I-Glyclazide isidakamizwa se-hypoglycemic esingeqembu le-sulfonylureas yesizukulwane sesibili. Umuthi uzisungule njenge-hypoglycemic ephumelelayo, ovame ukukhethwa ngabathengi be-endocrinologists njenge-monotherapy, futhi njengengxenye yenkambo ebanzi yokwelashwa kanye nezinye izidakamizwa.
Igama Lezwe elingafanele
I-INN yesidakamizwa iyafana negama layo lokuhweba.
Igama lomuthi ngesiLatini yi-gliclazide.
Abakhiqizi be-Gliclazide babanakekela abasebenza ngesifo sikashukela ngokudambisa umuthi ngendlela elula yokuphatha - amaphilisi.
I-ATX
A10BB09
Khipha amafomu nokwakheka
Abakhiqizi be-Gliclazide babanakekela abasebenza ngesifo sikashukela ngokudambisa umuthi ngendlela elula yokuphatha - amaphilisi. Banombala omhlophe (umthunzi wekhilimu kungenzeka) kanye nomumo wefulethi.
Ingxenye esebenzayo yesidakamizwa yi-gliclazide. Amathebulethi atholakala ngamanani ahlukile ale nto - 30, 60 no-80 mg. Izingxenye ezingeziwe zalo muthi yi-hypromellose, cellulose, stearate magnesium, njll.
Amatafula agcwele emaphakeji weseli - amabhulukwe, afakwe ngaphezulu emabhokisini amakhadibhodi.
Indlela yokusebenza
Ngaphansi kwethonya lalokhu kulungiswa komlomo kwe-hypoglycemic, ukugcinwa kwe-insulin kwenzeka kumanyikwe, ukuzwela kwezicubu zamaseli kuleli hormone kukhuphuka. Umuthi wehlisa ushukela wegazi.
Umphumela ongezekile we-Gliclazide ukwehla kokukhiqizwa kwe-glucose yesibindi. Amathebulethi anomphumela we-antioxidant, othinta kahle umzimba weziguli ezinesifo sikashukela. Labo abathatha umuthi banobungozi obuncishisiwe be-thrombosis.
I-Pharmacokinetics
Emahoreni angama-24, ukugcwala kokusebenza okusebenzayo egazini lomuthi osingathi kugcinwa ezingeni elidingakalayo kwabanesifo sikashukela. Izinto zokwelapha zidlulwa yizinso.
Izinkomba zokusetshenziswa
Kuhlobo 2 sikashukela mellitus, umuthi ubekelwa njenge-ejenti yokwelapha futhi njenge-prophylactic. Umuthi usiza ukugwema izinkinga zesifo sikashukela esingancikeli i-insulin - i-nephropathy, i-retinopathy.
I-Glyclazide - umuthi we-hypoglycemic, isizimele njenge-hypoglycemic esebenzayo.
Contraindication
I-Gliclazide ine-contraindication eminingi yokusebenzisa. Phakathi kwazo kukhona:
- thayipha i-1 isifo sikashukela;
- ukungabekezeleli izinto ngesisekelo okwenziwe ngalo umuthi, ne-lactose;
- i-ketoacidosis (i-pathology ehambisana nokungasebenzi kahle kwe-carbohydrate metabolism);
- ukuba khona komlando wesiguli we-hypoglycemic coma;
- ukuvinjwa kwamathumbu;
- i-hyperthyroidism, i-hypothyroidism;
- ukulimala, izimo zempilo.
Ngokunakekela
Ngokuqapha, umuthi ubekelwe abantu abangaphezu kweminyaka engu-65 ubudala, labo abahlushwa izinhlobo ezinzima zenhliziyo nezifo ze-vascular, izidakwa ezingalapheki. Ngokudla okungajwayelekile, umuthi kufanele futhi uphathwe ngokucophelela. Futhi ebuntwaneni, ukusetshenziswa kwe-Gliclazide akunconywa ngisho nangokuqapha.
Ungayithatha kanjani iGliclazide
Kunconywa ukuthatha umuthi isikhathi esisodwa ngosuku. Kungcono ukukwenza ngesikhathi sebhulakufesi. Uma isiguli singazange siphuze iphilisi ngesikhathi esifanele, khona-ke umthamo olandelayo akufanele unyuswe.
Amathebulethi awahlafuneki noma awachotshoziwe ngaphambili, kepha agwazwe aphelele.
Ukuthatha umuthi wesifo sikashukela
Udokotela ukhetha umthamo ngamunye esigulini ngasinye. Ngokuhambisana nemiyalo, kunconywa ukuqala ukwelashwa ngomthamo wansuku zonke we-30 mg we-gliclazide.
