Umuthi uyatholakala ngesimo isiraphu, amaphilisi, amaphilisi kanye nama-ampoule wokujova okungaphakathi kanye nokulimazeka emzimbeni. Ngaphambi kokusebenzisa umuthi, isiguli kufanele sifunde imiyalo yokusebenzisa futhi sinake imininingwane ngemiphumela emibi.
Igama Lezwe elingafanele
IMeldonium.
I-ATX
C01EV.
Khipha amafomu nokwakheka
Umuthi okukhulunywa ngawo uyinto ye-metabolic ethengiswa ngendlela yamakhompiyutha aqine amhlophe. Umuthi uqukethe i-hygrallopic crystalline powder ngaphandle kwephunga elishiwoyo.
Umuthi uyatholakala ngesimo samaphaphu kanye nama-ampoules wokujova we-intramuscular and intravenous.
Ikhabethe ngalinye liqukethe:
- isakhi esisebenzayo yi-meldonium dihydrate (500 mg);
- ababukeli: isitashi samazambane, i-calcium stearate ne-colloidal silicon dioxide.
Umzimba nesembozo somkhiqizo kwenziwa nge-gelatin ngokufakwa kwenani elincane le-titanium dioxide.
I-Burliton 600 - imiyalo esetshenzisiwe.
I-Chitosan yezidakamizwa: izinkomba kanye nokuphikisana.
Ukusebenzisa ini nokuthi usebenzise kanjani uNarine - funda kulesi sihloko.
Isenzo se-Pharmacological
Amaseli womzimba aqukethe into esebenza ngokomzimba - i-gamma-butyrobetaine. IMeldonium iyi-analogue yale ngxenye futhi isebenza njengesidakamizwa esinciphisa inani lokuphendula kwamakhemikhali. Umuthi ulungisa izinqubo ze-metabolic, uthinta kahle ukuhanjiswa kanye nenqwaba yama-acid acids.
Ezinqubweni ze-ischemic, umuthi uvimbela ukushoda kwe-oksijini emangqamuzaneni, ubuyisela ukungena kwe-adenosine triphosphoric acid - umthombo wamandla wazo zonke izinqubo ze-biochemical.
Ngaso leso sikhathi, isidakamizwa senza inqubo ye-glucose oxidation futhi ithuthukise ukwakheka kwe-gamma-butyrobetaine, ebaluleke kakhulu ekwandiseni i-lumen yemithambo yegazi.
I-Pharmacokinetics
Ngemuva kokuphathwa ngomlomo, okuqukethwe ngamaphilisi kuyabanjwa ngokushesha futhi kugxilwe ku-plasma yesiguli emahoreni angama-1-2.
Ngenqubo yokugaya umzimba, kwakhiwa ama-metabolites amabili esibindini, athi kamuva akhululwe yizinso kungakapheli amahora angama-3-6.
Umuthi muphi?
Ngenxa yemiphumela ye-pharmacological efakiwe, umuthi usetshenziselwa:
- ukunciphisa umthwalo enhliziyweni nokuthuthukisa izinqubo ze-metabolic ku-myocardium;
- kusebenze kwezicubu zomzimba kanye nokulimazeka kokuthambisa;
- ukwelashwa kwe-pathologies yemikhumbi ye-fundus;
- thuthukisa inkumbulo, wandise ukumelana nokucindezela ngokomzimba nangokwengqondo emzimbeni;
- ukuvimbela ukweqisa kwengqondo;
- ukunciphisa ukubumbeka kwamasimu we-necrotic;
- ngcono ukuhamba kwegazi ebuchosheni nokuphuma kwegazi ngesikhathi se-ischemia;
- izindlela zokwelapha izifo zegazi;
- ukuncishiswa kwesikhathi sokuvuselelwa ngemuva kokuhlaselwa yisifo sohlangothi kanye ne-cerebrovascular isifo (CVB);
- ukwenza ngcono imisebenzi ebalulekile yomzimba kanye nokunciphisa izimpawu zokukhathala okungapheli:
- ukukhulisa ukusebenza ngokomzimba nangokwengqondo.
