I-Amoxiclav ngumenzeli wokuhlanganisa ogxile kwe-antibacterial. Isetshenziswa kabanzi ekwelapheni izifo ezahlukahlukene, kufaka phakathi izinhlobo ezingamahlalakhona. Sebenzisa lesi sidakamizwa ngokuqapha, ucubungula izici eziqondene nesiguli nokuthi kungenzeka ukuxhumana nezinye izidakamizwa.
Igama Lezwe elingafanele
I-INN Amoxiclav - Amoxicillin ne-enzyme inhibitor.
I-ATX
Ikhodi ye-ATX yesidakamizwa yi-J01CR02.
I-Amoxiclav ngumenzeli wokuhlanganisa ogxile kwe-antibacterial.
Ukwakheka
Umuthi ukhiqizwa ngezindlela eziningi. Kunamathebhulethi afakwe ngaphakathi entweni ekuhlanganiseni ifilimu kwe-hypromellose, inguqulo yethebhulethi yokutholwa kabusha kanye nezinhlobo ezi-2 zikafulawa zokumiswa komlomo nezixazululo zomjovo. Izakhi ezisebenzayo kuzo zonke izimo zinosawoti we-potassium we-clavulanic acid ne-antibiotic amooticillin ngesimo sikasawoti we-sodium (ngento yomjovo) noma ngendlela ye-trihydrate (yezinhlobonhlobo zomlomo zomuthi).
Ezithebhuleni, okuqukethwe kwe-sodium clavulanate kungama-125 mg, kanti i-amooticillin ingaba ngu-250, 500 noma 875 mg. Embodiment yokumiswa, ukwakheka okuyinhloko kungamelwa yisilinganiso esilandelayo se-antibiotic and inhibitor (ku-5 ml wokumiswa kokuqeda): 125 mg no-31.25 mg, 250 mg no-62.5 mg, 400 mg no-57 mg, ngokulandelana. Abahambeli:
- i-citric acid;
- i-benzoate ne-sodium citrate;
- izinsini;
- ifomu le-colloidal le-silicon dioxide;
- sodium saccharase;
- i-carmellose;
- i-mannitol;
- ukunambitha.
I-Amoxiclav kit ifaka imiyalo kanye nomthamo wokuphothula nge-pipette / isipuni sokulinganisa.
Umuthi ufakwe emabhodleleni engilazi angu-140, 100, 70, 50 35, 25, 17,5 noma u-8.75 ml. Ukufakwa kwangaphandle okwenziwe ngekhadibhodi. Ikhithi ifaka imiyalo nethamo lokuphothula umthamo wepayipi / isipuni sokulinganisa.
Ukulungiswa kwe-powder komjovo kuqukethe kuphela amakhompiyutha asebenzayo - i-amoxicillin 500 noma i-1000 mg ne-clavulanic acid 100 noma 200 mg. Le powder ifakwa emabhodleleni engilazi, akhonjiswa izingcezu ezi-5. emasakeni amakhadibhodi.
Isenzo se-Pharmacological
I-Amoxiclav iyinhlanganisela yezakhi ezi-2 ezisebenzayo - i-amoxicillin ene-sodium clavulanate. Eyokuqala yalokhu ipenicillin eyakhiwe ngokwedlule, okuyiqembu lama-beta-lactam antibiotic agents. Iyakwazi ukuvimba ama-enzyme ahilelekile ekuhlanganiseni kwe-peptidoglycan odongeni lweseli lwezinto ezingamagciwane. Ngenxa yalokhu, amangqamuzana ayazenzakalisa kanye namagciwane ayafa.
Kepha ubukhulu bokusebenza kwe-amooticillin bunqunyelwe ngenxa yokuthi amanye ama-microorganisms afunde ukukhiqiza ama-β-lactamases - amaprotheni enzyme enza i-antibiotic ingasebenzi.
I-Amoxiclav ingabhubhisa ama-microorganisms amaningi we-gram-negative ne-gram-positive.
