Umuthi Oxodolin: Imiyalo esetshenzisiwe

I-Oxodolin isho izidakamizwa ze-antihypertensive, phakathi kwezinye izidakamizwa ezinomphumela ofanayo isebenza ngobumnene kakhulu. Ngaphambi kokuqala ukwelashwa, konke ukucatshangelwa nokuphikisana okungahle kwenzeke kufanele kubhekwe. Umthamo kanye nesikhathi sokwelashwa kukhethiwe esigulini ngasinye ngawodwana.

Igama Lezwe elingafanele

INN: IChlortalidone. NgesiLatin - Chlortalidone noma Oxodolinum.

I-Oxodolin isho izidakamizwa ze-antihypertensive, phakathi kwezinye izidakamizwa ezinomphumela ofanayo isebenza ngobumnene kakhulu.

I-ATX

Ikhodi ye-ATX: C03BA04.

Khipha amafomu nokwakheka

Umuthi uyatholakala ngesimo sethebhulethi. Amaphilisi amhlophe. Umthunzi ophuzi nawo uthathwa njengemukelekile. Ngokuvamile, amaphilisi afakwa ezitsheni ezikhethekile zengilazi emnyama. Zisekuhlanganisweni kwamakhadibhodi okuqala kanye nemiyalo esetshenzisiwe.

Isithako esisebenzayo yi-chlortalidone. Ithebhulethi eyodwa iqukethe u-0.05 g wekhompiyutha eyisisekelo. Izingxenye ezengeziwe: i-calcium stearate, i-lactose, inani elincane lesitashi kanye ne-polyvinylpyrrolidone enesisindo samangqamuzana. Isitsha ngasinye sinamathebhulethi angama-50.

Isenzo se-Pharmacological

Umuthi usiza ukucindezela ukubuyiselwa kabusha kwama-ion e-sodium kuma-tubules amancane we-ponsele. Izinga lokuphuma kwe-potassium ne-magnesium ion emzimbeni womuntu ngokuhlunga kwe-reety likhuphuka kakhulu, kanti futhi ukuphuma kwe-calcium ion kuncishisiwe.

Umphumela we-antihypertensive ubonakala emavikini ambalwa kuphela ngemuva kokuqala kwomuthi. Umfutho wegazi wehla uye emazingeni avamile ngokwanele. Umphumela we-diuretic wenzeka ngokunciphisa izinga le-polyuria, ebaluleke kakhulu ekwelapheni i-renalabetes insipidus.

Umuthi uyatholakala ngesimo sethebhulethi. Amaphilisi amhlophe. Umthunzi ophuzi nawo uthathwa njengemukelekile.

Isithako esisebenzayo yi-chlortalidone. Ithebhulethi eyodwa iqukethe u-0.05 g wekhompiyutha eyisisekelo.

Umfutho wegazi lapho usebenzisa i-Oxodoline wehla uye emazingeni ajwayelekile ngokushesha ngokwanele.

Umphumela we-diuretic wenzeka ngokunciphisa izinga le-polyuria, ebaluleke kakhulu ekwelapheni i-renalabetes insipidus.

Ukuqoqwa okukhulu kwekhompiyutha esebenzayo lapho usebenzisa umuthi ku-50 mg noma ku-100 mg ubonwa ngemuva kwamahora ayi-12.

Umthamo wegazi omncane uncishiswa kancane. Umthamo wayo kanye nokuhlushwa kwe-extracellular fluid nakho kuba yincane. Lo mphumela unqunywa kuphela ekuqaleni kokwelashwa. Ngokuhamba kwesikhathi, zonke izinkomba zibuyela kokujwayelekile.

I-Pharmacokinetics

Umuthi udonswa amahora ambalwa ngemuva kokuthatha iphilisi. I-Bioavailability kanye namandla okubopha ezinhlakeni zamaprotheni ziphakeme impela. Ukuqoqwa okukhulu kwekhompiyutha esebenzayo lapho usebenzisa umuthi ku-50 mg noma ku-100 mg ubonwa ngemuva kwamahora ayi-12.

Ukuqedwa kwesigamu sempilo kungafinyelela amahora angama-50. Kukhululwa ngemuva kokuhlungwa kwe-renal kungashintshiwe. Ngokuhluleka okungapheli kwezinso kungaqongelela.

Izinkomba zokusetshenziswa

Kuboniswa:

• ukwehluleka kwenhliziyo okungapheli;
• ukuqina kwesibindi;
• i-arterial hypertension;
• i-nephrosis ne-jade;
• isifo sikashukela sezinso;
• ukukhuluphala;
• ukuvuvukala.

