Abathengi bavame ukubuza amaphilisi e-Orlistat kumakhemisi. Lolu uhlobo olukhona lomuthi. Awukwazi ukuhlangana nayo ngendlela yamafutha okugcoba, ijeli, ukhilimu, i-lyophilisate noma isixazululo. Umuthi ungowezidakamizwa ezokwehlisa i-lipid. Ngokusebenzisa kahle, kungakusiza wehlise isisindo.
Amafomu akhona akhishwe kanye nokwakheka
Umuthi usesimweni samaphilisi. Into esetshenziswayo yikhompiyutha ye-orlistat yegama elifanayo. Umthamo wayo ku-1 capsule yi-120 mg. Ngaphezu kwalokho, ukwakheka komuthi kufaka phakathi ezinye izinto:
- i-magnesium stearate;
- i-acacia gum;
- i-sodium lauryl sulfate;
- i-crospovidone;
- mannitol.
Umuthi usesimweni samaphilisi.
Ebhokisini lekhadibhodi kukhona amanxeba (amakhompiyutha ayi-10 ngakunye). Inani lamaphakeji weseli liyahlukahluka: lisuka ku-1 liye ku-9 ama-PC.
Igama Lezwe elingafanele
I-Orlistat. NgesiLatini, into ibizwa ngokuthi i-orlistat.
I-ATX
A08AB01.
Isenzo se-Pharmacological
Umgomo wesidakamizwa uncike ekunciphiseni komsebenzi wama-enzyme (lipases) anomthelela ekuwohlokeni kwamafutha. Ngenxa yalokhu, izicubu ezinamafutha azakhiwa kancane emzimbeni. I-Orlistat isebenza ku-lumen yesisu namathumbu. Ngakho-ke, into esebenzayo ixhumana nokudla okuvela esophagus. Isakhi esiyinhloko ekwakhekeni kwalo muthi sivimbela ama-enzyme aqukethe amathumbu kanye noketshezi oluyimfihlo lwamanyikwe.
Ngaphezu kwalokho, kukhona ukubopha okuphezulu emafutheni. Lokhu kukuvumela ukuthi ubasuse emzimbeni ngamanani amakhulu. Le ndawo kungenxa ye-lipophilicity ye-orlistat (isakhiwo esifanayo namafutha). Ngenxa yalokhu, ama-enzyme alahlekelwa amandla okuguqula ama-triglycerides ama-metabolites kuma-metabolites amabili angangeneka: amahhala wamafutha acid nama-monoglycerides.
Ngokusebenzisa umuthi ngendlela efanele, unganciphisa isisindo.
Ngenxa yalokhu, isisindo somzimba siyeka ukwanda, okubalulekile uma ukhuluphele ngokweqile noma ukukhuluphala ngokweqile kukhula. Ngenkathi uthatha i-Orlistat, Amafutha awangenwa, kepha akhululiwe, okudala ukungabi nalutho ikhalori. Lesi yisici esiyinhloko esinomthelela ekunciphiseni isisindo.
Lapho wenza ucwaningo, kwatholakala ukuthi ngenxa yokuphathwa okuphindaphindiwe kwalesi sidakamizwa okukhulunywa ngaso, ukuqoqeka kwe-cholecystokinin ye-postprandial kuyancipha. Kodwa-ke, kuphawulwe ukuthi i-Orlistat ayithinti ukuhamba kwe-gallbladder, ukwakheka kwe-bile, kanye namandla okuhlukanisa amaseli wamathumbu. Umuthi awushintshi i-acidity yejusi esiswini. Ngaphezu kwalokho, umsebenzi wesisu nawo awuphazamiseki: isikhathi sokukhipha lesi sitho asikhuli.
