Imiyalo yokusebenzisa izidakamizwa iMetformin

Ekwelashweni kwesifo sikashukela, ama-ejenti ahlukahlukene we-hypoglycemic athathwa. Umuthi wethebhulethi iMetformin usetshenziswa kabanzi kwezokwelapha ngalesi sifo.

Umuthi lowo ufakwa kuhlu lwemithi ebalulekile eqeda ushukela ohlotsheni 2 sikashukela.

Imininingwane ejwayelekile, ukwakheka kanye nendlela yokukhululwa

I-Metformin umuthi osetshenziswa kabanzi ukwelapha isifo sikashukela sohlobo 2. Kungokwesigaba se-Biguanides. Kubonakaliswa ukubekezelela okuhle, imiphumela emibi ngokusetshenziswa okufanele ayivelakancane. Yilo kuphela umuthi osesigabeni sawo ongalimazi abantu abanokwehluleka kwenhliziyo.

Isiza ukunciphisa i-triglycerides ne-LDL. Ingabekwa futhi ekwelashweni okuyinkimbinkimbi ekwelapheni ukukhuluphala. Akuthinti ukuqina kwesisindo, kunciphisa ingozi yezinkinga zenhliziyo kwisifo sikashukela. Lapho uthatha umuthi, ubungozi be-hypoglycemia abunakwa.

Isibonakaliso esiyinhloko sokusebenzisa uhlobo lwesifo sikashukela sohlobo 2. Ingabekelwa ukuthomba kokuthomba, nge-ovary polycystic, izifo ezithile zesibindi. Umuthi uphatha neziguli ngombuso we-prediabetesic.

Into esebenzayo yesidakamizwa yi-metformin hydrochloride.

Ithebhulethi ngayinye ingaqukatha umthamo ohlukile wengxenye esebenzayo: 500, 800, 1000 mg.

Kutholakala ngesimo amaphilisi egobolondo. Iphakethe liqukethe amanxeba ayi-10. Ihlamvu ngalinye liqukethe amaphilisi ayi-10.

Isenzo se-Pharmacological ne-pharmacokinetics

Umuthi wehlisela kokubili ushukela ophelele kanye nokuxineka kwawo ngemuva kokudla. Umuthi ubandakanyeka ekushukumiseni kwe-glycogen synthesis futhi kusebenze ukuhamba kwegazi esibindini. Inqanda i-gluneocogenesis emzimbeni. Yehlisa i-LDL futhi inyusa i-HDL.

Ithuluzi libambezela ukwanda kwezakhi zemisipha ebushelelezi yezindonga zemithambo yegazi. Yehlisa ukufakwa kwe-glucose emgodini wokugaya ukudla, icindezela isifiso sokudla. Ukwehla kokuxinwa ushukela kuchazwa ngokuthuthuka kokugaya kwayo ngamaseli ngenxa yokwanda kokuzwela kwe-insulin.

Umuthi awusebenzi ukukhiqizwa kwe-insulin, wehlise amazinga kashukela, ngenkathi ungavuseleli umphumela we-hypoglycemic. Uma usebenzisa umuthi kubantu abanempilo, akukho ukwehla kwamanani eglucose. Imisa i-hyperinsulemia, okucasulayo ukuzuza kwesisindo nokukhula kwezinkinga.

Ngemuva kokuphatha, into cishe icwile ngokuphelele. Ngemuva kwamahora we-2,5, okuhlushwa kufinyelela isilinganiso sawo. Lapho usebenzisa umuthi ngenkathi udla, isilinganiso sokumunca siyancipha.

Ngemuva kwamahora ayi-6, ukuqoqwa kweMetformin kuyancipha, ukumuncwa kwawo kancane kancane kuyeke. Ngemuva kwamahora we-6.5, impilo yengxenye yesidakamizwa iqala. Umuthi awubophele amaprotheni egazi. Ngemuva kwamahora ayi-12, ukuqedwa ngokuphelele kwenzeka.

