lekhadibhodi lomuthi kukhona amaphilisi ayi-14 noma angama-28 ezinhlakeni.
Ezibhebheni, into esetshenziswayo (i-irbesartan) iqukethe inani le-150 mg. Izingxenye ezisizayo yile:
- i-lactose monohydrate;
- i-microcrystalline cellulose;
- i-croscarmellose sodium;
- i-hypromellose;
- i-magnesium stearate;
- isilika.
Izinto ezakha ukuhlanganiswa kwamafilimu:
- I-Opadra imhlophe;
- i-carnauba wax.
I-Aprovel 150 yenziwa ngendlela yamathebulethi amhlophe amafilimu.
Isenzo se-Pharmacological
Isenzo se-Pharmacological - antihypertensive (ukwehlisa umfutho wegazi).
Into esebenzayo yesidakamizwa i-angiotensin II receptor antagonist (i-oligopeptide hormone). Umuthi uveza isenzo se-hormone. Ngenxa yalokho, izinga le-renin egazini liyakhuphuka futhi okuqukethwe kwe-aldosterone kuyancipha.
Umphumela we-antihypertensive wenzeka emahoreni angama-3-5 futhi uhlala usuku lonke. Ngomphumela wesikhathi eside, udinga ukuthatha umuthi amasonto ama-2-4. Ngemuva kokuhoxiswa kwamathebulethi, asikho isifo esibukhali sokuhoxa (ingcindezi ikhuphuka kancane).
I-Pharmacokinetics
Umuthi ubonakala ngokufakwa ngokushesha egunjini lokugaya ukudla. Ukudla akuguquki isilinganiso sokumunyiswa. I-Ibersartan ine-bioavailability ephezulu (ifinyelela ku-80%) nokubopha okuhle kumaphrotheni egazi (aze afike ku-96%). Okuqukethwe okuphezulu kakhulu kwento esegazini kutholakala ngemuva kwamahora ama-2.
Umuthi ukhishwa emchameni ikakhulukazi ngendlela yama-metabolites.
Ukuguqulwa kwamandla kwento emzimbeni kwenzeka kwesibindi. Isikhathi sokuqothula singamahora angama-22-30. Umuthi ukhishwa ku-bile, umchamo nezindunduma ikakhulu ngendlela yama-metabolites. Ngokulashwa isikhathi eside nge-irbesartan, ukunqwabelana kwayo okuncane egazini kuyabonakala (kuze kufike ku-20%).
Izinkomba zokusetshenziswa
Umuthi usetshenziselwa ukwelapha:
- I-hypertension ye-Arterial (izinhlobo ezahlukahlukene zezifundo). Amathebulethi angaba yingxenye yokwelashwa kwe-antihypertensive.
- Isifo sezinso esibangelwa umfutho wegazi ophakeme noma uhlobo II sikashukela mellitus.
Contraindication
I-Aprovel ayivunyelwe kwabesifazane abakhulelwe nabancelayo, kanye nezingane ezingaphansi kweminyaka engu-18. Okunye ukwephulwa yile:
- I-Psychology Yesibindi (ukwehluleka kwesibindi).
- Ukushoda kwe-lactase.
- I-Lactose noma i-galactose ukungabekezeleli (malabsorption).
- Ukungabekezelelani komuntu ngamunye kuma-irbesartan noma abathola.
Ngokunakekela
Odokotela banquma isidakamizwa ngokuqapha ngezinga eliphansi le-sodium ku-plasma, aortic kanye ne-mitral stenosis, ukwehluleka kwezinso, i-hypovolemia, i-atherosranceotic pathologies nezifo zenhliziyo (isifo se-coronary, i-cardiomyopathy). Ngala ma-pathologies, ukwehla okukhulu kwengcindezi kungenzeka, okuhambisana nezimpawu zomtholampilo.
Awukwazi ukuthatha umuthi we-pathologies yesibindi.
Ungayithatha kanjani i-Aprovel 150?
Umuthi wenzelwe ukusetshenziswa komlomo.
Esigabeni sokuqala sokwelashwa, isiguli sinqunywe i-150 mg ye-irbesartan (1 ithebhulethi ye-Aprovel). Umphumela we-antihypertensive uphikelela usuku. Uma umfutho wegazi ungancipha, khona-ke umthamo unyuswa waba ngu-300 mg.
Iziguli ezine-nephropathy ziyelulekwa ukuba zithathe i-300 mg ye-irbesartan ngemiphumela ehlala njalo. Udokotela anganciphisa umthamo wokuqala ube ngu-75 mg ekwelashweni kwabantu asebekhulile (abangaphezu kuka-65) kanye neziguli ezikwi-hemodialysis.
