I-Apidra Solostar iyisidakamizwa esinomphumela we-hypoglycemic. Kusetshenziswa ekwelapheni uhlobo lwesifo sikashukela sohlobo 1 nohlobo 2 kubantu abadala, ebusheni nasezinganeni. Ngaphambi kokuqokwa, kuyadingeka ukwenza ucwaningo lweveli likashukela egazini.
Igama Lezwe elingafanele
Insulin glulisin
I-ATX
I-A10AV06
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo sesisombululo sokuphathwa kumafuthumeli angenasici, onendlela yoketshezi olucacile, olungenamibala. Ukwakheka kwe-1 ampoule kufaka phakathi okulandelayo:
- i-insulin glulisin (100 AMA-PIECES);
- metacresol;
- i-sodium chloride;
- trometamol;
- i-hydrochloric acid;
- amanzi wokujova;
- polysorbate.
I-Apidra Solostar iyisidakamizwa esinomphumela we-hypoglycemic.
Isenzo se-Pharmacological
Umuthi osebenzayo ungukubambela i-insulin yabantu. Inomphumela osheshayo, omfushane kunowokuvikelwa kwemvelo okwemvelo, ubude besikhathi. Umuthi unezici ezilandelayo:
- ilawula imetabolism ye-glucose;
- kwehlisa ushukela wegazi ngokushukumisa ukuthathwa kwe-glucose ngezicubu ezithambile;
- inhibits gluconeogenesis esibindini;
- kunciphisa isilinganiso sokuqhekeka kwamafutha kuma-adipocytes;
- ivimbela ukuwohloka kwamaprotheni futhi yenyuse ukukhiqizwa kwamaprotheni.
I-Pharmacokinetics
Umuthi unemingcele elandelayo ye-pharmacokinetic:
- Ukuhlelwa. Lapho umuthi uhanjiswa ezigulini ezinesifo sikashukela esincike ku-insulin, ukuqina kwe-insulin glulisin egazini kutholakala ngemuva kwehora. Ukuqoqwa okuphezulu kwento kunqunywa ngemuva kwemizuzu engama-80. Ukuba khona kwomuthi osegazini kuyimizuzu eyi-100.
- Ukusatshalaliswa. Umuthi usatshalaliswa njenge-insulle human insulin.
- Ukuzala. Ngokuphathwa kwe-subcutaneous, i-glulisin ishiya umzimba ngokushesha kune-insulin yemvelo. Ukuqedwa kwesigamu sempilo akuhlali isikhathi esingaphezu kwemizuzu engama-40, kuyilapho i-insulin yomuntu isuswa isigamu sempilo esilingana nemizuzu engama-85.
Izinkomba zokusetshenziswa
Umuthi usetshenziselwa ukwelapha isifo sikashukela esincike ku-insulin.
Contraindication
Umuthi unokuphikisana okulandelayo:
- ukungabekezelelani komuntu ngamunye kwento esebenzayo nezinto ezisizayo;
- hypoglycemia
Ungayithatha kanjani i-Apidra Solostar
I-Apidra injekelwa ngokungazelelwe ngenaliti emincane esifundeni semisipha esidonsayo noma udonga olungaphakathi lwesisu ngaphambi noma ngokushesha ngemuva kokudla. Umuthi kufanele ufakwe emithini yokwelapha, kufaka ne-insulin yesikhathi esiphakathi noma esiphakeme sokwenza. Kuhlobo lwe-2 isifo sikashukela, singasetshenziswa sihlangane nama-ejenti we-hypoglycemic etafuleni. Umthamo usethwa ngokuya ngokuzwela komzimba ukuya ku-insulin.
Isixazululo sikhishwa kusetshenziswa isirinji noma ipeni-isenzo sokufaka esinikeza ukumfaka okuqhubekayo kwento entuthwini ye-adipose. Ngesicelo esisha ngasinye, indawo yomjovo kufanele ishintshe. Izinga lokumunca lincike kusayithi lomjovo, ukusebenza ngokomzimba kanye nohlobo lokudla oluthathiweyo. Lapho ingeniswa odongeni lwesisu, into esebenzayo idonswa ngokushesha. Lapho ubeka umjovo, ukungena kwezidakamizwa emithanjeni nasemithanjeni kufanele kugwenywe. Akunakwenzeka ukucwilisa indawo yomjovo ngemuva kokukhipha inaliti.
Umuthi usetshenziselwa ukwelapha isifo sikashukela esincike ku-insulin.
Imiphumela emibi Apidra Solostar
Imiphumela emibi ye-Apidra ayihlukile emiphumeleni emibi eyenzeka ngokufakwa kwamanye ama-insulin asebenza ngokufushane.
Engxenyeni yesikhumba
Ukuphathwa kwe-subcutaneous kwekhambi kungadala ubomvu, ukuvuvukala kanye nokucasuka kwesikhumba endaweni yomjovo. Lezi zimpawu ziyeka ukuvela ezinsukwini ezimbalwa ngemuva kokuqala kokwelashwa. Kwesinye isikhathi imiphumela emibi ihambisana nokusetshenziswa kwama-antiseptic agents ekwelapheni isikhumba ngaphambi kwenqubo noma umjovo ongalungile.
Ngasohlangothini lwe-metabolism
Umphumela ojwayelekile kakhulu we-glulisin yi-hypoglycemia, lapho kuvela khona lezi zimpawu ezilandelayo:
- ubuthakathaka bemisipha;
- ukukhathala;
- kwehlise i-acuity ebonakalayo;
- ikhanda
- ukungazi kahle;
- ukubanjwa okukhokhisa;
- umuzwa onamandla wendlala;
- ukujuluka ngokweqile;
- uvalo
- ukuzamazama kwemilenze;
- ukuzindla kwenhliziyo.