Izinkomba kanye ne-contraindication

Izinkomba zokuphuza umuthi yilezi:

• isifo sikashukela esinga-insulin (Thayipha isifo sikashukela sesi-2) njenge-monotherapy lapho ungekho umphumela ofanele ngemuva kokwelashwa kokudla;
• Thayipha isifo sikashukela sohlobo 2 kanye nabenzeli be-antidiabetic;
• Thayipha isifo sikashukela sesibili ekwelapheni izingane ezisukela eminyakeni eyi-10 lapho zihlanganiswa noma zodwa;
• kanye ne-insulin;
• ekwelashweni okuyinkimbinkimbi kokukhuluphala, uma ukudla kungalethi imiphumela;
• Ukuqedwa kwezinkinga zesifo sikashukela.

Umuthi awunconyelwe ukusetshenziswa ezimweni ezilandelayo:

• isifo sikashukela sikashukela;
• ukungabekezeleli izingxenye zomuthi;
• infarction myocardial;
• utshwala;
• ukwehluleka kwezinso;
• ucwaningo lwe-radiographic ngokwethula umehluko okhethekile;
• izifo ezithathelwanayo ezinkulu;
• isifo sikashukela sikashukela, i-precoma;
• ukwehluleka kwesibindi.

Umyalo wokusetshenziswa

Iziphakamiso zabantu abadala: ekuqaleni kokwelashwa, kuthathwa umthamo okungenani we-500 mg. Umuthi uphuzwa izikhathi ezi-2 ngosuku ngemuva kokudla. Ngemuva kwamasonto amabili, ushukela uyakalwa bese umthamo ulungiswa ngokuya ngemiphumela.

Umuthi ukhombisa umsebenzi wokwelapha ngemuva kwezinsuku eziyi-14 zokuphatha. Ukungezelela umthamo kwenzeka kancane kancane - lokhu kunciphisa umphumela oseceleni wokugaya ukudla.

Ukudla okuphezulu kakhulu nsuku zonke kungama-3000 mg.

Iziphakamiso zezingane: Ekuqaleni, i-400 mg yomuthi inqunyelwe (ithebhulethi ihlukaniswe ngesigamu). Ngokulandelayo, ukwamukela kwenziwa kwesikimu esivamile. Isilinganiso esiphakeme sansuku zonke yi-2000 mg.

Umuthi uhlanganiswa ne-insulin. I-Metformin ithathwa ngendlela ejwayelekile: 2-3r. ngosuku. Umthamo we-insulin unqunywa udokotela ngokuya ngemiphumela yokuhlaziywa.

Iziguli Ezikhethekile Nezinkomba

Iqembu leziguli ezikhethekile lifaka:

1. Ikhulelwe futhi iletha. Umuthi awusetshenziswa ngesikhathi sokukhulelwa nokuqunjelwa. Udokotela unquma ukwelashwa kwe-insulin.
2. Izingane. Ezinganeni ezingaphansi kweminyaka eyi-10, isidakamizwa siyaboshwa. Ukuphepha kokwamukelwa ngesikhathi sokuthomba akukasungulwa.
3. Abantu abadala. Kunqunyelwe ngokuqapha kubantu asebekhulile, ikakhulukazi ngemuva kweminyaka engama-60. Umthamo ukhethiwe ucatshangelwa ukusebenza kwezinso.

Ukusetshenziswa kwesidakamizwa isikhathi eside kudinga ukuqapha isimo sezinso. Kanye njalo ezinyangeni eziyisithupha, i-creatinine kufanele ihlolwe - uphawu> 135 mmol / l, umuthi ukhanseliwe. Ikakhulu ngokucophelela kufanele kubhekwe izinkomba ezephula umsebenzi womzimba.

