Ukwelashwa kwesifo sikashukela sohlobo 2 sikashukela kubandakanya hhayi ukunamathela ekudleni okukhethekile kuphela, kepha futhi kudinga ukusetshenziswa njalo kwemithi ekwehlisa ushukela.
IGlucophage 500 isinye isidakamizwa esinjalo se-hypoglycemic.
Uchwepheshe wezokwelapha anganquma ukuthi athathe iphilisi uma isiguli sinezinga le-glucose egazini futhi, ngasikhathi sinye, sihlakulela ukumelana ne-insulin.
Kuze kube manje, inkambo yokwelashwa yokwelashwa yenqubo ye-pathological ifaka izinkomba eziphambili zokwenza ushukela wegazi usayizi ngosizo lwemithi:
- Imithi ekwazi ukukhulisa inani le-insulin egazini. Ngenxa yokudla kwabo, amanyikwe aqala ukusebenza ngokuzikhandla futhi izinga le-hormone likhuphuka. Iqembu lemithi enjalo lifaka okuphuma ku-sulfonylurea nama-glinides.
- Imikhiqizo yezokwelapha, ukuthathwa kwayo okunikeza ukwehla kokumelana kwezicubu kwe-insulin. Bona ezingeni lamaselula bandisa ukuzwela kwehomoni futhi, ngasikhathi sinye, bangavusi ukuhlaselwa kwe-hypoglycemia. Izici ezinhle zemithi enjalo futhi zifaka phakathi amandla okuthuthukisa ukusetshenziswa kwe-glucose ngezicubu futhi kunciphise inani layo esibindini. Abamele abaphambili baleli qembu yi-greatuanides ne-thiazolinediones.
- Imithi evimbela ukumuncwa kwama-carbohydrate ezingxenyeni zephepha esiswini yi-alpha glucosidase inhibitors.
Yisiphi isidakamizwa esilungele isiguli kuncike ebukhali balesi sifo, inkambo yomuntu ngamunye yempilo, nezinye izici. Ngokusekelwe kulolu lwazi, udokotela ohambelayo ukhetha umuthi ofanele kakhulu emaqenjini angenhla.
Izici ze-Pharmacological ze-hypoglycemic drug
Amathebhulethi e-Glucofage 500 ayokulungiselela kwezokwelapha kwe-hypoglycemic eqenjini leqembu elikhulu. Isithako esiyisisekelo esisebenzayo esinciphisa isilinganiso se-glucose egazini yi-metformin hydrochloride. Umkhiqizo owethulwe wezokwelapha ufaka uhhafu wegramu yesithako esisebenzayo. Ngaso leso sikhathi, emakhemisi ungathola umuthi onomthamo ophakeme (0.85 noma 1 g).
Umuthi usetshenziswa ngenkuthalo ekwenziweni kwesimo esizimele sikashukela njenge-monotherapy noma ukwelashwa okuyinkimbinkimbi. Kumele kuqashelwe ukuthi ngaphezu komphumela omkhulu wokwehlisa ushukela, umuthi unomphumela onenzuzo wokwehlisa isisindo ngokweqile. Kwabanesifo sikashukela, le mpahla ibaluleke kakhulu, ngoba inqubo ye-pathological ihlala ihambisana nokuba khona kohlobo lwesisu sokukhuluphala.
Izinkomba zokusetshenziswa kwomuthi zihlanganisa ukubonakalisa ukubekezelela i-glucose esigulini, ukuthuthukiswa kwe-metabolic syndrome. Imvamisa, umuthi usetshenziswa ku-gynecology ukwelapha i-polycystic ovary.
Enye yezinzuzo eziphambili zethebhulethi amandla ayo okunciphisa amazinga kashukela, kodwa hhayi ukuwela umkhawulo wezimpawu ezijwayelekile. Futhi lokhu, kukuvumela ukuthi uguqule engcupheni ye-hypoglycemia.
I-ejenti elwa nesifo sikashukela ivimbela inqubo ye-gluconeogenesis, ukuthutha kwama-elektroni kwamaketanga okuphefumula kwe-mitochondria. I-Glycolysis ivuselelwa, amangqamuzana aqala ukumunca kangcono ushukela, futhi ukumunca kwawo odongeni lwamathumbu kuyancipha.
Kukhona ukuthuthuka kwe-cholesterol yegazi, evumela ukusetshenziswa komuthi ukuvimbela izinkinga zenhliziyo.
Imiyalo esetshenzisiwe ikhombisa ukuthi umuthi ngemuva kokudla ngokweqile uthuthwe emgudwini wesisu. Izinga eliphezulu kakhulu lokuhlushwa kwalo ku-plasma yegazi libonwa ngemuva kwamahora cishe amabili (amabili nesigamu).
Uma uthatha amaphilisi ngasikhathi sinye sokudla, ukumuncwa kwesithako esisebenzayo kuyancipha bese kuyabambezeleka.
