I-Diabefarm ingeyeqembu lemithi, okubandakanya izinkomba zokwelapha okuxilongwa ukuthi kutholakale isifo sikashukela sohlobo 2 esigulini. Umuthi unendlela engu-1 yokukhishwa, yokulawulwa ngomlomo. Umuthi wanikezwa inombolo yokubhalisa - P N003217 / 01 ka-11.24.2009 Kunokuphikisana, lapho kungadingeka khona ukuphatha ngokucophelela noma ukuwuhoxisa umuthi. Ngokusetshenziswa isikhathi eside, imiphumela emibi ingahle ibe khona. Isidakamizwa sinconywa ukuba sithathwe njengokuyalelwa udokotela oholayo.
Igama Lezwe elingafanele
Imithi ye-INN - IGliclazide (Gliclazide).
I-Diabefarm ingeyeqembu lemithi, okubandakanya izinkomba zokwelapha okuxilongwa ukuthi kutholakale isifo sikashukela sohlobo 2 esigulini.
I-ATX
Ikhodi ye-ATX yesidakamizwa yi-A10BB09.
Khipha amafomu nokwakheka
Indlela yokudedelwa yomuthi ngamathebulethi. Amaphilisi ama-planethi ama-cylindrical amhlophe noma aphuzi-amhlophe ahlanganiswe nefilimu ye-enteric futhi afaka izinto ezisebenzayo nezisizayo. Ingcuphe yeChamfer ne-sefinatform (ngemuva) ikhona. Ingxenye esebenzayo yesidakamizwa yi-gliclazide, okuqukethwe kwayo kungukuthi kwe-1 iphilisi kungaphezu kwe-40-80 mg.
Okungeziwe kufaka phakathi:
- ushukela wobisi (i-lactose monohydrate);
- i-magnesium stearate;
- i-povidone.
Amaphilisi athengiswa emabhulashini ama-10 ama-blister. lilinye. Ebhokisini lekhadibhodi - ama-3 noma ama-6 ama-blices, imiyalo yokusebenzisa (ngendlela yephepha).
Indlela yokudedelwa yomuthi ngamathebulethi. Amaphilisi ama-cylindrical amhlophe qwa noma aphuzi ahlanganiswe nefilimu ye-enteric.
Isenzo se-Pharmacological
Umuthi ungowemithi ye-hypoglycemic yeqembu le-sulfonylurea lesizukulwane sesibili, okuhloswe ngalo ukusetshenziswa komlomo. I-Pharmacodynamics iqukethe amandla ento esebenzayo yokuvusa imfihlo ye-insulin noma indawo yayo yokufakelwa amaseli e-pancreatic, ukuthuthukisa isenzo se-glucose egazini, futhi kwandise ukuzwela kwe-insulin kwezicubu. Umuthi unezinto ezincane ezilwa ne-atherogenic. Ngaphansi kwethonya lomuthi, ama-synthetases e-glycogen yemisipha asebenza kakhulu.
Ngokusetshenziswa njalo, ukwehla kwe-postprandial ekugxilweni kweglue glucose kuyabonakala. Umuthi uthinta izinga lama-carbohydrate kanye nesilinganiso sawo se-metabolic, kuthuthukisa ukugcwala kwegazi futhi kuvikele ukwakheka kwezigaba zegazi. Kukhona ukwehla kokuzwela kwama-receptors ku-adrenaline. I-retinopathy yesifo sikashukela iyeka ukuthuthukisa ukusetshenziswa komuthi isikhathi eside. Akuthinti ukuzuza kwesisindo, futhi ngokudla okufanele, umuthi usiza ukunciphisa isisindo.
UGlidiab angathuthukisa isimo sesiguli esinesifo sikashukela sohlobo 2.
Ungayisebenzisa kanjani iMetformin Zentiva?
Kusetshenziselwa ini Ukuxilongwa? Funda kabanzi ngomuthi osesihlokweni.
I-Pharmacokinetics
Izinga lokumunca liphezulu, lapho lithathwa, lo muthi usheshe uqhekeke ezingxenyeni ezingenhla zamathumbu amancane. Ukuhlushwa kwe-Plasma kutholakala ngemuva kwamahora angama-2-3 (40 mg) ngemuva komthamo wokuqala noma ngemuva kwamahora ama-4 (80 mg). Ngamaprotheni egazi abopha ama-96-97%. I-Metabolism yenziwa isibindi, ngesikhathi senqubo kwenziwa ama-metabolites asebenzayo.
