Izinkinga ze-vascular zingadala izifo eziningi. Ukwelashwa kwabo kuzodinga ukwelashwa okuyinkimbinkimbi, okubandakanya ukuthatha imishanguzo, efaka i-angiopril. Ngaphambi kokusebenzisa, udinga ukutadisha imiyalo enamathele emithini ukuze kungabikho zinkinga.
Igama Lezwe elingafanele
Igama lomhlaba elingabambeki kumkhiqizo yi-Captopril.
Ekwelashweni kwabo kwemithambo yegazi, kuyadingeka ukwelashwa okuyinkimbinkimbi, okubandakanya ukuthatha imithi, efaka i-angiopril.
I-ATX
Umuthi unekhodi elandelayo ye-ATX: C09AA01.
Khipha amafomu nokwakheka
Ukukhishwa komuthi kwenziwa ngendlela yamaphilisi abekwe emapheshana ama-10 ama-pcs kanye nama-4 ama-pcs. Isixha sekhadibhodi singaba ne-1, 3, 10 strip yamathebulethi ayi-10 ngalinye noma umucu ongu-1 onamathebulethi ayi-4. Isithako esisebenzayo yi-Captopril - 25 mg. Ngaphezu kwalokho, kusetshenziswa i-stearic acid, i-lactose, isitashi sommbila, i-colloidal silicon dioxide ne-microcrystalline cellulose.
Isenzo se-Pharmacological
Umuthi osebenzayo uvimbela isenzo se-enzyme eguqula i-angiotensin. Ibambezela ukwakheka kwe-angiotensin 1 no-2, iqeda umphumela wayo we-vasoconstrictor emithanjeni nasemithanjeni yemithambo yegazi. Ukuthatha umuthi kusiza ukwehlisa ukulayishwa kuqala nangemva kokulayisha, ukwehla kwegazi, ukunciphisa ukumelana okuphathelene nemithambo yegazi, kunciphisa ukukhishwa kwe-aldosterone emithanjeni ye-adrenal, kanye nokunciphisa ingcindezi ekujikelezweni kwe-pulmonary kanye ne-atrium yangakwesokudla.
I-Pharmacokinetics
Ngemuva kokuthatha amaphilisi, imunwa ngokushesha emgodini wesisu ngenxa ye-bioavailability ka-60-70%. Ukwehla kancane kuyabonakala ngokusetshenziswa kanyekanye kwe-Captopril ngokudla. Ukuphila kwesigamu kwesidakamizwa kuzothatha amahora angama-2-3. Ingxenye yesithako esisebenzayo ivezwa njengomchamo ngendlela engaguquki.
Izinkomba zokusetshenziswa
Izinkomba:
- umfutho we-arterial hypertension, kufaka phakathi ukuvuselelwa komzimba;
- isifo sikashukela esinesifo sikashukela sohlobo 1;
- ukwehluleka kwenhliziyo okungapheli;
- ukuphazamiseka kwe-ventricle yangakwesobunxele ngemuva kokufakelwa kwe-myocardial ezigulini ezinesimo sazo somtholampilo sizinzile.
Contraindication
Abesifazane abakhulelwe futhi abakhubazekile, izingane ezingaphansi kweminyaka engu-18 ubudala nabantu abangabekezeleli izingxenye zomuthi nezinye izithiyo ze-ACE, kanye neziguli ezine-cerebrovascular insufficiency, kufanele zenqabe ukwelashwa nomuthi.
Ungayithatha kanjani
Umuthi wenzelwe ukuphathwa ngomlomo. Ithebhulethi zidakwa izikhathi ezingama-2-3 ngosuku ku-6.25-12.5 mg. Uma kunesidingo, inani lemithi lenyuswa laya ku-25-50 mg. Umthamo omkhulu wansuku zonke akufanele udlule ku-150 mg. Akunconywa ukuguqula umthamo ngokwakho.
