I-Angioflux 600 ikhombisa imiphumela ye-antithrombotic, angioprotective and anticoagulant. Igama libonisa umthamo wengxenye esebenzayo - 600 IZITHOMBE. Umuthi ubonakala ngokusebenza kwendawo yonke - isetshenziselwa izifo ezahlukahlukene ezihambisana nokwanda kwe-viscosity yegazi, i-thrombosis eyeqile.
I-ATX
B01AB11.
I-Angioflux 600 isetshenziselwa izifo ezahlukahlukene ezihambisana nokukhuphuka kwegazi, i-thrombosis ngokweqile.
Khipha amafomu nokwakheka
Umuthi unikezwa ngezindlela ezimbili: amakhompiyutha kanye nesisombululo semijovo ye-intramuscular and intravenous. Zihlukile kumthamo wento esebenzayo, okuyi-sodebide. Umuthi osefomini le-liquid uyatholakala kuma-ampoules we-2 ml. I-sulodexide kuleli cala iyunithi ezingama-600. Ukuqhathanisa, i-1 capsule iqukethe amayunithi angama-250 ezinto. Ukwakheka kwesixazululo kufaka izinto ezisizayo:
- i-sodium chloride;
- amanzi ngomjovo.
Ungathenga umuthi ngesimo sesisombululo emaphaketheni ama-ampoule ayi-5 nama-10.
Isenzo se-Pharmacological
Ithuluzi libhekisela kuma-anticoagulants aqondile. Umsebenzi oyinhloko we-Angioflux yikhono lokuthonya izakhiwo zegazi. Ngaphansi kwethonya lazo, kuyehla ukwehla kobukhulu bokwakheka kweziqeshana zegazi. Lokhu kungenxa yokwehla kokubonakala kwegazi.
Umphumela we-antithrombotic unikezwa ngenxa yomsebenzi wezakhi ze-sulodexide. Ngakho-ke, iqukethe ingxenye encane efana ne-heparin yesenzo esisheshayo. Into esebenzayo ye-Angioflux ingama-80% eyakhiwa le nto. Ngaphezu kwalokho, i-sulodexide iqukethe i-20% dermatan sulfate, eseduze ne-heparin cofactor ezindaweni.
Ngenxa yokuba khona kwalezingxenyana, kutholakala umphumela we-profibrinolytic. Ngenxa yalokhu, akugcini ngokubona kwegazi kuphela, kodwa nekhono lomuthi lokuqothula izigaxa ezakhiwe kakade liyaphawulwa. Ngenxa yale mpahla, umuthi ungasetshenziswa kunoma yisiphi isigaba sokuthuthuka kwezifo ezihambisana ne-thrombosis enkulu noma ukwanda kwe-viscosity yegazi.
Ngaphansi kwethonya le-Angioflux, kwehla ukujula kwenqubo yenqubo yokwakheka kwezigaxa zegazi.
Ukwephula ukwakheka kweziqeshana zegazi ngenxa yokuvinjwa kwezinto ezenziwa ku-Xa ne-Pa ezithinta ukuvela kwegazi. Ezinye izizathu: ukukhuphula ukukhula komkhiqizo nokukhululwa kwe-prostacyclin, kanye nokwehla kokuqukethwe kwe-plasma fibrinogen. Enye impahla (i-profibrinolytic) ibonakaliswa njengomphumela wokuvinjwa komsebenzi wama-inhibitors we-activ plasminogen activator. Ngasikhathi sinye, izinga le-tishu ye-plasminogen activator iyakhuphuka.
Ngenxa yalezi zinqubo, okuphambene nemishini, ukwakheka kwegazi kwenziwa njengokujwayelekile. Enye impahla yesidakamizwa (i-angioprotective) ibonakaliswa njengokuvezwa kwamaseli womuntu ongaphakathi emithanjeni yegazi. Ngasikhathi sinye, ukuthuthuka kwesimo sabo kuyaphawulwa: ubuqotho buyabuyiselwa, nobuningi be-pore yecala likagesi elibi le-membalane basement membrane lifanelwejwayelekile. Njengomphumela, imvume iyancishiswa, ngenxa yokuthi kunikelwa imiphumela yokulinganisela enokuthambile nebuthakathaka. Ngokwengeziwe, i-microcirculation yenziwa ejwayelekile.
