I-Eilea iyisidakamizwa ngosizo lwayo lomzabalazo ngokuyinhloko olusebenza ngokusebenza kwezitho zombono.
Igama Lezwe elingafanele
Aflibercept.
I-Eilea iyisidakamizwa ngosizo lwayo lomzabalazo ngokuyinhloko olusebenza ngokusebenza kwezitho zombono.
I-ATX
S01LA05.
Khipha amafomu nokwakheka
Umuthi uyisixazululo sokuphathwa kwe-intraocular. Into esebenzayo ingama-40 mg we-aflibercept nge-1 ml yesisombululo. Kunoma yiluphi olunye uhlobo lomthamo, akunakwenzeka ukuthola ikhambi. Usebenzisa ibhodlela elingu-1, ungafaka umthamo owodwa we-2 mg aflibercept, ofana no-50 μl wesisombululo.
Isenzo se-Pharmacological
Umuthi uvimbela i-neoangioisuis. I-Aflibercept imvelaphi yezilwane futhi ikhiqizwa ngokuya ngobuchwepheshe beDNA obuhlanganayo. Kwenziwe izifundo eziningi zezokwelapha eziye zakwazi ukuqinisekisa ukusebenza ngempumelelo komkhiqizo ngezinjongo zokwelapha. Kwatholakala ukuthi kuyasiza ukulwa nama-pathologies amaningi wamehlo.
Izici ze-Endothelial kanye ne-vascular ukukhula yizo ezenza umphumela wezokwelapha ube ngosizo lomuthi.
I-Pharmacokinetics
Ukuze ube nomphumela wasendaweni, umuthi uphathwa ngqo emzimbeni we-vitreous. Ngemuva kwalokhu, ukufakwa okuncane kwento esebenzayo egazini elihlelekile lesiguli kuyaqala.
Ukuze ube nomphumela wasendaweni, umuthi uphathwa ngqo emzimbeni we-vitreous.
Ngemuva kwamaviki ama-4 ngemuva kokusebenzisa umuthi kokugcina, umuthi awunqunywa emzimbeni wesiguli ngokuphathwa kwe-intravitreal. Njengoba umkhiqizo unemvelo yamaprotheni, izifundo eziphathelene ne-metabolism yayo azenziwanga.
Izinkomba zokusetshenziswa
Umenzeli uyadingeka ukwelapha lezi zinkinga zombono olandelayo:
- kwehlise i-acuity ebonakalayo edonswa yi-myopic CNV;
- ukwehla ku-visual acuity okubangelwa yi-diemaic macular edema;
- ifomu elimanzi lokuwohloka okuhlobene nobudala obuhlobene nobudala;
- ukungasebenzi kahle kwamehlo ngenxa yokuvela kwe-retin vein occlusion;
- isifo sikashukela sikashukela.
Contraindication
Ngezansi kwezimo lapho ukwelashwa ngomuthi kubekwe khona umthetho:
- ukutheleleka okusebenzayo noma okusolwayo kwe-intra- noma i-pericular;
- ukwanda kokucabanga kokunye kokunye kwezakhi zomuthi;
- ukuvuvukala okukhulu kwe-intraocular;
- i-macular gap 3-4 degrees.
Ngokunakekela
Kukhona futhi izimo lapho kubalulekile ukunquma umuthi ngokuqapha. Lokhu ukwephula ubuqotho be-epinallium ye-retinal pigment, glaucoma elawulwa kabi, ukuhlasela kwesikhashana, istroke noma umlando wokuqanjwa kwe-myocardial.
Sebenzisa isidakamizwa ngokuqapha ku-glaucoma engalawulwa kahle.
Ungamthatha kanjani u-Eilea
Iminyaka yesiguli, ubulukhuni be-pathology nohlobo lwayo kuthinta isikhathi esingakanani umuthi ozojovwa kanye nokuthi ukwelashwa kuzokwenziwa kanjani. Lesi sinqumo singenziwa kuphela ngudokotela.
Zingaki izinsuku
Umuthi osuka kubhodlela owodwa unanele umjovo owodwa. Udokotela kuphela onolwazi lokusebenzisa imishini enjalo yezokwelapha kufanele anikeze imijovo esweni.
Ngefomu emanzi ye-AMD, umthamo ophelele uthathwa njenge-2 mg ye-aflibercept. Kuyisiko ukuqala ukwelashwa ngemijovo emi-3 njalo ngenyanga, emva kwalokho kwenziwa njalo ezinyangeni ezi-2. Phakathi kwemijovo, isimo sesiguli kufanele siqashelwe udokotela noma nini lapho kungenzeka.
Unyaka owodwa ngemuva kokuqala kokwelashwa, isikhathi esiphakathi kwemijovo singakhuphuka ngokususelwa ekushintsheni kwamapharamitha we-anatomical. Uma umbono ungathuthuki futhi izinkomba ziba zimbi kakhulu, isibhamu kufanele sinikezwe kaningi.
Ukwelashwa ngomuthi kufanele kunqanyulwe uma kungekho mzamo omuhle ngemuva kokwelashwa okuqhubekayo.
Lapho ujova, kubalulekile ukunikeza izimo ezidingekayo zokuhlanzeka, i-anesthesia kanye ne-asepsis. Lokhu futhi kusho ukuthi i-iodine ye-povidone kufanele ifakwe esikhunjeni esiseduze kwamehlo, ngaphansi kwejwabu leso kanye neso leso. Ngemuva kokunikezwa umjovo, kuyadingeka ukuqapha izinguquko ekucindezelweni kwe-intraocular kwesiguli. Lokhu kungenziwa kusetshenziswa i-ophthalmotonometry noma ukubheka ukugcotshwa kwekhanda le-optic nerve.