Ngokusetshenziswa njalo kwesidakamizwa, kwehla ukwehla kokuxineka koshukela egazini.
Izinso zithinteka ku-excretion, ingxenye encane ishiya umzimba kanye nezindundana zingashintshiwe. Ingxenye-yokuphila yinde, amahora angu-18-20.
Izinkomba ze-Diabefarma
Imiyalo ipela izinkomba eziphambili ezisetshenziswayo, ezibandakanya isifo sikashukela sohlobo 2. Ukuthatha umuthi kufanele kuhambisane nokudla okufanele, ukudla kanye nokuzivocavoca okulinganiselayo.
Contraindication
Umuthi unezici eziningi zokuqhekeka kanye nezihlobo. Ngokusebenzisa ngokuphelele umuthi awemukeleki. Lokhu kufaka phakathi:
- thayipha i-1 isifo sikashukela;
- I-precom yesifo sikashukela nekhohlisa;
- i-hyperosmolar coma;
- isifo sikashukela sikashukela;
- i-edema yamakhemikhali;
- ukwehluleka kwesibindi;
- ukwehluleka kwezinso;
- izifo ezithathelwanayo ezidala i-hypoglycemia;
- ukuhlinzwa kwenhliziyo okubanzi;
- ukusha, ukulimala;
- isikhathi sokuzala ingane;
- ukucaphuka
- iminyaka yezingane.
Ukuphulwa okuhlobene kufaka phakathi:
- isifo se-yegilo;
- isifo se-febrile;
- ukuba khona kwamagciwane emzimbeni;
- utshwala.
Kulokhu, isiguli singadinga irejimendiyamu elenziwe futhi elawulwa ngudokotela ohambelayo.
Ungayithatha kanjani iDiabefarm?
Uhlobo lomthamo lukhethiwe ngokuhlukile, ngokusekelwe empilweni jikelele yesiguli. Umthamo omkhulu wansuku zonke wesiguli esikhulile akufanele udlule kuma-320 mg, okulingana namaphilisi ayi-3 80 mg kanye namaphilisi ayi-8 40 mg. Ekuqaleni kokwelashwa, udinga ukuthatha iphilisi eli-1, kancane kancane ukhulisa umthamo.
Isilinganiso esiphezulu sansuku zonke kufanele sihlukaniswe ngemithamo engu-2-3. Amatafula kufanele athathwe esiswini esingenalutho, amahora angu-1-1,5 ngaphambi kokudla.
Uhlobo lomthamo lukhethiwe ngokuhlukile, ngokusekelwe empilweni jikelele yesiguli.
Imiphumela emibi Diabefarma
Ukusetshenziswa kabi komuthi kukhulisa ubungozi bemiphumela emibi. Lokhu kufaka phakathi:
- i-hypoglycemia;
- ikhanda
- Ukudana
- gxuma ushukela wegazi;
- ukubambezeleka kokuphendula;
- ukungazi kahle;
- ukungaboni kahle
- i-bradycardia;
- ukuphefumula okungashonile;
- ukungahambi kahle komzimba.
Uma ukuvela okuvela ku-maculopapular kusikhumba, udinga ukuxhumana nochwepheshe ozokusiza ekukhetheni uwoyela we-antihistamine.
Umthelela ekhonweni lokulawula izindlela
Ukusetshenziswa kwomuthi kungadala ukwehla kwezimpendulo ze-psychomotor, ngakho-ke kunconyelwa ukwenqaba ukushayela ngesikhathi sokwelashwa.
Imiyalo ekhethekile
Ngesikhathi sokusebenzisa umuthi, kuyadingeka ukunamathela ekudleni okufanele, okunempilo ngokulinganayo nenani lama-carbohydrate. Ushukela wegazi kumele ulinganiswe njalo: ngemuva kokudla nasesiswini esingenalutho. Ngokuwohloka kwesifo sikashukela noma ukuhlinzwa, kungadingeka ukufaka izidakamizwa eziqukethe i-insulin ekwelashweni.
Ngokubulawa yindlala okuhleliwe, ukuthatha ama-NSAIDs, ubungozi bokukhula kwe-hypoglycemia buyanda. I-Disulfiram-like syndrome (ikhanda, isicanucanu, izinhlungu ze-epigastric) ivela nge-ethanol. Uma ushintsha indlela odla ngayo nokusebenza kakhulu ngokomzimba, ungadinga ukulungiswa komthamo.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Isikhathi sokukhulelwa nokuncelisa ibele kungukuphambana okuphelele.
