I-Diabeteson MV: Imiyalo ephelele yokusetshenziswa, ukubuyekezwa kwabanesifo sikashukela

I-Diabeteson MV umuthi osetshenziswa kabanzi ekwelapheni isifo sikashukela sohlobo 2. Kunqunywa kaningi kwabanesifo sikashukela ngaphandle kwesisindo ngokweqile futhi kumelana nokumelana nezicubu kwe-insulin, ngoba amaphilisi anegalelo ekuzuzeni kancane kancane kwesisindo futhi kuvuselela ama-pancreas.

Igama elejwayelekile lomuthi yi-gliclazide. I- "Diabeteson MV" igama lokuhweba lesidakamizwa senkampane yezemithi yaseFrance uServier, ngendlela efisayo, la maphilisi awanikezwa kaningi ekhemisi, ngoba abiza kakhulu kunama-generics (uDibinax, Glidiab, Diabefarma) akhiqizwa ngesisekelo se-gliclazide.

Isifinyezo se-MV sisho ukuthi i-Diabeteson ngokukhululwa okuguquliwe kanye nengxenye esebenzayo ayizivezi ngokushesha, kepha phakathi nosuku, ngezingxenye ezilinganayo.

Izinzuzo ze-Diabeteson MV

Uma siqhathanisa umuthi nokuhlukahluka okuhlukile kochungechunge lwe-sulfonylurea, khona-ke lapho kungekho khona ulaka, ukusebenza kwalo kuzoba ngaphezulu.

1. I-Diabeteson MV ithembekile ibuyisa ukulinganisela kwe-glycemic;
2. I-Gliclazide ivuselela isigaba sesibili secretion yama-hormone, ifinyelela ngokushesha isilinganiso esiphezulu ekuthatheni ama-carbohydrate.
3. Umuthi unciphisa ubungozi be-thrombosis;
4. Amathuba we-hypoglycemia phakathi kwemiphumela emibi ancishiselwe ku-7% (kwezinye izidakamizwa zeqembu le-sulfonylurea, ubungozi buphakeme kakhulu);
5. Ukuphuza amaphilisi isikhathi esisodwa, esilungele ukusebenza kwabanesifo sikashukela nabathatha umhlalaphansi abakhohliwe;
6. Ukukhishwa kancane kwesidakamizwa akunamthelela ekuzuzweni okusheshayo kwesisindo njengamaphilisi e-Diabeteson ajwayelekile;
7. Udokotela ongenaso isipiliyoni nalesi sidakamizwa uzolungisa kalula umthamo, ngoba ubungozi bemiphumela emibi buphansi;
8. Ama-molecule we-Gliclazide anezinto ezingama-antioxidant;
9. Umuthi unezibalo ezinhle zemiphumela engathandeki - kufinyelela ku-1%.

Kanye nohlu olunjalo olukholisayo lwezinzuzo, umuthi futhi unezinkinga.

• Amaseli e-B abhekene nokukhiqizwa kwe-insulin ancishisiwe.
• Iminyaka emi-2-8 (ngokuya ngesisindo somzimba, ngokushesha kubantu abanciphile), onesifo sikashukela esinohlobo lwesibili lwesifo sithola uhlobo olubi kakhulu lwesifo sikashukela.
• Umuthi awuqedi ukuzwela izicubu kwe-insulin, kepha kuze kuthi ngezinga elithile ulithuthukise.
• Ukuthuthukisa iphrofayili ye-glycemic akuqinisekisi ukuthuthuka kokushona kwabantu kusuka kushukela (ngokusho kocwaningo olwenziwe isikhungo esidumile samazwe onke i-ADVANCE).

Ukuze ungaphoqeleli umzimba ukuba ukhethe phakathi kokuphazamiseka komoya kusukela esimweni sokukhubazeka kanye nemithambo yenhliziyo, amaphilisi kufanele asizwe ngokulawula umsebenzi owudlayo nowemisipha.