Ngemuva kokuthi umjovo wenziwe, kuyadingeka ukuqapha izinguquko ekucindezelweni kwe-intraocular kwesiguli, lokhu kungenziwa kusetshenziswa i-ophthalmotonometry.
Isiguli kufanele saziswe ngezimpawu ezingaba khona ze-endophthalmitis, ezozibonakalisa ngesimo sokufiphala kombono, izinhlungu zamehlo, i-Photophobia, kanye ne-conjunctival virus.
Ngoshukela
Umthamo ophelele obukhona kwale ndlela yeziguli esigulini kufanele ukhonjiswe udokotela kuphela ngemuva kokuthi kuthathwe konke ukuhlolwa okufanelekile bese kuthathwa izinkomba.
Imiphumela emibi ye-Eilea
Ukusabela okuningana okuvela ohlangothini lwezitho zombono ukungaboni, ukucwiywa komzimba, ukubanjwa kwamathambo, ukuphuma kwesibindi emgodini we-vitreous, i-endophthalmitis, ukukhuphuka kwengcindezi ye-intraocular, umbuthano omnyama nama-goosebumps.
I-Rare uveitis, ukuqhuma kwe-retinal, ukucasuka endaweni yomjovo, i-corneal edema, ne-lens opacation kuqashelwa njengokuphendula okungathandeki.
Umthelela ekhonweni lokulawula izindlela
Njengoba isitho sombono singase sihlushwe ngesikhathi sokwelashwa, akudingekile ukushayela imoto nokwenza izinto ezidinga ukunakwa kakhulu kokunakwa ngesikhathi sokwelashwa.
Imiyalo ekhethekile
Sebenzisa ebudaleni
Ukulungiswa komdosi kuyadingeka kuphela uma kunokuphazamiseka okukhulu ekusebenzeni komzimba.
Isabelo sezingane
Umuthi awubekelwe abantu aze afike eminyakeni eyi-18.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Inani elanele lemininingwane ngokuphepha kwezidakamizwa ngesikhathi sokukhulelwa alitholakali. Lokhu kusho ukuthi ukusetshenziswa ngesikhathi sokukhulelwa akuvunyelwe, kepha lokhu kugwenywa kangcono. Akukwaziwa ukuthi into esebenzayo ingena kubisi lwebele yini, ngakho-ke kungcono ukwenqaba ukwelashwa isikhathi sokudla kwendalo.
Uma owesifazane onomsebenzi ophelele wokuzala ezothola ukwelashwa nomuthi, kuyadingeka ukufaka izindlela ezingeziwe zokuwuvikela ekukhulelweni okungafuneki ekugcineni.
Ukweqisa kwe-ailea
Uma umthamo udluliwe, ingcindezi ye-intraocular ingakhula kakhulu. Udokotela kufanele anqume izindlela zokulungiswa kwayo.
Ukuxhumana nezinye izidakamizwa
Izifundo zokuhambelana kokungumuthi neminye imithi azenziwanga.
Ukuhambisana notshwala
Kuyadingeka ukuyeka ukusetshenziswa kotshwala isikhathi sokwelashwa.
Ama-Analog
I-Zaltrap ne-Aflibercept.
I-analogue yesidakamizwa yi-Zaltrap.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela?
Ngaphandle kwencwadi kadokotela, ukuthenga isidakamizwa ngeke kusebenze.
Intengo ye-Eilea
Izindleko zomuthi ziqala kusuka kuma-ruble angama-40,000.
Izimo zokugcina zomuthi
Izindebe ezingavuthiwe zingagcinwa emazingeni okushisa egumbini. Isixazululo esilungele - emazingeni okushisa ayi-2 kuye ku-8 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-2
Umkhiqizi
IBayer Pharma AG, iMullerstrasse 178, 13353 Berlin, Germany.
Ukubuyekezwa kwe-Eilea
U-Anton, oneminyaka engama-34 ubudala, uLipetsk: "Welashwa ngalo muthi emtholampilo yangasese. Izindleko zayo ziphezulu, kepha umphumela owatholwa usufanele imali esetshenzisiwe. Ukwelashwa kwenzeka ngaphandle kwezinkinga, i-eye retina ayizange ihlupheke, nengcindezi ye-intraocular ayikakhuphuki. Ngiyakholelwa ekutheni Lokhu kungachazwa ngokwengxenye yobudala obusha kanye nokuhlangenwe nakho okuningana udokotela ofake i-vitreous body. Ngingaluleka abantu abangenayo i-pathologies yezempilo eyengeziwe. "
U-Irina, oneminyaka engama-39, uTyumen: "Ngiyabona ukuthi ukwelashwa akuhambanga nemiphumela. Kwakungasheshe kodwa, kepha kudinga ubuciko besifo, obutholakale ngokubonana nodokotela ophthalmologist. Izindleko zomuthi ziphezulu, kepha zazikhokhelwa yinhlangano engisebenza kuyo. Uma isiguli sikhokhela ukwelashwa nalo muthi, lokho kuphathwa kuzobonakala kubiza kakhulu kuye. Ngakho-ke, kufanelekile ukukala konke okuhle nokulimala ngaphambi kokuthatha isinqumo ngenqubo.Kodwa uma impilo ikudinga, kubalulekile ukwenza okushiwo ngudokotela. imali. "
U-Oleg, oneminyaka engama-26 ubudala, u-Ivanovo: "Umuthi usizile ukuqeda izifo zamehlo ezinzima. Ngakho-ke, ngikubona kusebenza futhi kuphephile."
