I-Sanovask yi-ejenti ye-antiplatelet esetshenziswa ekuziphatheni komtholampilo njengesidakamizwa se-analgesic nokunciphisa imfiva. Umuthi usetshenziselwa ukulwa nezifo ezithathelanayo nezivuvukelayo. Umuthi uyatholakala ngefomu lethebhulethi elungele ukuphathwa.
Igama Lezwe elingafanele
Acetylsalicylic acid.
I-Sanovask isetshenziswa ukulwa nezifo ezithathelanayo nezivuvukelayo.
I-ATX
B01AC06
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo samaphilisi afakwe ngaphakathi entweni. Njengomuthi osebenzayo, i-100 mg ye-acetylsalicylic acid isetshenziswa. Izingxenye ezisizayo zifaka:
- i-colloidal silicon dioxide;
- i-microcrystalline cellulose;
- i-lactose monohydrate;
- isitashi se-sodium carboxymethyl.
Umuthi uyatholakala ngesimo samaphilisi afakwe ngaphakathi entweni.
Igobolondo langaphandle lesidakamizwa liqukethe i-Copolymer ye-methaconic acid, i-macrogol 4000, ipovidone, i-ethyl acrylate. Amayunithi omuthi anobujamo be-biconvex eyindilinga futhi apendwe mhlophe. Amatafula afakwe izingcezu eziyi-10 emabhokisini e-blister yezingcezu eziyi-10 noma emgqonyeni wepulasitiki wezingcezu ezingama-30, ezingama-60. Amakhadibhodi amaphakethe aqukethe u-3, 6 noma 9 amanxeba.
Isenzo se-Pharmacological
Umuthi ungowesiqhema sezidakamizwa ezingezona ezokwelapha ezibulala amagciwane. Ukusebenza kwesenzo kungenxa yomsebenzi we-acetylsalicylic acid, onomphumela wokulwa nokuvuvukala kanye ne-antipyretic. Isakhiwo samakhemikhali sinomphumela othile we-analgesic futhi sinciphisa ukunamathela kweplatelet.
Isithako esisebenzayo eSanovask sinqanda i-cycloo oxygenase, isihluthulelo se-metabolic ye-arachidonic fatty acid, okuvela ku-prostaglandins enegalelo kubuhlungu, ukuvuvukala kanye nomkhuhlane. Ngokuncipha kwezinga lama-prostaglandins, ukuguquguquka kwezinga lokushisa kubonwa ngenxa yokunyuka kokujuluka kwesitashi kanye ne-vasodilation ku-subcutaneous fat layer.
Umphumela we-analgesic kwenzeka nge-blockade ye-thromboxane A2. Lapho uthatha umuthi, ukunamathela kweplatelet kuyancipha.
Umuthi unciphisa ingozi yokufa ngenxa yokufakelwa kwe-myocardial kanye ne-angina engazinzile. Umuthi uyasebenza njengesilinganiso sokuvimbela izifo zohlelo lokujikeleza kwegazi nokuqothuka kwemisipha yenhliziyo. Ama-acetylsalicylates, lapho ethathwa ngaphezulu kwe-6 g, inhibit synthesis of prothrombin in hepatocytes.
Umuthi usiza ukunciphisa ukunqwabelana kwe-coagulation factor, kuye ngokuthi imfihlo ye-vithamini K. Emithanjeni ephezulu, kubhekwa ukwehla komgodi we-urinary acid. Ngenxa yokuvinjwa kokuhlanganiswa kwe-cycloo oxygenase-1, ukwephulwa kwenzeka mucosa wesisu, okungaholela ekwakhiweni kwezilonda ezalapha ngokuphuma kwegazi okwalandela.
Umuthi uyasebenza njengesilinganiso sokuvimbela izifo zohlelo lokujikeleza kwegazi nokuqothuka kwemisipha yenhliziyo.
I-Pharmacokinetics
Lapho kuthathwa ngomlomo, into esebenzayo isheshe imungene kwi-microvilli yamathumbu amancanyana futhi ingxenye ethile esiswini sesisu. Ukudla kubambezela ukumunca umuthi. I-acetylsalicylic acid iguqulwa kuma-hepatocytes abe yi-salicylic acid, okuthi uma ingena ekujikelezweni kwe-systemic, ibophele amaprotheni e-plasma ngo-80%. Ngenxa yenqubo eyakhiwe eyinkimbinkimbi, ikhemikhali liqala ukusatshalaliswa ngaphezulu kwezicubu namanzi omzimba.
I-60% yezidakamizwa ikhishwa ngefomu yayo yasekuqaleni ngohlelo lobuchwephesha. Ukuphila kwesigamu kwe-acetylsalicylate imizuzu eyi-15, ama-salicylates - amahora angama-2-3. Lapho uthatha umthamo omkhulu womuthi, impilo yesigamu ikhuphuka ibe amahora angama-15-30.
Izinkomba zokusetshenziswa
Umuthi wenzelwe ekwelashweni nasekuvinjelweni kwezinqubo ezilandelayo ze-pathological:
- i-pain syndrome ye-etiologies ehlukahlukene yobumnene kuya kobukhulu obulinganiselayo (neuralgia, ubuhlungu bemisipha yamathambo, ikhanda);
- ingozi ye-cerebrovascular phambi kweziza ze-ischemic;
- umkhuhlane wokulwa nezifo ezithathelanayo zemvelo esithathelwanayo;
- ukutheleleka nokungezwani komzimba;
- i-rheumatism;
- i-thrombosis ne-thromboembolism;
- infarction kwemisipha yenhliziyo.
Kwi-immunology kanye ne-allergology, umuthi usetshenziselwa ukwenza umtholampilo ukuqeda i-aspirin triad kanye nokwakhiwa kokumelana kwezicubu kuma-NSAIDs ezigulini ezine-asthma ye-aspirin. Umuthi usetshenziswa ngokwanda kancane kancane kwithamo losuku.
Contraindication
Umuthi awuvunyelwe ukusetshenziswa ezimweni ezilandelayo:
- ngezifo zokulimala kwezifo zesisu kanye ne-duodenum esigabeni esibuhlungu;
- i-aspirin triad;
- ukwanda kokucasuka kwezicubu kuma-NSAIDs;
- i-aneurysm yama-stratified;
- ukopha emgodini wesisu;
- ukwanda kwe-portal komfutho wegazi;
- ukuntuleka kwe-Vitamin K ne-glucose-6-phosphate dehydrogenase;
- Isifo sikaReye
- i-hemorrhagic diathesis;
- ukungabekezelelani kwe-lactose kanye ne-malabsorption yama-monosaccharides.
Kunconywa abantu abaphethwe i-asthma ye-bronchial, ukhuphuka kokopha kanye nokukhubazeka kwegazi. Umuthi awukhuthazelwa ezigulini ezihlushwa ukwehluleka kwenhliziyo okungapheli esigabeni sokuhlaziya noma eselashwa nge-anticoagulation.
Ungayithatha kanjani iSanovask
Umuthi unqunywe kumthamo wansuku zonke we-150 mg kuya ku-8 g. Umuthi unconywa ukuphuza izikhathi ezi-2-6 ngosuku, ngakho-ke umthamo onomuthi owodwa ungama-40-1000 mg. Inani eliqondile lansuku zonke lisethwe ngokuya ngemininingwane yezifundo zaselebhu kanye nesithombe somtholampilo walesi sifo.
Ngoshukela
Umuthi ukhulisa umphumela wezidakamizwa ze-hypoglycemic, kepha awuthinti umsebenzi wamanyikwe futhi awulawuli amazinga kashukela egazini.
Imiphumela emibi Sanovaska
Ukuvela okungalungile okuvela ezinhlotsheni nasezinhlelweni kungenzeka ngokusetshenziswa kwezidakamizwa nokungahambisani nezincomo zezokwelashwa. Kwezinye izimo, ukuthuthukiswa kwesifo sikaReye kungenzeka.
Ngokuphikisana nesizinda sokwelashwa isikhathi eside, kukhona ubungozi bezimpawu zokwehluleka kwenhliziyo.
Amapheshana wesisu
Ezimweni eziningi, ukusabela okungekuhle kubonakaliswa ngendlela yesicanucanu, ukugabha nokulahlekelwa isifiso sokudla, kuze kufike ekukhuleni kwe-anorexia. Ubuhlungu be-epigastric nohudo kungenzeka. Mhlawumbe ukuthuthukiswa kokopha emgodini wokugaya ukudla, isibindi esithukuthele, ukubonakala kwezilonda ezivuvukala.
Izitho zeHematopoietic
Kunobungozi bokwehla kokuxineka kwamangqamuzana egazi, ikakhulukazi ama-platelet namaseli abomvu egazi, okuholela ku-thrombocytopenia kanye ne-hemolytic anemia.
Isistimu yezinzwa ephakathi
Ngokusebenzisa isikhathi eside umuthi, isiyezi nekhanda kuyavela. Ezimweni ezingavamile, kukhona ukwephulwa kwe-acuity ebonakalayo yesimo sesikhashana, i-tinnitus kanye ne-aseptic meningitis.
Ngokulashwa isikhathi eside neSanovask, i-aseptic meningitis iyivelakancane ezimweni ezingavamile.
Kusuka ohlelweni lomchamo
Endabeni yokwanda komphumela we-nephrotoxic wesidakamizwa ezinso, kungenzeka ukungabikhona kahle kwalezi zitho kanye nephrotic syndrome.
Kusuka ohlelweni lwezinhliziyo
Mhlawumbe ukuthuthukiswa kwe-hemorrhagic syndrome kanye nokwanda kwesikhathi sokuphuma kwegazi.
Allergies
Ezigulini ezithambekele ekubonakalisweni kokuphendula komzimba, ukuqhuma kwesikhumba, i-bronchospasm, ukushaqeka kwe-anaphylactic, ne-Quincke edema kungahle kube nokukhula. Ezimweni ezingavamile, kukhona inhlanganisela ngasikhathi sinye ye-polyposis yesisu samazinyo nezono zesitho somoya esine-asthma ye-bronchial.
Umthelela ekhonweni lokulawula izindlela
Ngenxa yobungozi bemiphumela emibi evela ebuchosheni, ukunakekelwa kufanele kuthathwe lapho ushayela imoto futhi usebenza ngamasu ayinkimbinkimbi adinga ukuphendula okusheshayo nokuxineka.
Ngenxa yemiphumela emibi ethatha iSanovask, ukunakekelwa kumele kuthathwe lapho ushayela.
Imiyalo ekhethekile
I-Acetylsalicylate iyakwazi ukunciphisa ukuphuma kwe-uric acid emzimbeni, yingakho isiguli singaba nokuqunjelwa yisifo esifanele. Ngokulashwa isikhathi eside kwama-NSAIDs, kuyadingeka ukuhlola njalo izinga le-hemoglobin, isimo segazi elijwayelekile, nokuhlolwa kwesitulo sokuba khona kwegazi okufihliwe.
Ngaphambi kokuhlinzwa okuhleliwe, kunconywa ukuthi ukhansele ukuthatha i-Sanovask ezinsukwini ezingama-5-7 ngaphambi kwenqubo. Lokhu kuyadingeka ukunciphisa ingozi yokopha.
Isikhathi sokwelashwa akufanele singeqi izinsuku eziyi-7 lapho kunqunywa umuthi njengomuthi wokubulala izinzwa. Uma umuthi usetshenziswa njenge-antipyretic, khona-ke inkambo ephezulu yokwelashwa yizinsuku ezi-3.
Sebenzisa ebudaleni
Abantu asebekhulile abadingi ukulungiswa okungeziwe kohlobo lomthamo.
Isabelo sezingane
Kuze kube yiminyaka eyi-15 ebuntwaneni nasebusheni, kusenamathuba akhulayo okuthi isifo sikaReye sisezingeni lokushisa eliphakeme, okuqubuke ngemuva kwesizinda sezifo ezithathelwanayo noma ezibangelwa yigciwane. Ngakho-ke, ukuqashwa kwesidakamizwa ezinganeni akuvunyelwe. Izimpawu zesifo zifaka i-encephalopathy ebaluleke kakhulu, ukugabha isikhathi eside, kanye nokwanda kwesibindi.
Ukuqokwa kweSanovask yezingane ezingaphansi kweminyaka engu-15 kuyavunyelwa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi awuvunyelwe ukusetshenziswa kuma-trimesters we-I ne-III wokukhula kombungu. Kwi-trimester yesi-II, iSanovask ivunyelwe ukusetshenziswa ngokuqinile ngokuya ngemiyalo nezincomo zezokwelapha. I-Contraindication kungenxa yomthelela we-teratogenic wesakhi esisebenzayo.
Ukuncelisa ibele ekwelapheni kweSanovask stop.
Isicelo sokusebenza kokulimala kwezinso
Ukuqwashisa kuyelulekwa lapho kukhona i-pathology ezinso. Ukuthatha umuthi ngakwisizinda sokungasebenzi kahle kwezitho kuvunyelwe.
Sebenzisa umsebenzi wesibindi okhubazekile
Lapho kukhona izifo zesibindi, kubalulekile ukuthi uphuze umuthi ngokuqapha.
I-Sanovask ayinconyelwa ukuqokwa kwabantu abaphethwe ukungasebenzi kahle kwesibindi.
Umuthi awukhuthazelwa ukuqokwa kwabantu abahlushwa isibindi.
Ukweqisa kwe-Sanovask
Ngomthamo owodwa womthamo omkhulu, izimpawu ze-overdose ziqala ukuvela:
- Ukudakwa okuthambile nokunokulinganisa kubonakaliswa ukuthuthukiswa kwemiphumela emibi ohlelweni lwezinzwa oluphakathi (isiyezi, ukudideka nokulahlekelwa ukwazi, ukulahleka kokuzwa, ukukhala ezindlebeni), ipheshana lokuphefumula (ukukhuphuka kakhulu kokuphefumula, i-alkalosis yokuphefumula). Ukwelashwa kuhloswe ukubuyisa ibhalansi kasawoti wamanzi kanye ne-homeostasis emzimbeni. Isisulu sinqunyelwe ukudliwa okuningana kwe-adsorbent kanye nokuqubuka kwesisu.
- Ukudakwa kakhulu, ukucindezelwa kwe-CNS, ukwehla okubukhali kwengcindezi yegazi, i-asphyxia, i-arrhythmia, ukwanda kwamapharamitha okusetshenzelwa elabhoratri (hyponatremia, ukwanda kokuqina kwe-potassium, ukungasebenzi kahle kweglucose), izindlebe, i-ketoacidosis, ikhava, ukuqina kwemisipha neminye imizwa ehlukile.
Ezimweni zokuma ngokudakwa okunamandla, kuyaphathwa ukwelashwa okuphuthumayo - isisu siyagezwa, i-hemodialysis iyenziwa bese kugcinwa izimpawu ezibalulekile.
Ukuxhumana nezinye izidakamizwa
Ngokusebenzisa ngasikhathi sinye kweSanovask neminye imithi, ukuthuthukiswa kwezinqubo ezilandelayo kuyabonakala:
- I-Acetylsalicylic acid ithuthukisa umphumela wezokwelapha wezidakamizwa ezingezona ze-antiidal (i-NSAIDs), i-methotrexate (ukuncishiswa kwe-renal), i-insulin, i-anticoagulants engaqondile, izidakamizwa ze-antidiabetic kanye ne-phenytoin. Ngasikhathi sinye, ama-NSAIDs andisa imiphumela emibi.
- Imithi equkethe igolide inomthelela kumonakalo kuma-hepatocytes. I-Pentazocine inyusa umphumela we-nephrotoxic weSanovask.
- Ingozi yomphumela we-ulcerogenic lapho uthatha ama-glucocorticosteroids ayanda.
- Ukuwohloka kwomphumela wokwelapha we-diuretics kuyabonakala.
- Amathuba okukhula kwegazi akhuphuke ngokuhambisana nemithi evimba ukukhululeka kwethambo lezinso futhi inciphise ukuphuma kwe-calcium emzimbeni.
- Ukufakwa kwe-acetylsalicylate kwehlisa ijubane lapho uthatha ama-antacid kanye nemithi equkethe usawoti we-aluminium ne-magnesium, kuyilapho umphumela ophambene ubonwa lapho kusetshenziswa i-caffeine. Ukugcotshwa kwe-plasma kwekhompiyutha esebenzayo kuyanda ngokusetshenziswa kwe-metoprolol, dipyridamole.
- Lapho uthatha i-Sanovask, imiphumela yezidakamizwa ze-uricosuric iyancipha.
- I-Alendronate sodium icasule ukuthuthukiswa kwe-esophagitis enzima.
Ukuhambisana notshwala
Ngesikhathi ukwelashwa ngeSanovask kunconywa ukwenqaba ukuphuza utshwala. I-Ethanol ekwakhiweni kophuzo oludakayo ivusa ukuthuthukiswa komthelela ongemuhle engxenyeni yesistimu yezinzwa, ibangela ukuphazamiseka kwesistimu yenhliziyo futhi inesandla ekutholakaleni kwe-pathologies esibindini.
Ama-Analog
Ukufaka esikhundleni salomuthi, okufana nokwakheka kwamakhemikhali nezakhiwo ze-pharmacological, kufaka phakathi:
- Acecardol;
- I-Thrombotic ACC;
- Aspirin Cardio;
- Acetylsalicylic acid.
Ukuzithathela umuthi akunconywa. Ngaphambi kokuthatha omunye umuthi, udinga ukubonana nodokotela.
Imibandela yekhefu lekhemisi
Umuthi uthengiswa ngomuthi onikezwe wona.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ngenxa yobungozi obandayo bemiphumela emibi noma i-overdose lapho uthatha i-Sanovask ngaphandle kwezinkomba eziqondile zezokwelapha, ukuthengiswa kwamahhala kwamathebulethi kukhawulelwe
Intengo
Izindleko ezijwayelekile zesidakamizwa zifinyelela kuma-ruble angama-50-100.
Izimo zokugcina zomuthi
Umuthi ugcinwa endaweni eyomile, uvikelwe umswakama nokukhanya kwelanga, emazingeni okushisa afinyelela ku- +25 ºะก.
ISanovask kufanele igcinwe endaweni eyomile, ivikelwe umswakama nokukhanya kwelanga.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
I-OJSC "Irbit Chemical Farm", eRussia
Ukubuyekezwa
U-Anton Kasatkin, oneminyaka engama-24, uSmolensk
Udokotela unikeze amaphilisi kamama weSanovask maqondana nesifo senhliziyo ukuthambisa igazi. Kuthatha njalo.Ngenxa yokuba khona kwenhlanganisela ekhethekile ezibhebheni, akukho miphumela emibi eye yenzeka. Ithebhulethi liqala ukuncibilika kuphela emathunjini, ngaphandle kokuqhekeka ngaphansi kwesenzo se-asidi esiswini.
UNatalia Nitkova, oneminyaka engama-60, u-Irkutsk
Ukuguga sekwenze wazwakala ngokwanda kwesifo senhliziyo. Futhi, nginesifiso sokufa ngokuhlaselwa yinhliziyo nemivimbo. Ngemuva kokuhlaselwa yisifo senhliziyo, odokotela banquma ithebhulethi engu-1 yeSanovask ngaphambi kokulala ukuvimbela ukukhula kwezicucu zegazi. Ngokungafani ne-acetylsalicylic acid ehlanzekile, lesi sidakamizwa asilimazi isisu, ngakho-ke ngiyasincoma.
