Amathebhulethi we-Augmentin 125: iziyalezo zokusetshenziswa

Amathebhulethi we-Augmentin 125 angamenzeli ohlanganisiwe we-antimicrobial nge-spectrum ende yokuboniswa. Kuyo, izinto ezilwa namagciwane e-amoxicillin zithuthukiswa ngokwethulwa kwe-clavulanic acid, esebenza njenge-beta-lactamase inhibitor, ekwakhiweni.

Igama Lezwe elingafanele

I-INN yalo muthi yi-Amoxicillin ne-Clavulanic acid.

Amathebhulethi we-Augmentin 125 angamenzeli ohlanganisiwe we-antimicrobial nge-spectrum ende yokuboniswa.

I-ATX

Umuthi unekhodi ye-ATX J01CR02.

Ukwakheka

Umkhiqizo uqukethe izingxenye ezi-2 ezisebenzayo - ifomu le-amohydillin (i-antibiotic) ne-clavulanic acid ngendlela kasawoti we-sodium (β-lactamase inhibitor). Kwithebhulethi i-Augmentin ingu-125 mg we-clavulanate, ne-antibiotic - 250, 500 noma 875 mg. Kugcwaliswa ukugcwaliswa:

• isilika;
• i-magnesium stearate;
• i-sodium starch glycolate;
• i-microcellulose.

Amatafula ane-coach emelana ne-gastro equkethe i-hypromellose, i-macrogol, i-titanium dioxide ne-dimethicone. Zisakazwa ngezingcezu ezi-7 noma eziyi-10. ezishwabeni, ezihlanganisiwe kanye ne-desiccant, kufakwe uphawu ku-foil. Ithebhulethi i-250 mg + 125 mg igcwele izingcezu ezi-10 kuphela. Amapuleti ama-2 blister abekwe emakhadini amakhadibhodi.

Ithuluzi liqukethe uhlobo olunamandla we-amoxicillin.

Isenzo se-Pharmacological

I-pharmacodynamics ye-Augmentin iqinisekiswa umsebenzi ohlanganyelwe we-amoxicillin ne-sodium clavulanate, okukhona njengezinto ezisebenzayo ekwakhiweni komuthi. I-Amoxicillin iyi-synthetic penicillin antibiotic yeqembu le-β-lactam. Ivimbela umsebenzi we-enzyme yamagciwane, ebamba iqhaza ekwakhekeni kwengxenye yesakhiwo sodonga lweseli, okuholela ekufeni kwamagciwane.

Isibuko somsebenzi we-bactericidal we-antibiotic sibanzi impela, kepha sichithwa ngaphansi kwethonya lama-beta-lactamases akhiqizwa ngamagciwane athile. Ngakho-ke, i-clavulanic acid iyasetshenziswa - into efana nesakhiwo nama-penicillin. Inika amandla ama-enzyme athile we-β-lactam, ngaleyo ndlela enwebisa imiphumela yemiphumela yokulwa ne-antibacterial ye-amooticillin.

U-Augmentin usebenza ngokumelene namagciwane amaningi, kufaka phakathi:

• i-hemophilic ne-E. coli;
• i-staphilo ne-streptococci;
• ISalmonella
• cholera vibrio;
• chlamydia
• UShigella
• clostridia;
• Klebsiella;
• leptospira;
• I-Proteus
• i-acineto-, i-citro- ne-enterobacteria;
• ama-bacteroids;
• ama-causative agents we-pertussis, inyumonia, i-anthrax, i-syphilis, i-gonorrhea.

Izakhi ezisebenzayo ezivela endaweni yokugaya zidonswa ngokushesha futhi zigcwele.

I-Pharmacokinetics

Izakhi ezisebenzayo ezivela endaweni yokugaya zidonswa ngokushesha futhi zigcwele. Iqoqo eliphezulu le-amoxicillin ku-plasma inqunywa ngemuva kwamahora we-1-2. Kusatshalaliswa kahle emzimbeni. Kutholakala i-bile, i-synovia, uketshezi olungamathambo, izinsalela, izicubu, izingqimba ezinamafutha, izitho zesisu, i-purulent exudate nobisi lwebele.