Imiyalo yokusebenzisa umuthi
I-Glucophage 500mg ithathwa kuphela njengoba kuyalelwe udokotela ohambelayo. Izinga lokugaywa kweglucose egazini kanye nokuba khona kwezifo ezihlanganyelayo esigulini kuyaphoqelelwa.
Ukwelashwa nge-monotherapeutic kufanele kuqale ngomthamo omncane womuthi futhi kube uhhafu wegramu yengxenye esebenzayo. Ukwemukelwa kwethebhulethi kwenziwa kathathu noma kathathu ngosuku ngokudla.
Izinsuku eziyisikhombisa kuya kweziyishumi ngemuva kokuqala kokwelashwa, uchwepheshe wezokwelapha, ngokususelwa emiphumeleni yokuhlaziywa kwesiguli, wenza isinqumo ngesidingo sokulungisa imithamo ekhona ngaphezulu.
Njengomthetho, umthamo ojwayelekile wokugcina isilinganiso esidingakalayo sikashukela egazini usukela ku-1500 kuya ku-2000 milligrams wento esebenzayo.
Ukunciphisa ubungozi bokusabela okungekuhle kusuka kumasistimu ahlukahlukene omzimba ngesikhathi sokwelashwa, inani lemithamo kufanele lihlukaniswe kaningi (kabili kuya kathathu phakathi nosuku).
Umthamo omkhulu wansuku zonke okwanele wokulashwa okwelapha awunakuba ngaphezulu kwamagremu amathathu esithako esisebenzayo.
Uma isiguli sidinga ukuthatha umuthi ngemithamo emikhulu ukuqinisekisa izinga elijwayelekile le-glucose, kunconyelwa ukuba kususwe kusuka kumthamo omncane womuthi i-Glucofage 500 mg kuye kweliphezulu (kukhona namalungiselelo wethebhulethi okuyi-850 ne-1000 mg yento esebenzayo.)
Ukwelapha usebenzisa i-Glucofage nakho kwenziwa ezinganeni ngemuva kokuba zifinyelele eminyakeni eyishumi. Kulokhu, irekhodi lethebhulethi lizohluka ekwelashweni kwesiguli esikhulile. Indlela yokuphuza umuthi ezinganeni ukulandela imithetho elandelayo:
- ukuqala kokwelashwa okwelashwa akufanele kuthathe uhhafu wegamu lomuthi;
- inani lokudla ngosuku - kanye nokudla;
- ukukhuphuka komthamo kungenzeka ngaphambi kwezinsuku eziyishumi kuya kweziyishumi nane emva kokuqala kokwelashwa;
- umthamo omkhulu kakhulu wezingane akufanele ube ngaphezulu kwamagremu amabili ento esebenzayo ngosuku, athathwe amahlandla amabili kuya kwamathathu.
Ukwelashwa kweziguli esezikhulile kwenzeka ngokubheka njalo ukusebenza kwezinso. Uchwepheshe wezokunakekelwa kwempilo kufanele aqinisekise ukuthi amazinga we-serum creatinine awekho ngaphezu kwama-59 ml / min.
Umthamo wesidakamizwa unqunywe ngokuhlukile esigulini ngasinye.
Ukuphendula okungahambi kahle nokuphikisana nokusetshenziswa kwe-Glucofage 500
Lapho usebenzisa lesi sidakamizwa se-hypoglycemic, kuyadingeka ukwazisa udokotela oholayo ngokuthatha amanye ama-pharmacological agents.
Iqiniso ngukuthi kunezinhlanganisela zezidakamizwa zamaqembu ahlukile ezingahambisani, zithuthukisa noma zenze buthaka umphumela wezokwelapha. Kwenqatshelwe ukuthatha i-Glucofage kanye nezinto eziqukethe iodine, njengoba kungenzeka ukusabela okuhlukahlukene okuvela emzimbeni wesiguli.
Ngaphezu kwalokho, ukuhlanganiswa kwengxenye esebenzayo yomenzeli obhebhekile nge-ethyl alcohol kuyandisa kakhulu ingozi yokuhlakulela i-lactic acidosis.
Ukuhlanganiswa okulandelayo kwe-Glucofage nemithi kungaholela ekwandeni komphumela we-hypoglycemic:
- Ama-inhibitors e-ACE.
- Imithi eqenjini lama-salicylates.
- Umjovo we-insulin
- I-Acarbose ne-sulfonylurea.
Ukuphendula okungalungile emithini kungahle kube ngezinga elikhulu noma elincane. Ikakhulu kaningi ngesimo semiphumela emibi, isicanucanu nokuhlanza, izinhlungu esiswini ziyabonakala. Ngakho-ke, ipheshana lesisu somuntu liyaphendula emithini.
Njengomthetho, lokhu kusabela kukhulunyelwa ikakhulukazi emazingeni okuqala okwelashwa. Ukunciphisa ubungozi bokubonakaliswa kwabo, kunconywa ukwandisa umthamo wezidakamizwa kancane kancane, futhi uphule imithamo emikhulu emithamo eminingana.
