Ukwelashwa kwe-insulin - ukwethulwa kwezidakamizwa ezenzelwe i-insulin ngezinhloso zokwelapha. Kunenamba enkulu yemithi esekwe kule hormone, ehlukaniswe ngamaqembu amaningana ngokuya ngesikhathi sokuqala komphumela kanye nesikhathi esenziwayo. Omunye wabamele izidakamizwa zesikhathi esiphakathi yi-Insulin -isophane. Funda kabanzi ngokusebenza kwaso esihlokweni.
Isenzo se-Pharmacological
I-Insulin-isophan (injinjini yezofuzo yomuntu) yenziwa ngokushintsha i-DNA ye-hormone ngokufaka uhlobo lwesikhunta esingunembeza olungezansi kwesigaba se-saccharomycetes. Lapho ungena emzimbeni, into ihlanganisa ukwakheka okukhethekile kumaseli wamaseli asebenzisa ukuvela okuningi ngaphakathi kwamaseli ngokwawo, kufaka phakathi ukwakheka kwezinto ezibalulekile.
Umphumela we-hypoglycemic we-Insulin-isophan uhlotshaniswa nokusheshiswa kwezinqubo zokuthatha ushukela kusuka egazini zingene emangqamuzaneni omzimba womuntu, kanye nokwehla kokutholakala kweglucose ngama-hepatocytes wesibindi. Futhi, umuthi uvuselela ukwakheka kwezinto ezinamaprotheni, uhlanganyela ekudleni kwamafutha.
Isikhathi sokusebenza ngemuva kokuphatha umuthi sincike kumazinga awo okufaka, wona, anqunywa yizici eziningi:
- umthamo wento;
- indlela yokuphatha;
- indawo yesingeniso;
- isimo somzimba wesiguli;
- ukuba khona kwezifo ezihlangene (ikakhulukazi ezithathelwanayo);
- ukusebenza komzimba;
- isisindo somzimba wesiguli.
Uchwepheshe we-endocrinologist onguchwepheshe ozokusiza ukhethe uhlobo lwe-insulin therapy
Ngokwezibalo, umsebenzi we-Insulin-isophan uvela ngemuva kwamahora angu-1.5 kusukela esikhathini somjovo, ubude besikhathi sokusebenza bufika emahoreni angama-24. Izinga eliphakeme kakhulu lezinto ezisegazini libonakala kusuka emahoreni amabili kuya kwayi-18 ngemuva kokuphathwa kwomuthi ngaphansi kwesikhumba.
Umuthi awudluleli ubisi lapho uncelisa ibele. Kuze kufinyelele kuma-75% ento leyo ekhishwe emchameni. Ngokusho kocwaningo, lo muthi awunawona ubuthi ohlelweni lokuzala kanye ne-DNA yomuntu, awunawo umphumela wokubangwa kwezitho zomzimba.
Ngabe kubekwa nini into?
Imiyalo esetshenzisiwe ikhombisa ukuthi izinkomba zokusetshenziswa kwe-Insulin-isophan yilezi:
I-Insulin Injection Technique- ifomu lesifo sikashukela esincike ku-insulin;
- i-mellitus yesifo sikashukela esinga-insulin;
- ukumelana okuyingxenye esenzweni sezidakamizwa ezisehlisa ithebhulethi;
- ukuba khona kwezifo ezenzeka ngasikhathi sinye (lezo ezihlangana ngamathuba, kepha zandisa inkambo yesifo esikhona);
- isifo sikashukela sokukhulelwa sabesifazane abakhulelwe.
Indlela yokusebenzisa
Ifomu lokukhishwa lomuthi ukumiswa komjovo we-40 IU ku-1 ml. Ibhodlela liqukethe u-10 ml.
I-Isulin insulin isetshenziswa kuphela njengomjovo ongama-subcutaneous. Umthamo uqokwa nguchwepheshe ozobakhona, kucatshangelwa ubulili, ubudala besiguli, isisindo somzimba wakhe, izinkomba zoshukela kanye nokuzivocavoca umzimba. Njengomthetho, i-0.5-1 IU ngosuku inqunyelwe ikhilogremu ngayinye yesisindo somzimba.
Umuthi ungahanjiswa:
- ethangeni;
- ukuqothuka;
- udonga lwesisu lwangaphakathi;
- umsipha odabukisayo wehlombe.
Umuthi wezidakamizwa uphathwa kuphela ngaphandle kokuzenzela, uguqula indawo yomjovo njalo
Indawo idinga ukushintshwa njalo. Lokhu kuyadingeka ukuvikela ukukhula kwe-lipodystrophy (isimo lapho ama-atrophies angama-subcutaneous fat ungqimba).
Ukuthatha i-insulin ukwelashwa usebenzisa i-Insulin-isophan, njenganoma yisiphi esinye isidakamizwa esuselwa kuma-analogue e-pancreatic hormone, kufanele kuhlanganiswe nokubheka izinga le-glycemic ku-dynamics.
Imithamo yomuthi kumele ilungiswe kulezi zimo ezilandelayo:
- ukungasebenzi kahle kwe-adrenal cortex;
- i-hypothyroidism;
- i-pathology enzima yezinso noma isibindi;
- izifo ezithathelwanayo ezihambisana nokushisa komzimba okuphezulu;
- ukuguga kwesiguli.
