Ukwelashwa kwe-insulin ezigulini ezinesifo sikashukela, kusetshenziswa izidakamizwa ezihlukile esikhathini sokusebenza.
Lokhu kungenxa yokuthi ukwelashwa esikhundleni se-insulin kumele kunikeze ukukhululwa kwe-insulin kanye nokungena kwayo egazini ngemuva kokudla.
Ukugcina inani le-insulin elingapheli njenge-analogue yesasement secaltion, kusetshenziswa ama-insulin amade. Enye yezidakamizwa ezintsha kuleli qembu yi-insulin degludec ngaphansi kwegama lokuhweba iTresiba FlexTouch. Le i-insulin eyenzelwe umuntu isikhathi eside ngokwelashwa kohlobo 1 lwesifo sikashukela.
Ukwakheka nendlela yokukhishwa kweTresib
Into esebenzayo yesidakamizwa i-Tresib iphindaphindwe nge-insulin degludec yabantu. I-insulin iyatholakala njengesisombululo esingenamibala sokuphatha ngaphansi kwesikhumba. Izinhlobo ezimbili zokukhishwa zibhalisiwe:
- Imithamo ye-100 PIECES / ml: i-insulin degludec 3.66 mg, ipeni yesirinji ene-3 ml yesisombululo. Ikuvumela ukuthi ufinyelele kumayunithi angama-80 ekunikelweni kweyunithi engu-1. Ephaketheni amaphakethe ama-5 FlexTouch.
- Umthamo wama-PIECES angama-200 nge-1 ml: i-insulin degludec 7.32 mg, ipeni lesirinji le-3 ml, ungafaka ama-PIECES ayi-160 ngeziqu ze-2 PIECES. Esiphaketheni kukhona 3 FlexTouch pens.
Ipeni lokwethula i-insulin liyatholakala, kumijovo ephindaphindwe yomuthi.
Izakhiwo zeTresiba Insulin
I-insulin entsha esebenza isikhathi eside inempahla yokwakha idepho kwezicubu ezingaphansi kwesimo se-multihexamers encibilikayo. Lesi sakhi siyikhipha kancane kancane i-insulin iye egazini. Ngenxa yokuba khona njalo kwe-insulin egazini, kuqinisekiswa izinga likashukela osegazini njalo.
Inzuzo enkulu yeTresib yiprofayili yasesiteji ye-hypoglycemic ngisho nebucayi. Lesi sidakamizwa ezinsukwini ezimbalwa sifinyelela eluhlaza lwamazinga kashukela bese uligcina ngaso sonke isikhathi sokusetshenziswa, uma isiguli singephuli uhlelo lokuphatha futhi sinamathela kumthamo obaliwe we-insulin futhi silandela imithetho yokudla kokudla.
Isenzo se-Tresib ngezinga le-glucose esegazini kubonakala ngenxa yokusebenzisa ushukela ngemisipha nezicubu ze-adipose njengomthombo wamandla ngaphakathi kweseli. I-Tciousba, isebenzisana nama-insulin receptors, isiza i-glucose ukuwela ulwelwesi lweseli. Ngaphezu kwalokho, ivuselela umsebenzi owakha i-glycogen wesibindi nezicubu zomzimba.
Ithonya leTresib kuma-metabolism liboniswa eqinisweni lokuthi:
- Awekho amangqamuzana amasha eglucose akhiwa esibindini.
- Ukuqhekeka kwe-glycogen evela esitokisini kumaseli wesibindi kuyancishiswa.
- Ama-acid acid aqukiwe, bese kuqhekeka amafutha.
- Izinga lama-lipoproteins egazini liyanda.
- Ukukhula kwezicubu zomzimba kuyashesha.
- Ukwakhiwa kwamaprotheni kuyathuthukiswa futhi ukunqwabelana kwawo kuncishiswe ngasikhathi sinye.
I-Tresiba FlexTouch insulin ivikela ngokumelene noshukela wegazi ngosuku ngemuva kokuphathwa. Isikhathi sonke sesenzo saso singaphezu kwamahora angama-42. Ukuhlushwa njalo kutholakala kungakapheli izinsuku ezimbili noma ezintathu ngemuva komjovo wokuqala.
