I-Lysiprex yisidakamizwa esenzelwe ukwelashwa kwezifo zenhliziyo kanye nohlelo lwe-vascular. Ngokubhekwa kobunzima becala lomtholampilo, lisetshenziswa lihlanganiswe nezinye izidakamizwa noma njengethuluzi elizimele. Ukuze uhlelo lwezinhliziyo lusebenze ngokujwayelekile ezifweni ezingamahlalakhona, umuthi ubekelwe ukuphathwa kwe-prophylactic.
Igama Lezwe elingafanele
Lisiprex.
I-ATX
S.09.A.A. 03 Lisinopril.
I-Lysiprex yisidakamizwa esenzelwe ukwelashwa kwezifo zenhliziyo kanye nohlelo lwe-vascular.
Khipha amafomu nokwakheka
Amathebhulethi, into esebenzayo kuzo yi-5, 10 no-20 mg. Ijamo liyindilinga, liyisicaba. Umbala umhlophe. Ingxenye eyinhloko: i-lisinopril, emelelwa kulungiselelo yi-lisinopril dihydrate. Izinto ezengeziwe: i-anhydrous calcium hydrogen phosphate, i-mannitol, i-magnesium stearate, isitashi sommbila.
Isenzo se-Pharmacological
Umuthi ufakwa eqenjini le-ACE inhibitors. ILisinopril ibambezela umsebenzi we-ACE (i-eniotensin-converting enzyme). Ngenxa yalokhu, izinga lokuwohloka kwe-angiotensin yohlobo lokuqala kuye kwesibili, elinomphumela we-vasoconstrictive futhi elikhuthaza ukukhiqizwa kwe-aldosterone yi-adrenal cortex, kuncishisiwe.
Umuthi wehlisa ingcindezi emithanjeni yegazi emincane yamaphaphu, ikhulisa ukumelana kwethamo lenhliziyo. Ibuyisela amandla i-endometheli ye-glomerular, imisebenzi yayo iphazamisekile ezigulini ezine-hyperglycemia.
Into esebenzayo yandisa izindonga zempi kunezethinta embhedeni we-venous. Ngokusetshenziswa isikhathi eside kwesidakamizwa, i-cardiac myocardial hypertrophy iyancipha. Ithuluzi linganciphisa ukungasebenzi kwengqondo yenhliziyo yesobunxele, lithuthukise isimo sabantu abaye bahlaselwa yisifo senhliziyo.
I-Pharmacokinetics
Ukuphuza umuthi akuhlobene nokudla. Inqubo yokumuncisa ihamba ifinyelela kuma-30% wezinto ezisebenzayo. I-Bioavailability ingama-29%. Ukuhlanganiswa ngamaprotheni egazi kuncane. Ngaphandle kokushintsha, into esemqoka nezinto ezisizayo zingena egazini.
Ukuhlaziywa kwe-plasma okuphezulu kakhulu kubonwa kungakapheli amahora ayi-6. Cishe akubandakanyekanga kumetabolism. Kuthululwa kungashintshiwe ngokusebenzisa izinso ngomchamo. Ukuphila kwesigamu kuthatha amahora angama-12,5.
Kubekelwe ini?
Izinkomba zokusetshenziswa kwe-lysiprex:
- uhlobo olubalulekile nolungisa kabusha lwe-hyperension ye-arterial;
- isifo sikashukela se-nephropathy;
- ukwehluleka kwenhliziyo okungapheli;
- i-infarction ye-myocardial eyingozi.
Ekushayweni kwenhliziyo okukhulu, umuthi kufanele uthathwe ngosuku lokuqala ngemuva kokuhlaselwa ukuvimbela ukungasebenzi kwengqondo yenhliziyo yesokunxele.
Contraindication
Amacala wemitholampilo anciphisa ukuphathwa kweLysiprex:
- hypersensitivity ezingxenyeni ngazinye zomuthi;
- ukuba khona kwe-Quincke edema emlandweni womndeni;
- ukuthambekela kofuzo kokusabela okufana ne-angioedema.
Ukuphulwa okuhlobene, lapho ukusetshenziswa kweLysiprex kuvunyelwe, kepha ngokucophelela nangokuqapha njalo isimo sesiguli, kuyabhekwa:
- i-mitral stenosis, i-aortic, imithambo yezinso;
- inhliziyo ischemia;
- ukuthuthukiswa kwe-hypotension ye-arterial;
- ukulimazeka okukhulu kwezinso;
- ukuba khona kwenqwaba yama-potassium emzimbeni;
- izifo ezithinta izicubu ze-autoimmune.
Kwenqatshelwe ukusebenzisa umuthi ekwelapheni izifo zenhliziyo ezigulini ezingabamele ubuhlanga obumnyama.
Ungayithatha kanjani i-lisiprex?