Ukushintshwa kwendlela yokuphila kuzophinde kunciphise nengozi yenhliziyo ngendlela ye-glycemia ephezulu, ukwehla komfutho wegazi, ukukhuluphala ngokweqile, nokuphazamiseka kwengqondo yomzimba we-lipid.

Incazelo yokwakhiwa nefomu lomthamo

Ingxenye eyinhloko yefomula yi-gliclazide - umuthi onamandla we-hypoglycemic, ummeleli wesigaba sezidakamizwa se-sulfonylurea. Ukwakheka kwalesi sidakamizwa kuhlanganiswa nomphumela wesikhathi eside we-lactose monohydrate, i-maltodextrin, i-hypromellose, i-magnesium stearate, i-silicon dioxide.

Amathebulethi angakhonjwa ngesimo se-oval enomugqa ohlukanisayo nesifinyezo esithi "DIA 60" ohlangothini ngalunye.

Umuthi ufakwa emabhulokini izingcezu eziyi-15-30, ebhokisini lekhadibhodi kanye nemiyalo kungenzeka kube khona amapuleti anjalo angama-1-4.

Uyakhishwa umuthi kadokotela. Kwi-Diabeteson MV, intengo akuyona imali ebhajethelwa kakhulu, ngoba kufanele kukhokhwe amaphilisi angama-30 isilinganiso sama-ruble angama-300. Umuthi awufakwa ohlwini lwezidakamizwa ezikhethekile zokulwa nesifo sikashukela. Isikhathi sokuphelelwa yisikhathi esivezwe ngumenzi asisekho iminyaka emi-2. Umuthi awudingi izimo ezikhethekile zokugcinwa.

I-Pharmacodynamics

Izidakamizwa zaseSulfonylurea, ezibandakanya iDiabeteson MV, zivusa umsebenzi wamanyikwe kanye namaseli we-b, alawula ukukhiqizwa kwe-insulin. Izinga lokuvezwa lomuthi onjalo liyisilinganiso, ngokwesibonelo, iManinil yendabuko inolaka ngokwengeziwe.

Umuthi ungaba wusizo ngezimpawu ezishiwo zokuqothulwa kwamanyikwe, lapho ngaphandle kokukhuthaza kungasanikeli ezingeni le-insulin edingekayo ukunxephezela i-glycemia. Nganoma iliphi izinga lokukhuluphala, umuthi awusabekelwa.

I-Diabeteson MV ibuyisela isigaba sokuqala se-insulin synthesis uma ukwehla kokusebenza kwayo kubonwa emzimbeni. Esikhathini sikashukela esinesifo sohlobo 2, isidakamizwa sandisa ukuqina kwe-insulin lapho ama-carbohydrate engena emzimbeni futhi abuyisa isigaba sesibili somjikelezo.

Ngaphezu kokwehla okuqinisekisiwe kwama-glycemic indices, ukuphuza umuthi kuthinta kahle impilo yemithambo yegazi kanye nohlelo lokujikeleza kwegazi. Ngokunciphisa ukunamathela kwe-platelet (ukuhlanganisa), kunciphisa ubungozi be-vascular thrombosis, kuqinisa kubo kusuka ngaphakathi, kunikeze isivikelo se-angioprotective.

Ithonya lezidakamizwa i-algorithm ukulandelana okuthile.

1. Okokuqala, ipancreas ivuselelwa ukukhipha i-hormone iye egazini;
2. Ngemuva kwalokho isigaba sokuqala secretion se-insulin senziwa futhi sabuyiselwa;
3. Ukunciphisa ukwakheka kwezigaba zegazi ezitsheni ezincane, ukuhlanganiswa kweplatelet kuyancishiswa;
4. Ngokufana, kunomphumela othile we-antioxidant.

Ukusetshenziswa okukodwa kwesidakamizwa kunikeza ukugcwala okuphelele kwe-glibenclamide ngosuku. Izinga elizinzile le-C-peptide ne-insulin lakhiwa emzimbeni hhayi ngaphambi kweminyaka emi-2 yemithi ejwayelekile.