Kwesinye isikhathi ezigulini ngesikhathi sokwelashwa nomuthi, ibhalansi yezinto ezithile zokulandela, isibonelo, phosphorus, calcium, magnesium, iron, zinc, ithusi, kuyaphazamiseka. Ngakho-ke, kuyadingeka ukuthatha inkimbinkimbi yamavithamini ngasikhathi sinye ne-Orlistat. Ngaphansi kwezimo ezijwayelekile, ukushoda kwezakhamzimba kunxephezelwa ngokulungiswa kohlelo lokudla okunempilo. Imenyu yethula inyama eningi, inhlanzi, ubhontshisi, amantongomane, imifino nezithelo. Kodwa-ke, ngenkomba ephezulu yomzimba (BMI) kanye nokukhuluphala, kufanele ulandele ukudla okune-khalori ephansi. Ngakho-ke, kuphoqelekile ukuthatha i-vitamin tata.
Ngenxa ye-Orlistat, isimo esijwayelekile somzimba siyathuthuka: ubungozi bokuthola izifo zenhliziyo, ukwakheka kwe-calculi esikhungweni senyongo, nokungasebenzi kahle kokuphefumula kuncishisiwe. Umuthi uphuzwa isikhathi eside. Kodwa-ke, isiguli kufanele sixwayiswe ngobungozi bokuthi sizuze isisindo size sifinyelele ezingeni ebelizolungiswa ngaphambi kokuqala kokwelashwa.
I-Pharmacokinetics
Umuthi udonswa kancane. Ngenxa yalesi sizathu, i-plasma concentration yayo incane. Ithuluzi libonakaliswa ngokubopha okuphezulu kumaphrotheni egazi. I-Orlistat iguqulwa emathunjini. Lapha kukhululwa ama-metabolites ayo. Zibonakaliswa umsebenzi omncane futhi empeleni azithinti i-lipase.
I-Orlistat isiza ukumisa ukukhuluphala kwesisindo sokukhuluphala.
Iningi lezidakamizwa likhishwa emzimbeni lingashintshiwe. I-Excretion yenzeka ngamathumbu. Isikhathi sokususwa kwento esebenzayo emzimbeni yizinsuku ezingama-3-5. Umuthi usiza ukususa ama-27% wamafutha esilinganisweni sokudla semihla ngemihla.
Izinkomba zokusetshenziswa kwamaphilisi we-Orlistat
Leli thuluzi lisiza ukumisa ukukhuluphala kwesisindo sokukhuluphala (inkomba yobukhulu bomzimba - kusuka kuma-30 kg / m²), ngokweqile (BMI idlula ama-28 kg / m²). Umuthi unqunyelwe kanye nokudla. Ngaphezu kwalokho, kubalulekile ukuthi isibalo semihla ngemihla sama-kilocalories singeqi ku-1000. I-Orlistat ibekelwe iziguli ezisengozini (ngohlobo 2 lwesifo sikashukela).
Contraindication
Izimo eziningana zokusebenzisa emzimbeni lapho umuthi ungasetshenziswanga:
- ukungabekezelelani kwengxenye esebenzayo;
- ushintsho ekwakhekeni kwegazi, okuhambisana nokwanda kokuqoqeka kwezinto ezidalulwe ku-bile;
- iminyaka efinyelela eminyakeni eyi-12;
- isifo se-malabsorption syndrome;
- umsebenzi we-renal ophazamisekile, lapho i-metabolism ishintsha khona, kufakwa usawoti we-oxalic acid ezithweni ezahlukahlukene;
- isifo sezinso.
Ungawathatha kanjani amaphilisi we-Orlistat?
Ukwehla kwesisindo
Imiyalo esetshenzisiwe:
- umthamo owodwa - i-120 mg (i-1 capsule);
- inani lomuthi lansuku zonke liyi-360 mg, kufanele ihlukaniswe ngemithamo emithathu, lona umthamo omkhulu okungafanele wedlule.
Uma okuqukethwe kwamafutha okudla kuphansi, umuthi udliwa ngesikhathi sokudla okulandelayo. Lokhu kungenxa yokuthi i-Orlistat isebenza ngempumelelo ngokudla okunamafutha kuphela. Uma kungenzeki ukuthatha i-capsule ngokudla, ezimweni ezimbi kakhulu kuvunyelwe ukuhlehlisa ukubamba isikhathi sehora eli-1 ngemuva kokudla, kepha kungabi ngakusasa. Izingane ezineminyaka engaphezu kwengu-12 neziguli ezindala zinconyelwa uhlobo olulodwa lokwelashwa.