Konke ukufundwa kuphelele. Ochwepheshe banquma umthamo kanye nesikhathi sokwelashwa ngakunye esigulini ngasinye.

I-Oxodolin ikhonjiswa ngokwehluleka kwenhliziyo okungapheli.

Isidakamizwa sisetshenziselwa futhi i-renalabetes insipidus.

I-Oxodoline inconyelwe ukusetshenziselwa ukukhuluphala kanye ne-edema.

Contraindication

Umuthi wenqatshelwe ngokuphelele ukuwuthatha lapho ukhona ama-pathologies:

• hypersensitivity kuzakhi zomuthi;
• i-hypokalemia ne-hypomagnesemia;
• ukwehluleka kwezinso okwenzeka kakhulu;
• ifomu elinzima le-jade;
• i-hepatitis eyingozi, kuze kufike ku-hepatic coma;
• ukwehluleka kwezinso okwenzeka kakhulu;
• gout
• isifo sikashukela mellitus;
• inkathi yokuhlanza;
• ukwephulwa kwemali esele ye-electrolyte;
• iminyaka yezingane.

Konke lokhu kuphambana, okwenziwa kukholamu ehlukile yemiyalo, kufanele kubhekwe ngaphambi kokuqala ukwelashwa kwezidakamizwa.

Umuthi wenqatshelwe ngokuphelele ukuwuthatha lapho kukhona ukwehluleka okukhulu kwe-renal.

Ngenkathi yokuqunjelwa, i-Oxodolin ifakwa emgqeni ukuze isetshenziswe.

Nge-gout, ukuphuza umuthi nakho kwenqatshelwe.

Ngokunakekela

Ngokuzibophezela, umuthi kufanele unqunywe kuma-pathologies:

• ukwehluleka okungapheli kwezinso nezinso;
• ukubonakaliswa komzimba;
• isifuba somoya;
• systemic lupus erythematosus.

Lapho uthatha, udinga ukuqaphela asebekhulile. Ngakho-ke, lapho kuvela imiphumela emibi yokuqala, kufanelekile ukwehlisa umthamo noma ukuwuyeka ngokuphelele umuthi.

Ungayithatha kanjani i-Oxodoline

Amacwecwe anconywe ukuba athathwe ekuseni ngesikhathi sasekuseni. Umthamo uqokelwa isiguli ngokwahlukile. Kuya ngamandla kobukhulu bezimpawu zesifo esingaphansi, kumiphumela yokwelashwa elindelekile.

Amacwecwe anconywe ukuba athathwe ekuseni ngesikhathi sasekuseni.

Umthamo uqokelwa isiguli ngokwahlukile. Kuya ngobukhulu bezimpawu zesifo esikhona.

Kwesinye isikhathi ama-diuretics anconyelwa ngaphezu kwalokho ukusebenza okuhle.

Ngezinga eliphansi le-hypertension, ithebhulethi eyi-1 ye-50 mg kathathu ngesonto inqunyelwe. Nge-edematous syndrome, umthamo wokuqala ungama-100 mg njalo ngosuku. Kwesinye isikhathi ama-diuretics anconyelwa ngaphezu kwalokho ukusebenza okuhle. Kwi-insulin yesifo sikashukela sezinso, i-100 mg yesidakamizwa ichazwa kabili ngosuku.

Ngoshukela

Ukuthatha umuthi akuvunyelwe ngokuphelele, ngoba kuqukethe inani elikhulu le-lactose, okuthinta kabi ukwanda koshukela wegazi.

Imiphumela emibi ye-Oxodoline

Ngokusebenzisa isikhathi eside, ukusabela okungathandeki kwezinhlangothi kwenzeka kaningi. Uma zenzeka, kunconywa ukuthi ubonane nodokotela ukuze uthole ukwelashwa okulimazayo.

Engxenyeni yesitho sombono

Ukuphazamiseka okuqhubekayo ekusebenzeni okujwayelekile komhlaziyi obonakalayo kwenzeka. Mhlawumbe ukuthuthukiswa kwe-xanthopsia.

Ku-mellitus yesifo sikashukela, ukuthatha i-Oxodolin akuvunyelwe ngokuphelele, ngoba kuqukethe inani elikhulu le-lactose.

Ngokusetshenziswa isikhathi eside, ukuphazamiseka okuqhubekayo ekusebenzeni okujwayelekile komhlaziyi obukwayo kuvame ukwenzeka.