Ngoshukela
Iziguli ezinesifo sikashukela sohlobo 2 zinqunywa ithebhulethi elilodwa ngosuku ekuqaleni kokwelashwa. Uma kunesidingo, umthamo wansuku zonke kufanele ukhushulwe kumathebhulethi ama-2. Umuthi kufanele uphathwe ngaphansi kokuqondisa udokotela.
Imiphumela emibi ye-Aprovel 150
Ubudlelwano phakathi kokuvela kokunye okungahambi kahle nokusetshenziswa kwalesi sidakamizwa akukaze kufakazelwe. Lokhu kungenxa yemiphumela yocwaningo olulawulwa yi-placebo, lapho imiphumela emibi nayo yenzeka kubantu abathatha i-placebo.
Ngesikhathi sokwelashwa, izimpawu ze-malaise ezijwayelekile zingavela:
- ukukhathala okukhulu;
- ukuqaqamba kwemisipha;
- i-asthenia.
Ukuphazamiseka kwemetabolic (hyperkalemia) kuyenzeka.
Amapheshana wesisu
Imiphumela emibi ejwayelekile evela emgudwini we-gastrointestinal yi-nausea nokuhlanza. Izimpawu ze-dyspeptic kanye nohudo akuvamile ukwenzeka.
Lapho uthatha i-Aprovel, imiphumela emibi ejwayelekile evela emgodini wesisu yi-nausea nokuhlanza.
Isistimu yezinzwa ephakathi
Ezinye iziguli zizwa i-migraines nesiyezi.
Kusuka ohlelweni lokuphefumula
Ukukhwehlela okuphefumulayo kungenzeka.
Kusuka ohlelweni lwezitho zofuzo
Ezinye iziguli zithola umsebenzi ocansini ongafanele.
Kusuka ohlelweni lwezinhliziyo
Umphumela omubi emsebenzini wenhliziyo ubonakaliswa ukwephulwa kwenhliziyo (tachycardia), i-orthostatic hypotension, kanye ne-hyperemia yesikhumba sobuso.
Allergies
Lapho uthatha umuthi, kungenzeka ukuthuthukisa ukungezwani komzimba okufana ne-Quema ye-Quema, i-urticaria, kanye nokulunywa.
Umthelela ekhonweni lokulawula izindlela
Umphumela walesi sidakamizwa ekuhlushwa awuqondakali ngokuphelele. Kodwa phakathi nokwelashwa, imiphumela emibi evela ohlelweni lwezinzwa oluyinhloko ingavela. Iziguli ezithola isiyezi ne-asthenia azinconywa ukushayela izimoto noma ezinye izindlela.
Imiyalo ekhethekile
Nge-aldosteronism eyinhloko, kunokuntuleka komphumela kusuka ku-RAAS inhibitors (uhlelo lwe-retin-angiotensin-aldosterone), kufaka phakathi i-Aprovel.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi awuvunyelwe kubantu besifazane abakhulelwe futhi abakhipha izisu ngenxa yokuntuleka kwezifundo ezinokwethenjwa zemitholampilo.
Ukuqokwa kwe-Aprovel ezinganeni eziyi-150
Umuthi uhloselwe ukwelashwa kwabantu abadala kuphela.
Sebenzisa ebudaleni
Ezigulini esezikhulile, umuthi unqunywa kumthamo ojwayelekile. Ngokwesincomo sikadokotela, umthamo wokuqala ungancishiselwa ku-75 mg. Ngesikhathi sokwelashwa, kuyadingeka ukuqapha isimo sesibindi, izinso nokuqukethwe kwe-potassium emzimbeni.
Isicelo sokusebenza kokulimala kwezinso
Kubantu abanomsebenzi we-renal okhubazekile (ezigabeni zokuqala), umuthi ubekiwe ngokuqapha. Ukwemukelwa kwe-Aprovel kufanele kuhambisane nokuqapha izinga le-creatinine ne-potassium esegazini.
Akunconyelwe ukunquma lesi sidakamizwa uma ukusebenza kwezinso kuncike ku-RAAS. Umsebenzi wayo lapho uthatha i-Aprovel uvinjelwe, okuholela kuma-pathologies ezinso ezinzima.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukwehluleka kwesibindi okukhulu kungukuphikisana nokusetshenziswa komuthi. Ezigabeni zokuqala ze-pathology, umuthi usetshenziswa ngaphansi kokuqashwa ngokuqinile kodokotela.
Ukweqisa kwe-Aprovel 150
Ngokusetshenziswa isikhathi eside komthamo omkhulu womuthi, ama-pathologies abucayi nezimo ezisongela impilo azikasungulwa. Mhlawumbe ukuthuthukiswa kwe-hyperension ye-arterial kanye nokudakwa komzimba (ukuhlanza, ukuhudula).