Ngoshukela
Ngokuphikisana nesizinda sokuthatha ama-hypoglycemic agents, umthamo ojwayelekile womuthi usetshenziswa: 120 mg kathathu ngosuku. Uma kuvela iziphikiso ezingezinhle, inani lomuthi lingashintshwa. Isikhathi inkambo yokwelashwa sinqunywa esimweni ngasinye ngamunye, kucatshangelwa isisindo sokuqala isiguli, isimo somzimba, ukuba khona kwezinye izifo.
Ngokuphikisana nesizinda sokuthatha ama-hypoglycemic agents, umthamo ojwayelekile womuthi usetshenziswa: 120 mg kathathu ngosuku.
Imiphumela emibi yamaphilisi we-Orlistat
Ngesikhathi sokuphathwa kwalesi sidakamizwa, ukwakheka kwezindunduma kuyashintsha - kuba oily.
Amapheshana wesisu
Isizukulwane esisebenzisa igesi ngokweqile, ngaphezu kwalokho, kukhishwa amagesi ngesikhathi sokuhamba kwamathumbu. Noma kunjalo kunobuhlungu esiswini, ukunxenxa okuvame kakhulu kokukhipha indle, uhudo, ukungasebenzi kwesiqu, nobuhlungu ku-rectum.
Izitho zeHematopoietic
I-Hypoglycemia (ngokumelene nesizinda sikashukela sohlobo 2).
Isistimu yezinzwa ephakathi
Ubuhlungu bekhanda, isiyezi, ukukhathazeka nezinye izibonakaliso zokuphazamiseka kwengqondo.
Kusuka ezinso nasegunjini lokuchama
Ukwanda kwamathuba okukhula kwezifo ze-urethra, i-bladder.
Allergies
Ngokungakwazi ukubekezelelwa kwe-orlistat, izimpawu zokusabela okungekuhle kwe-systemic (ukuqubuka, ukulunywa) kungavela.
Ngokungakwazi ukubekezelelwa kwe-orlistat, izimpawu zokusabela okungekuhle kwe-systemic (ukuqubuka, ukulunywa) kungavela.
Umthelela ekhonweni lokulawula izindlela
Akunamikhawulo lapho wenza izinto ezidinga ukunakwa kakhulu. Kodwa-ke, iziguli ezinesifo sikashukela sohlobo 2 ziyelulekwa ukuba ziqaphele lapho zishayela, ngoba kukhona ubungozi be-hypoglycemia.
Imiyalo ekhethekile
Ukudla ngesikhathi sokwelashwa kwe-Orlistat akuneli nje ekunciphiseni isisindo, kodwa futhi kusiza ekujwayezeni i-carbohydrate metabolism.
Ukuthola umphumela oyifunayo, kuvunyelwe ukusebenzisa izindlela ezihlangene (ngokwesibonelo, i-hirudotherapy, izinqubo eziningi ze-biochemical emzimbeni zenziwa ngosizo lwe-leeches).
Uhlelo olusekelwe ekudleni okune-khalori ephansi nokuzivocavoca okusesilinganisweni kufanele luqhubeke ngemuva kokuthatha i-Orlistat.
Sebenzisa ebudaleni
Akunamininingwane ngokuphepha kwezidakamizwa ekwelashweni kweziguli ezikuleli qembu. Ngenxa yalesi sizathu, i-Orlistat akufanele isetshenziswe ekukhulelweni.
Ngesikhathi sokukhulelwa nokuqunjelwa
Umuthi uphambaniswe neziguli ngokuzala izingane, ukuncelisa ibele.
Umuthi lo uphethwe ngemibono ezigulini ngokuzala ingane.
Ukweqisa
Ukwanda kwenani lomuthi akuholeli ekubonakaleni kwemiphumela engathandeki.
Ukuxhumana nezinye izidakamizwa
Umuthi okukhulunywa ngawo ufaka ukwehla kokuxakaniseka kwe-cyclosporin.