Ngoshukela
Uma isiguli sine-nephropathy yesifo sikashukela, khona-ke umuthi uthathwa ku-75-150 mg ngosuku. Umthamo ungaguqulwa ngumhlinzeki wakho wezokunakekelwa kwempilo.
Uma isiguli sine-nephropathy yesifo sikashukela, khona-ke umuthi uthathwa ku-75-150 mg ngosuku.
Imiphumela emibi
Kwezinye izimo, ukusabela okungekuhle komzimba kusuka ohlelweni lwezinzwa nezinye izitho kungenza ngesimo:
- i-tachycardia;
- ukwehlisa umfutho wegazi;
- i-edema yangaphandle;
- i-orthostatic hypotension;
- i-angioedema yemilenze, izingalo, ulwelwesi lwe-mucous, ubuso, i-larynx, ulimi, izindebe kanye ne-pharynx;
- ukukhwehlela okomile;
- i-pulmonary edema;
- i-bronchospasm;
- Isiyezi
- ikhanda;
- ukungaboni kahle
- i-ataxia
- ukozela
- i-paresthesia;
- i-thrombocytopenia;
- i-anemia
- neutropenia;
- i-agranulocytosis;
- i-acidosis;
- i-proteinuria;
- hyperkalemia
- i-hyponatremia;
- amazinga akhuphuka e-creatinine ne-urea nitrogen egazini;
- umlomo owomile;
- i-stomatitis;
- Ubuhlungu esiswini;
- ukunambitha ukuphazamiseka;
- ukulahleka kwesifiso sokudla;
- umsebenzi owengeziwe wama-enzyme wesibindi;
- i-hyperbilirubinemia;
- i-hepatitis;
- isifo sohudo
- i-gingival hyperplasia.
Uma imiphumela emibi yenzeka, amaphilisi kufanele ayekwe.
Umthelela ekhonweni lokulawula izindlela
Iziguli eziphuza lo muthi kufanele ziqaphele lapho zishayela imoto futhi zenza izinto ezidinga ukunakwa okwandayo nokunakwa okusheshayo kwe-psychomotor, ngenxa yokuvela kwesiyezi.
Imiyalo ekhethekile
Ngesikhathi sokwelashwa kwe-Angiopril, umphumela ongemuhle ongabonakala ungaqhubeka ngokuhlolwa komchamo we-acetone. Nge-hypertension ye-arterial, inani lomuthi liyancishiswa. Phuza amaphilisi ngokuqapha nge-granulocytopenia.
Nge-hypertension ye-arterial, inani lomuthi liyancishiswa.
Isabelo sezingane
Ukusetshenziswa kwezidakamizwa ukwelapha izingane akuvunyelwe. Ukwelashwa kungabekwa esimweni se-hypertension ezinzima. Umthamo ubalwa ngokuya ngesisindo sengane. Ungu-0,0-0.4 mg wesidakamizwa nge-1 kg yesisindo somzimba. Ukuphindaphindwa kokwamukelwa akufanele kudlule izikhathi ezi-2 ngosuku.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Lapho uthwala ingane futhi uncelisa, i-Captopril akufanele ilashwe. Uma kutholakala ukuthi ukhulelwe ngesikhathi sokwelashwa, kuyadingeka ukuyeka ukuthatha amaphilisi. Uma kunesidingo, yenza izindlela zokwelapha zokuncelisa ibele ziphazamiseke.
Isicelo sokusebenza kokulimala kwezinso
Uma kwenzeka umsebenzi we-renal ongasebenzi kahle kanye nokwehluleka kwe-renal, kunciphisa umthamo wansuku zonke kuyadingeka.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokucophelela nangaphansi kokuqashwa ngudokotela, baphuza umuthi wezinkinga zesibindi.
Ukweqisa
Uma usebenzisa kabi inani lemithi elinconyiwe, kungavela i-overdose, kuvela ngesimo sokuncipha okukhulu komfutho wegazi. Kulesi simo, isiguli sifakwa ngesisombululo se-isotonic sodium chloride noma okunye ukubuyisela uketshezi okwenziwa ngeplasma kanye ne-hemodialysis kwenziwa.