Ngaphezu kwalokho, umuthi uyithuluzi elisebenzayo lokwelashwa kwezifo zohlelo oluphambili lwezinzwa, kubandakanya nezimpawu zokuhoxiswa kotshwala obungamahlalakhona.
Ukusetshenziswa kweMildronate kwezemidlalo
Umuthi unomphumela omuhle empilweni yabasubathi ngesikhathi somncintiswano nokuqeqeshwa, ukhulisa amandla omzimba wokusebenzisa izinsiza kusebenza futhi usheshe uvumelane nezimo ezicindezelayo.
Umuthi awukhulisi ubukhulu bemisipha, kepha usheshisa inqubo yokulungiswa kwezicubu.
Phambilini, le nto yayisetshenziswa ngokuqinile kuyo yonke imidlalo: ukugijima, ukuhamba ngebhayisikile, ithenisi, ukwakha umzimba, ukushushuluza, ukubhukuda, izivivinyo zokuzivocavoca. Kepha namuhla, ukusetshenziswa kwalesi sidakamizwa ukwandisa amandla ngesikhathi sokuqeqeshwa nokuncintisana kunqatshelwe.
Contraindication
Umuthi awuvunyelwe kwiziguli ezinale mibandela elandelayo:
- ukungabekezelelani komuntu ngamunye ezingxenyeni zomuthi;
- ukukhulelwa nokuqunjelwa;
- ukukhuphuka kwengcindezi ye-intracranial okubangelwa ukuba khona kwe-tumor noma ukungasebenzi kahle kwe-venous.
Ngokunakekela
Ukusetshenziswa kwomuthi ezifweni zesibindi noma izinso kungenzeka kuphela ngaphansi kokuqashwa okuqinile kodokotela ohambelayo.
Ungayithatha kanjani iMildronate 500
Umthamo nesikhathi sokuqhubeka kwenkambo sisungulwa uchwepheshe wezokwelapha ngemuva kokwenza izivivinyo ezidingekayo.
Ukusetshenziswa kwenqola enconyiwe:
- Ukwandisa ukusebenza kahle, futhi uma kwenzeka ukucindezela ngokweqile ngokomzimba nangokwengqondo - 500 mg izikhathi ezi-2 ngosuku amasonto ama-2. Ukusetshenziswa okuphindaphindwe ngomuthi kungadingeka ngemuva kwamaviki ama-2-3.
Abasubathi - 500 mg noma ama-1 g izikhathi ezi-2 ngosuku ngaphambi kokuqeqeshwa amasonto ama-2-3. Ngesikhathi somncintiswano - azikho izinsuku ezingama-14. - Ezimweni ezingaluphuzo oludakayo nezimpawu zokuhoxa - 500 mg izikhathi ezi-4 ngosuku izinsuku eziyisikhombisa. Ukusetshenziswa kwesidakamizwa kunqunyelwe ngokuhambisana neminye imithi ethile.
- Nge-angina pectoris, infarction ye-myocardial kanye nokwehluleka kwenhliziyo okungamahlalakhona - 500 mg noma i-1 g ngosuku ngemithamo e-1 noma emi-2 kumaviki ayi-6.
- Nge-menopausal cardiomyopathy - 500 mg ngosuku izinsuku eziyishumi nambili. Ukwelashwa kufaka ukusetshenziswa okuhlanganisiwe kwezidakamizwa.
- Ezimweni zokuhlinzekelwa kwegazi okungahambi kahle ebuchosheni bemvelo engapheli futhi engamahlalakhona, ama-500 mg ngosuku ngemithamo e-1 noma emi-2 yamaviki ayi-6. Ngemuva kokushaywa unhlangothi noma i-cerebrovascular syndrome, kunikezwa umuthi kanye neminye imithi futhi kusetshenziswe ngemuva kokuphela kwenkambo yokwelashwa ngomjovo. Uma kunesidingo, ekwelashweni okuphindaphindwayo (kungabi ngaphezu kwezikhathi ezingama-2-3 ngonyaka), umthamo ubekwa udokotela oya kuye, kuye ngezinkomba.
Umuthi unomphumela othokozisayo, ngakho-ke ukusetshenziswa kwamaphilisi kufanele kwenziwe kungakapheli amahora ayi-17:00.