Inzuzo yesibili engathandabuzeki yalesi sidakamizwa ukukhula okungavamile kwe-hypoglycemia, kufaka phakathi nobusuku, uma kuqhathaniswa namanye amalungiselelo e-insulin. Ocwaningweni, iphethini enjalo yaphawuleka kuzo zombili iziguli ezisencane nezikhulile.
Ukubuyekezwa kweziguli ezisebenzisa lo muthi kuqinisekisa ukuphepha kokusetshenziswa kwaso maqondana nokwehla okubukhali kokuhlaselwa ushukela ne-hypoglycemia. Izifundo eziqhathaniswayo zikaLantus noTresib zikhombise ukusebenza kwazo ngokulinganayo ekugcineni ukugxilwa kwe-insulin okugxile emuva.
Kepha ukusetshenziswa komuthi omusha kunezinzuzo, ngoba kungenzeka ukuthi wehlise umthamo we-insulin ngokuhamba kwesikhathi ngo-20-30% futhi unciphise kakhulu imvamisa yokuhlaselwa ebusuku kwehla koshukela egazini.
I-Tresiba inethonya elihle kuzinga le-hemoglobin ye-glycated, okusho ukuthi inganciphisa ubungozi bokuthi kube nesifo sikashukela.
UTreshiba ukhonjiswa obani?
Isibonakaliso esiyinhloko sokunquma i-Treshib insulin, engagcina izinga lokuhlaselwa kwe-glycemia, yisifo sikashukela.
Ukuxhumana okusetshenziselwa umuthi kungukuzwela ngakunye kuzakhi zekhambi noma ngento esebenzayo. Futhi, ngenxa yokuntuleka kolwazi ngomuthi, awubekelwe izingane ezingaphansi kweminyaka eyi-18, omama abancelayo nabesifazane abakhulelwe.
Yize isikhathi sokuphuma kwe-insulin isikhathi eside kunezinsuku eziyi-1.5, kunconyelwa ukuyifaka kanye ngosuku, okungcono ngasikhathi sinye. Isifo sikashukela esinohlobo lwesibili lwesifo singathola i-Treshiba kuphela noma sihlanganise nezidakamizwa ezinciphisa ushukela ezibhebheni. Ngokwezinkomba zohlobo lwesibili sikashukela, kufakwa insulin esebenza ngokufushane kanye nayo.
Kuhlobo lwe-1 mellitus yesifo sikashukela, iTrecib FlexTouch ihlala ichazwa nge-insulin emfushane noma emfushane kakhulu ukumboza isidingo sokufakwa kwe-carbohydrate ekudleni.
Umthamo we-insulin unqunywa isithombe somtholampilo sikashukela i-mellitus futhi siyalungiswa kuye ngezinga le-glucose elisheshayo.
Ukuqokwa komthamo omusha weTresib wenziwa:
- Lapho ushintsha umsebenzi womzimba.
- Lapho ushintshela kokunye ukudla.
- Ngezifo ezithathelwanayo.
- Ngokuphula umsebenzi wohlelo lwe-endocrine - i-pathology ye-gland yegland, i-pituitary gland noma i-adrenal gland.
I-Tresiba ingabekelwa iziguli esezikhulile ezinokungasebenzi kahle kwe-renal noma hepatic, inqobo nje uma amazinga weglucose egadwe ngokucophelela.
Ezigulini ezinesifo sikashukela sohlobo 2, ziqala ngomthamo wama-PIECES ayi-10, zikhetha umthamo ngamunye. Iziguli zohlobo lokuqala lwesifo, lapho ziguqukela eTreshiba namanye ama-insulin asebenza isikhathi eside, zisebenzisa umgomo "wokubuyisela esikhundleni iyunithi."
Uma isiguli sithola imijovo ye-basal insulin amahlandla ama-2, khona-ke umthamo uqokwa ngokusekelwe kuphrofayili ye-glycemic ngawodwana. I-Tresiba ivumela ukuphambuka kumodi yokuphatha, kepha isikhathi sinconywa okungenani amahora angu-8.