Ukuthatha umuthi kuhambisana nokuqapha okuphathelene noshukela wegazi. Uma izinkomba zivamile, khona-ke umthamo awushintshi - umuthi uthathwa njengokwelashwa kokulungiswa. Ngaphandle kwalokho, umthamo wanda kancane kancane - ufike ku-60, 90 no-120 mg. Ukwanda komthamo ngamunye kwenzeka ngemuva kwenyanga eyi-1. Uma izinga likashukela linganciphi zingakapheli izinsuku eziyi-14 zokusebenzisa umuthi, khona-ke isikhathi sokuncipha phakathi kokunyuka komthamo singancishiswa.
Kungakapheli amahora angama-24, awukwazi ukuthatha ngaphezu kwe-120 mg.
Imiphumela emibi
Uma izincomo zikadokotela zingalandelwa, ezinye iziguli ziba ne-hypoglycemia, ehambisana nezimpawu eziningi ezingemnandi: indlala, ukuguguleka, ulaka, ukwehluleka, njll.
Imiphumela emibi ingenzeka kwizitho ezahlukahlukene nezinhlelo.
Amapheshana wesisu
Ukusinda esiswini nobuhlungu esiswini, isicanucanu nokuhlanza, ukuqunjelwa nohudo. Ezigulini eziphuza amaphilisi ngesikhathi sokudla kwasekuseni, izimpawu ezinjalo azivamile.
Izitho zeHematopoietic
Ukuthuthukiswa kwe-anemia nezinye izifo zegazi. Ngokuhoxiswa komuthi, isimo sempilo sijwayelekile.
Isistimu yezinzwa ephakathi
Isiyezi, ukuphazamiseka kokulala, ikhanda, ukungazi kahle.
Engxenyeni yesikhumba
Ukusabela komzimba ngendlela ye-urticaria kanye nokulunywa kwesikhumba, ukuqubuka kwepopular, i-angioedema.
Kusuka ohlelweni lwezinhliziyo
Ukwehluleka kwenhliziyo, i-arrhythmias yenhliziyo, ukushaya kwenhliziyo, hypotension, i-edema yemikhawulo engezansi.
Imiyalo ekhethekile
Lapho uthatha i-Glyclazide, kufanele ulandele ukudla okune-carb ephansi. Kuyadingeka ukubheka njalo izinga le-glucose - ekuseni esiswini esingenalutho nangemva kokudla.
Uma isiguli siqala i-hypoglycemia, khona-ke kudingeka athathe isisombululo sikashukela. Uma kungenakwenzeka ukwenza lokhu (ngokwesibonelo, umuntu ulahlekelwe ukwazi), ushukela uphethwe ngaphakathi. Lapho nje ukwazi ukuthi ingqondo ibuyiselwe, isiguli kufanele sinikezwe ukudla okugcwele ama-carbohydrate.
Umthelela ekhonweni lokulawula izindlela
Ngesikhathi sokuthatha i-Glyclazide, umuntu kufanele alahle leyo misebenzi ehambisana nezinqubo eziyinkimbinkimbi, noma ngokunakekela okukhulu ukwenza lowo msebenzi. Lokhu kungenxa yokuthi ngokuthuthuka kwe-hypoglycemia, ukugxilisa ukunakwa kuyancipha, umuntu ulahlekelwa ukuzithiba, ukusabela kwakhe kwe-psychomotor kwehlisa ijubane.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Akunconyelwe ukuphuza amaphilisi abesifazane abakhulelwe kanye nabomama abancelisa ibele.
Kunquma uGliclazide ezinganeni
Iziguli ezingaphansi kweminyaka engu-18 ubudala azinqunyelwe.
Sebenzisa ebudaleni
Thatha amaphilisi asebekhulile kufanele aqaphele, ngoba kunengozi enkulu ye-hypoglycemia.
Isicelo sokusebenza kokulimala kwezinso
Umuthi ungabekelwa abantu abaphethwe yisifo sezinso. Kepha iziqephu ze-hypoglycemia uma kwenzeka ukukhula kwazo kweziguli zihlala isikhathi eside. Isimo se-pathological sidinga ukunakekelwa kwezokwelashwa.
Sebenzisa umsebenzi wesibindi okhubazekile
Izifo zesibindi zinciphisa ukuqina kwe-gluconeogeneis futhi kuholele ekuthuthukisweni kwe-hypoglycemia, iziqephu zazo ezihlala isikhathi eside impela. Ezimweni ezinjalo, ukwelashwa okufanele kwenziwa.