Uma uthatha iMetformin, utshwala kufanele bushiywe. Lokhu kuyasebenza nezidakamizwa eziqukethe notshwala. Ngaphambi kokuhlanganisa umuthi nezinye izidakamizwa ezingezona ezinesifo sikashukela, udinga ukwazisa udokotela wakho. Lapho kuhlanganiswa nokuphuma kwe-sulfonylurea, ukuqapha okuthuthukile kwamazinga kashukela wegazi kuyadingeka.

Ngaphambi kokuhlinzwa, iMetformin ikhanseliwe ezinsukwini ezi-2. Qhubeka nokusebenzisa kungakapheli izinsuku ezingama-2 ngemuva kwenqubo, ucubungula ukusebenza kwezinso. Ezifundweni ze-radiological (ikakhulukazi ngokusetshenziswa kokuqhathanisa), ukwelashwa kwezidakamizwa futhi kukhanselwa ezinsukwini ezi-2 futhi kubuyiselwe emuva kwezinsuku ezi-2, ngokulandelana.

Imiphumela emibi kanye ne-overdose

Imiphumela emibi uma usebenzisa umuthi:

• i-lactic acidosis;
• i-megaloblastic anemia;
• umsebenzi wesibindi okhubazekile;
• i-urticaria, ukulunywa, ukuqunjelwa, i-erythema;
• kuyaqabukela i-hepatitis;
• umsebenzi wezinso ongonakalisiwe;
• ukwephula ukunambitheka;
• ukubonakaliswa okuvame kakhulu kubonwa kusuka kumgudu wesisu: ukuntuleka kwesifiso sokudla nesicanucanu, isihlalo sokucasuka, ukuthamba, ukuhlanza;
• ukunciphisa ukumuncwa kwe-B12.

Lapho uthatha umuthi, akukho ukubonakaliswa kwe-hypoglycemia, ngokungafani neminye imithi yeqembu lesifo sikashukela. Ngokukhula komthamo, i-lactic acidosis ingahle ikhule. Ngokwelashwa okuyinkimbinkimbi okuphathelene nokukhipha i-sulfonylurea, i-hypoglycemia kungenzeka.

Lapho kunqunywa i-hypoglycemia, isiguli sinconywa ukuthatha i-25 g ye-glucose. Uma i-lactic acidosis isolwa, isiguli silashwa esibhedlela ukuze sicacisa (sichaze) ukutholakala, ukuthatha umuthi kukhanseliwe. Uma kunesidingo, i-hemodialysis iyenziwa.

Ukusebenzisana kwezidakamizwa kanye nama-analog

Kubhekelwa kakhulu ekusebenzeni kweMetformin nezinye izidakamizwa. Abanye bangakhuphula izinga le-glucose, abanye, ngokuphambene nalokho, baphansi. Ukusetshenziswa kanyekanye kwemithi ngaphandle kokubonisana nodokotela ngaphambi kwesikhathi akunconywa.

UDanazole angadala i-hyperglycemia. Uma kunesidingo, ukwelashwa ngezidakamizwa kuguqula isilinganiso se-Metformin futhi kuqinise ukulawulwa koshukela. Ama-diuretics, ama-glucocorticosteroids, ama-hormone abesifazane, ama-antidepressants, ama-hormone egilo, i-adrenaline, i-nicotinic acid derivatives, i-glucagon inciphisa umphumela.

Lapho kusetshenziswa kanye ne-fibrate, ama-hormone besilisa, okuphuma ku-sulfonylurea, i-ACE inhibitors, i-insulin, amanye ama-antibiotic, ama-acarbose, ama-clofibrate derivatives, nezinye izidakamizwa ze-antidiabetes, umphumela weMetformin uyathuthukiswa.

Ukuphuza utshwala kungadala ukuthuthukiswa kwe-lactic acidosis. Ngesikhathi sokulashwa, izidakamizwa eziqukethe i-ethanol nazo azikhishwa. I-Chlorpromazine inciphisa ukukhishwa kwe-insulin.