Ngaphambi noma ngemuva kokudla
Ukusheshisa isenzo samaphilisi, umuthi kufanele usetshenziswe imizuzu engama-20 kuya kwengama-30 ngaphambi kokudla.
Ngingaphuza kangaki
Umthamo omkhulu ovunyelwe wesidakamizwa ngosuku ngu-1 g. Ngokusebenzisa izikhathi ezimbili zamaphilisi, isikhathi esinconyiwe phakathi komthamo amahora angama-12, futhi uma usebenzisa umuthi isikhathi esingu-1 ngosuku - amahora angama-24.
Umthamo wesifo sikashukela
500 mg izikhathi ezi-2 ngosuku.
Imiphumela emibi yeMildronate 500
Kwezinye izimo, ngokusebenzisa komlomo umuthi ezigulini, kutholakala imiphumela emibi elandelayo:
- umphimbo obuhlungu nokukhwehlela;
- ubunzima bokuphefumula: i-apnea noma i-dyspnea;
- ukwephulwa kwemisebenzi yephephana lesisu: ukulahleka kwesifiso, isifo sohudo, isicanucanu, ukugabha, ukunambitheka kwensimbi emlonyeni;
- ukukhuphuka kwesifiso sokuchama;
- ukukhuphuka kwenhliziyo;
- ukwanda noma ukuncipha komfutho wegazi;
- ukwanda kwenani lama-eosinophils;
- ukungahambi kahle komzimba: ukuqubuka esikhunjeni, i-urticaria, ukulunywa, i-edema kaQuincke;
- ukweqisa ngokweqile;
- Ukuwohloka kwesimo esijwayelekile: ubuthakathaka, ukozela, ukuqwasha, umuzwa ongazelelwe wabanda noma wokushisa, wekhanda nesiyezi.
Umthelela ekhonweni lokulawula izindlela
Ukusetshenziswa kwesidakamizwa akuyona inkambiso yokusetshenziselwa umuthi ozimele. Kodwa-ke, uma kwenzeka le miphumela emibi, kufanele wenqabele ukushayela izimoto.
Imiyalo ekhethekile
Ukunquma uMildronate ezinganeni ezingama-500
Umuthi ubekelwe iziguli ezingaphezulu kweminyaka engu-18.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kuqinisekisiwe.
Sebenzisa ebudaleni
Ezigulini esezikhulile, umthamo womuthi ubekiwe ngawodwa. Esikhathini esiningi, uchwepheshe wezokwelapha wehlisa umthamo onconyelwe umuntu omdala.
I-overdose ye-Mildronate 500
Uma kwenzeka kweqisa, izimpawu ezilandelayo ziyabonakala ezigulini:
- ukonakala kwesimo esejwayelekile;
- ikhanda
- ukwehlisa umfutho wegazi;
- tachycardia.
Ngokusetshenziswa ngokweqile kwesidakamizwa, ukwelashwa okulondoloziwe kunqunyelwe ukudambisa izimpawu. Uma kwenzeka kweqa ngokweqile, ukuqapha ukusebenza kwesibindi nezinso kudingekile.
Ukuxhumana nezinye izidakamizwa
Umuthi okukhulunywa ngawo uthuthukisa umphumela wezidakamizwa wehlisa umfutho wegazi, unwebise imithambo emincane nemithambo, uvimbele i-beta-blockers. Umuthi ubuye wenyuse ukusebenza kwezidakamizwa ezibandakanya i-nifedipine ne-nitroglycerin.
Umphumela omuhle wesidakamizwa wabuye wabonwa ngokusetshenziswa kanyekanye kweMeldonium neLisinopril.
Umuthi uvunyelwe ukuhlanganiswa nemithi ethinta kahle i-myocardial oxygen satellite, ukuvimbela ukushayeka kwegazi nokukhula kokuphazamiseka kwesigqi senhliziyo. Umuthi ungasetjenziswa ngokuhlangana nama-bronchodilators ne-diuretics.