Ngesikhathi sokusetshenziswa isikhathi eside somuthi, kukhishwa izikhala zemisipha ebushelelezi.

Ezithweni zokugaya, isicanucanu, ukuhlanza kungabonakala.

Kusuka ezicutshini zemisipha

Kukhona ukwanda okuthile kwezicubu ezixhunyiwe, ikakhulukazi ngomonakalo wayo wokuqala. Ama-spasms wemisipha ebushelelezi ayabonakala.

Amapheshana wesisu

Ezithweni zokugaya, isicanucanu, ukuhlanza kungabonakala. Kwesinye isikhathi ukuqunjelwa kuhlangana nesifo sohudo. I-hepatitis cholestasis iba yinsakavukela. Ezimweni ezinzima, i-jaundice ingaqhamuka. Kwesinye isikhathi kuvela izimpawu ze-pancreatitis.

Izitho zeHematopoietic

Ekuhlolweni kwegazi, kunezinguquko ezibukhali. I-Agranulocytosis, i-anemia, ne-thrombocytopenia iyakhula. Inani lamaseli amhlophe wegazi liyancipha, bese kukhuphuka ama-eosinophils.

Isistimu yezinzwa ephakathi

Kusukela ohlangothini lwesistimu yezinzwa, izinkinga zingenzeka: isiyezi esinamandla, ubuthakathaka obukhulu nokukhathala. Ukungaholeli nokungadideki okuthile esikhaleni kungenzeka.

I-Hepatic cholestasis yinto evame ukwenzeka yokusabela okungekuhle. Ezimweni ezinzima, i-jaundice ingaqhamuka.

Ekuhlolweni kwegazi, kunezinguquko ezibukhali. I-Agranulocytosis, i-anemia, ne-thrombocytopenia iyakhula.

Kusukela ohlangothini lwesistimu yezinzwa, izinkinga zingenzeka: isiyezi esinamandla, ubuthakathaka obukhulu nokukhathala.

Ngenxa yokuvela kwe-hypokalemia, i-arrhythmia iyakhula.

Imikhuba eminingi evame ukwenzeka. Zingavela ngesimo se-urticaria kanye neminye imishayo ethize emzimbeni.

Kusuka ohlelweni lwezinhliziyo

Ngenxa yokuvela kwe-hypokalemia, i-arrhythmia iyakhula. I-Orthostatic hypotension ingahle ivele. Ngokuthuthukiswa kwezimpawu ezinjalo, kungcono ukwenqaba ukuphuza umuthi.

Allergies

Imikhuba eminingi evame ukwenzeka. Zingavela ngesimo se-urticaria kanye neminye imishayo ethize emzimbeni. Ezimweni ezimbi kakhulu, kungavela ukusabela kwe-photosensitization.

Kwesinye isikhathi, ekwelapheni ukubonakaliswa kwe-allergic, ukwelashwa okuqondile kwe-detoxification kungadingeka ukusiza ukususa i-allergen emzimbeni.

Umthelela ekhonweni lokulawula izindlela

Isikhathi sokulashwa kwezidakamizwa, kungcono ukwenqaba ukushayela imoto nemishini esindayo, umsebenzi odinga ukugxilwa kakhulu. Into esebenzayo iyakwazi ukuthinta ama-peripheral nerve receptors. Ngasikhathi sinye, ukusabela kwengqondo okudingekayo kungancishiswa, okuthinta kabi ukuthatha izinqumo ngokushesha ezimweni eziphuthumayo.

Imiyalo ekhethekile

Kunconywa ukuthi ngezikhathi ezithile wenze izivivinyo, ubheke izinga lama-electrolyte egazi. Lokhu kuyiqiniso ikakhulukazi ezigulini ezinqunywe ukwelashwa kwedijithali ngaphambili. Ukudla okuqinile okungenawo usawoti akufanele kunqunywe.

Isikhathi sokulashwa kwezidakamizwa, kungcono ukwenqaba ukushayela imoto nemishini esindayo, umsebenzi odinga ukugxilwa kakhulu.

Kunconywa ukuthi ngezikhathi ezithile wenze izivivinyo, ubheke izinga lama-electrolyte egazi.

Ukudla okuqinile okungenawo usawoti akufanele kunqunywe ngenkathi uthatha i-Oxodoline.

iziguli eziningi zingadinga ukwelashwa esikhundleni se-potassium.

