Ama-Glucovans enzelwe abanesifo sikashukela. Isikhathi esiningi isetshenziswa lapho kungekho ukusebenza kwezinye izindlela zokwelapha, ukudla nokuzivocavoca.
Igama Lezwe elingafanele
I-Metformin + Glibenclamide.
I-ATX
A10BD02.
IGlucovans iyisidakamizwa soshukela.
Khipha amafomu nokwakheka
Umuthi uyatholakala ngefomethi yethebhulethi.
Izinto eziphambili ezisebenzayo:
- 500 mg metformin hydrochloride;
- glibenclamide ngevolumu engu-2,5-5 mg, kuya ngohlobo lokukhululwa.
Izinto ezengeziwe:
- i-magnesium stearate;
- i-povidone;
- i-croscarmellose sodium;
- I-MCC;
- i-povidone K-30;
- amanzi ahlanziwe;
- i-iron iron oxide;
- i-macrogol;
- i-iron iron oxide;
- I-Opadry 31F22700 noma i-Opadry PY-L-24808.
I-Glucovans yezidakamizwa iyatholakala ngesimo samathebulethi, lapho izithako ezisebenzayo eziyinhloko zi-metformin hydrochloride ne-glibenclamide.
Isenzo se-Pharmacological
Umuthi uyinhlanganisela yezidakamizwa zomlomo ze-hypoglycemic. I-Metformin hydrochloride iyi-greatuanide. Umuthi usiza ukunciphisa ukugxila kwe-glucose glucose. Akukwenzi kusebenze ukukhiqizwa kwe-insulin ngakho-ke akukukhuthazi ukuthuthukiswa kwe-hypoglycemia. I-Metformin ngokushesha inezindlela ezi-3 ezihlukile zesenzo se-pharmacotherapeutic:
- kunciphisa ukuhlanganiswa kwe-hepatic glucose ngokuvimbela i-glycogenolysis ne-gluconeogeneis;
- kukhulisa ukuzwela kwenamba yama-receptor entweni ye-insulin, ukusetshenziswa / ukusetshenziswa kweglucose ngamaseli emisipha;
- kuvimbela ukufakwa kweglucose emgodini wokugaya ukudla.
I-Glibenclamide ingenye yezinto ezithathwe kwi-sulfonylurea.
Amazinga we-glucose ancipha ngenxa yokuqalwa kokukhiqizwa kwe-insulin ngamaseli e-beta atholakala endaweni kumanyikwe.
Izinto okukhulunywa ngazo zinezindlela ezahlukahlukene zokwenziwa, kepha ziyahambelana ngokuhambisana komsebenzi we-hypoglycemic futhi zithuthukisa imisebenzi yamahomoni.
I-Pharmacokinetics
Lapho ihanjiswa ngomlomo, i-glibenclamide ingama-95% amuncwa amathumbu. Ukuqoqeka okuphezulu kwento ku-plasma kubonakala ngemuva kwamahora angama-4-4,5. Ihlukaniswe ngokuphelele esibindini. Isigamu sempilo singamahora ama-4 ukuya kwele-12.
Ngokuphathwa ngomlomo kwe-Glucovans yezidakamizwa, into yayo esebenzayo - i-glipenclamide - idonswa amaphesenti angama-95 isesibelethweni futhi iphukile ngokuphelele esibindini.
I-Metformin igxotshwa emgodini wokugaya ukudla. Izinga layo eliphezulu kunsamu litholakala kungakapheli amahora angama-2-2,5.
Cishe i-30% yaleyo nto idonswa amathumbu ngesimo esingaguquki. Ethambekele kokuthamba kalula, owembiwa izinso. Isigamu sempilo singamahora ayi-7. Ezigulini ezinenkinga yokwehluleka kwezinso, le nkathi inyuka yaba amahora angama-9 kuya kwayi-12.
Izinkomba zokusetshenziswa
Thayipha isifo sikashukela kubantu abadala:
- ukungabikho kwamandla ashukumisayo kusuka kokuzivocavoca, ukwelashwa kokudla kanye ne-monotherapy;
- ezigulini ezine-glycemia elawulwayo nezinzile.
Isifo sikashukela sohlobo II siyinkomba enkulu yokuthatha ama-Glucovans, kubandakanya neziguli ezine-glycemia ezinzile.
Contraindication
Umuthi awukwazi ukusetshenziswa kumacala alandelayo:
- ukukhulelwa kanye nokuncelisa;
- ukungabekezelelani ngakunye;
- uhlobo lwesifo sikashukela ketoacidosis;
- i-porphyria;
- amafomu obunzima besifo senhliziyo;
- ukwehluleka kwesibindi;
- ukwehluleka kwezinso nge-CC kuze kufike ku-60 ml / min;
- isifo sikashukela sikashukela / i-precoma;
- ukuhlanganiswa ne-miconazole;
- uhlobo olungamahlalakhona kotshwala nokudakwa okucasulwa ukusetshenziswa kotshwala;
- i-lactic acidosis;
- thayipha i-1 isifo sikashukela;
- ukungenelela kokuhlinzwa (okubanzi);
- izifo ezingamahlalakhona / ezinzima kakhulu ezihambisana ne-tishu hypoxia (kufaka phakathi ukuphefumula / ukuhluleka kwenhliziyo).