Ukweqisa
I-overdose ye-Gliclazide iholela ku-hypoglycemia.
Ukuxhumana nezinye izidakamizwa
Isiguli kudingeka sitshele udokotela ukuthi uluphuza muphi umuthi, ngoba i-ejenti yokuphikisana nesifo sikashukela enemithi ethile ayinconywa.
Ukuhambisana notshwala
Ukuphuza utshwala ngesikhathi sokwelapha kungadala i-hypoglycemic coma. Kuyadingeka ukwenqaba utshwala kuphela, kodwa nemithi equkethe i-ethanol.
Inhlanganisela ehlanganisiwe
IMiconazole ithuthukisa umphumela weGliclazide, ikhulisa ingozi ye-hypoglycemia kuze kufike ku-coma.
Akuhlanganisiwe ukuhlanganisa
I-Phenylbutazone ithuthukisa umphumela we-hypoglycemic womuthi we-antidiabetesic. Uma i-phenylbutazone ingeke yabiwa nayo, udokotela uxwayisa isiguli ngesidingo sokuqashwa kwe-glucose ejwayelekile.
UDanazole wenza buthaka umphumela weGliclazide. Uma udinga ukuthatha iDanazol, kufanele ulawule ushukela wegazi lakho. Umthamo wesidakamizwa we-antidiabetic uyalungiswa.
Inhlanganisela edinga ukuqashelwa
Amanye ama-hypoglycemic agents (insulin, Metformin, Fluconazole, njll.) Akhulisa ubungozi be-hypoglycemia. Kufanele zithathwe ngokuqapha, ngaphansi kokuqashwa kukadokotela nangokuqapha okuphathelene nezinga loshukela.
Ama-Analog
Umuthi lo unamagama wokuvumelanisa amaningi, i.e. izidakamizwa ezifaka into efanayo esebenzayo. Phakathi kwemithi enjalo kukhona iDiabetes, Gliclada, Gliclazide MV, Glidiab, Diabefarm, njll.
Ukulungiselela ngesenzo esifanayo, kepha ngesinye isakhi esisebenzayo ekwakhekeni kwabo - Glibenclamide, Metformin Canon, Glucostabil, Maninil, njll.
Izimo zokusabalalisa ze-Gliclazide kusuka kumakhemisi
Umuthi umuthi obhalwe phansi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Amanye amakhemisi awaceli ikhasimende ukuthi lilethe incwadi kadokotela.
Intengo
Izindleko zokufaka ngamathebhulethi angama-60 ngomthamo wama-30 mg cishe ngama-ruble ayi-130.
Izimo Zesitoreji se-Glyclazide
Umuthi ugcinwa emazingeni okushisa omoya aze afike ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
I-Ozone LLC, eRussia.
Ukubuyekezwa mayelana neGliclazide
Ukubuyekezwa okuningi kwesidakamizwa kulungile.
Umuthi lo unamagama wokuvumelanisa amaningi, i.e. izidakamizwa ezibandakanya into efanayo esebenzayo (Gliclada, njll).
Odokotela
UGennady Nikitin, oneminyaka engama-44, u-Oryol: "Ngokuvamile kunconyelwa ukuthatha i-Glyclazide. Umuthi awubizi, wehlisela ushukela ngempumelelo, kanti ngomthamo ofanele awutholi imiphumela emibi. Umuthi lowo usohlwini lwemithi ekhethekile, iziguli eziningi akumele ziyikhokhele."
Isifo sikashukela
USergey Nosov, oneminyaka engama-51, uKaluga: "Sekuyiminyaka eminingana selokhu kwatholakala isifo sikashukela. Ezinyangeni eziyisithupha ezedlule, ushukela ufike kuma-unit angu-9 ekuseni. Udokotela watusa ukuthatha i-Glycloside kwimthamo ka-60 mg. Njengakwezinye izidakamizwa ezinciphisa ushukela, kuyadingeka ukugcina ukudla futhi ukhuthele ngokomzimba. Umphumela wokwamukelwa wawumuhle: ushukela ubuyela kokujwayelekile. Kepha uma ukudla sekuphukile, kuyavuka futhi. "
U-Ivan Prokhorenko, oneminyaka engama-41 ubudala, uLipetsk: "Ngiqale ukusebenzisa i-Glyclazide kungekudala. Udokotela wasikisela esikhundleni sikashukela. Ekuqaleni angizange ngifune ukushintshela kulo muthi omusha, kepha ngifunde ukubukeza nganquma. Umphumela wangithokozisa: umuthi wehlisela ushukela kahle futhi awubizi kakhulu."