Izidakamizwa ezifanayo ezinomphumela ofanayo zihlanganisa: iMetamine, iBagomet, iMetfogamma, iGlycomet, Meglifort, Dianormet, Diaformin Sr, Glyukofazh, Insufor, Langerin, Meglukon. Isakhi esiyinhloko sale mishanguzo i-metformin hydrochloride.

Ividiyo evela kuDkt Malysheva mayelana neMetformin:

Umbono weziguli nochwepheshe

Iziguli eziningi ezidingidwa yi-Metformin therapy ziphawula amandla amahle kuzibuyekezo. Gqamisa ukusebenza kwayo nokuphatheka okuhle. Ezinye iziguli ziphawule umphumela omuhle wokulungiswa kwesisindo, inani lentengo elingabizi lomuthi. Phakathi kwamaphuzu amabi - ukuphazamiseka kwamathumbu emathunjini.

Banqume iMetformin yesifo sikashukela ngemuva kokuthi ukudla okunqunyiwe kungasizanga. Ilawula ushukela kahle futhi ayibangeli imiphumela emibi. Ngemuva kwamasonto ambalwa, udokotela walungisa umthamo. Ngosizo lomuthi, ngakwazi ukunciphisa ama-kilos ngokweqile. Izinga likashukela lehlisa kahle. Ngokuvamile, isidakamizwa esivamile.

U-Antonina Stepanovna, oneminyaka engama-59, uSaratov

Ithuluzi libuyise izinkomba ezijwayelekile hhayi ushukela kuphela, kodwa futhi ne-cholesterol ephelele. Isiza ekulweni nesisindo ngokweqile. Ngazizwa ngibonakaliswa kabi kimi - ukuntuleka kwesifiso sokudla kanye nenausea. Ngiyabona ukuthi ukwamukelwa kweminye imishanguzo yesifo sikashukela nakho akuhambanga kahle. Ngicabanga ukuthi uMetformin waziveza ohlangothini oluhle.

U-Roman, oneminyaka engama-38 ubudala, eSt

Ekuqaleni kokudla, imiphumela emibi yayinamandla - isifo sohudo esinamandla izinsuku ezimbili kanye nokuntuleka kokudla. Bengifuna ukuyeka ukuthatha iMetformin. Ngiphuze ama-decoctions kwathi ngemuva kwezinsuku ezi-4 isihlalo sibuyele kokujwayelekile. Umphumela wokuthatha izinga elijwayelekile likashukela bese ususa amakhilogremu amahlanu esisindo. Ngifuna futhi ukuqaphela intengo engabizi yomuthi.

U-Antonina Aleksandrovna, oneminyaka engama-45, eTaganrog

Ochwepheshe baphinda babone umphumela omuhle nokubekezeleleka kwalo muthi, kepha bancoma ukuwusebenzisa ngenhloso eyenzelwe wona, hhayi ukwehliswa kwesisindo.

I-Metformin ibhekwa njengesidakamizwa esisebenzayo sohlobo 2 sikashukela. Inokubekezelela okuhle ngokuvuma okufanele kanye nokuhambisana nezincomo zikadokotela. Ngokungafani nezinye izidakamizwa ze-antidiabetes, iMetformin inobungozi obuncane be-hypoglycemia. Ucwaningo luqinisekisile ukuthi akunangozi ngokuphelele kubantu abanokuhluleka kwenhliziyo. Iziguli ezinempilo azikhuthazi ukusebenzisa umuthi ukulungisa isisindo somzimba.

Antsiferova S.M., endocrinologist

Intengo yesidakamizwa icishe ibe ngama-ruble angama-55. Metformin umuthi.

I-Metformin iyisidakamizwa esenzelwe ukwehlisa ushukela kushukela ongancike ku-insulin. Kubonakaliswa ukubekezelela okuhle ngengozi encane ye-glycemia eyandayo. Futhi ilungisa isisindo somzimba kubantu abanesifo sikashukela, yehlisa i-cholesterol embi. Umphumela oyinhloko we-lactic acidosis.