Umthamo ophuthelwe ungafakwa nganoma yisiphi isikhathi, ngakusasa ungabuya ohlelweni lwangaphambili.
Imithetho yokusebenzisa iTreshiba FlexTouch
I-Tresib ilawulwa kuphela ngaphansi kwesikhumba. Ukuphathwa kwe-Intravenous ku-contraindicated ngenxa yokuqalwa kwe-hypoglycemia enzima. Akunconyelwe ukuphathwa nge-intramuscularly nakumaphampu we-insulin.
Izindawo zokulawulwa kwe-insulin zingaphezulu kwangaphandle noma ngaphezulu kwethanga, ihlombe, noma udonga lwangaphakathi lwesisu. Ungasebenzisa isifunda esisodwa esivumelanayo se-anatomical, kepha isikhathi ngasinye ukuze unikeze indawo entsha ukuvimbela i-lipodystrophy.
Ukuphatha i-insulin usebenzisa ipeni yeFlexTouch, udinga ukulandela ukulandelana kwezenzo:
- Bheka ukumakwa kwepeni
- Qinisekisa ukuvela kwekhambi le-insulin
- Beka inaliti ngokuqinile esibambo
- Linda kuze kwehle i-insulin ngenaliti
- Setha umthamo ngokuguqula okhethiweyo wethamo
- Faka inaliti ngaphansi kwesikhumba ukuze ikhompiyutha yedatha ibonakale.
- Cindezela inkinobho yokuqala.
- Faka insulin.
Ngemuva komjovo, inaliti kufanele ibe ngaphansi kwesikhumba eminye imizuzwana emi-6 yokugeleza okuphelele kwe-insulin. Lapho-ke isibambo kumele sisuswe. Uma igazi libonakala esikhunjeni, khona-ke limiswa ngotshani bekotini. Musa ukwenza isisulu indawo yomjovo.
Ukufakwa kufanele kwenziwe kuphela usebenzisa amapeni ngamanye ezimeni zokungabinazi ngokuphelele. Kulokhu, isikhumba nezandla ngaphambi komjovo kufanele ziphathwe ngezixazululo ze-antiseptics.
Ipeni leFlexTouch akumele ligcinwe emazingeni okushisa aphakeme noma aphansi. Ngaphambi kokuvula, lesi sidakamizwa sigcinwa esiqandisini eshalofini eliphakathi lokushisa ngamazinga ayi-2 kuye kwayi-8. Musa iqhwa ikhambi. Ngemuva kokusetshenziswa kokuqala, ipeni ligcinwa ekushiseni kwegumbi isikhathi esingaphezu kwamaviki ayi-8.
Musa ukugeza noma gcoba isibambo. Kufanele ivikelwe ekungcoleni futhi ihlanzwe ngendwangu emanzi. Ukuwa namaqhubu akumele kuvunyelwe. Ngemuva kokusebenzisa ngokuphelele, ipeni ngeke ligcwalise futhi. Awukwazi ukuyilungisa noma uyihlanganise ngokwakho.
Ukuvimbela ukuphatha okungalungile, udinga ukugcina ama-insulin ahlukene ngokwehlukana, bese uhlola ilebula ngaphambi kokuyisebenzisa ukuze ungafaki i-insulin ngephutha. Udinga futhi ukubona ngokucacile izinombolo kwikhawunta yedosi. Ngombono ongakhubazeki, udinga ukusebenzisa usizo lwabantu abanamehlo amahle futhi abaqeqeshiwe ekwethulweni kweTresib FlexTouch.
Imiphumela emibi iTreshiba
IDegludek, njengamanye ama-insulin, imvamisa ibangela i-hypoglycemia ngethamo elikhethwe ngendlela engafanele. Izimpawu ezisheshayo ezinokwehla koshukela ngesimo sokujuluka okubandayo, ukufiphaza isikhumba, ubuthakathaka obukhali kanye novalo, kanye nendlala nezandla eziqhaqhazelayo, kungenzeka zingabonakali zonke iziguli ngesikhathi.
