I-Rosuvastatin ne-Atorvastatin: yikuphi okungcono?

Izidakamizwa i-Rosuvastin ne-Atorvastatin zingama-ejenti we-hypolipidemic. Ngaphezu kwekhono lokwehlisa i-cholesterol yegazi, banezinto ze-antioxidant futhi zivimbela ukukhula kanye nokuhlukaniswa kwamaseli we-tumor. Kukhiqizwa yizinkampani zemithi ezahlukahlukene zaseRussia futhi ziphakathi kwemithi kadokotela.

Izici ze-rosuvastatin

Umuthi uyithebulethi emhlophe ye-biconvex equkethe i-rosuvastatin esebenzayo, koku kugxilwe okulandelayo:

• 5 mg;
• 10 mg;
• 20 mg;
• 40 mg

Izidakamizwa i-Rosuvastin ne-Atorvastatin cholesterol ephansi yegazi, zinezindawo ze-antioxidant futhi zivimbela ukukhula kwamangqamuzana wesimila.

Amathebulethi athengiswa emabhokisini. Ubungako obuncane kwephakethe yi-7 ama-pcs., Okuphezulu ngama-pcs ayi-300.

I-bioavailability yesidakamizwa icishe ibe ngama-20%. Ukuhlushwa okuphezulu egazini kufinyelelwa emahoreni angama-5 ngemuva kokuphathwa. Ukuqedwa kwesigamu sempilo kungamahora ayi-19.

Umthamo onconyelwe umuthi ngu-10 mg (weziguli zohlanga lwamaMongoloid - 5 mg), othathwa kanye ngosuku. Uma kunesidingo, ingakhushulwa ibe ngu-20 mg kanye ngosuku, kepha hhayi ngaphambi kwenyanga yokuphatha. Ukusetshenziswa komthamo we-40 mg kungenzeka kuphela ezifweni ezinzima zesifo futhi kuphela ngaphansi kokuhlolwa udokotela.

Isici se-Atorvastatin

Ingxenye esebenzayo yesidakamizwa yinto efanayo esebenzayo, engatholwa kwithebhulethi ekugxileni okulandelayo:

• 10 mg;
• 20 mg;
• 40 mg;
• 80 mg

Ngokuya ngomenzi, amaphilisi angaba yindilinga noma awoli, abe nombhalo kolunye lwezinhlangothi. Umuthi uyathengiswa emabhokisini amakhadibhodi. Inani eliphansi lamathebulethi kuphakeji yizingcezu eziyi-10, inani eliphakeme izingcezu ezingama-300.

I-Atorvastatin kumele ithathwe esiswini esingenalutho, ngoba ukuhlanganiswa nokudla kuvimbela ukufakwa kwento esebenzayo.

Umuthi ubonakala nge-bioavailability ephansi (12%). Ukuhlushwa okuphezulu kutholakala emahoreni angama-1-2 ngemuva kokuphatha. Isigamu sempilo singamahora ayi-13.

Umthamo wesidakamizwa uncike ekuhlushweni kokuqala kwe-cholesterol futhi kufanele kukhethwe ngakunye esigulini ngasinye. Umthamo wokuqala onconyiwe ngu-10 mg kanye ngosuku. Umthamo omkhulu ovunyelwe ngosuku ngu-80 mg. Umuthi kumele uphuzwe esiswini esingenalutho. Ukuhlanganiswa nokudla kuphazamisa ukumuncwa kwento esebenzayo.

Ukuqhathanisa Izidakamizwa

Zombili lezi zidakamizwa ezibhekwayo zingamalungu eqembu lama-synthetic. Uma kuqhathaniswa nezinye izinto zalesi sigaba, zibonakaliswa ukwehla okushiwo emazingeni we-TG. Kodwa-ke, izithako zabo ezisebenzayo azifani.