Lapha kusiza i-clavulanic acid. Alunazindawo ezibonakalayo zokulwa namagciwane, kepha luyakwazi ukuvimbela umsebenzi wama-β-lactamases athile. Ngenxa yalokhu, ukumelana kwe-penicillin kwamagciwane kuncipha futhi ukubonwa kwesenzo se-antibiotic kuyanda. Ebukhoneni be-clavulanate, kungabhubhisa ama-microorganices amaningi we-gram-negative ne-gram-positive, njenge:
- i-staphilo, i-strepto ne-gonococci;
- i-enterobacteria;
- clostridia;
- Helicobacter;
- Ama-preotellas;
- i-bacillus yamathumbu kanye ne-hemophilic;
- i-salmonella;
- UShigella
- I-Proteus
- chlamydia
- leptospira;
- ama-causative agents we-anthrax, pertussis, cholera, syphilis.
I-Pharmacokinetics
Ngemuva kokuphathwa ngomlomo, isidakamizwa singena ngokushesha ku-plasma. Izinga le-bioavailability yalo lifinyelela ku-70%. Izakhi zalo ezisebenzayo zisatshalaliswa kahle phezu kwezicubu ezahlukahlukene nemidiya yewuketshezi, zidlulela kubisi lwebele nokuphuma kwegazi kwe-kany, kepha isithiyo sobuchopho begazi lapho kungekho ukuvuvukala kwendawo singehlulelwa zona.
Umuthi i-Amoxiclav ngemuva kokuphathwa ngomlomo ungena ngokushesha ku-plasma.
Iningi lama-antibiotic lihlungwa izinso lize likhishwe emchameni ngesimo salo sokuqala. I-metabolite yayo engasebenzi ishiya umzimba ngendlela efanayo. Cishe ingxenye yesilinganiso se-clavulanic acid isuswa ngokuhlunga kwe-glomerular kwifomu elingashintshiwe. Okunye okusetshenziselwe ukuthungwa kukhipha umchamo, indle nomoya ophelelwe yisikhathi.
Ukuphila kwesigamu kwezingxenye ezisebenzayo ze-Amoxiclav cishe amahora angama-1-1,5. Ekusebenzeni kanzima kwezinso, isikhathi sokuqedwa komuthi sikhuphuka kaningana.
Izinkomba zokusetshenziswa kwe-Amoxiclav powder
Umuthi ubekelwe ukulwa nezifo ezinama-pathogen azwela isenzo sawo. Izinkomba:
- i-tracheitis, i-bronchitis ebukhali, kufaka phakathi inkimbinkimbi ngokubuka phezulu, ukubuyela emuva kwe-bronchitis, i-pneumonia, i-pleurisy;
- sinusitis, sinusitis, mastoiditis;
- abezindaba ze-otitis, ezigxile endlebeni ephakathi;
- izifo ze-pharyngeal;
- ukuvuvukala kwezakhi zomchamo;
- i-prostatitis
- i-osteomyelitis, i-periodontitis;
- ukuvuvukala kwezitho zangasese sowesifazane;
- ukutheleleka kwesendlalelo sesikhumba nezicubu ezithambile, kufaka phakathi ithumba lamazinyo, ukuluma, ukutheleleka nge-postoperative;
- cholecystitis, angiocholitis.
Ukwelashwa ngomjovo we-Amoxiclav kukhonjelwa izifo ezithinta isisu esisesiswini kanye nezifo ezithathelwana ngocansi.
Contraindication
Umuthi awunakuthathwa lapho kukhona i-hypersensitivity esenzweni sanoma yiziphi izingxenye zayo. Okunye ukuphikisana okunamandla kufaka phakathi:
- ukubekezelela i-beta-lactam antibiotic ukungabekezeleli (umlando);
- ukungasebenzi kwesibindi, kufaka phakathi i-cholestatic jaundice, kuphakama ngokuphendula i-amoxicillin noma i-β-lactamase inhibitor (umlando);
- i-monocytic tonillitis;
- i-lymphocytic leukemia.
Ukunakekelwa okukhethekile kufanele kuthathwe ezigulini ezibhekene ne-pseudomembranous colitis, ezinezilonda zomgudu wokugaya ukudla, i-renalatic kanye ne-hepatic pathologies, kanye nabesifazane ngesikhathi sokukhulelwa nokuqunjelwa.