Sebenzisa ebudaleni
Iziguli esezikhulile zizwela kakhulu i-gliclazide, ngakho-ke ukwelashwa kufanele kuqalwe ngemithamo yesigamu.
Iminyaka yezingane ukuya eminyakeni eyi-18 kuwukuphikisana ngokuphelele.
Isabelo sezingane
Iminyaka yezingane ukuya eminyakeni eyi-18 kuwukuphikisana ngokuphelele.
Isicelo sokusebenza kokulimala kwezinso
Ukuthatha umuthi akuvunyelwe ngokuphelele kwiziguli ezinomlando wokwehluleka kwezinso.
Sebenzisa umsebenzi wesibindi okhubazekile
Ama-pathologies wesibindi, kufaka phakathi ukwehluleka kwesibindi, kubhekwa njengokuphula umthetho ngokuphelele.
Ukweqisa
Uma inqubo evunyelwe udokotela idlulwa kaningi, kuvela izimpawu zokuqina futhi isimo sesiguli siba sibi kakhulu. Mhlawumbe ukuthuthukiswa kwe-pathology eyingozi ehambisana nokusabela kohlelo lwezinzwa oluphakathi. Ezimpawu zokuqala zokuphuza ngokweqile (isiyezi, isicanucanu, ukufiphala), i-ambulensi kufanele ibizwe ngokuphuthumayo. Ngenkathi isiguli siqaphela, kudingeka simnikeze ucezu oluncibilisiwe.
Ukuxhumana nezinye izidakamizwa
I-Anaprilin, i-ACE inhibitors, imishanguzo eyenzelwe ukwelashwa kwezikhunta, izidakamizwa ezingezona i-steroidal anti-inflammatory, izidakamizwa ezilwa ne-TB, izithasiselo ze-steroid, izidakamizwa eziqukethe i-ethanol, i-sulfonamides zithuthukisa umsebenzi wesidakamizwa.
I-Corticosteroids, i-barbiturates, i-thiazide diuretics, imithi equkethe ama-hormone, iMetformin ne-Reserpine ingawenza buthaka umphumela we-hypoglycemic womuthi. Imithi evimba ama-adrenergic receptors ingavala izimpawu zokuncipha okukhulu kweglucose yegazi. Ingozi yokwehla okukhulu kwamaplatelet kanye namaseli abomvu egazi ayanda ngokusetshenziswa okuhlanganisiwe kwezidakamizwa ze-hypoglycemic nemithi engavimbela ukuhamba kwethambo.
Ukuhambisana notshwala
Umuthi awuhambisani notshwala. Ngesikhathi sokulashwa, kunconywa ukwenqaba ukuphuza utshwala.
Ama-Analog
Kukhona ukuvumelanisa okuningana okunomphumela ofanayo wokwelapha. Izihloko ezingezansi zifaka:
- I-Diabefarm MV. Isidakamizwa saseRussia esiseqenjini lezidakamizwa ze-hypoglycemic. Kuyatholakala ngesimo sethebhulethi. Amaphilisi wokukhishwa modified aqukethe i-30 mg ye-glycoslazide. Indlela yokusebenza isebenza ngokufana neyasekuqaleni. Intengo ekhemisi isuka kuma-ruble ayi-120.
- I-Glimepiride. Ifomu lokukhishwa ngamaphilisi, umuthi uthathwa njenge-analogue. Okuqukethwe kwengxenye esebenzayo efomini lomthamo akuyona ngaphezu kwe-2 mg. Izinkomba eziphambili zokusetshenziswa yi-Type 2 sikashukela mellitus. Izindleko zomuthi zivela kuma-ruble ayi-100.
- I-Glibenclamide. I-Hypoglycemic Umuthi wokulawulwa komlomo. Iphakethe liqukethe kusuka kumaphilisi ayi-10 kuye kwangama-120. Ithebhulethi eyi-1 iqukethe u-5 mg wento esebenzayo. Kuvunyelwe ukusetshenziselwa isifo sikashukela sohlobo 2. Izindleko ekhemisi zivela kuma-ruble ayi-540-1100.
I-analogue yesidakamizwa i-Glimepiride.
Noma iyiphi i-analogue ine-contraindication. Ukuzelapha ngokwakho kwenqatshelwe.