Uma kwenzeka ukuphazamiseka kwesigqi senhliziyo, okuvame ukutholakala esimweni se-hypokalemia, kulahleka okwengeziwe kwe-potassium. Lokhu kungabonakala ngokuhlanza, isifo sohudo esinamandla, i-hyperaldosteronism, ukudla okungalingani kahle. Ngakho-ke, iziguli eziningi zingadinga ukwelashwa esikhundleni se-potassium.

Endabeni yokudla okungapheli kwama-diuretics, ukwanda kwezimpawu ze-systemic lupus erythematosus kwenzeka. Yize lesi simo sinqabile.

Sebenzisa ebudaleni

Akunconywa ukuthatha asebekhulile. Uma kunesidingo esinjalo, khona-ke isilinganiso semithi ebekiwe kufanele sibe sincane.

Isabelo sezingane

Umuthi awusetshenziswa neze emikhubeni yezingane.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Kukhona ucwaningo olunganele lokuthi umuthi ungena yini ekuvinjelweni kwe-placenta. Ngakho-ke, odokotela bezingane batusa ukungasebenzisi umuthi ngenkathi uthwele ingane, ikakhulukazi ngalezo zikhathi lapho ukwakheka kwezitho ezibalulekile kwenzeka.

I-Oxodoline ayinconywa kwabadala.

Umuthi awusetshenziswa neze emikhubeni yezingane.

Izisebenzi zokuthambisa izidakamizwa zincoma ukungasebenzisi umuthi ngenkathi uthwala ingane.

Awukwazi ukuphuza umuthi ngenkathi uncelisa ibele, ngoba isakhi esisebenzayo ngendlela engaguquki sidlula singene ebisini lwebele. Ngakho-ke, ngesikhathi sokwelashwa kufanele ushiye ukuncelisa ibele.

Isicelo sokusebenza kokulimala kwezinso

Ukuphazamiseka okungaba khona kohlelo lwe-excretory. Ngakho-ke, udinga ukuthatha ngokucophelela umuthi wabantu abanokwehluleka okungapheli kwe-renal. Uma kwenzeka noma yikuphi ukwephulwa, kubalulekile ukulungisa umthamo omncane.

Sebenzisa umsebenzi wesibindi okhubazekile

Ekungasebenzi kahle kwesibindi, umuthi kufanele uyekwe.

Ukweqisa kwe-Oxodoline

Izimpawu ze-overdose azibonwa. Uma ngephutha uthatha umthamo omkhulu, kungaba nemiphumela engathandeki: ukwethuka, isiyezi, ukuqina okushisayo, i-hypovolemia, i-arrhythmia, kanye nokwehla okukhulu kwezinkomba zokucindezela.

Ukwelashwa kuyimpawu. Do lavage gastric, conduct detoxification therapy. Ukubuyisela ibhalansi elejwayelekile le-electrolyte, yenza ama-infusions angaphakathi ezixazululo ze-saline.

Ukuxhumana nezinye izidakamizwa

Ngokuphathwa okuhlanganyelwe kwe-Oxodoline enama-restresh revisis, ama-inhibitors we-MAO, amanye ama-vasodilators kanye ne-beta-blockers, umphumela wezidakamizwa ezilwa nomfutho wegazi uyathuthukiswa. Ama-NSAIDs anciphisa kakhulu umphumela we-hypotensive ne-diuretic somuthi.

Ukuqunjelwa kwama-lithium ion egazini kuyanda, okunomthelela ekuthuthukisweni kwezimpawu zokudakwa. Ngokuphathwa kanyekanye nge-glycosides yenhliziyo, ukuphazamiseka kwesigqi senhliziyo kuyanda.

Uma ngephutha uthatha umthamo omkhulu womuthi, kungaqhekeka kungenzeka.

Ngokuphathwa okuhlanganyelwe kwe-Oxodoline nge-restresh yemisipha, ama-inhibitors we-MAO, umphumela wezidakamizwa ezilwa nomfutho wegazi uyathuthukiswa.

Ungathathi i-Oxodoline ngotshwala.

Ngaphambi kokuthi uqale ukuhlanganisa ukusetshenziswa kwalesi sidakamizwa neminye imithi, okungathinta ukulingana kwe-electrolyte emzimbeni kanye nezinga le-potassium kuwo, kufanele nakanjani udlule kuzo zonke izivivinyo bese uthintana nodokotela wakho ngesidingo sokwelashwa okuyinkimbinkimbi.