I-Amoxiclav ayikwazi ukuthatha umsebenzi wesibindi ongasebenzi kahle.
Ungayithatha kanjani i-Amoxiclav powder
I-Amoxiclav powder inqunywe ngudokotela, naye ubandakanyeka kwi-dosing futhi unquma isikhathi sokwelashwa. Kunconywa ngokuqinile ukuthi wenqabe ukuzelapha. Umthamo wansuku zonke unqunywa ngobunzima besifo. Imithamo yezingane, kufaka phakathi izinsana, incike kusisindo somzimba wengane. Udinga ukuphuza umuthi ngezikhathi ezithile ezithile ukuze ulondoloze ukuqina kwalo ezingeni elifanele.
Ukuzalela
Ukumiswa komlomo kulungiswa ngokungeza amanzi abilisiwe ku-powder. Umjovo wempuphu ungahlanjululwa nge-distillate kabili, usawoti, isisombululo sikaRinger noma umxube weHartman.
Ngaphambi noma ngemuva kokudla
Ukuze uvikele isisu emiphumeleni emibi ye-Amoxiclav, kunconywa ukuthatha umuthi ekuqaleni kokudla noma ngokushesha ngaphambi kokuqala.
I-Amoxiclav iyanconywa ekuqaleni kwesidlo.
Ukuthatha umuthi wesifo sikashukela
Inkambo ende yokwelashwa kwesinye isikhathi iyadingeka.
Imiphumela emibi ye-Amoxiclav powder
Umuthi ubekezelelwa kahle yiziguli. Imiphumela engathandeki iyivelakancane.
Amapheshana wesisu
Isifo sohudo sivame ukuvela, kungabi kaningi - isicanucanu, ukuphambuka kokugaya, ubuhlungu besisu, i-gastritis, i-colitis, i-dysbiosis, ukuba mnyama kwebala lamazinyo, i-stomatitis, ukungasebenzi kahle kwesibindi, i-hepatitis. I-Hepatic pathologies ingaba nzima ngokuphathwa isikhathi eside ngomuthi noma ngokuqokwa kwezidakamizwa ezingaba i-hepatotoxic.
Izitho zeHematopoietic
Mhlawumbe ushintsho ekwakhekeni kwegazi elingaphezulu kanye nokwephulwa kwe-coagulability.
Isistimu yezinzwa ephakathi
Ubuhlungu bekhanda, isiyezi, izimpawu eziqinisayo zenzeka. Ukuphumelela kungenzeka. Amacala we-meneptitis ye-aseptic abikwe.
Ubuhlungu bekhanda bungaba ngumthelela oseceleni we-Amoxiclav powder.
Kusuka ohlelweni lomchamo
I-Tubulointerstitial nephritis ingahle ikhule. Ukulandelwa kwegazi noma amakristalu kasawoti kwesinye isikhathi kutholakala kumchamo.
Kusuka ohlelweni lwezinhliziyo
I-Thrombophlebitis endaweni yokujova kungenzeka.
Allergies
Ukusabela komzimba kungabonakaliswa ukulunywa, ukuqunjelwa, ukukhonkotha kwe-integument, i-erythema, kufaka phakathi nokuba khona kwe-exudate, ukuvuvukala, i-anaphylaxis, vasculitis, nezimpawu ze-serum syndrome. I-necrolysis engaba khona yesendlalelo se-epidermal.
Imiyalo ekhethekile
Ngesikhathi sokwelashwa ngama-antibiotic, kuyadingeka ukuqapha isimo sezakhiwo ze-renal, isibindi nezitho ze-hematopoietic. Lapho kukhona i-anuria nezinye izinkinga zezinso, umthamo womuthi kufanele ulungiswe. Ukujova okungaphakathi kwemvelo akuvunyelwe.
Ukusetshenziswa kwesidakamizwa kungadala ukukhula okungalawuliwe kwe-microflora engahambelani nesenzo sayo, egcwele ukungezelelwa kwegciwane lesibili, kufaka phakathi ukutheleleka ngefungus.