Contraindication kanye nemiphumela emibi
I-Isulin insulin ayinqunyelwe ukwelashwa kwe-insulin phambi kokuzwela ngakunye kwezakhi ezisebenzayo, lapho kukhona i-hormone-secreting tumor pancreatic kanye nokwehla kwe-glycemia.
Ukwethulwa komthamo omkhulu womuthi kunokudingekile kungadala isimo se-hypoglycemic. Ukuvezwa kwayo okuyinhloko ikhanda nesiyezi, umuzwa wokulamba wendlala, ukujuluka ngokweqile. Iziguli zikhononda ngokuqhaqhazela kwezandla, iminwe, ukubukeka kwenhliziyo nokuhlanza, ukwesaba nomuzwa wokukhathazeka.
Kubalulekile! Ekuhlolweni, ukukhumbula inkumbulo, ukuxhumeka okungahambi kahle, ukudideka emkhathini, kanye nenkulumo engasebenzi kahle kunganqunywa.
I-Hypoglycemia - ushukela wegazi ophansi ongabangelwa ngokweqile kwe-pancreatic hormone
Ngaphezu kwe-overdose, izici ze-etiological ze-glycemia ephansi zingangeqa isidlo esilandelayo, siguqule ukulungiswa kwe-insulin kwesinye, ukusebenza ngokweqile komzimba, kuguqula indawo yezokuphatha, ukwelashwa kanyekanye namaqembu amaningana emithi.
Okunye umphumela ongema okungenzeka ngenxa yokungahambelani nohlelo lokuphathwa kwezidakamizwa noma umthamo okhethwe ngokungalungile kungaba isimo se-hyperglycemic. Izimpawu zayo zivele kanjena:
- isiguli sivame ukuphuza futhi sichaze;
- ukuphefumula kwenhliziyo kanye nokuhlanza;
- Isiyezi
- isikhumba esomile nolwelwesi lwe-mucous;
- umuzwa wephunga le-acetone emoyeni ophelile.
Umuthi futhi ungadala ukungahambi kahle komzimba, okukhonjiswa ngama-syndromes alandelayo:
- i-urticaria;
- I-edema kaQuincke;
- ukwethuka kwe-anaphylactic.
Esizeni somjovo, i-edema, ukusabela kokuvuvukala, ubomvu, ukulunywa, i-hemorrhage kanye ne-lipodystrophy kungenzeka.
Kukhona futhi izimo lapho ukusetshenziswa kwe-Insulin-isophan kuhlukumeza khona amandla okushayela izimoto nezinye izindlela. Lokhu kungahle kube ngenxa yokusetshenziswa okuyinhloko komuthi, ukuguquka kusuka kwesinye isidakamizwa kuya kwesinye, umphumela wokuxineka, kanye nomsebenzi omkhulu womzimba.
Kwezinye izimo, isiyezi singakhula, okuyisithiyo ekushayeleni izimoto.
Ukukhulelwa nokukhulelwa
Umuthi osebenzayo wesidakamizwa awungeni ubisi lwebele futhi ngomgoqo we-placental, Ngakho-ke, i-insulin-isofan ingabhekelwa kwabesifazane ngesikhathi sokukhulelwa nokuqunjelwa. Kubalulekile ukubala ngokunembile umthamo womuthi olungiselelwe, ngoba ukukhuphuka okungathi sína noma ukuncipha koshukela egazini likamama lapho usebenzisa umthamo ongafanele kukhanyisiwe kosana.
Ukusebenzelana kwezidakamizwa
Kukhona izidakamizwa ezingakhulisa umphumela we-hypoglycemic we-Insulin-isophan, kepha kukhona lezo, kunalokho, ziwenza buthaka, okuholela ekwandeni kashukela wegazi wesiguli.
Iqembu lokuqala lezidakamizwa lifaka:
- ama-ejenti abekwe etafuleni;
- Ama-inhibitors e-ACE;
- ama-sulfonamides;
- amanye ama-antibiotic;
- ama-anabolic steroid;
- ama-antifungal agents;
- Theophylline;
- amalungiselelo e-lithium-based;
- Clofibrate.
Abamele iqembu le-tetracycline bayakwazi ukuthuthukisa umphumela we-insulin
Iqembu lesibili lifaka:
- ama-hormone e-adrenal cortex;
- Ama-COC;
- ama-hormone egilo;
- i-heparin;
- okokugcoba
- antidepressants;
- ama-audiathomimetics.
Amagama wezohwebo
I-Isulin insulin yinto esetshenziswayo yama-analogu amaningi we-insulin yabantu, ngakho-ke igama layo lokuhweba linezinhlobo eziningana (iziphawulo):
- I-Biosulin-N;
- I-Protafan NM;
- I-Protafan NM Penfill;
- Rosinsulin C;
- AmaHumodar B 100 Imifula;
- I-Humulin NPH.
I-insulin ibhekwa njengesidakamizwa esinqunyelwe. Ukuzilapha ngethuluzi elinjalo akwamukeleki.