Imibandela yekhefu lekhemisi
Umuthi ufakwa ohlwini B. Udinga umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Umuthi woqobo awunakuthengwa ngaphandle kwemithi kadokotela.
Intengo ye-Diabefarm
Intengo emakhemisi yesidakamizwa ivela kuma-ruble angama-700.
Izimo zokugcina zomuthi
Umuthi kufanele ugcinwe endaweni eyomile, emnyama kude nezingane nasezilwaneni, ekushiseni kuka + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Gcina ngaphezu kwezinyanga ezingama-24.
Umkhiqizi
I-FARMAKOR PRODUCTION LLC, eRussia.
Ukubuyekezwa kweDiabefarm
Ukubuyekezwa kodokotela neziguli ngomuthi.
Odokotela
UPavel Zaretsky, udokotela we-endocrinologist, uMurmansk.
Isifo sikashukela sibhekwa njengesifo esingalapheki esidinga ukubhekwa njalo kwesimo sesiguli. Isiguli kufanele siphuze imishanguzo efanelekile impilo yaso yonke, ikakhulukazi uma kutholakale ukuthi unesifo sikashukela sohlobo 1 noma uhlobo 2. Le mishanguzo ifaka phakathi izidakamizwa ze-hypoglycemic. Umuthi osebenzayo ekwakhiweni kwomuthi wehlisa umthwalo emithanjeni yegazi futhi wenze izicubu zizwele kakhulu nge-insulin.
Umuthi onikezwa imithi uyabiwa. Kungcono ukuthenga umuthi ezindaweni ezikhethekile, lapho u-oda imali nge-Intanethi, ungagijimisa isikimu. Ngokuzijwayeza, bengihlala ngisebenzisa umuthi isikhathi eside, ngiwubona usebenza. Iziguli zivame ukukhononda ngemiphumela emibi, ukuthuthukiswa kwayo okubangelwa yizimpawu zomzimba ngamunye noma uma kuthathwe ngokungafanele.
U-Inessa Buryakova, i-endocrinologist, uZheleznogorsk.
Umuthi uyasebenza, kepha uyingozi. Ukwedlula okuncane kakhulu komthamo obekwe udokotela kungaholela ekwakhiweni kwe-pathologies, kufaka phakathi i-coma. Ngincoma ukuqala ukwelashwa ngemithamo uhhafu, ikakhulukazi ezigulini esezikhulile. Uhlobo lokwenza umthamo olinganiselwe lunikezwe kwimiyalo esetshenzisiwe, akufanele unamathele kuyo.
I-Glibenclamide iyi-analogue yesidakamizwa.
I-Glibenclamide iyi-analogue yesidakamizwa.
Isifo sikashukela
UStanislava, oneminyaka engama-47, Magnitogorsk.
Ngiqale ukuhlangana nalesi sifo eminyakeni engu-4 edlule lapho kubikwa ukuthi ubaba wami unesifo sikashukela sohlobo 2. Manje uphoqelekile ukuphuza umuthi njalo. I-endocrinologist yathatha isikhathi eside ukukhetha umuthi, lapho uthatha khona ubaba ongeke abhekane nokubi. Simile endaweni yemithi, ekwakhiweni kwayo okukhona i-gliclazide.
Ezinsukwini zokuqala zokwelashwa, ikhanda elincane nokuqaqamba kwabonwa. Udokotela uxwayise ngokuthi umuthi awuhambelani neminye imithi, ngakho-ke ikhanda eliqediwe laqedwa ngosizo lwamakhambi abantu. Kancane kancane, imiphumela emibi yahamba yodwa.
UValentine, oneminyaka engama-57 ubudala, e-Ekaterinburg.
Sekuphele iminyaka emithathu ngidla lo muthi. Ukuxilongwa kokugcina kwenziwa eminyakeni eyi-2 eyedlule, i-endocrinologist emtholampilo isikhathi eside ayikwazanga ukwenza isifo. Waqala ukwelashwa ngemithamo enesigamu, ethatha amaphilisi ama-0.5 kabili ngosuku. Imvamisa yanda kancane kancane ngemvume kadokotela. Ngokunyuka komthamo, imiphumela emibi nayo yavela.
Ekuqaleni kwavela isiyezi, khona-ke amakhanda aqala ukuphazamiseka. Udokotela uxwayise ngokuphendula okungenzeka futhi wenqabele ukukhetha ngokuzimela umuthi we-migraine. Udubule imiphumela emibi esebenzisa umuthi wendabuko.