Ukufana

Le mishanguzo inenhloso efanayo yokuthatha - ukwehlisa i-cholesterol. Umphumela wazo wemithi uyancishiswa ekuvinjelweni kwe-HMG-CoA reductase. Umphumela wale miphumela ukwehla kwe-cholesterol kumaseli nokusebenza kwe-LDL cholesterol catabolism. Izinga okuhlushwa ngalo lincipha ngalo kuxhomekeka kumthamo womuthi.

Eminye imiphumela emihle ekuthatheni iRosuvastatin noma i-Atorvastatin izoba:

• ukuphuculwa kwe-endothelium ngokungasebenzi kwayo;
• ukufaniswa kwezakhi zegazi ezibucayi;
• ukuphuculwa kwesimo sezindonga ze-vascular kanye ne-atheroma.

I-Rosuvastatin ne-Atorvastatin kunconyelwa abaguli ababhemayo ukuvimbela izifo zenhliziyo.

I-Rosuvastatin ne-Atorvastatin kusetshenziselwa ukuvikela isifo senhliziyo ezigulini ezineminyaka engaphezu kwengama-55.

I-Rosuvastatin ne-Atorvastatin zisetshenziselwa ukuvikela umfutho wegazi ophakeme.

Ngokuqapha, izidakamizwa kufanele zisetshenziselwe utshwala.

I-Rosuvastatin ne-Atorvastatin zichasene ezinganeni nasebusheni.

I-Rosuvastatin ne-Atorvastatin ayinqunyelwe ngesikhathi sokukhulelwa nokuqunjelwa.

Imithi ayinqunyelwe izifo zesibindi esigabeni esisebenzayo.

Izinkomba zokusetshenziswa kwazo yilezi zifo ezilandelayo:

• i-hypercholesterolemia yemisuka ehlukahlukene, kufaka phakathi i-homozygous Famer hypercholesterolemia;
• uhlobo lwe-hyperlipidemia IIa ne-IIb;
• Uhlobo lwesithathu lwe-dysbetalipoproteinemia;
• i-endo native hypertriglyceridemia (uhlobo IV).

Ngaphezu kwalokho, izidakamizwa ezinjalo zisetshenziselwa i-prophylaxis yiziguli ezinezici eziningi zokuthuthukisa izifo zenhliziyo ezi-coronary, ezifana:

• iminyaka engaphezulu kweminyaka engama-55;
• ukubhema
• isifo sikashukela mellitus;
• umfutho wegazi ophakeme
• i-cholesterol ephansi (HDL) egazini;
• umlutha wozalo.

Zibekelwe nalabo bantu asebetholakale ukuthi bane-ischemia, ukuze banciphise amathuba okukhula kwe-angina pectoris, ukushaya kwenhliziyo noma unhlangothi.

Imithi ine-contraindication efanayo. IRosuvastatin noma i-Atorvastatin ayinqunyelwe:

• nezifo zesibindi esigabeni esisebenzayo;
• ngesikhathi sokukhulelwa nokuqunjelwa;
• izingane nentsha.

Ngokuqapha, izidakamizwa kufanele zisetshenziswe ne:

• utshwala;
• isiphetho se-myopathy;
• ukwehluleka okunzima kwezinso.

Ukuphuza imithi kungadala ukuqwasha.

Lapho usebenzisa iRosuvastine ne-Atorvastatin, ungahlangabezana nokubonakaliswa okungekuhle njenge-tinnitus.

Ngemuva kokuthatha iRosvvine ne-Atorvastatin, ezinye iziguli zakha i-angina pectoris.

Ukuthatha i-rosuvastine ne-atorvastatin kungadala i-anemia.

I-asthma ye-bronchial ingumphumela we-rosuvastine ne-atorvastatin.

Ngokuphikisana nesizinda sokulashwa kwezidakamizwa nge-rosuvastatin ne-atorvastatin, kungenzeka ukwanda kwesisindo somzimba.

Ukuphuza imithi kungadala isifo samathambo.