I-Pharmacokinetics

Umuthi udonswa egunjini lokugaya ngokugcwele. Egazini, okuqukethwe kwayo kuqongelela kancane esikhathini esingamahora ayi-6. Izinga elitholile lihlala kusuka emahoreni ayisithupha kuya kwayi-12. Ukuhlukahluka kwezigaba ezahlukahlukene zabanesifo sikashukela kuphansi.

Kanyekanye nokudla izidakamizwa emzimbeni, izici ze-pharmacokinetic ze-gliclazide azishintshi. Ukuxhumana namaprotheni egazi kugcinwa ku-95%, Vd - kuze kufike kumalitha angama-30.

I-Gliclazide metabolism iyenzeka esibindini, awekho ama-metabolites asebenzayo atholakele egazini.

Izinso zabo ziyaqedwa (kuze kufike ku-1% ngendlela efanayo). I-T1 / 2 ye-gliclazide iyahlukahluka ebangeni lamahora ayi-12-20.

Lapho umthamo ukhushulwa uye phezulu (120 mg), indawo engaphansi komugqa ebonakalisa ubudlelwane besikhathi nokusatshalaliswa kuyanda ngokwesilinganiso esiqondile.

Izinkomba zokusetshenziswa

Uhlobo oluthuthukisiwe lomuthi onomphumela wesikhathi eside lwakhiwa ukuze kubuyiswe iphrofayili ye-glycemic futhi kuvikeleke izinkinga zesifo sikashukela (unhlangothi, i-retinopathy, ukushaya kwenhliziyo, i-nephropathy, i-gangrene yemikhawulo).

Kunqunyelwe abanesifo sikashukela abanesisindo esijwayelekile somzimba abanesifo sikashukela sohlobo 2 sefomu eliphakathi nelilingene ngaphandle kwezimpawu zokungamelana nezicubu kwe-insulin.

Isetshenziswa futhi nabasubathi ukuthuthukisa ukuzwela kwezicubu ukungena ku-insulin, okusheshisa inzuzo yemisipha.

Njengomuthi wokuqalisa wesifo sikashukela, iDiabeteson MV ayifanele. Kuyingozi futhi ukunquma umuthi wokukhuluphala, ngoba amanyikwe asevele esebenza emkhawulweni wekhono lawo, ekhiqiza izinhlobo ezi-2 kuya kwezi-insulin ezingakwazi ukuguqula ushukela onolaka. I-Diabeteson MV kuleli cala ingavusa nokufa (kusuka ezinkingeni zenhliziyo).

Ukutadisha ubudlelwano phakathi kokukhethwa kwezidakamizwa zohlobo lokuqala ukuphathwa kukashukela wohlobo 2 nobungozi bokushona, kwenziwa izifundo ezikhethekile. Iziphetho zisobala.

1. Ezimweni ezinesifo sikashukela esithola izidakamizwa ze-sulfonylurea, uma siqhathanisa nabasebenza ngokuzithandela abathatha i-metformin, amathuba okufa okuvela ezimweni zenhliziyo aphakama izikhathi ezi-2, isifo senhliziyo (CHD) - amahlandla angu-4,6, ukugeleza kwegazi okuku-cerebral (NSC) - Izikhathi ezi-3.
2. Amathuba okushona kwe-NMC ne-CHD abephezulu kwizifo sikashukela ethatha i-glibenclamide, glycvidone, izidakamizwa ezenzelwe i-glyclazide kunalezo eziphathwa nge-metformin.
3. Uma kuqhathaniswa neqembu eliphathwe nge-glibenclamide, ababambiqhaza abathola i-gliclazide bakhombisile imiphumela elandelayo: ukuncishiswa okungu-20% ekufeni kwabantu bonke, kanye nokwehla okungu-40% kwabantu ababulawa yi-UC ne-CCC.