Ukuhambisana notshwala

Musa ukuthatha notshwala. Umphumela wezindlela zokwelapha izidakamizwa uncishiswa kakhulu, futhi izimpawu zokudakwa zibonakaliswa ngamandla avuselelwe.

Ama-Analog

Namuhla kunzima ukuthola lo muthi emakhemisi. Ngakho-ke, odokotela abaningi baphendukela ekuqashweni kwemithi ejwayelekile futhi engabizi kakhulu. Kunezidakamizwa eziningana ezihlukile ekwakhiweni, kepha zinomphumela ofanayo wokwelapha:

• I-Urandil;
• IGygroton;
• Isoren;
• URenon;
• I-Chlortalidone;
• Famolin;
• Natriuran;
• I-Saluretic;
• UZamebezil.

Ngaphambi kokukhetha umuthi wokufaka esikhundleni, udinga ukutadisha imiyalo ngokucophelela bese unaka zonke izinkomba kanye ne-contraindication ukuze uzisebenzise.

Imibandela yekhefu lekhemisi

Ezitolo zezidakamizwa, umuthi awuvamile ukutholakala.

Odokotela abaningi basebenzisela ukunikezwa kwemithi ejwayelekile futhi engabizi kakhulu, ngokwesibonelo, iGygroton.

Kunezidakamizwa eziningana ezihlukile ekwakhiweni kwe-Oxodolin, kodwa zinomphumela ofanayo wokwelapha, ngokwesibonelo, uRenon.

Gcina umuthi kuphela endaweni emnyama neyomile. Kuvikelwa kakhulu ezinganeni ezincane.

Ngingakwazi ukuthenga ngaphandle kadokotela

Imithi ayikwazi ukuthengwa ngaphandle kokuthola incwadi ekhethekile.

Intengo

Njengoba imali ingekho endaweni yomphakathi, ingenziwa kuphela uku-oda, khona-ke akunakwenzeka ukwahlulela inani layo.

Izimo zokugcina zomuthi

Gcina umuthi kuphela endaweni emnyama neyomile. Kuvikelwa kakhulu ezinganeni ezincane. Ukushisa kwesitoreji akufanele kudlule okushisa kwegumbi.

Isikhathi sokuphelelwa yisikhathi

Yiminyaka emi-5 ukusuka ngelanga lokukhiqizwa.

Umkhiqizi

Inkampani yokukhiqiza: EMPILS-FOH CJSC (Russia).

Ukubuyekezwa

UNatalia, oneminyaka engama-42 ubudala, uNizhny Novgorod: "Udokotela wanikeza umuthi wokudambisa izimpawu zokuphazamiseka komfutho wegazi. Kwakunenkinga ye-edematous. Ngemuva kokuthi ngiqale ukuphuza amaphilisi, ukuvuvukala kwavele kwanyamalala. Ngakolunye uhlangothi ikhanda lami lahamba lalimala. Ingathengwa kuphela ngesicelo nangodokotela okhethekile.Ukuqala kokwelashwa, ukusabela okungekuhle kwabonwa ngendlela yokuphazamiseka kokugaya ukudla ne-urticaria.Ngakho-ke, lo mbono ukabili, kepha nge-edema isiza kahle. "

UVladimir, oneminyaka engama-63, eSt. ngaphandle komzimba.

Lakanye wathatha ngengozi enkulu umuthi. Kwakudakwe kakhulu. Kwadingeka ukuthi ngilaliswe esibhedlela ngenze ulwelwesi lwesisu. I-overdose ithinte isimo sezinzwa. Umbono ukhula kakhulu. Kodwa ngemuva kokuhoxiswa kwalo muthi, konke kancane kancane kwaqala ukubuyela kwesejwayelekile. Qiniseka ukuthi ubheka ukuhambisana nomthamo. "

U-Ana, oneminyaka engama-38, eMoscow: "Ngiphuza lo muthi kuphela lapho ubalulekile kakhulu ngalezo zikhathi lapho kungekho ezinye izidakamizwa ezisiza ekuguleni kwegazi. Ngenxa yomthelela omuhle wokugaya, ingcindezi isheshe yehle. Ikhanda liyayeka ukulimala nezimpawu zokuphuza zidlula cishe ngaphandle komkhondo. Angizwanga lutho olubi olungaphendulwayo. Umuthi ufanelekile, ngiyawuncoma kuwo wonke umuntu. Kepha udinga ukuthi uphuze amaphilisi kuphela njengoba kuchazwe udokotela, ngoba i-overdose igcwele impilo. "