Ukubonakaliswa kokungaphenduki kahle komzimba wokwelapha ngale mishanguzo kuyafana. Lapho zithathwa, ukuthuthukiswa kwemiphumela emibi efana:

• ukuqwasha nesiyezi, kanye nokunye ukusabela okuvela esimisweni sezinzwa esiphakathi;
• ukungasebenzi kwemizwa, njengokulahlekelwa ukunambitheka noma i-tinnitus;
• Ubuhlungu besifuba, i-arrhythmia, i-angina pectoris;
• i-anemia, ukuphazamiseka kwegazi;
• i-bronchitis, inyumoniya, i-asthma ye-bronchial, i-nosebleeds;
• isicanucanu nezinye izindlela zokugaya ukudla;
• isifo samathambo, ukwanda kwe-gout;
• ukuvuvukala
• ukuthuthukiswa kwezifo ze-urogenital;
• ukusabela kwesikhumba;
• ushintsho ekubaleni kwegazi kwelebhu;
• isisindo somzimba;
• ukukhula kwesifuba;
• ukubonakaliswa komzimba.

Umphumela omkhulu wokwelapha utholakala ngemuva kwamaviki ama-4 elashwa ngale mishanguzo.

Lapho uthatha le mithi, abesifazane besikhathi sokuzala kufanele basebenzise izindlela ezinokwethenjelwa zokuvimbela inzalo.

Uyini umehluko

Yize ukufana, le mithi ingeyizizukulwane ezahlukahlukene zama-statin. I-Rosuvastatin yintuthuko entsha evumela ukuthi wena unciphise isilinganiso kanye nesilinganiso esiphezulu sento esebenzayo ngenxa yokusebenza kahle kakhulu.

Izidakamizwa okukhulunywa ngazo zinezindlela ezahlukile zokuqeda:

• i-atorvastatin ikhishwa emzimbeni nge-bile ngendlela yama-metabolites lapho iguqulwa khona ngama-enzyme wesibindi;
• rosuvastatin - engashintshiwe indle.

I-Rosuvastatin iyinto ye-hydrophilic, kanti i-Atorvastatin iyanyibilika emafutheni.

Kuhlobo 2 sikashukela mellitus, kungcono ukukhetha i-rosuvastatin, ngoba inethonya elincane kumetabolism wama-carbohydrate.

Okuphephile

Ucwaningo lukhombisa ukuthi izehlakalo zokungaphenduki ngokungemthetho ziyefana kuzo zombili lezi zidakamizwa.

Kwaphawuleka ukuthi ngesifo sikashukela sohlobo 2, kungcono ukukhetha ama-hydrophilic statins, ahlanganisa neRosvvatin, ngoba izinto ezinjalo zinomthelela omncane ekusebenzeni kwama-carbohydrate.

Yikuphi okushibhile

Amanani weRosuvastatin ne-Atorvastatin ancike ezicini eziningana:

• inani lamathebulethi ngephakethe ngalinye;
• umenzi wezidakamizwa;
• inqubomgomo yamanani entengo ekhemisi;
• isifunda sokuthengwa kwalo muthi.

Ikhemisi elaziwa nge-inthanethi lithenga ukuthenga iRosuvastatin ngamanani alandelayo:

• Amacwecwe ama-30 we-10 mg akhiqizwa ngu-Izvarino Pharma - ama-ruble angama-545.7;
• Amacwecwe ama-30 we-10 mg akhiqizwa iVertex - 349.3 ruble;
• Amacwecwe ama-60 we-20 mg, enziwe yiCanonpharm Production LLC, - ama-ruble ayi-830.5 .;
• Amathebulethi angama-90 e-20 mg akhiqizwa yinkampani i- "North Star" - ama-ruble ayi-1010.8.

I-Atorvastatin ingathengwa ngezindleko ezilandelayo:

• Amacwecwe ama-30 we-10 mg akhiqizwa yinkampani yeNorth Star - ama-ruble ayi-138;
• Amacwecwe ama-30 we-10 mg akhiqizwe yi-Ozone LLC - ama-ruble angama-65.4;
• Amacwecwe ama-60 we-40 mg akhiqizwa yinkampani yeNorth Star - ama-ruble angama-361.4;
• Amathebulethi angama-90 e-20 mg ka-Vertex brand - ama-ruble ayi-799.