Ngaphezu kwalokho, imiphumela emibi emithini esetshenzisiwe ingaba yile:
- ukumuncwa okungafanele kwamavithamini we-B
- ukunambitheka okuphazamisayoꓼ
- ukulahleka kwesifisoꓼ
- erythema
- i-anemiaꓼ
- ukwenzeka kwezinkinga ngesikhumba ngendlela yokulunywa, ukugoqa noma ubomvu, ngakho-ke umzimba uphendula ngokuthatha lo muthi uma ngabe kunezinga elithile lokuzwela kwezinye izingxenye zethebhulethi;
- ukonakala kwesibindi kuze kukhule i-hepatitis;
- ukubonakaliswa kwe-lactic acidosis.
Ukuchazwa komkhiqizo wokwelapha kukhombisa ubukhona bezimo lapho ukusetshenziswa kwalesi sidakamizwa se-hypoglycemic kungavunyelwe.
Umuthi uvunyelwe:
- Abesifazane ngesikhathi sokukhulelwa nokuqunjelwa, ngenxa yokuntuleka kwedatha eyenele ngomphumela womuthi ekukhuleni nasekuphileni kwengane.
- Uma kunezinga elikhulayo lokuzwela kwenye yezakhi zomuthi.
- Uma isiguli sinezinkinga zokuphazamiseka kwezinso.
- Uma kunezimpawu ze-lactic acid lactic acidosis kuhlobo 2 sikashukela (kufaka nomlando).
- Uma kuvela izimpawu zokhokho noma abanesifo sikashukela.
- Ngokudakwa komzimba, okuhambisana nokuhlanza kakhulu noma uhudo, futhi kungaholela ekusebenzeni kabi kwezinso.
- Lapho kukhona ukubonakaliswa kwezinqubo ezahlukahlukene ze-pathological ngamazinga ahlukahlukene wokuthuthuka, aba imbangela yohlobo lwethishu hypoxia.
- Ngesikhathi sokulimala okukhulu noma ukungenelela kokuhlinzwa.
Ngaphambi kokuqala ukwelashwa, kunconywa ukuthi ufunde ngokucophelela uhlu lwe-contraindication, inhlanganisela yethebhulethi nezinye izidakamizwa.
I-Glucophage 500 Izidakamizwa
Njengomthetho, umuthi uyatholakala kwisiguli ngasinye ngokutholakala emakhemisi asedolobheni kanye nezindleko ezisunguliwe.
Imvamisa iziguli zibheka lezi zinto njengezinzuzo zethebhulethi.
Intengo ye-Glucofage 500 isekhemisi yedolobha kusuka ema-ruble ayi-100 kuye kwangama-130 ngephakethe ngalinye (amaphilisi angamashumi amathathu). Umuthi ungoweqembu lemithi engabizi kanye nesabelomali.
Ukubuyekezwa kwamakhasimende kukhombisa ukubekezelela kwethebhulethi okulula kanye nezinga eliphakeme lokusebenza.
Ngokusho kweziguli, iGlucofage 500 inalezi zinzuzo ezilandelayo:
- ukuncishiswa okusebenzayo kweglucose yegazi, ukuqina kwe-glycemia;
- ukutholakala komuthi ngentengo;
- ukuqedwa kwezimpawu ezijwayelekile zenqubo ye-pathological;
- ukwehla kancane kancane kwesisindo, okusiza inqubo yesifo futhi kuthuthukise inhlala-kahle yesiguli.
Ngasikhathi sinye, amacala awafakwa uma kunesidingo sokubuyisela umuthi. Futhi-ke iziguli ziba nentshisekelo ngokutholakala kwezidakamizwa ezithatha indawo yeGlucofage 500, izinkomba zazo zokusebenzisa nokuthi kubiza malini.
Kumele kwaziwe ukuthi abakhiqizi bezidakamizwa ze-hypoglycemic eqenjini le-Biguanide (izidakamizwa ezisuselwa ku-metformin hydrochloride) zinikeza abathengi bazo ukukhetha okubanzi kwama-analogues. Ethandwa kakhulu zazo ngomthamo ofanayo yilezi zindlela ezilandelayo zethebhulethi:
- Siofor 500.
- I-Bagomet.
- I-Metogram 500.
- IFomu.
- UGlatiniin.
Yonke le mithi engenhla inokwakheka kwayo isithako esisodwa esisebenzayo - i-metformin hydrochloride.
Inani laso liboniswa kwimiyalo yokusebenzisa umuthi futhi ingama-milligram angama-500. Izindleko zabo zingahluka phezulu noma phansi, kuya ngomkhiqizi.
Kufanele kukhunjulwe ukuthi izidakamizwa ezifuywayo, njengomthetho, ashibhile, futhi ngokwemigomo yokusebenza azifani kubalingani babo abangenisile.
Akufanele uthathe isinqumo sokushintshela komunye umuthi ngokwakho, ukufakwa esikhundleni somuthi kufanele kwenziwe uchwepheshe wezokwelapha.
Yimuphi umuthi ozosiza ukwehlisa ushukela wegazi ozotshela uchwepheshe kule vidiyo ekulesi sihloko.