Ngakho-ke, ukukhethwa kweDiabeteson MV njengomuthi womugqa wokuqala, njenganoma yisiphi esinye isidakamizwa se-sulfonylurea, kwandisa amathuba okufa eminyakeni emi-2 amahlandla ama-2, kuthola ukuqunjelwa kwe-myocardial - amahlandla ama-4,6, isifo sohlangothi - izikhathi ezi-3. Ngokwesifo sikashukela esisanda kutholwa, i-metformin njengosizo lokuqala lwezokwelapha iyindlela engcono kunazo zonke.

Ngokulunga, kufanele kuqashelwe ukuthi ngokuthatha iminyaka emithathu noma ngaphezulu i-Diabeteson MV, ubungozi bokuthola i-atherosclerosis bancishiswa kakhulu. Abanye abameleli balesi sigaba sezidakamizwa abakhombisanga imiphumela efanayo. Amandla okubulala izinzwa kwe-Diabeteson MV angachazwa ubukhona bawo ekwakhekeni kwama-antioxidants avikela izicubu ku-oxidation.

Izinzuzo nokulimala kweDiabeteson - kuvidiyo:

Contraindication

I-Diabeteson MV umuthi omusha wesizukulwane osezingeni eliphezulu. Kuhlukile kuzo zonke izifaniso zesigaba se-sulfonylurea ngokuya ngokuthuthukiswa kwezinkinga kanye nephesenti elincane lemiphumela emibi.

Kepha, njenganoma yimuphi umuthi wokwenziwa, i-gliclazide inezinto eziningi eziphikisayo:

• Ukuzwela okuphezulu kwezakhi zefomula nezidakamizwa zochungechunge lwe-sulfonylurea ngokubanzi;
• Uhlobo 1 sikashukela;
• Izimo ze-ketoacidosis yesifo sikashukela, ukoma kanye nencazelo;
• Izinga elinzima le-pathology yezinso nesibindi, lapho kudingeka khona ukuguqulwa kwe-insulin;
• Ukukhulelwa nokukhulelwa;
• Ukwelashwa okufanayo kanye ne-miconazole;
• Iminyaka engu-18.

Umuthi uqukethe i-lactose, ngakho-ke awuboniswa ukungabekezeleli kwayo, i-glucose-galactose malabsorption, galactosemia. Akunconywa ukuhlanganisa i-danazol ne-phenylbutazone ne-Diabeteson MV.

Ukukhulelwa

Akukho okuhlangenwe nakho kokwelapha abesifazane abakhulelwe nge-gliclazide, kanye nemininingwane yokwelashwa kwalesi sigaba sabanesifo sikashukela esinezidakamizwa ze-sulfonylurea isiyonke.

Ekuhlolweni kwezilwane zowesifazane, umphumela we-teratogenic we-gliclazide awuzange uboniswe.

Ukuze sinciphise ubungozi be-pathologies yokuzalwa kabusha, kudingeka ukuthi kuqashwe njalo futhi kwelashwe kahle uhlobo 2 sikashukela. Izidakamizwa ze-Oral hypoglycemic azisetshenziswa ngalesi sikhathi, abesifazane abakhulelwe badluliselwa kwi-insulin, futhi kungcono ukufeza lokhu kuguqulwa ngisho nasesigabeni sokuhlela ukukhulelwa.

Akukho mininingwane ngokungena kwe-gliclazide kubisi lwebele, ingozi ye-neonatal hypoglycemia ayikasungulwa, ngakho-ke, ngesikhathi sokwelashwa nge-Diabeteson MV, ukuncelisa ibele kuphambene.
Akunasisekelo sobufakazi bokusebenza nokuphepha kokusetshenziswa kwe-Diabeteson MV ezinganeni, ngenxa yalokho, lesi sidakamizwa naso asinqunyelwe abanesifo sikashukela esingaphansi kweminyaka engu-18 ubudala.

Imiphumela emibi

I-Diabeteson MV inesipiliyoni esiqinile sokusebenzisa ubuncane be-contraindication kanye nemiphumela emibi, eyinhloko ebhekwa njenge-hypoglycemia, lapho ukufundwa kwe-glucometer kuwela ngaphansi kwebanga okuqondiwe.