Izindleko zamathebhulethi angama-60 e-Atorvastatin 40 mg ngayinye ekhiqizwa uSevernaya Zvezda ngama-ruble angama-361.4.

Amacwecwe ama-30 we-10 mg rosuvastatin, akhiqizwa iVertex, abiza ama-ruble angama-349.3.

Amacwecwe angama-90 e-rosuvastatin 20 mg ngalinye, akhiqizwa uSevernaya Zvezda, abiza ama-ruble ayi-1010.8.

Ezintweni ezicashunwe, kuyacaca ukuthi i-Atorvastatin isidakamizwa eshibhile kuneRosuvastatin.

Yini engcono - rosuvastatin noma atorvastatin?

Idatha etholakalayo ngokuqhathanisa ukusebenza kwale mithi ikhombisa ukuthi ukwelashwa kwe-rosuvastatin kunomthelela omenyezelwa wokwehlisa ukugxila kwe-cholesterol. Ngaphezu kwalokho, lo muthi ungowama-statins wezizukulwane ezi-4 futhi uphakamisa ukusebenza okukhulu njenge-prophylactic yesifo se-coronary artery.

Kodwa-ke, ukukhetha izidakamizwa kufanele kwenziwe ngudokotela oholayo esigulini ngasinye, kucatshangelwa izici zakhe ezithile, izifo ezihlangene kanye nekhono lezezimali.

Ingabe i-rosuvastatin ingathathelwa indawo nge-atorvastatin?

Naphezu kweqiniso lokuthi ukuqhathaniswa kwezingoma kukhombisa ukuthi into esebenzayo yeRosuvastatin ne-Atorvastatin akuyona into efanayo, ziyizimpawu futhi ziyaguquguquka. Kodwa-ke, ngaphambi kokusuka kwesinye isidakamizwa uye kwesinye, kufanele ngaso sonke isikhathi ubonane nodokotela, ngoba ama-pharmacokinetics ale mishanguzo ahlukile, ngenxa yalokho le mithi ithinta amaseli wesibindi nobuchopho ngezindlela ezihlukile, futhi futhi inemizila ehlukahlukene yokuphuma.

Ukubuyekezwa kodokotela

UGrigory, oneminyaka engama-46, eMoscow: "Into esemqoka okudingeka ukuthi isiguli sazi lapho sisebenzisa le mishanguzo ukuthi injongo yaso ayiqedi isidingo sokubambelela ekudleni okunqunyiwe. Okokuqala, ngihlala ngincoma iRosuvastatin, ngoba ukusebenza kahle kakhulu kufakazelwe emtholampilo. Uma kwenzeka imiphumela emibi, ngibahumushela kuma-analogues" .

UValentina, oneminyaka engu-34 ubudala, uNovosibirsk: "Ngicabanga ukuthi ukuthatha lo muthi njengephrokhthiliya enhle yezifo zenhliziyo kanye ne-cerebral arteriosclerosis. Ngibanikeza zonke iziguli ezinayo i-cholesterol ephezulu."

Ukubuyekezwa kweziguli kweRosuvastatin ne-Atorvastatin

UNikolai: oneminyaka engama-52, uKazan: "Okuwukuphela kwenzuzo ka-Atorvastatin yizindleko zayo eziphansi. Kimina, ukuphatha kwayo bekuhambisana nenqwaba yokuphendula okungathandeki: isicanucanu kanye nekhanda bekuphazamiseka njalo. Ngaso leso sikhathi, izinga le-cholesterol yegazi lihlale liphakeme."

USvetlana, oneminyaka engama-45, uMurmansk: "Ngokuyalelwa udokotela, ngaphuma ekuthatheni i-Atorvastatin ngaya eRosuvastatin, ngenxa yokwelashwa njalo kwenhliziyo. Ngingasho ukuthi umuthi omusha awubanga ukusabela okunjalo, kanti futhi uthinta namazinga e-cholesterol."