Ngokuvela kaningi kokuhlaselwa kwe-glypoglycemia enzima, uhlelo lwezinzwa luhlupheka, olufaka isandla ekuthuthukiseni izimo ezisongela impilo, kufaka phakathi ukubulawa kwe-hypoglycemic coma.
Allergies
Izimpawu zokungezwani nomuthi yilezi ezilandelayo:
- ukuqubuka kwesikhumba emaphashini;
- i-urticaria;
- ukusabela kwe-anaphylactic;
- ukucindezela izinhlungu ngemuva kwe sternum;
- ukuhlaselwa kwe-asphyxia;
- ukwehla kwengcindezi yegazi;
- ukuzindla kwenhliziyo;
- umkhuhlane.
Umthelela ekhonweni lokulawula izindlela
I-Apidra ingadala ukuphazamiseka kwemizwa okwehlisa izinga lokuphendula kwengqondo, ngakho-ke uma ulapha udinga ukwenqaba ukushayela imoto namanye amadivaysi ayinkimbinkimbi.
Imiyalo ekhethekile
Sebenzisa ebudaleni
Lapho ukhetha umthamo weziguli esezikhulile, udokotela kufanele acabangele amathuba ezifo zezinso anciphisa isidingo somzimba se-insulin.
Isabelo sezingane
Umuthi awunconyelwanga ukukhululeka kwezimpawu zesifo sikashukela ezinganeni ezingaphansi kweminyaka engu-6.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
I-insulin glulisin ayinamphumela we-teratogenic noma we-mutagenic kwi-fetus, noma kunjalo, ngesikhathi sokukhulelwa, umuthi kufanele usetshenziswe ngokuqapha. Ngesikhathi sokuncelisa, ukuguqulwa komthamo kungadingeka.
Isicelo sokusebenza kokulimala kwezinso
Ngokuphulwa okubonakalayo kohlelo lwe-excretory, umthamo wesidakamizwa uyancishiswa.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukwehluleka kwesibindi okunzima, isidakamizwa sisetshenziswa ngokuqapha.
Ukweqisa kwe-Apidra Solostar
Ngokwazisa kwe-insulin eyeqile, i-hypoglycemia iyenzeka. Izimpawu ze-hypoglycemia emnene zingasuswa ngokudla ukudla okuqukethe ushukela.
Kwi-overdose eyingozi, ehambisana nokungazi kahle, ukuphathwa kwe-intramuscular noma i-subcutaneous ye-glucagon kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Umphumela wesidakamizwa uyathuthuka lapho ulawulwa ngokuhambisana nama-ejenti we-hypoglycemic etafula, ama-inhibitors we-ACE, i-fibrate ne-pentoxifylline. Ukusebenza kwe-glulisin kuncishiswa ngama-glucocorticosteroids, isoniazid, salbutamol, adrenaline, diuretics. Ama-Beta-blockers angawenza buthaka futhi andise umphumela womuthi. Ukuphathwa okuhlanganayo nge-pentamidine kukhuthaza ukukhula kwe-hypoglycemia, okuthi kancane kancane iphenduke i-hyperglycemia.
Ukwethulwa kwalesi sidakamizwa akunconywa ukuhlanganisa nokusetshenziswa kotshwala.
Ukuhambisana notshwala
I-Ethanol ingaguqula amapharamitha we-pharmacokinetic wento esebenzayo, ngakho-ke ukwethulwa kwalesi sidakamizwa akunconywa ukuthi kuhlanganiswe nokusetshenziswa kotshwala.
Ama-Analog
I-Apidra inomphumela ofanayo.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi awunakuthengwa ngaphandle kwemithi.
Intengo
Intengo ephakathi yesidakamizwa ama-ruble ayi-1900.
Izimo zokugcina zomuthi
Isixazululo sigcinwa esiqandisini ngaphandle kokubanda.
Isikhathi sokuphelelwa yisikhathi
Umuthi ufanele ukusetshenziswa ezinyangeni ezingama-24.
Umuthi ugcinwa esiqandisini.
Umkhiqizi
Lesi sidakamizwa senziwa yizinkampani zemithi iSanofi-Aventis Vostok, iRussia neSanofi-Aventis Deutschland, eJalimane.
Ukubuyekezwa
UNatalia, oneminyaka engama-52, eMoscow: "Umphumela wesidakamizwa uyafana nesenzo se-insulin yemvelo. I-Apidra iyahlukahluka ngokuthi ingalayishwa ngaphambi kokudla. Ngiphuza isidakamizwa imizuzu emi-2 ngaphambi kokudla, lokhu kusiza ekugwemeni ukwanda okukhulu koshukela wegazi. I-Apidra iza endaweni eyodwa. ipeni lesirinji elenzelela ukufakwa. Kulula ngangokunokwenzeka. "
UTamara, oneminyaka engama-56, uKursk: "Umuthi wawunqunyelwe umama. Njengoba ingowesifazane oneminyaka yobudala, umthamo obekiwe wawungaphansi kwesilinganiso. Umuthi usebenza ngokushesha, uma kunemiphumela emibi ngokuya ngemiyalo. Sijova ngaphambi kokudla. Isixazululo sihanjiswa ngemijovo efanelekile. "Anginayo imizwa engemnandi ngemuva komjovo. Sekuphele izinyanga eziyisithupha ngisebenzisa i-insulin, sijabule ngomphumela."