Ungahlukanisa isimo esiyingozi ngo:

1. Ubuhlungu bekhanda nesiyezi;
2. Isifiso sokudla seWolf;
3. Ukuphazamiseka kwe-dyspeptic;
4. Ukuphelelwa amandla, ubuthakathaka;
5. Ukujuluka ngokweqile;
6. Ukuphazamiseka kwesigqi senhliziyo;
7. Isimo esibuhlungu, esijabulisayo, sokudangala;
8. Ukusabela kwe-Adrenergic, ukwethuka;
9. Izinkinga zokukhuluma, i-delirium;
10. Ukulimazeka kokubonakalayo;
11. Imisipha imisipha;
12. Isimo esingasizi ngalutho, ukulahleka kokuzibamba;
13. Ukuhluleka, i-coma.

    
    

Ngendlela emnene ye-hypoglycemia, isisulu sinikezwa ushukela, nefomu elinzima, ukulaliswa esibhedlela okuphuthumayo kuyadingeka. Isimo se-hypoglycemia siyingozi futhi siphinde sibuyele emuva, ngakho-ke kubalulekile ukulawula inhlala-kahle ngemuva kokukhululeka kwesifo.

Ngendlela, ngokuqhathaniswa ne-Diabeteson evamile, i-analogue yayo (ngokukhululwa kancane) ikuvumela ukuthi usabalalise umthwalo emzimbeni ngokulinganayo. Lokhu kunciphisa kakhulu ingozi ye-hypoglycemia.

Ngaphezu kwe-hypoglycemia, kuneminye imiphumela engalindeleki:

• I-Urticaria, ukuqubuka komzimba, i-edema kaQuincke;
• Ukuphazamiseka kwendlela yomgudu wesisu;
• Ukuphazamiseka kokunikezwa kwegazi ngesimo se-anemia, ukwehla kwezinga lamangqamuzana amhlophe egazi;
• Ukuphazamiseka kwekhwalithi yokubuka kwesikhashana ngenxa yokungafani kwe-glycemia, kaningi ngesikhathi sokujwayela umuthi;
• Ukwanda komsebenzi we-enzymes wesibindi AST ne-ALT ezimweni ezingavamile, i-hepatitis.

Uma iDiabeteson MV ichazwe esikhundleni somunye umuthi we-hypoglycemic, kubalulekile ukubheka amapharamitha we-glycemic amasonto amabili ukuze uvikele ukubekwa kwemiphumela emiphumeleni yemithi emibili eyingozi ye-hypoglycemia.

Ngesikhathi sokuvivinywa kwemitholampilo kwalesi sikhungo esidumile se-ADVANCE, kubonakale umehluko omncane (osuka endaweni yokubukwa) umehluko phakathi kolawulo namaqembu wokuhlola. Imvamisa nobukhali be-hypoglycemia kusungulwe kuphansi. Izimo eziningi ze-hypoglycemia ziphawulwa ngokungemuva kokwelashwa okuyinkimbinkimbi ngokuhlangana namalungiselelo we-insulin.

Imiphumela Yokusebenzelana Kwezidakamizwa

Igqamisa umsebenzi we-Diabeteson MV miconazole (zombili ngesimo semijovo nokusetshenziswa kwangaphandle). Inhlanganisela iphikisana ngokuphelele, ngoba ingavusa i-hypoglycemia.

Akunconywa ukuhlanganisa i-gliclazide ne-phenylbutazone. Ngokuphatha okuhleliwe, amandla we-hypoglycemic of sulfonylurea derivatives ayathuthukiswa: ukuhoxiswa kwezidakamizwa kubambezela, i-phenylbutazone ikhipha endaweni eyi-protein ligament. Uma kungabikho okunye esikhundleni somuthi, kuyadingeka ukulungisa umthamo we-gliclazide futhi uqaphe ngokucophelela i-glycemia kuyo yonke inkathi yokwelashwa nangemva kokuphela kwenkambo.