Ngokusetshenziswa kwe-meldonium, kanye nemithi eklanyelwe ukwelapha i-immunodefasure syndrome, kunomkhuba omuhle mayelana nokuqedwa kwezimpawu ze-AIDS.
Umphumela omuhle wesidakamizwa wabuye wabonwa ngokusetshenziswa kanyekanye kweMeldonium neLisinopril. Ngakho-ke, phakathi nokwelashwa okuyinkimbinkimbi, ukwanda kwe-lumen yemithambo yegazi, ukukhuphuka kwezinga lokunikezwa kwegazi, kanye nokuqedwa kwemiphumela yokuxineka ngokomzimba noma kwengqondo kuyabonakala.
Ukuhambisana notshwala
Ukuphuza utshwala ngenkathi ukwelashwa kukhulisa imiphumela emibi.
Ama-Analog
Phakathi kokufana kwesidakamizwa, okukhiqizwe ngesimo samaphilisi, okulandelayo kuyabonakala:
- IVasomag;
- I-Cardionate;
- IMeldonium;
- I-Mildronate 250 mg;
- I-Medatern;
- Mildroxin;
- IMeldonius-Eskom;
- Midolat.
Imibandela yekhefu lekhemisi
Ngokusebenzisa umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Kunezimo zokutholwa kwemithi ngaphandle kokuqokwa udokotela. Kodwa-ke, ukuzilapha uvame ukuholela emiphumeleni emibi, futhi lokhu, kungadala imiphumela engenakuphikwa.
Intengo yeMildronate 500
Intengo yeMildronate 500 eRussia ingama-ruble ayi-500-700, kuya ngendawo ethengiswa kuyo.
Izimo zokugcina zomuthi
Umuthi kufanele ugcinwe endaweni evikelwe umswakama, emazingeni okushisa angeqi ku-25 ° C. Ukutholwa kwezingane ngomuthi kumele kukhawulelwe.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-4 kusukela ngosuku lokukhishwa.
Umkhiqizi
Grindeks AO.
Ukubuyekezwa kwe-Mildronate 500
Izazi zezenhliziyo
U-Igor, oneminyaka engama-47 ubudala, u-Irkutsk
Emphakathini, umuthi ubhekwa njengosebenza ekwelapheni izifo zenhliziyo. Umuthi unemiphumela emihle, kepha asikho isizathu sokuqokwa kwawo emithini. Kulokhu, akumelwe sikhohlwe ukuthi umuthi unemiphumela emibi emningi.
ULily, oneminyaka engama-38, uSaratov
Ngenxa yezwi lomlomo, iziguli ngokwazo ziletha lo muthi ehhovisi lodokotela ukuze uqinisekise ukusebenza kwawo kahle futhi uthole nomuthi. Ekwelapheni izifo zenhliziyo, umuthi uyasebenza, kepha kuphela ngokuhlangana nokwelashwa kwe-pathogenetic.
Iziguli
U-Olesya, oneminyaka engama-29, uKursk
Ngiqale ukuthatha imishanguzo njengokuyalelwa udokotela wami. Ukhathazekile mayelana ukozela, i-lethargy, i-tinnitus yesikhathi esithile. Ngiphuze amaphilisi angama-500 mg amasonto ama-2 futhi ngezwa ukuqina kwamandla. Yize ekuqaleni kwesifundo angizange ngiqaphele izinguquko.
U-Ilya, oneminyaka engama-30 ubudala, uKolomna
Eminyakeni yami ngihlushwa i-angina pectoris. Ngemuva kokuba efunde ngalesi sifo, waqala ukutadisha umphumela womuthi ngamunye onconywayo. Usebenzise i-Intanethi, futhi kwasabeka ukusebenzisa ithuluzi. Abantu babhala ngemiphumela emibi: umlutha, isiyezi, isicanucanu, isifo sohudo, izinkinga zokucindezela. Ngabheka udokotela, wangifundela imiyalo yokuthi angisebenzise futhi wakhipha isinqumo sokuthi umlutha awunawo. Ngabe sengithembela futhi manje angizisoli. Umuthi uyasebenza, unomphumela omuhle enhlalakahleni. Awukwazi ukukholwa abakubhalayo, yize kunamacala ahlukile.