Umuthi weqa i-placenta, kepha isithiyo segazi-ingqondo sisangeneka kuso. Ukuxhumana ngamaprotheni egazi ku-antibiotic acishe abe yi-17%, ku-inhibitor - aze afike ku-25%.

I-Amoxicillin ayisetshenziswanga kahle, i-metabolite ephumelelayo ayisebenzi. I-Excretion yenziwa ngomchamo. I-Codiumulanate sodium icutshungulwa ngenkuthalo, ichazwa yizinso, amaphaphu (ngesimo sekhabhoni dioksijini) nezindunduma.

Izinkomba zokusebenzisa amaphilisi we-Augmentin 125

Umuthi uhloselwe ukuqeda ukutheleleka ngegciwane okubangelwa amagciwane atheleka ethonyeni lawo. Izinkomba ezisetshenziswayo:

1. Izifo zesistimu ephezulu yokuphefumula.
2. Izifo ze-Otorhinolaryngological, kufaka phakathi i-otitis sinusitis ne-pharyngotonzillitis.
3. Izilonda ze-Bronchopulmonary: i-bronchitis, bronchopneumonia, i-pneumonia.
4. Ukulimazeka komgudu we-genitourinary kanye nezitho zokuzala, kufaka phakathi i-cystitis, irethral syndrome kanye ne-gonorrhea.
5. Izilonda zesikhumba, izingqimba ezingaphansi, amathambo kanye nokuhlangana kwazo.
6. Ukutheleleka kwendawo yobuso nomlomo, njenge-abscess yamazinyo ne-periodontitis.
7. I-Sepicemia.
8. Umkhuhlane womama, izifo ezihlangene.

Umuthi wenzelwe izifo zohlelo lokuphefumula oluphezulu.

Umuthi uhloselwe i-bronchitis.

Umuthi wenzelwe inyumoniya.

Umuthi uhloselwe izifo zepheji lezitho zofuzo.

Kungenzeka yini ngesifo sikashukela

Abanesifo sikashukela bangaphuza umuthi njengokuyalelwa udokotela nangaphansi kokugadwa kwakhe.

Contraindication

Umuthi awunakusetshenziswa nge-hypersensitivity esenzweni sanoma yiziphi izingxenye futhi uma kunomlando wokungezwani nokwelashwa ngamakhambi we-penicillin. Okunye ukwephulwa:

• i-benign lymphoblastosis;
• i-lymphocytic leukemia;
• ukungasebenzi kahle kwesibindi, kufaka phakathi i-cholestasis, ebonwa phambilini nge-clavulanic acid noma i-amoxicillin;
• ukwehluleka kwezinso (i-creatinine ngezansi kwe-30);
• iminyaka efinyelela eminyakeni eyi-12.

Iziguli ezine-pseudomembranous colitis, kanye nabesifazane abakhulelwe nabancelisa ibele, zidinga ukulawulwa okukhethekile.

Ungawaphuza kanjani amaphilisi we-Augmentin 125

Umuthi awusetshenziselwa ukuzelapha. Uhlobo lwesilinganiso kanye nesikhathi sokwelashwa kunqunywa udokotela ngokuya izinkomba eziqondene nomuntu ngamunye. Kuyadingeka ukubheka ukuthambekela kwamagciwane, ubunzima besibindi, ubudala, isisindo somzimba kanye nesimo sezinso sezinso.

Uhlobo lwethebhulethi lomuthi lwenzelwe abantu abadala nezingane kusuka eminyakeni eyi-12 enesisindo esingaphezu kwama-40 kg. Uma ingane ingaphansi kweminyaka engu-12 ubudala, udinga ukumnika umuthi ngendlela yokumiswa.

Amatafula adakiwe esiswini esingenalutho ngenani elikhulu lamanzi. Ukuvikela imgudu yokugaya ukudla, kungcono ukuyiphuza nokudla, ekuqaleni kwayo ukudla. Inketho yomuthi olwa elisezingeni eliphansi isetshenziselwa ukwelapha izilonda ezibandayo. Ithathwa ngezikhathi ezithile ezingama-8. Kwezifo ezinzima, kusetshenziswa amaphilisi anomthamo we-500 mg + 125 mg noma we-875 mg + 125 mg.