Lapho unquma imithamo emikhulu ye-Amoxiclav, kubalulekile ukunamathela kuhlobo olufanele lokuphuza ukuvikela i-crystalluria.
Ukuphathwa kwe-intramuscular of the drug Amoxiclav akuvunyelwe.
Umuthi ungathinta imiphumela yokuhlolwa kwesibindi nokuhlolwa kweCoombs.
Ngemuva kokunyamalala kwezimpawu ezinzima, ukwelashwa kunconyelwa ukwelulwa ezinye izinsuku ezingama-2-3.
Ungazinikeza kanjani izingane
Ifomu lomlomo elithandwayo ukumiswa. Kusuka eminyakeni eyi-12, kuthathwa imithamo yabantu abadala.
Ngesikhathi sokukhulelwa nokuqunjelwa
Ayikho idatha eyanele yokulinga ngemiphumela yomuthi ekukhulelweni. Ngesikhathi sokuzala nengane, kungakuhle ukuthi abesifazane banqabe ukuphuza umuthi.
Ukweqisa
Uma umthamo wedlulile, ukwelashwa okubonakalayo kuyadingeka. Ukugeza kwenziwa kungakapheli amahora ama-4 ngemuva kokuphathwa ngomlomo. Zombili izakhi ezisebenzayo zomuthi zisuswa kahle yi-hemodialysis. I-Peritoneal dialysis ayisebenzi kangako.
Uma kwenzeka kune-overdose, zombili izingxenye ezisebenzayo ze-Amoxiclav zisuswa kahle yi-hemodialysis.
Ukuxhumana nezinye izidakamizwa
Umuthi akufanele uhlanganiswe nezinto ezifana:
- ama-anticoagulants;
- I-Allopurinol;
- Disulfiram;
- I-Rifampicin;
- izinhlanganisela zamaprotheni;
- i-emulsions yamafutha;
- ama-sulfonamides;
- ama-bacteriostatic antibiotic;
- izindlela zokuvimbela inzalo ngomlomo, njll.
Ama-Analog
Amacwecwe esenzo esifanayo:
- Panklav;
- Flemoklav;
- I-Augmentin.
Faka izimpuphu zokulungiselela izixazululo zomjovo:
- I-Amoxivan;
- I-Amovicomb;
- I-Verklav;
- I-Clamosar;
- UFibell;
- INovaklav;
- I-Foraclav.
Imibandela yekhefu lekhemisi
Asikho isidakamizwa esithengiswayo.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ikhishwe ngumbhalo.
Intengo
Izindleko zempuphu zokwenziwa kwe-fluid yokumiswa zivela kuma-ruble ayi-110. kwe-125 mg, into yomjovo - kusuka kuma-ruble angama-464.
Izimo zokugcina zomuthi
Umuthi ugcinwa emazingeni okushisa afinyelela ku- + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshelufu yokumiswa okulungiselelwe ingafika kuviki eli-1, isisindo se-powder yiminyaka emi-2.
Umkhiqizi
Lesi sidakamizwa senziwa yinkampani yezokwelapha e-Austrian Sandoz International Gmbh.
I-Amoxiclav igcinwa emazingeni okushisa aze afike ku- + 25 ° C.
Ukubuyekezwa kweziguli nodokotela
I-Korvatov V. L., udokotela wezifo ezithathelwanayo, uTyumen
I-Amoxiclav iyisidakamizwa esilwa ne-antibacterial esinamandla kodwa esiphephile. Into esemqoka ukulungisa isikhathi esifanele futhi ungakhohlwa ngesidingo sokuvikela i-microflora yamathumbu.
U-Arina, oneminyaka engama-26 ubudala, u-Izhevsk
U-Amoksiklav uthathe indodana yakhe wayene-bronchitis enzima. Ngithanda ukuqaphela ukunambitheka okumnandi, ukusebenza kahle okuphezulu nokubekezelela umuthi omuhle kakhulu. Ngemuva kwezinsuku ezi-5, kwakungekho umkhondo walesi sifo.