Kanye nemiphumela echaziwe, ukubuyiselwa kwempahla yegazi kuyaphawulwa. Ngakho-ke, i-triglycerides ejwayelekile ihlelwe ngokwejwayelekile. Lezi yizakhi zokwakheka kwama-membranes weseli, nawo ayabona umsebenzi wamandla. Ukwanda kokuxineka kwabo kungenxa yokuvuswa kwe-enzyme ebandakanyeka kwi-lipolysis. Umsebenzi wayo ophambili ukwenza kusebenze inqubo yokukhiqiza ye-triglyceride. Ngaphezu kwalokho, ukwehla kwezinga lokwanda kwamaseli e-mesangium kuyaphawulwa. Kodwa-ke, ubukhulu be-membrane engaphansi buyancipha.
Lapho usebenzisa isixazululo semijovo, amathuba okuchithwa kwezingcezu ezinjenge-heparin awafakwa.
I-Pharmacokinetics
Izici ezinhle zomuthi zifaka inani lokusabalala eliphezulu emzimbeni wonke. Iningi (90%) lomuthi limunca izindonga zangaphakathi zemikhumbi. Ngenxa yokwethulwa kwekhambi intramuscularly noma intravenly, umsebenzi wethisthi wezinto eziphambili i-Angioflux ufinyelelwa imizuzu eyi-15 ngemuva komjovo, kwesinye isikhathi ngaphambili - ngemuva kwemizuzu emi-5. Izinga lokufakwa kanye nokusatshalaliswa kwalo muthi kuya ngesimo somzimba, isigaba sesifo kanye nezakhiwo zegazi ngesikhathi sokwelashwa.
Lapho usebenzisa isixazululo semijovo, amathuba okuchithwa kwezingcezu ezinjenge-heparin awafakwa. Lokhu kungathandeki kutholakala kuma-heparin aphansi wesisindo. Ngenxa yalokhu, ubukhulu bezenzo ze-anticoagulant ziyancipha. Isibindi nezinso zibamba iqhaza ezinqubweni zokuguqulwa kanye nokuphuma kwe-sulodexide emzimbeni.
Izinga lokususa kwengxenye eyinhloko liphezulu: le nqubo iba amahora ama-4 ngemuva komjovo. Inani elithile le-sulodexide likhishwa ngosuku lokuqala, ingxenye esele ngosuku lwesibili.
Izinkomba zokusetshenziswa
Izimo zePathological lapho zingasetshenziswa khona i-Angioflux:
- Izifo ezahlukahlukene ezihambisana nokwanda kwe-thrombosis, ukwanda kwe-viscosity yegazi, ushintsho ezimweni zalo zokuhlaziya;
- ukwehla kwe-vascular lumen, okuyimbangela ye-ischemia ephansi yomlenze;
- i-pathologies emboza imithambo ye-retina yezitho zombono (i-retinopathy) yama-etiologies ahlukahlukene;
- ingozi ye-cerebrovascular;
- i-encephalopathy;
- izinqubo zokuwohloka kwezicubu zemithambo yegazi;
- isifo semithambo ye-atherosclerotic;
- umsebenzi wezinso ongonakalisiwe, obonakaliswa ngumonakalo we-pelvis kanye ne-glomerular apparatus (nephropathy), okubangelwa izizathu ezahlukahlukene;
- isifo sikashukela se-nephropathy, i-retinopathy, kanye nesifo sikashukela sonyawo sikashukela.
Contraindication
Umuthi awusetshenziswa ezimweni ezinjalo:
- i-diathesis ehamba ne-hemorrhage, ebonakaliswa ngokukhishwa kwegazi ngokusebenzisa izindonga zemithambo yegazi;
- noma yiziphi izimo ze-pathological lapho i-hypocoagulation ikhula khona;
- ukusabela okungekuhle komuntu ngamunye ezingxenyeni ze-Angioflux;
- hypersensitivity to heparin, ngoba into esebenzayo ekwakhiweni komuthi ibonakala ngesakhiwo esifanayo samangqamuzana;
- ukuthambekela komzimba ukopha, ngoba umuthi ungathinta ukubukeka kwegazi.
Ukuphulwa okuhlobene nakho kuyaphawulwa. Kulokhu, umuthi uvunyelwe ukuthi usetshenziswe, kodwa kuphela ngaphansi kokuqondisa udokotela. Ngakho-ke, i-Angioflux ingasetshenziswa ezimweni lapho kunconywa khona ukudla okungenasawoti esigulini, kepha ngokucophelela. Lokhu kungenxa yokuthi ukwakhiwa kwaleli thuluzi kufaka phakathi ingxenye equkethe i-sodium.