Yandisa ubungozi be-glycemia ethanol nezidakamizwa ezisuselwa kuyo. Esikhathini sokwelashwa nge-Diabeteson MV, kuyadingeka ukuyeka ngokuphelele uphuzo oludakayo nemithi esekwe kotshwala.

Ukuhlanganiswa kwezidakamizwa ze-antidiabetesic kunqunywa ngokuqapha: i-insulin, i-biguanides, i-acarbose, i-diazolidinediones, i-GLP-1 antagonists, ama-DPP-4 inhibitors, ama-β-blockers, ama-MAO kanye ne-ACE inhibitors, i-fluconazole, izidakamizwa ze-sulfonamide, NPs. Noma ikuphi kwalokhu kuhlanganiswa kukhulisa amandla e-hypoglycemic we-Diabeteson MV futhi kudinga ukuhlukaniswa komthamo nokuqapha ngokucophelela iphrofayili ye-glycemic.

Yenza buthaka ikhono le-Diabeteson MV Danazole, elikhulisa ukugcwala koshukela ku-plasma. Ngokusetshenziswa okufanayo, ukuqaphela umthamo nokuqapha kwe-glycemic kuyadingeka kuyo yonke inkambo yokwelashwa nangemva kwayo. Isimo esifanayo sibonwa ngomjovo we-iv we-b-adrenergic agonists.

Izakhiwo ze-Glyclazide + chlorpromazine zinqunywa ngokuqapha. Kwimithamo ephezulu, i-antipsychotic inciphisa ukukhiqizwa kwe-insulin, isiza ukunqwabelana koshukela egazini. Kuyadingeka ukubala umthamo wemithi ngokucophelela.

I-GCS ne-tetracosactide nganoma iyiphi indlela yokufaka isicelo (amalunga, isikhumba, indlela elingunxande) yenyusa ushukela wegazi, kuvuse ukuvela kwe-ketoacidosis, okunciphisa ukubekezelelwa kwemikhiqizo ye-carbohydrate. Esigabeni sokuqala sokwelashwa, umthamo ohamba kancane wethamo kanye nokuqashwa kwamapharamitha we-glucometer kuyo yonke inkathi yokusetshenziswa okuhlangene nangemva kokuba kudingekile.

Indlela yokusebenzisa

Kwi-Diabeteson MV, imiyalo yokusebenzisa incoma ukuthi abanesifo sikashukela baphuze umuthi ekuseni, kanye nesidlo sasekuseni. Njengazo zonke izidakamizwa ezilwa nesifo sikashukela, i-endocrinologist ikhetha umuthi uqobo, icubungula imiphumela yokuhlolwa, isigaba sesifo sikashukela, izifo ezihambisanayo, ukusabela komzimba ekwelashweni.

Kunoma yiluphi uhlobo (kusuka ku-30 ​​kuye ku-120 mg, okungamacwecwe angu-0.5-2), ukuthatha i-gliclazide kukodwa. Uma uhlelo luphukile, ukuphinda umthamo kuyingozi - umzimba udinga isikhathi ukumunca ngokuphelele, ngaphandle kwemiphumela engathandeki, okujwayelekile.

Ngohlobo olujwayelekile, umthamo wokuqala yi-Ѕ ithebhu. (30 mg). Kwabanesifo sikashukela sobudala obuvuthiwe, ukunikezwa kwemithamo akudingeki.

Uma inqubo enjalo ihlinzeka ngokulawulwa ngokuphelele kwe-glycemia, ingasetjenziswa njengokwelashwa kokulungiswa. Ngokulawula okunganele, umthamo uguqulwa, uletha okujwayelekile kwansuku zonke ku-60.90 futhi ngisho no-120 mg. I-dosing titration yenziwa ngemuva kwezinsuku ezingama-30 - kuthatha isikhathi esiningi ukuhlola ukusebenza kwesikimu esikhethiwe.