I-hypoglycemia eyandayo ibonakaliswa ukwephulwa kokugxilisa ingqondo nokunaka endaweni, ukudakwa kuyaqala, umbono ungathinteki, kukhona ikhanda elinesifo sikashukela kanye nenausea. Kungahle kube nezikhathi zokukhishwa kwenhliziyo. Uma kungekho zinyathelo ezithathwayo ngalesi sikhathi, khona-ke ukwaziwa kuyaphazamiseka, kuqubuke ukuvela, isiguli singase siwele. Noma umphumela obulalayo kungenzeka.
Ngesikhathi se-hypoglycemia, izinga lokuphendula kanye nekhono lokuphendula ngendlela efanele, kanye nokunaka ukunakwa, kungancipha, okungaba yingozi empilweni lapho ushayela noma usebenzisa ezinye izindlela emsebenzini.
Ngakho-ke, ngaphambi kokushayela, kufanele uqiniseke ukuthi izinga likashukela lijwayelekile futhi linoshukela noma imikhiqizo efanayo nawe. Uma isiguli esinesifo sikashukela singazizwa sisondelene ne-hypoglycemia noma sinemibandela enjalo, kuyanconywa ukuyeka ukushayela.
Indlela yesibili ejwayelekile yokuphendula kabi ekusetshenzisweni kweTresib yi-lipodystrophy endaweni yomjovo. Ukuvimbela kwalo, udinga ukufaka umuthi ngaso sonke isikhathi endaweni entsha. Kungahle kube nobuhlungu, ukugqekeza, ubomvu, noma ukucasuka endaweni yomjovo. Isikhumba singashintsha umbala, ukuvuvukala, ukuvuvukala. Esizeni sokujova, kwesinye isikhathi kwakhiwa izihlakala zezicubu ezithintekayo.
Okuncane okuvame ukuba yizinkinga ezifana nokusebenzisa iTresib:
- Ukungezwani komzimba nomuthi noma okubukwayo.
- Ukuvuvukala.
- Isicanucanu
- Ukuqinisa i-retinopathy.
Ukwelapha i-hypoglycemia ngesimo esigculisayo esigulisayo, udinga ukuthatha imikhiqizo equkethe ushukela noma ufulawa. Esimweni esingazi lutho, ushukela uphethwe ngaphakathi kanye neglucagon ngaphansi kwesikhumba. Ukuvimbela ukuhlaselwa okulandelayo, ngemuva kokubuyiselwa kokungazi, udinga ukuthatha ukudla kwe-carbohydrate.
ITresiba ayikwazi ukuxutshwa nezinye izidakamizwa. Umuthi awungezelwa izixazululo infusion. Ngokuqokwa kukaTresib no-Aktos noma u-Avandia, kube nezimo zokuthuthuka kokuhluleka kwenhliziyo. Lapho kukhona i-pathology yenhliziyo kanye nengozi yokubuyiselwa kwemali kwenhliziyo yeTresib, le mithi ayihlanganisiwe.
Ngokuhoxiswa kwezidakamizwa okuzimele noma umthamo onganele, i-hyperglycemia ne-ketoacidosis yesifo sikashukela ikhula. Lokhu kusungulwa yizifo ezibangelwa amagciwane noma izifo, izifo zezitho ze-endocrine, kanye nokuphathwa kwezidakamizwa ze-glucocorticosteroid, ama-estrogens, ama-contraceplication omlomo, ama-diuretics, ama-hormone okukhula noma iDanazole.
Izimpawu ze-hyperglycemia zanda kancane futhi zibonakaliswa isicanucanu, ukoma, ukuphuma komchamo, ukudonsa, ubomvu kwesikhumba, umlomo owomile. Lapho kunephunga le-acetone, ubungozi be-ketoacidosis ne-coma luyanda. Iziguli zikhonjiswa esibhedlela ngokuphuthumayo. I-Ultrashort insulin isetshenziselwa ukwelashwa.
Ukuphuza utshwala kungathinta ukuqiniswa nobuthakathaka besenzo se-insulin.
Izici zamakhemikhali ze-insulin Treshiba zizotshela ividiyo ekulesi sihloko.