Izibhebhe zithathwa zigcwele ngaphandle kokuhlafunisisa, kungakhathalekile ukuthi kudliwani. Isilinganiso esiphakanyisiwe umthamo ngu-20 mg ngosuku, inani elivumelekile lansuku zonke yi-40 mg. Isikhathi sokwelashwa sibalwa ngawodwana, kuya ngobukhulu besifo kanye nobukhulu bezimpawu. Umphumela wokwelapha ukuthatha umuthi ubonakala ngemuva kwezinsuku eziyi-14-30.
Umthamo we-monotherapy wokuhluleka kokuqina kwenhliziyo: umthamo wokuqala - 2.5 mg ngosuku. Ngezinsuku ezingama-3-5, ukwanda okufika ku-5-10 mg ngosuku kungenzeka. Ubukhulu obuvunyelwe yi-20 mg.
Ukwelapha ngemuva kokuhlaselwa yisifo senhliziyo emahoreni okuqala angama-24 ngemuva kokuhlaselwa: ama-5 mg, zonke ezinye izinsuku umthamo uphindwa kumthamo ofanayo. Ngemuva kwezinsuku ezi-2, udinga ukuthatha u-10 mg, ngosuku olulandelayo, umthamo uphindaphindwa kumthamo we-10 mg. Izifundo zokwelapha zingahlala amasonto amane kuya kwayisithupha.
I-nephropathy yesifo sikashukela - kuze kufike ku-10 mg ngosuku, esimweni esithombeni esinamandla, umthamo ungandiswa ube isilinganiso esivumelekile sansuku zonke sama-20 mg.
Ngoshukela
Ukuhlushwa ushukela akushintshi ngaphansi kwethonya le-lisiprex. Ukwelashwa kweziguli ezinokuxilongwa okufanayo akudingi ukulungiswa komthamo.
Imiphumela emibi ye-lisiprex
Imvamisa kuba nemiphumela emibi efana nokushayeka ekhanda, ukozela nokunganaki, isiyezi, i-tachycardia kanye nokwehlisa umfutho wegazi, ukungezwani komzimba esikhunjeni. Eminye imiphumela emibi engavamile: ukuthuthukiswa kwe-myalgia, vasculitis, arthralgia.
Amapheshana wesisu
Isifo sohudo, izinhlungu zokucanuzelelwa kwenhliziyo ngokuhlanza.
Izitho zeHematopoietic
Ukwehla kokuxineka kwe-hemoglobin, ukuthuthukiswa kwe-agronulocytosis. Akuvamile - ukwanda kwe-ESR ngaphandle kokuba khona kwezinqubo zokuvuvukala emzimbeni.
Isistimu yezinzwa ephakathi
Ukuhlasela kwekhanda nesiyezi, ukwehluleka kwemisipha.
Kusuka ohlelweni lomchamo
Ukuphazamiseka kwasemzimbeni, i-anuria, ukwehluleka kwenhliziyo okukubi.
Kusuka ohlelweni lokuphefumula
Ukukhwehlela kwe-paroxysmal ngaphandle kokukhiqizwa kwesikhwehlela.
Engxenyeni yesikhumba
I-Urticaria, ukulunywa esikhunjeni. Ukujuluka ngokweqile, ukubonakala kwe-alopecia kungenzeka.
Kusuka ohlelweni lwezinhliziyo
Ubuhlungu enhliziyweni, kancane kancane - hypotension arterial. Akuvamile - i-tachycardia, i-bradycardia, isithombe esibonakalayo sokwehluleka kwenhliziyo.
Uhlelo lwe-Endocrine
Amacala angavamile ukungasebenzi kahle kwe-adrenal.
Ngasohlangothini lwe-metabolism
Ukwanda kokuhlushwa kwe-creatinine. Kubantu abane-dysfunction ne-diabetesic pathology, i-urea nitrogen iyanda.
Allergies
Isikhumba isikhumba, ukuthuthukiswa kwe-angioedema.
Kuyinto engathandeki ukulawula imishini eyinkimbinkimbi yabantu abahlangabezana nesiyezi nekhanda lapho bethatha iLisiprex.
Umthelela ekhonweni lokulawula izindlela
Kuyinto engathandeki ukuphatha imishini eyinkimbinkimbi kubantu abathi, ngemuva kokuthatha iLysiprex, banokuphambuka ohlelweni oluphambili lwezinzwa: isiyezi, ikhanda.
Imiyalo ekhethekile
Ukwelashwa akunqunyelwe iziguli ezitholakala ngenhliziyo ye-pulmonary kanye ne-aortic stenosis. Kwenqatshelwe ukunikeza lesi sidakamizwa ku-infutureal myocardial infarction, uma kunengozi enkulu yokulimazeka kwe-hemodynamic.
Ngaphambi kokuqala ukwelashwa, kubalulekile ukuhlola izinso. Ukuqapha, kuphela lapho kukhona izinkomba ezikhethekile, lapho ezinye izidakamizwa zingakwazi ukunikeza umphumela owufunayo wokwelapha, lo muthi ubekelwe iziguli ezinokuwohloka komthambo kanye ne-stenosis.
I-Arterial hypotension iba kubantu abathola ukulahleka okusheshayo koketshezi lomzimba ngenxa yesisu, ukudla okuvinjelwe usawoti, ukucanuzelelwa kwenhliziyo njalo nohudo.