Ngokusetshenziswa okuhlangene kwe-Orlistat ne-Amiodarone, kudingeka i-ECG ejwayelekile.
Umuthi osebenzayo ekwakhiweni kwe-ejenti okukhulunywa ngayo usiza ukunciphisa ukumuncwa kwamavithamini ancibilikiswa ngamafutha.
Ngokuphathwa kanyekanye kwezidakamizwa ze-Orlistat nezama-anticonvulsant, ukusebenza kwalokhu kwehla kuyancipha.
Ukuhambisana notshwala
Akunamininingwane ngokutholakala kokusabela okungekuhle lapho uphuza iziphuzo eziqukethe utshwala ngesikhathi sokwelashwa nomuthi okukhulunywa ngawo.
Ama-Analog
Ukufakwa esikhundleni se-Orlistat:
- I-Orsoten;
- I-Xenical
- ULeafa;
- I-Orlistat Akrikhin.
Ngenhloso yokunciphisa isisindo, ama-analogues enza imigomo ehlukile angabhekwa: iSibutramine, iLiraglutid.
Imibandela yekhefu lekhemisi
Umuthi uhanjiswa ngaphandle kwencwadi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Yebo
Kubiza malini?
Intengo emaphakathi ama-ruble angama-530. (kubonise izindleko zokufakwa ngenani elincane lamaphilisi).
Izimo zokugcina zomuthi
Ukushisa okunconyelwayo - okungekho ngaphezulu kuka- + 25 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Umuthi ungagcinwa ungadluli iminyaka emi-2 kusukela ngosuku lokukhishwa.
Umkhiqizi
IStada, eJalimane.
I-Orlistat akufanele isetshenziswe ekukhulelweni.
Ukubuyekezwa
Odokotela
I-Kogasyan N.S., i-endocrinologist, iminyaka engu-36, uSamara
Umuthi uyasebenza ekwelapheni iziguli othambekele ekudla ngokweqile. Kulokhu, umphumela uzoshesha. Kunconywa ukuthatha i-Orlistat isikhathi eside, ukwelashwa kwesikhashana esifushane ngeke kunikeze umphumela omuhle.
Kartoyatskaya K.V., gastroenterologist, iminyaka engama-37, iSt
Umuthi awunikeli ekunciphiseni isisindo. Kuyasiza kuphela ukukhipha amafutha ngokweqile, okuhambisana nezinye izinyathelo kungathinta isisindo. Izindlela ezikhethekile zokunciphisa umzimba azikho.
Iziguli
UVeronica, oneminyaka engama-38, uPenza
Ukwehla kwesisindo kwakungeyona inhloso lapho uthatha i-Orlistat. Kimi, umphumela omuhle ukugcina isisindo somzimba ezingeni eliku manje. Ithuluzi libhekane nalo msebenzi.
U-Ana, oneminyaka engama-35, u-Oryol
Umuthi omuhle, obekelwe ukukhuluphala. Umphumela waba, kepha wavezwa kabi. Kuze kube manje, ngosizo lokudla kwe-hypocaloric nomsebenzi womzimba, inkinga ayixazululwa. I-Orlistat isuse kancane isisindo, kodwa hhayi kakhulu. Ngemuva kwalokho washayisana nethafa. Ngasikhathi sinye, isisindo sayeka ukungahambi, yize nginamathela ekudleni okunempilo.
Isiyezi kuyinto yokusabela okubi komzimba ekuthatheni umuthi.
Ukulahlekelwa isisindo
UMarina, oneminyaka engama-38, uP Pskov
Nginqume ukuthatha lesi sidakamizwa, yize ngingenalo ukukhuluphala, kepha kunamaphawundi ambalwa awengeziwe. Phezu kokuthi amafutha amaningi aphuma namagundane, angibonanga olunye ushintsho.
U-Antonina, oneminyaka engama-30, uVladivostok
Ngikhuluphele ngokweqile kwavela ngemuva kwesifo sikashukela. Wathatha u-Orlistat iminyaka emi-2. Isisindo sincipha kancane kancane, kepha nami ngiyangenela imfundo yenyama, ngizame ukunamathela ekudleni.