Ukuxhumana nezinye izidakamizwa
Ukusetshenziswa okuhlanganisiwe kwe-indomethacin nezinye izidakamizwa ezingezona ezingama-anti -idalidal kungahle kunciphise umphumela we-angotopril. Ingozi ye-hyperkalemia inyuka ngokusetshenziswa kanyekanye nokufakwa esikhundleni sikasawoti, i-potassium-sparing diuretics, amalungiselelo e-potassium kanye nezithako ze-potassium. Umphumela we-antihypertensive uncishiswa ngokusetshenziswa kwe-erythropoietins ne-acetylsalicylic acid.
Ukwanda kokuxineka kwe-serum lithium kungabonakala lapho uhlangana nosawoti we-lithium. Ukuqinisa isenzo somuthi kwenzeka lapho kuhlanganiswa nama-diuretics nama-vasodilators. Ukuphazanyiswa kwe-hememological kungenzeka ngokusetshenziswa okuhlangene kwama-antidepressants ne-Captopril. Iziguli zisebenzisa i-procainamide noma i-allopurinol zinengozi eyandayo ye-neutropenia.
Ukuhambisana notshwala
Ngesikhathi sokwelashwa, kwenqatshelwe ukuphuza utshwala. Ukusebenzisana kwabo nengxenye esebenzayo kungadala umfutho wegazi ophikelelayo.
Ngesikhathi sokwelashwa, kwenqatshelwe ukuphuza utshwala.
Ama-Analog
Uma kunesidingo, umuthi uthathelwa indawo yi-analog. Phakathi kwazo kukhona okulandelayo:
- I-Alkadil;
- I-blockordil;
- Kapoten;
- Catopil;
- I-Epsitron.
Ushintsho ekwelashweni kufanele lwenziwe udokotela okhetha umuthi obheka izici zomzimba wesiguli kanye nobunzima be-pathology.
Imibandela yeholide I-Angiopril evela emakhemisi
Ithuluzi lingathengwa ekhemisi ngencwadi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Amathebulethi awakwazi ukuthengwa ngaphandle kokuthola umuthi.
Intengo
Izindleko zomuthi zincike kunqubomgomo yamanani ekhemisi futhi ngokwesilinganiso ama-ruble angama-95.
Izimo zokugcina zomuthi
Umuthi ubekwa endaweni emnyama, eyomile futhi engenakufinyeleleka ezinganeni ezinamazinga okushisa angeqi ku-25 ° C.
Isikhathi sokuphelelwa yisikhathi
Umuthi ugcina izakhiwo zawo iminyaka emi-3 kusukela ngosuku lokukhiqizwa, ngokuya ngemibandela yokubekelela. Lapho usuku lokuphelelwa yisikhathi luphela, luzolahlwa.
Umkhiqizi u-Angiopril
Umkhiqizo ukhiqiza i-TORRENT PHARMACEUTICALS Ltd. (India).
Ithuluzi lingathengwa ekhemisi ngencwadi kadokotela.
Ukubuyekezwa mayelana ne-Angiopril
UVladimir, oneminyaka engama-44 ubudala, uKrasnoyarsk: "Ngisebenzise lesi sidakamizwa ngemuva kokufakelwa i-myocardial. Naphezu kwesibalo esikhulu semiphumela emibi, ukwelashwa kwahamba kahle. Ngangihlela izindleko ze-Angiopril. Kushibhile futhi kuyasebenza. Ngiyakuncoma."
ULarisa, oneminyaka engama-24, uMurmansk: "Udokotela ubeke ikhambi lesifo sikashukela. Wathatha imali encane cishe inyanga. Ezinsukwini zokuqala, isiyezi nokukhwehlela owomile kwangikhathaza, kodwa ngokuzayo konke kwahamba. Angizange ngithole lo muthi ngaso leso sikhathi, futhi intengo yamangala. Ngacabanga ukuthi iyabiza. ukwelashwa kuzokubiza. "