Inkambo encane yokwelapha yizinsuku ezi-5.

Uhlobo lwesilinganiso kanye nesikhathi sokwelashwa kunqunywa udokotela ngokuya izinkomba eziqondene nomuntu ngamunye.

Imiphumela emibi yamaphilisi we-Augmentin 125

Umuthi ubekezelelwa kahle, kepha kwesinye isikhathi kuvela izindlela ezingathandeki.

Amapheshana wesisu

Isicanucanu, ukuhlanza, isifo sohudo, i-gastritis, i-stomatitis, i-drug colitis, ubuhlungu besisu, kanye ne-dysbiosis kungavela. Izimo ezingejwayelekile zilulimi olumnyama, kumnyama umbala koqweqwe lwawo.

Izitho zeHematopoietic

Shintsha izinkomba zokulinganisa zokwakheka kwegazi, ukwanda kwesikhathi sokuphuma kwegazi.

Isistimu yezinzwa ephakathi

Isiyezi, i-migraines, ushintsho ekuziphatheni, i-hyperactivity, ukuqwasha, ukuquleka (ngethamo elikhulu noma umsebenzi wezinso ongasebenzi kahle) kuyabonakala.

Kusuka ohlelweni lomchamo

Ukulandelwa kwegazi kwesinye isikhathi kuvela emchini, i-nephritis kungenzeka, futhi ngamanani aphezulu - i-crystalluria.

Isikhumba nolwelwesi lwe-mucous

Imvamisa, iziguli zakha i-candidiasis. I-erythema, ukuqubuka komzimba, ukulunywa, ukuvuvukala. Amacala okubonakala kwe-exudate necrolysis ye-integument aqaphelekile.

Imvamisa ngemuva kokuthatha i-Augmentin 125, iziguli zakha i-candidiasis.

Kusuka ohlelweni lwezinhliziyo

Ngesinye isikhathi ukopha.

Engxenyeni yesibindi ne-biliary

Umsebenzi we-Enzymatic ungakhuphuka, ukwehluleka kwesibindi nokukhula kwe-cholestasis.

Umthelela ekhonweni lokulawula izindlela

Imiphumela ehlukahlukene engazelelwe evela ohlelweni lwezinzwa kungenzeka. Ngakho-ke, kufanele uqaphele lapho wenza umsebenzi ongaba yingozi.

Imiyalo ekhethekile

Ukonakala kwe-microorganisms kungaxhomekeka ekufundeni komhlaba futhi kwehluka ngokuhamba kwesikhathi, ngakho-ke kunconyelwa ukwenza ukucubungula kokuqala.

Leli thuluzi alisetshenziselwa i-mononucleosis esolwayo.

Uma kuvela ukungezwani komzimba okukhulu, ukwelashwa kwe-oksijeni kanye nokuphathwa kwama-corticosteroids kungadingeka.

Ngokwelashwa okuhlala isikhathi eside, kufanele uphuze uketshezi oluningi, ugcine ulawulwa ukwakheka kwegazi, isimo sesibindi, umgudu wokuphefumula nezinso. Ukuqhakambisa kungakhula ngesikhathi sokwelashwa.

Leli thuluzi alisetshenziselwa i-mononucleosis esolwayo.

Sebenzisa ebudaleni

Emsebenzini ojwayelekile wezinso nesibindi, kusetshenziswa imithamo ejwayelekile.

Isabelo sezingane

Amaphilisi awenzelwe izingane. Bangadakwa yintsha (kusuka eminyakeni eyi-12) basebenzise imithamo yabantu abadala uma isisindo sesiguli sidlula ama-40 kg.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Umuthi okukhulunywa ngawo awunawo umphumela we-teratogenic, kepha kufanele uthathwe ngesikhathi sokukhulelwa njengesixazululo sokugcina. Izakhi ezisebenzayo zomuthi zingena buthaka zibe ubisi (ezitholakala ngesimo sokulandela). Ezinganeni, lokhu akuvame ukudala isifo sohudo; kuye kwaba nezimo ze-candidiasis ze-mucosa zomlomo. Ngakho-ke, kunconyelwa ukwelashwa ngama-antibiotic ukuphazamisa ukuncelisa ibele.