Ungayithatha kanjani
Inani lansuku zonke le-Angioflux 600 ngendlela yesisombululo ngu-2 ml, ohambelana nokuqukethwe kwe-1 ampoule. Umuthi ungalawulwa ngokuhlinzwa: ngemithamo emikhulu ukuze ngokushesha ukhuphule ukuqina kwento esebenzayo noma i-Drip, kuleli cala, i-sulodexide ihanjiswa egazini kancane, evimbela ukubonakala kwemiphumela emibi eminingana. Ngaphezu kwalokho, isixazululo sisetshenziswa ngokungenantambo. Imiyalo esetshenzisiwe:
- uma kuhlelwa ukuphatha i-Angioflux ngokwehla, okuqukethwe i-ampoule kuhlanganiswa nesisombululo se-0.9% sodium chloride kwisilinganiso: 2 ml yesidakamizwa ngo-150-200 ml we-NaCl;
- Ukwelashwa ezimweni eziningi kuqala ngokulawulwa kwesidakamizwa komzali, ngemuva kwamasonto angama-2-3 kunconyelwa ukushintshela kumaphilisi (i-1 kc. izikhathi ezi-2 ngosuku), inkambo yokuphatha kuleli cala ihlala izinsuku ezingama-30 kuya kwengama-40.
Umuthi usetshenziswa kabili ngonyaka. Ukuphindaphindeka kwemithamo yomuthi, kanye nesikhathi sokwelashwa, kuvame ukunqunywa ngokulandelana, okungathintwa yisimo sesiguli, imiphumela yokuhlolwa kwegazi, kanye nokuba khona kwamanye ama-pathologies.
Ukuthatha umuthi wesifo sikashukela
Ngokubona ukuthi phakathi kwezinkomba zokusetshenziswa kwomuthi, lesi sifo siyabonakala futhi, asikho isidingo sokuphinda siphindaphinde umthamo. Iziguli ezinesifo sikashukela esitholakele zinikezwa irejimeni ejwayelekile, kepha uma kwenzeka izehlakalo ezimbi, isifundo singaphazamiseka. Kulokhu, isikhathi sokwelashwa sinqunywa ngawodwana, ngoba ezinye i-pathologies zivame ukutholakala ezinomthelela wokunciphisa / ukunweba isikhathi sokwelashwa.
Imiphumela emibi
Kuvezwa lezi zinto ezingezinhle ezilandelayo:
- usizi endaweni yenaliti ngesikhathi sokujova;
- umuzwa ovuthayo, i-hematoma endaweni yokubhoboza.
Amapheshana wesisu
Ngemuva kokushintshwa kusuka ekuphathweni kwabazali kuya ekuphathweni komlomo, kuvela izinhlungu esiswini, isicanucanu kanye nokuhlanza kwenzeka.
Allergies
Lapho usebenzisa umuthi (kunoma yiluphi uhlobo lomthamo), ukuvela komzimba kungaqhamuka, izimpawu yilezi: ukuqunjelwa, ukuvuvukala, ukulunywa, ukubomvu kwesikhumba.
Imiyalo ekhethekile
Ithuluzi alithinti amandla okushayela imoto, ngoba ayivuseli ukungasebenzi kahle kwezitho ezibalulekile (uhlelo lwenhliziyo, isistimu yezinzwa ephakathi, izitho zombono nokuzwa, uhlelo lokuphefumula).
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi ungabekwa ku-2nd no-3 trimesters. Ukuqapha kumele kwenziwe ngesikhathi sokwelapha. Ezinyangeni zokuqala ezintathu zokukhulelwa, i-Angioflux ayisetshenziswa.
Imininingwane ngemiphumela yomuthi emzimbeni wengane ngesikhathi sokuncelisa ibele ayanele, ngakho-ke umuthi kufanele usetshenziswe ngokuqapha.
Sebenzisa ebudaleni
Umuthi ubekiwe, ngoba iziguli zaleli qembu zivame ukutholakala nezifo zemithambo, kufaka phakathi lezo ezihambisana nokuwohloka kwezicubu zemvelo. Ukuphinda usebenzise i-dose akudingeki uma kungekho okubonakalisayo okungesihle ngesikhathi sokwelashwa.
Umthamo we-Angioflux ezinganeni ezingama-600
Umuthi awusetshenziswanga, ngoba akukho mininingwane eyanele mayelana nethonya lomphumela wawo emzimbeni weziguli zalesi sigaba sobudala.
Ukweqisa
Uma inani le-sulodexide landa njalo, i-plasma yalo ikhula kancane kancane, ngoba isigamu sempilo yalesi sithako yizinsuku eziyi-1-2. I-overdose iba ukopha. Kulokhu, masinyane uphazamise inkambo yokwelashwa futhi wenze ukwelashwa okunezimpawu.
Ukuxhumana nezinye izidakamizwa
I-Angioflux yenyusa izinga lokusebenza kwezidakamizwa eziningana: ama-anticoagulants angaqondile, ama-antiplatelet agents, i-heparin. Ngokuphathwa kanyekanye, ukubalwa kabusha komthamo kwesinye isikhathi kuyadingeka, futhi nokulawula ukwakheka kwegazi kuyadingeka.