Uma umuntu onesifo sikashukela engenalo ushintsho kumaviki ama-2, ukunikwa amandla emzimbeni kungenzeka phakathi kwengxenye yenyanga. Umthamo omkhulu ovunyelwe wokwelapha we-gliclazide ngu-120 mg.

Uma isifo sikashukela sidluliswa sisuka ku-Diabeteson ejwayelekile ngokukhishwa ngokushesha kwe-gliclazide kuyi-analogue ende, khona-ke ithebulethi engu-80 mg yesifo sikashukela ingafakwa esikhundleni somuthi ofanayo nomphumela wesikhathi eside wama-60 mg noma ama-30 mg.

Lapho kuthathelwa indawo umuthi ohlukile we-glycemic nge-Diabeteson MV, inqubo yokwelashwa edlule kanye nesikhathi sokuqeda umuthi kuyabhekelelwa. Imvamisa asikho isidingo sesigaba sokushintsha. Umthamo wokuqalisa unqunywa ku-30 ​​mg ngokulungiswa kancane kancane uma umphumela wokwelashwa ungejwayelekile.

Uma i-T1 / 2 yesidakamizwa esedlule yinde, ukuze kugwenywe ukufakwa kwemiphumela evusa i-hypoglycemia, ikhefu kufanele lithathwe phakathi kwezifundo. Imvelo yokuqala yesifo sikashukela i-MV iphinde ichazwe njengongenamkhawulo - 30 mg ngokuthola amandla okuphinda akhishwe.

I-Diabeteson MV ingasetshenziswa ekwelashweni okuyinkimbinkimbi. Ukuze uthuthukise ukusebenzisa i-insulin, ama-biguanides, ama-b-glucosidase inhibitors. Uma kwenzeka imiphumela engagculisi, kuchazwe isilinganiso se-insulin.

Izincomo ezingeziwe

Ama-diabetesologists ane-renal pathologies ngendlela emnene futhi elinganiselayo awanconywa i-dermation titigation, kubalulekile kuphela ukuqapha ukusebenza kwe-glycemia nokusebenza kwezinso.

Ukunakwa ikakhulukazi kuyadingeka ezigulini ezisengozini yokudla okuphansi kilojoule, ukungasebenzi kahle komzimba, i-endocrine pathologies (ukungasebenzi kahle kwe-adrenal ne-pituitary, hypothyroidism, ukwesulwa kwama-corticosteroids ngemuva kokusebenzisa isikhathi eside noma imithamo ephezulu, i-CVD ebucayi ngesimo se-atherosulinosis noma isifo senhliziyo). Lesi sigaba sabanesifo sikashukela sinqunyelwe okungenani i-Diabeteson MV - 30 mg.

Ukuthola umphumela we-100%, umthamo ungakhuphuka ngokungeziwe ufike ku-120 mg / ngosuku. Isidingo sokuqala sizoba ukuguqulwa kwendlela yokuphila - ukuguqulwa kokudla okune-carb ephansi, ukuvivinya umzimba njalo, nokulawulwa kwesimo somzwelo.

Uma kunesidingo, ungangezela irekhodi lokwelashwa nge-Diabeteson MV metformin, insulin, thiazolidinediones. Kulokhu, kubalulekile ukukhumbula ubukhona bemiphumela emibi ekwelashweni ngakunye nokusebenzelana kwabo. Okokuqala, sikhuluma ngengozi ye-hypoglycemia.

Siza ngokweqile

Ingozi enkulu ye-overdose yisimo se-hypoglycemic. Ngezimpawu ezinobumnene nokuzithiba okwanele, kuyadingeka ukunciphisa umthamo we-Diabeteson MV neminye eminye imishanguzo yesifo sikashukela, ulungise ekudleni ukwandisa okuqukethwe kwekhalori. Ukuqapha impilo yesifo sikashukela kubalulekile kuze kube yilapho i-glycemia isenziwa ngokuphelele, ngoba ukubuyela emuva kulesi simo kuvamile.