Isicelo sokusebenza kokulimala kwezinso

Uma imvume ye-creatinine ingaphezulu kuka-30 ml / min, khona-ke ukulungiswa kwamthamo akudingekile. Ngamanani aphansi, imvamisa yemithi kufanele incishiswe. Ithebhulethi i-875 mg + 125 mg ayikwazi ukubekelwa iziguli ezinje.

Sebenzisa umsebenzi wesibindi okhubazekile

Ukwelashwa ngemithi elwa namagciwane kwenziwa ngaphansi kokuqashwa kukadokotela. Kuyadingeka ukuqapha isimo sezakhiwo zesibindi.

Thatha u-Augmentin 125 ngesikhathi sokukhulelwa kufanele kube yiso sokugcina kuphela.

Ukweqisa

Ukweqisa imithamo ebekiwe nokwelashwa isikhathi eside ngemithamo ephezulu kungaholela ekwenqeni ngokweqile. Izimpawu zomlingiswa:

• ukuphefumula kwenhliziyo, ukugabha;
• isifo sohudo
• ukomisa;
• i-crystalluria;
• ukwehluleka kwezinso;
• ukulimala kwesibindi
• izicubu zomsipha.

Lapho kuvela izimpawu ezethusayo, udinga ukuthulula isisu bese ubuyisela amanzi nezinqolobane zamaminerali. Uma kunesidingo, phendukela kwi-hemodialysis.

Ukuxhumana nezinye izidakamizwa

Mhlawumbe ukuncipha komphumela wokuvimbela inzalo ngomlomo. Ngokusetshenziswa kanye kanye nama-anticoagulants, kungadingeka ushintsho kumthamo wokugcina. Akufanele ihlanganiswe ne-allopurinol, methotrexate, probenecid.

Ukuhambisana notshwala

Kufanele wenqabe ukuphuza utshwala.

Ama-Analog

Umuthi awutholakali ezibhebheni kuphela, kepha nangesimo se-powder, lapho kulungiswa khona ukumiswa komlomo. Kukhona nefomu le-powder elenzelwe umjovo. Ukulungiselela okufanayo:

• Panklav;
• I-Amoxiclav;
• Flemoklav Solutab;
• INovaklav;
• Arlet et al.

I-Panclave isidakamizwa sokwakheka esifanayo.

I-Amoxiclav yisidakamizwa sokwakheka esifanayo.

UFlemoklav Solutab - umuthi ofanayo wokuqamba.

Imibandela yekhefu lekhemisi

Ngokusebenzisa umuthi.

Intengo

Izindleko zamathebulethi zingama-250 mg + 125 mg - kusuka kuma-ruble angama-210.

Izimo zokugcina zomuthi

Umuthi kufanele uvikeleke ezinganeni. Igcinwe endaweni eyomile futhi emnyama. Ukushisa kwesitoreji akufanele kudlule + 25 ° С.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emithathu Ngemuva kokuvula iphakethe - izinsuku ezingama-30.

Umkhiqizi

Umuthi wenziwa nguSmithKline Beecham PLC (United Kingdom).

Ukubuyekezwa

Umuthi uthola izibuyekezo ezinhle kakhulu.

Odokotela

I-Kravets K.I., isazi sezokwelapha, iKazan

I-ejenti esebenza ngempumelelo ye-antibacterial enezinhlobonhlobo zemiphumela. Ubuthi bayo buphansi, kepha udinga ukubheka isimo sesibindi, ikakhulukazi lapho kukhona ama-pathologies alesi sitho.

I-Trutskevich E.A., udokotela wamazinyo, eMoscow

Umuthi ubekezelelwa kahle. Kepha kufanele kukhunjulwe ukuthi isisekelo sawo singama-antibiotic. Ngakho-ke, kuyadingeka ukulondoloza i-microflora yamathumbu, uthathe izindlela ezifanele.

Iziguli

U-Ana, oneminyaka engu-19 ubudala, Perm

Amaphilisi asize ukubhekana nemithombo ye-otitis ezinsukwini eziyi-5.

U-Eugene, oneminyaka engama-44, uRyazan

UDrank Augmentin ngesonto nge-sinusitis. Kwakungekho zinkinga nemiphumela emibi.