I-Angioflux ayikwazi ukusetshenziswa kanye nama-he hentatic agents. Kulokhu, umphumela ophambene uyatholakala.
Izidakamizwa Iningi (izidakamizwa ezingavikeleli, izidakamizwa ezilwa namagciwane, njll.) Azithinti isidakamizwa okukhulunywa ngaso.
Ama-Analogs we-Angioflux 600
Uma ngenxa ye-hypersensitivity akwenzeki ukusebenzisa lesi sidakamizwa, esikhundleni salaba abasebenza esikhundleni:
- UWessel Douai F;
- Clexane;
- I-Fraxiparin;
- Fragmin.
Eyokuqala yezinketho iyi-analogue eqondile ye-Angioflux, ngoba iyafana ekwakhekeni nasendleleni yokukhululwa. Kuboniswa izakhiwo ezifanayo nendlela yokusebenza yesenzo, ngakho-ke ungasebenzisa lesi sibambiso ngaphandle kokuphinda umthamo.
I-Clexane iqukethe i-enoxaparin sodium ekugxileni okuhlukahlukene njengento esebenzayo. Ingathengwa ngesimo somjovo. Umuthi ungoweqembu lezidakamizwa elisuselwa ku-heparin ephansi yesisindo.
I-Fraxiparin iqukethe i-calcium nadroparin. Le ngenye i-heparin ephansi yesisindo. Izindlela zaleli qembu zingaphansi kwe-Angioflux ekusebenzeni kahle, ngoba zigcina izakhiwo zesikhathi esifushane.
UFragmin yisigungu esisebenza ngokuqondile. Kuqukethe i-dalteparin sodium. Ngokuya ngentengo kanye nokusebenza kahle, lo muthi uyafana ne-Angioflux, kepha uhlukaniswa ngenani elikhulu le-contraindication nemiphumela emibi.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi kadokotela.
Intengo
Izindleko ezijwayelekile ngama-ruble ayi-1720.
Izimo zokugcina ze-Angioflux 600
Ukutholakala kwezingane ngomuthi kufanele kuvalwe. Izimo zesitoreji: izinga lokushisa lomoya - kufinyelela ku- + 30 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Umuthi ugcina izakhiwo zawo iminyaka emi-3 kusukela ngosuku lokukhishwa.
Ukubuyekezwa kwe-Angioflux 600
Odokotela
UVeremeev I. L., udokotela wezokwelapha, oneminyaka engama-39 ubudala, iKrasnoyarsk
Ithuluzi lihlinzeka ngempumelelo ephezulu. Ngokusola okuncane kokuthambekela kokopha, kungcono ukungayisebenzisi. Ngincoma ngokukhuphuka kwegazi.
U-Amirov O. O., udokotela wezifo zamazinyo, oneminyaka engama-45 ubudala, eSt
Ngokushesha lisho isimo semithambo yegazi. Ngezifo ku-gynecology nangesikhathi sokukhulelwa, angizukukuncoma ukuthi isetshenziswe - kunethuba eliphezulu lokopha kwe-uterine.
Iziguli
UGalina, oneminyaka engama-38, Perm
Bengihlala ngicabanga ukuthi amavithamini nezithasiselo zokudla kuyadingeka ukuze kuhlanganiswe ukwakheka kwegazi, kepha ngemuva kokuvakashela udokotela ngenxa yokuwohloka kwenhlala-kahle, lo mbuzo waba sobala: izidakamizwa ezikhethekile nazo zithinta igazi. Zincane, zivimbele ukuvela kweziqeshana zegazi. Uma ucabanga ukuthi ngithole ukuthi nginesifo sokuphazamiseka kwengqondo (ne-thrombosis eyandayo), angikwazi ukwenza ngaphandle kwe-Angioflux manje. Ngithatha izifundo kabili ngonyaka. Ngenkathi izinkinga zingakakhuli, isimo singalondolozwa sijwayelekile.
U-Ana, oneminyaka engama-42, uBelgorod
Ithuluzi elihle, kepha liyabiza. Ngalesi sizathu, ngacela udokotela ukuthi athathe i-analogue. Ngithole i-pathologies yemikhumbi yentamo ngenxa ye-osteochondrosis. Lokhu kusho ukuthi ngezikhathi ezithile udinga ukwelashwa ngezidakamizwa ezithuthukisa ukuhambisa kwegazi ubuchopho. Ama-ejensi wokunciphisa igazi nawo ayadingeka, ngoba ukubukeka kwegazi kukhuphuka kancane. Ukudla izidakamizwa ezibizayo akujwayelekile kimi.