Uma izimpawu ze-glycemic zivezwa kakhulu futhi zisongela impilo ngokusobala, ikakhulukazi uma ohlukumezekile engazi lutho, ekhefeni, ngokubanjwa okukhanyayo, kudingeka usizo lwezokwelapha oluphuthumayo ngokushesha, kulandele ukulaliswa esibhedlela. Emathubeni okuqala, umuntu onesifo sikashukela kufanele afakwe ngaphakathi nge-50 ml kashukela.

Ukuze ulondoloze ibhalansi (ngaphezulu kwe-1 g / l) - futhi nesixazululo se-10% dextrose. Ukuqashwa kwazo zonke izinkomba ezibalulekile kwenziwa okungenani amahora angama-48. Njengoba i-gliclazide ibopha ngokuqinile kumaprotheni egazi, i-hemodialysis kuleli cala ayisebenzi.

Ngingasithatha kanjani isikhundla se-Diabeteson MV

I-MV Diabeteson yasekuqaleni, ekhiqizwa yinkampani yaseFrance uServier, ine-analogues eshibhile esekwe kwi-gliclazide, kepha imiphumela emibi yale mishanguzo ingabizwa ngaphezulu, ngakho-ke lapho ukhetha akudingeki ugxile kuphela kuzindleko, kepha futhi nasezincomweni zikadokotela oholayo.

Ikhemisi lingakunika ama-generics:

1. I-RDiabefarm, Glyclazide, Glucostabil, Glidiab;
2. I-Czech Gliklad;
3. I-Yugoslavian Predian ne-Glioral;
4. I-Indian Diabinax, i-Diatik, i-Reklid, ne-Glisid.

Uma umkhiqizo osuselwa kwi-gliclazide ungalungile, isazi se-endocrinologist sizokhetha:

• Umuthi wuchungechunge lwe-sulfonylurea olususelwa ku-glibenclamide, glycvidone, glimepiride;
• Umuthi wesigaba esihlukile, kepha ngomshini ofanayo wokusebenza, ngokwesibonelo, uNovoNorm ovela esigabeni sobumba;
• Isidakamizwa esisebenza ngokufana noJanuvia noma uGalvus (DPP-4 inhibitors).

IGlidiab MV noma iDiabeteson MV: yini elungele isiguli esithile, ngudokotela kuphela onganquma. Imininingwane ihlinzekelwa ukuthola ireferensi ejwayelekile, hhayi ukuthola ukuthi ngubani ozithobayo kanye nokuzilawula wedwa wemithi engathi sína.

Ukucatshangelwa Kwesifo Sikashukela se-MV Abakhubazekile

Mayelana ne-Diabeteson MV, ukubuyekezwa kwesifo sikashukela akuvumelani: ushukela uyasiza ukulawula, kepha bambalwa abantu abakwazile ukugwema imiphumela engathandeki. Okuthusa kakhulu ukuthi ngemuva kwamaphilisi anjalo, cishe wonke ashintshela ku-insulin - amanye ngaphambili, amanye ngokuhamba kwesikhathi.

Ama-endocrinologists e-Diabeteson MV awabekelwe bonke abanesifo sikashukela, kodwa ngisho nalabo abalungele umuthi bangaqala ukulutha kulo muthi. Ngenxa yomthamo ongafanele noma ukungahambisani nohlelo lokuphatha, ukuphumelela kwomuthi ngeke kuhambisane nokumenyezelwe.

Ngokudonswa kanzima kwesifo sikashukela, ngisho nokudla okune-carb ephansi kanye nohlobo lokuzivocavoca, indlela ehlukile yokwelapha ingadingeka. Kunama-nuances amaningi, uma ngabe wabelwe i-Diabeteson MV, funda lo myalezo owenziwe lula ukuze uqiniseke ukuthi ukuqokwa kwenziwa ngokunembile.

Imininingwane eyengeziwe ngeDiabeteson MV - kuvidiyo: