INovomix Flekspen 30 ingeyezimali eziqukethe i-insulin. Usizo lwayo indlela yokusebenza yesigaba ezimbili. Leli thuluzi libonakala ngobubanzi obuncane, inani lemikhawulo lapho lisebenzisa.
Igama Lezwe elingafanele
I-insulin aspart isigaba sesibili
I-Novomix Flexspen 30 iboniswa yisikali esincane, isibalo esincane semikhawulo lapho usebenzisa.
I-ATX
A10AD05
Khipha amafomu nokwakheka
Ungawuthenga lo muthi ngesimo sokumiswa okuhloselwe ukumiliselwa kwe-insulin. Umkhiqizo ukhishwa ngepeni yesirinji engu-3 ml. Iqoqo lento esetshenziswayo ku-1 ml yesidakamizwa yi-100 IU. Inani eliphelele lomenzeli esibayeni yi-300 IU.
Isakhi esisebenzayo yi-insulin aspart. Le nto iqukethe izinhlobo ezi-2: i-soluble, ngesimo sezingxenyana ze-crystalline. Ukugxila kwabo ngokulandelana kungama-30 no-70%. Ungawuthenga umkhiqizo ngamaphakeji aqukethe amasirinji ama-5.
Isenzo se-Pharmacological
Ukwakheka kwalesi sidakamizwa kufaka i-analog ye-insulin yabantu. Lokhu yinto enezigaba ezimbili. I-insulin ikhombisa imiphumela emfushane nehlala isikhathi eside. Kuwona womabili la mazwe, izigaba ezahlukile zokumiswa ziyabandakanyeka. Indlela yokusebenza yesakhi esisebenzayo isuselwe emandleni okukhulisa izinga lokuhambisa ushukela. Umphumela ofiselekayo uyatholakala lapho i-hormone ixhumana nama-receptors wezicubu ezahlukahlukene (okunamafutha, izicubu zomzimba). Ngasikhathi sinye, kukhona ukwehla kwezindlela zokushukela kwesibindi. Ukwenza kusebenze kwenqubo ye-lipo- kanye ne-glycogenogeneis nakho kuyaphawulwa.
Umuthi ukhishwa ngesimo sokumiswa esibayeni se-sylinge engu-3 ml.
Ngokuya kwe-molarity, i-insulin aspart ifana ne-insulin yabantu. Kodwa-ke, ngenxa yokuba khona kwento encibilikayo ekwakhiweni kwayo, umphumela omuhle uyasheshiswa. Ingxenye esebenzayo ikuvumela ukuthi uthole imiphumela oyifunayo kungakapheli imizuzu eyi-10-20 emva kokulimala ngokungagudli. Ngakolunye uhlangothi, ngenxa yezingxenyana ezinjengekristalu, umphumela wokuqhubeka kwesikhathi uyaqinisekiswa. Kulokhu, izinga eliphakeme le-insulin lifinyelelwa emahoreni angama-4 okuqala ngemuva komjovo.
Umphumela umphumela ugcinwa amahora angama-24. Ngokusekelwe emiphumeleni yezifundo, kungaphethwa ngokuthi ukuthatha umuthi okukhulunywa ngawo kabili ngosuku (ngemuva kokudla) kukuvumela ukuthi ulawule kangcono amazinga eglucose egazini. Kuyaphawuleka ukuthi ukusetshenziswa kwe-insulin aspart akuholeli ekunciphiseni okukhulu kwe-glycated hemoglobin.
Ngaphezu kwalokho, kwatholakala ukuthi ngenxa yokusetshenziswa isikhathi eside kwe-insulin aspart, ubungozi bokukhula kwe-hypoglycemia ebusuku, kanye nefomu elinamandla lalesi simo se-pathological, liyancishiswa. I-Direct pharmacodynamics ekwelapheni iziguli esezikhulile ayizange ifundwe. Kodwa-ke, kwasungulwa ngokungaqondile ukuthi izinkomba eziphambili zihlala zisezingeni elifanayo nelabantu abasha.
I-Pharmacokinetics
Inqubo yokumuncwa kwe-insulin engamanzi equkethwe umuthi obhekene nayo iba ngokushesha lapho iqhathanisa izakhiwo ze-pharmacokinetic ne-insulin enganyibiliki yabantu. Ngenxa yalokhu, ungathola umphumela omuhle nge-hypoglycemia yesikhathi esifushane. Uma sicabangela izakhiwo zezingcezu ezinjengekristalu, khona-ke ubukhulu bokufakwa kwabo azihlukile ekusebenzeni kwe-insulin NPH yabantu.
Ukusetshenziswa kweNovomix Flekspen kwezifo zesibindi nezinso akuholeli ekubonakaleni kwezimpawu ezingezinhle.
Izinga eliphezulu lokuhlushwa lomuthi we-hypoglycemic lifinyelelwa ngokushesha ngokuqhathaniswa ne-insulin yomuntu. Ezigulini eziningi, i-insulin aspart ifinyelela imithamo ephakeme ngemizuzu engama-60-95. Ukuphila kwengxenye yayo kuyehluka kusuka emahoreni ayi-8 kuye kwayi-18, okuthintwa yisimo somzimba, ukuba khona kwamanye ama-pathologies. Isikhathi somuthi sincike ekujuleni kokugeleza kwegazi, umthamo we-insulin.
Ukusetshenziswa kwalesi sidakamizwa okukhulunywa ngakho kokulimala kwe-renal kanye ne-hepatic akufundiwe. Kodwa-ke, ekusebenzeni (ekwelashweni kweziguli ezinama-pathologies anjalo) kwatholakala ukuthi ushintsho oluncane enanini lomuthi ezifweni zalezi zitho aziholeli ekubonakaleni kwezimpawu ezingezinhle.
Izinkomba zokusetshenziswa
Umuthi ubekwa njengesidakamizwa esizimele noma, kanye nezinye izidakamizwa ze-hypoglycemic kulezi zifo:
- Uhlobo 1 isifo sikashukela (kuncike ku-insulin);
- thayipha 2 isifo sikashukela (nayo i-insulin-ezimele).
I-insulin ibekelwe i-hyperglycemia.
Contraindication
Imikhawulo ekusebenziseni umuthi imbalwa. Ayisetshenziswanga uma kuthuthukiswa ukusabela okuqondile komuntu kunoma iyiphi ingxenye ekwakhiweni komkhiqizo. Okunye ukwephulwa umthetho yi-hypoglycemia. Kulokhu, ukwethulwa komthamo we-insulin kuzoholela ekwehlelweni okukhulu kwe-glucose.
Ngokunakekela
Iqembu le-contraindication yesihlobo lifaka umsebenzi wokuphazamiseka wezinso, ukukhulelwa, isiguli esikhulile.
Ungayithatha kanjani i-Novomix Flekspen?
Ukugwema ukuthuthukiswa kwezinkinga, ikakhulukazi ukwephulwa okubalulekile kwe-carbohydrate metabolism, umuthi uphathwa kuphela ngokungahambi kahle. Inani lezimali lincike eminyakeni yobudala, isimo sesiguli, nezinye izifo. Umuthi ukhishwa ekugcineni kosuku (isikhathi esisodwa) noma leli nani lihlukaniswe ngemithamo emi-2. Amayunithi ayi-12 anqunywa ngosuku (uma isiguli singakaze sikuthole ukwelashwa kwe-insulin).
Inqubo yokuhlanganisa i-Insulin
Njengoba kunikezwe ukuthi ithuluzi okukhulunywa ngalo liyizigaba ezimbili, ukulungiselela kufanele kwenziwe ngaphambi kokulisebenzisa. Ngokwemiyalo, i-cartridge ifakiwe esibayeni sesirinji, inqobo nje uma ikhambi libonakala ngokushisa kwekamelo. Ifakwa endizeni enezingqimba, bese igingqwa phakathi kwezandla kuze kube izikhathi eziyi-10 ezindaweni ezahlukahlukene (emuva naphambili). Esigabeni esilandelayo, i-cartridge ihanjiswa endizeni emile mpo: ku-arc, ibhola elingaphakathi ligingqika lisuka komunye umkhawulo wesitsha liye kwelinye.
Izinyathelo ezichaziwe ziyaphindwa kuze kube yilapho isisombululo siba ngamafu bese siphenduka simhlophe. Kufanele kuvezwe ukungaguquguquki okufanayo. Ekupheleni kwakho konke ukukhohlisa, izinga lokushisa le-ejenti likhuphuka kancane (kufinyelela egumbini lokushisa) futhi lingangena ngokushesha.
Ungayisebenzisa kanjani ipeni yesirinji?
Indlela yokusebenzisa umuthi ichazwa udokotela. Ngemuva kokufakwa, inaliti kufanele ihlale kwizicubu zemizuzwana emi-6 elandelayo. Uma isusiwe, ungasusa isandla enkinobheni yepeni yesirinji. Inaliti iyatholakala, ngakho-ke kufakwa entsha ngaphambi komjovo ngamunye olandelayo. Kuyadingeka ukuyikhipha esibayeni sesirinji ngemuva komjovo. I-cartridge ayihloselwe ukugcwaliswa kabusha nge-insulin.
Eminye imithetho yokusebenzisa isirinji yepeni:
- lapho ufaka inaliti entsha, ithumba lokuvikela akufanele lithunyelwe ngokushesha emgqonyeni wezibi, lizokusebenziseka ngokuhamba kwesikhathi;
- Ngaphambi kokusebenzisa isirinji, ihlolwa ukuthi isebenza kanjani: kusetshenziswa isithasiselo sedosi, inani elifunekayo libekwa (ubuncane, ngokwesibonelo, amayunithi ama-2), bese ithuluzi liguqulwa ngenaliti phezulu bese kwenziwa isivivinyo se-inulin, ukwenza lokhu, cindezela inkinobho;
- uma ngesikhathi sokuhlolwa kwatholakala ukuthi i-insulin ayiveli ngenaliti, ipeni lesirinji kufanele lifakwe elinye;
- ngaphambi kokwethulwa kwento, isithombisi sedosi sisetshenziselwe okuphambene no-0;
- isikali esisele asikwazi ukusetshenziselwa ukushintsha inani elanele le-insulin;
- ngemuva kokusebenzisa ipeni-isirinji, kuyadingeka ukukhipha inaliti, futhi ngalokhu, isembozo kuqala sifakwa, khona-ke inalithi ayikhishwe.
Imiphumela emibi yeNovomix Flekspen
I-retinopathy, yakhelwe ngemuva kwesifo sikashukela i-mellitus, lipodystrophy.
Kusuka emasosheni omzimba
Ukuphendula kwe-Anaphylactoid.
Isistimu yezinzwa ephakathi
I-Neuropathy (esikhathini esibuhlungu kakhulu), ehambisana nobuhlungu.
Kusuka ohlelweni lokuphefumula
Kukhona ukwehluleka kokuphefumula, okuwumphumela wokuphendula kwe-anaphylactoid (kuthuthukisa ngemuva kwesizinda sokuvuvukala kwe-larynx).
Engxenyeni yesikhumba
Ukuqina kwesikhumba endaweni yomjovo we-insulin, ukuvuvukala okuncane, i-hematoma, ubomvu, ukulunywa, ukuvuvukala.
Kusuka ohlelweni lwezitho zofuzo
Ngokuphikisana nesizinda se-hypoglycemia, ukuguquguquka komchamo kuyavela (imvamisa yezicelo zokuchama ziyanda).
Ngasohlangothini lwe-metabolism
I-Hypoglycemia
Allergies
I-Urticaria.
Imiyalo ekhethekile
Ukwehliswa kwalesi sidakamizwa noma umthamo onqunyelwe ngokungeyikho (ukuntuleka kwe-insulin ngohlobo 1 sikashukela mellitus) kungadala i-hypoglycemia, kwesinye isikhathi i-ketoacidosis ivela kulayini.
Ukwethulwa kwenani elikhulu lomuthi nakho kufaka isandla ekuthuthukisweni kwe-hypoglycemia. Omunye umphumela ofanayo uyatholakala ngenxa yomthelela wokwanda kokuzivocavoca emzimbeni, nokuthi isiguli sikweqa ukudla.
Sebenzisa ebudaleni
Umuthi ungasetshenziswa, kepha ngokuqapha. Asikho isidingo sokuphinda ulandise umthamo we-insulin aspart.
Ukunquma uNovomix Flekspen ezinganeni
Akunamininingwane ngokuphepha kwezidakamizwa okukhulunywa ngazo lapho welapha iziguli ezingaphansi kweminyaka engu-18. Kodwa-ke, ngokuqondiswa yimiphumela yocwaningo lwethonya le-insulin aspart ezinganeni zamaqembu ahlukahlukene yobudala, kuyaphawuleka ukuthi ezinye izinkomba ziyaguquka (ngokwesibonelo, isikhathi sokufika kokuhlushwa okuphezulu). Lokhu kubonisa isidingo sokunqunywa komuntu ngamunye komthamo we-insulin. Umuthi uvunyelwe ukusetshenziselwa ukwelapha iziguli ezingaphezulu kweminyaka engu-6.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukuqapha kufanele kwenziwe ngesikhathi sokwelashwa lapho uzala ingane. Kukhona imininingwane enganele ngokuphepha komuthi. Kodwa-ke, ekusebenzeni kwatholakala ukuthi ngesikhathi sokukhulelwa umuthi okukhulunywa ngawo awukhuthazi ukuthuthukiswa kwezinkinga. Kwi-trimester ye-1, isidingo somzimba se-insulin siyancipha, khona-ke kancane kancane siyanda. Ngemuva kokuzalwa, isizinda se-hormonal sifinyelela ezingeni elalingaphambi kokukhulelwa.
Ngesikhathi sokuqunjelwa, umuthi ocatshangelwe uvunyelwe ukusetshenziswa.
Ukweqisa kweNovomix Flekspen
Ayisuswanga kulokho okushiwoyo izinkinga. Esimweni ngasinye, inani lomuthi lihlukile, ngokuya ngezinto ezihlobene. I-Hypoglycemia iba nokukhula kancane, okuhlinzekwa ukusetshenziswa okujwayelekile kwesilinganiso somuthi.
Izimpawu zobumnene balesi simo se-pathological ziqedwa ngokuthatha umkhiqizo oqukethe ushukela. Uma ukubonakaliswa kukhulu, kunconywa i-glucose engene ngaphakathi. Enye indlela umjovo we-glucagon (intramuscularly). Uma ngabe lesi silinganiso singanikeli ngomphumela oyifunayo, yenza umjovo we-dextrose.
Ukuxhumana nezinye izidakamizwa
Izinto ezilandelayo kanye nama-ejenti anegalelo ekwehliseni amazinga kashukela:
- eminye imishanguzo eyenzelwe ukwenza i-glycemia ihlale ngokwejwayelekile;
- izidakamizwa ezivimbela ukusebenza kwe-ACE;
- ama-beta-blockers angabonakali ngezenzo zokukhetha;
- ama-anabolics;
- imishanguzo ye-tetracycline;
- I-Ketoconazole;
- Mebendazole;
- Theophylline;
- I-Pyridoxine;
- ama-salicylates;
- imikhiqizo equkethe i-lithium.
Umuthi okukhulunywa ngawo ubonakala ngokusebenza okuphansi okuhambisana ne-heparin, ama-endocrine system mahormone, ama-thiazide group diuretics, ama-anticepressants ama-tricyclic, uDanazol, Morphine, njll.
Ngaphansi kwethonya le-beta-blockers, izimpawu zokwehla kwamazinga kashukela ziba ngaphansi.
Ukuhambisana notshwala
Iziphuzo eziqukethe notshwala zisebenza emzimbeni ngokungalindeleki ngokumelene nesizinda sokusetshenziswa kwe-insulin. Izinga le-glycemia lingakhuphuka futhi lehlise, okuthintwa yisimo sesiguli nokuba khona kwamanye ama-pathologies.
Ama-Analog
Izithasiselo eziqondile zomuthi okukhulunywa ngazo yilezi:
- I-Novomiks Penfill Flekspen 30;
- I-Novorapid Flekspen.
Izidakamizwa zitholakala ngesisombululo, ziqukethe i-insulin. Ungawathenga ngendlela yesirinji. Izindlela zibonisa uhlobo lwento esebenzayo, umthamo wayo. Ngakho-ke, basebenza ngesisekelo esisodwa. Ekuqesheni kufanele kubhekwe izinkomba, ama-contraindication. Ngokubuka ukwakheka okufanayo kwale mishanguzo, kungalindeleka ukuthi nabo bazosebenza ngokushesha. Ezinye izakhiwo zabo ze-pharmacokinetic nazo ziyafana.
Imibandela yekhefu lekhemisi
Ithuluzi umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha, ukuze uthole umuthi owudinga ukuthola umuthi kadokotela.
Intengo yeNovomix Flexspen
Izindleko ezijwayelekile ngama-ruble ayi-1850.
Izimo zokugcina zomuthi
Ibanga lokushisa eliphakanyisiwe + 2 ... + 8 ° ะก. Indawo efaneleka kakhulu yisiqandisi, kepha hhayi eduze nefriji. Ipeni lesirinji elisetshenzisiwe kufanele ligcinwe ekushiseni kwegumbi, kepha hhayi isikhathi esingaphezu kwamaviki ama-4. Indawo okukhishwa kuyo ezindlini kumele imbozwe ngesimbozi esivikelayo.
Isikhathi sokuphelelwa yisikhathi
Umuthi akufanele usetshenziswe ngemuva kweminyaka engu-2 kusukela ngosuku lokukhululwa.
Umkhiqizi
UNovo Nordisk (eDenmark).
Ipeni lesirinji elisetshenzisiwe kufanele ligcinwe ekushiseni kwegumbi, kepha hhayi isikhathi esingaphezu kwamaviki ama-4.
Ukubuyekezwa mayelana neNovomix Flekspen
UVera, oneminyaka engama-39, eMoscow
Umuthi usiza ngokushesha ukubuyisa amazinga kashukela. Mina, ukubonakaliswa okungekuhle akwenzekanga. Ngithatha umuthi isikhathi eside. Into engingayithandi intengo.
UVladlena, 34 weminyaka, uSaratov
Ngine-mellitus yesifo sikashukela esincike ku-insulin. Ngishintsha njalo irejimeni, ngizame izidakamizwa ezihlukile njengoba kushiwo ngudokotela. Ngeke ngasho lutho olubi ngeNovomix Flekspen: isebenza ngokujwayelekile, njengezichasiso zayo, intengo ingahle ibe ngaphansi, uma kungenjalo iyithuluzi elihle.