Sebenzisa ebudaleni
Iziguli ezingaphezu kweminyaka engama-65 ubudala zidinga ukusetshenziswa ngokucophelela kweLysiprex, lapho kukhona izifo ezingamahlalakhona, umthamo ubalwa ngawodwa.
Isabelo sezingane
Izifundo zemitholampilo ezigulini ezingaphansi kweminyaka engu-18 azenziwanga; akukho mininingwane ngokuphepha kwezidakamizwa kuleli qembu leziguli.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kukhona ubungozi bemiphumela emibi kuzingane, ikakhulukazi ku-2nd ne-3 trimester of gestation. Owesifazane ophuza amaphilisi eLysiprex ngemuva kokufunda ngokukhulelwa kufanele ayeke ukuthatha lo muthi. Akukho bufakazi bokuthi kungenzeka ukuthi izingxenye ezisebenzayo zomuthi zingene ebisini lwebele. Lapho uncelisa ibele, ukuphuza umuthi akuvunyelwe ngokuphelele ngenxa yezingozi ezingaba nomthelela omubi enganeni.
Isicelo sokusebenza kokulimala kwezinso
Kuyamukeleka, kepha ukuhlushwa kwe-potassium kufanele kugadwe.
Sebenzisa umsebenzi wesibindi okhubazekile
Kungenzeka ngezinkomba ezikhethekile. Ngaphambi nangesikhathi sokwelashwa, kubalulekile ukuthola ukulawula isimo nokusebenza kwesibindi.
Ukweqisa kweLysiprex
I-overdose kungenzeka lapho uthatha imithamo ye-50 mg noma ngaphezulu. Izimpawu: ukwehla ngokushesha komfutho wegazi, ukoma kakhulu emgodleni womlomo, umuzwa wokuwa, ubunzima bokuchama kanye nokuzikhulula. Ukuphazamiseka okungenzeka kwe-CNS: ukukhathazeka, ukungabikhona.
I-overdose kungenzeka lapho uthatha imithamo ye-50 mg noma ngaphezulu.
Usizo: ukuhlanza isisu, ukwelashwa okubonakalayo, ukuthatha izangoma kanye nama-laxative agents. Ngokukhula komfutho wokubonakaliswa kwezimpawu ze-overdose, i-hemodialysis iyenziwa.
Ukuxhumana nezinye izidakamizwa
Ngokusetshenziswa kanye kanye ne-sulfonylureas, kunengozi enkulu ye-hypoglycemia.
Iziguli ezinesifo sikashukela azivunyelwe ukuphuza umuthi kanyekanye neLovastatin ngenxa yezingozi ezinkulu ze-hyperkalemia enkulu.
Kwenqatshelwe ukuhlanganisa iLysiprex nezidakamizwa eziqukethe i-lithium. Le nhlanganisela iholela ekwandeni kwe-lithium enezimpawu zokudakwa.
Kuyenqatshelwe ngokuphelele ukuhlanganisa neBaclofen, Aliskiren, Estramustine.
Ukuhambisana notshwala
Kwenqatshelwe ngokuphelele ukusebenzisa imikhiqizo equkethe i-ethyl ngenkathi yokwelapha.
Ama-Analog
Izikhundla zeLysiprex: I-Liten, iLysacard, iDapril, i-Irumed, iDiroton.
Imibandela yekhefu lekhemisi
Umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Kukhishwe.
Intengo ye-lisiprex
Yimalini eRussia nase-Ukraine akwaziwa. Manje umuthi uthola isitifiketi.
Izimo zokugcina zomuthi
Amazinga okushisa aze afike ku- + 25 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-2
Umkhiqizi
I-Irbitsky KhFZ, OJSC, eRussia.
Ukubuyekezwa mayelana neLysiprex
U-Angela, oneminyaka engama-38, eMoscow: "Izifundo noLysiprex zisize ukubeka ubaba ezinyaweni ngemuva kokuhlaselwa yisifo senhliziyo. Kuyikhambi elihle, wayengenazo izimpawu eziseceleni. Kuyisihawu ukuthi akasakwazi ukuthengwa emakhemisi."
UKirill, oneminyaka engama-42 ubudala, uKerch: "Ngaphuza amaphilisi eLysiprex iminyaka eminingana. Ngiyehluleka ngokomzimba ngokungaphumeleli, kusetshenziswe izidakamizwa eziningi, kepha lo muthi kuphela obonise umphumela ongcono."
USergey, oneminyaka engama-45 ubudala, eKiev: "Ngithathe lesi sidakamizwa ngemuva kokuhlaselwa yisifo senhliziyo esibuhlungu. Selulama ngokushesha, kepha ngaba nezimpawu eziseceleni, ikhanda lami lilimele futhi nomfutho wegazi wami weqa. Umuthi awuzange ukhanselwe ngenxa yalokhu, ngoba uyasebenza, nekhanda elibuhlungu. uyakwazi ukubekezelela. "