Uma kunezimpawu ze-overdose, kuyadingeka ukuthi uhlambe isisu uthathe i-adsorbent (namalahle ocushiwe, iPolysorb MP noma i-Enterosgel). I-Hemodialysis yokususa izinto emzimbeni ayenziwa. Ukwelashwa okubonakalayo kungadingeka.
Ukuxhumana nezinye izidakamizwa
Umuthi ungahlanganiswa nezinye izidakamizwa ze-antihypertensive, ezifana ne-thiazide diuretics, i-calcium blockers blockers ne-β-blockers. Le nhlanganisela iholela ekwandeni komphumela we-hypotensive. Ngemithamo ekhethwe ngokungafanele, i-hypotension ingahle ikhule.
Yehlisa umphumela we-Aprovel drug Ibuprofen.
Ngokuqapha, i-Aprovel kufanele ithathwe nge-heparin, i-potureum-sparing diuretics nemikhiqizo equkethe i-potassium. Ukusetshenziswa okuvumelanayo ne-ACE inhibitors noma i-Aliskiren ene-nephropathy kuyinto engathandeki.
Izidakamizwa ezivela eqenjini le-NSAID zenza buthaka umphumela we-hypotensive (Paracetamol, Nurofen, Ibuprofen, njll.). Ukusetshenziswa okuhlangene kwalezi zidakamizwa kungadala ukwehluleka kwezinso ne-hyperkalemia.
Ukuhambisana notshwala
Ukuphuza utshwala ngesikhathi sokwelashwa kwe-Aprovel akuvunyelwe. Utshwala bandisa ingozi yokuba nemiphumela emibi kakhulu.
Ama-Analog
Izithonjana ezidumile zomuthi: u-Irbesartan no-Ibertan. Lezi zimali ziqukethe into efanayo esebenzayo - i-irbesartan.
Ama-analogues aseRussia yi-Irsar neBlocktran.
Imibandela yekhefu lekhemisi
I-Aprovel iyatholakala ngomuthi kadokotela.
Intengo ye-Aprovel 150
Intengo yephakethe lamathebhulethi ayi-14 isukela kuma-ruble angama-280 kuya kwangama-350. Iphakethe lamathebhulethi angama-28 libiza ama-ruble angama-500-600.
Izimo zokugcina zomuthi
Umuthi kufanele ugcinwe ngaphandle kokutholwa yizingane emazingeni okushisa afinyelela ku-30 ° C.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshelf iyiminyaka emithathu.
Umkhiqizi
Umkhiqizi - Imboni yeSanofi Winthrop (eFrance).
Ukubuyekezwa kwe-Aprovel 150
Izazi zezenhliziyo
UVladimir, oneminyaka engama-36, eSt
Emsebenzini wami, ngivame ukunikeza leli khambi kwiziguli ezinomfutho wegazi ophakeme. Kubekezelelwa kahle futhi kunomphumela osheshayo. Inzuzo elula yokwamukela nokugcina umphumela amahora angama-24. Imiphumela emibi ayivelakancane.
USvetlana, oneminyaka engama-43, uVladivostok
Lesi sidakamizwa esisebenzayo sokunciphisa umfutho wegazi. Ingabhekelwa iziguli esezikhulile kanye neziguli ezinesifo sikashukela i-mellitus. Ingozi yemiphumela emibi iphansi. Okuwukuphela kwengozi yaleli thuluzi yintengo.
I-analogue ye-Aprovel yisidakamizwa i-Irbesartan, esidonswa ngomuthi kadokotela.
Iziguli
UDiana, oneminyaka engama-52, Izhevsk
Sekuphele isikhathi eside ngihlushwa umfutho wegazi ophakeme. Ngiye ngazama izidakamizwa eziningi, kepha ngathola umphumela ohlala njalo kwa-Aprovel. Ingcindezi igcinwa ezingeni elijwayelekile. Angiboni imiphumela emibi.
U-Alexandra, oneminyaka engama-42, uKrasnodar
Ngiqale ukuphuza la mapilisi njengoba kuyalelwa ngudokotela. Ngiphuza umuthi ekuseni. Isenzo sihlala usuku lonke. Kusukela okokuqala ngaqala ukuzizwa ngingcono.
UDmitry, oneminyaka engama-66, eMoscow
Ngokuphikisana nesizinda sesifo sikashukela, umfutho wegazi wami waqala ukukhuphuka. Udokotela weluleke lo muthi. Isonto lokuqala lokwamukelwa lalingubuthakathaka obuncane, kepha lapho-ke ngazizwa kahle. Sekuphele izinyanga ezintathu ngiphuza lo muthi, futhi nengcindezi ayikhuphuki.