Ngokunakekela
Kuyinto engathandeki ukusebenzisa umuthi kubantu asebekhulile abasebenza kanzima. Lokhu kuhlotshaniswa nengozi ye-lactic acidosis kubantu baleli qembu.
Umuthi uqukethe i-lactose, ngakho-ke kunqunywa ngokuqapha kubantu abanezinhlobo ezingandile zezimpawu zofuzo ezihambisana ne-GGM syndrome, ukuntuleka kwe-lactase, noma i-hypersensitivity to galactose.
Ngaphezu kwalokho, umuthi ubekelwe ngokucophelela ukungapheleli kwe-adrenal, izifo ze-febrile kanye nezifo ze-yegilo.
Ungayithatha kanjani iGlucovans
Imithamo kunqunywa udokotela ngamunye. Okumaphakathi kokuqala - ithebhulethi eyi-1 isikhathi ngosuku. Inani lomuthi lingakhuphuka ngo-0.5 g we-metformin ne-5 mg ye-glibenclamide ngosuku njalo emavikini ambalwa kuze kube yilapho igxila likashukela egazini selizinzile.
Umthamo omkhulu ngamathebhulethi ayi-6 omuthi we-2,5 + 500 mg noma we-4 (5 + 500 mg).
Umuthi kufanele uphuzwe lapho kudliwa khona ukudla. Ngasikhathi sinye, ukudla kufanele kube nama-carbohydrate amaningi ngangokunokwenzeka.
Ukuthatha umuthi wesifo sikashukela
Isifo sikashukela esisebenzisa lesi sidakamizwa okukhulunywa ngaso kufanele siqinisekise ukulawulwa kweglucose yegazi nokulungiswa komthamo we-insulin.
Imiphumela Emibi Yama-Glucovans
Amapheshana wesisu
Ukulahlekelwa isifiso sokudla, ukungakhululeki esiswini, ukugabha / isicanucanu. Le Symbomatology ivame ukubonwa ekuqaleni kwezokwelapha bese ihamba zingakapheli izinsuku ezingama-3-4.
Izitho zeHematopoietic
Ezimweni ezingavamile, i-thromocytopenia, i-leukopenia, i-pancytopenia, i-aplasia yomongo, uhlobo lwe-hemolytic ye-anemia. Le miphumela engemihle inyamalala ngemuva kokumiswa kokusetshenziswa kwomuthi.
Isistimu yezinzwa ephakathi
Kusukela ohlangothini lwesistimu yezinzwa ephakathi, isiyezi esincane, ukudana, ukuhlaselwa ikhanda kanye nokunambitheka kwensimbi emgodini womlomo kungabonakala.
Engxenyeni yezitho zombono
Ezinsukwini zokuqala zokuphuza umuthi, ukukhubazeka okubukwayo kungenzeka ngenxa yokwehla kokuxineka kweglucose egazini.
Ngasohlangothini lwe-metabolism
Umphumela wecala ovame kakhulu yi-hypoglycemia. Lapho uthola i-megaloblastic hlobo anemia, ubungozi be-etiology efanayo kufanele bunakwe.
Umphumela wecala ovame kakhulu wokuthatha amaGlucovans yi-hypoglycemia.
Allergies
Ezimweni ezingavamile, i-anaphylaxis. Ukusabela kokungabekezeleli komuntu ngamunye kwe-sulfonamide derivatives kungabonakala.
Umthelela ekhonweni lokulawula izindlela
Isiguli kufanele saziswe ngamathuba okukhula kwe-hypoglycemia nokuthi uma ushayela, usebenza ngezindlela eziyinkimbinkimbi futhi ezimweni lapho kudingeka ukunakwa kakhulu, kufanele aqaphele.
Imiyalo ekhethekile
Sebenzisa ebudaleni
Kumuntu kuleli qembu, imithamo imiselwe ngokuya ukusebenza kwezinso.
Inani lokuqala akufanele libe ngaphezulu kwethebhulethi eyi-2,5 + 500 mg. Kulokhu, isiguli kufanele sinikezwe ukuqapha izinso.
Ukuyalela izingane zeGlucovans ezinganeni
Akunconyelwe ukusetshenziswa ezigulini zeminyaka emincane.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi awuthathekile ukusisebenzisa ngesikhathi sokukhulelwa. Lapho uhlela ukukhulelwa, umuthi kufanele ukhanseliwe bese kuqalwa ukwelashwa kwe-insulin.
Lapho uhlela ukukhulelwa, umuthi weGlukvans kumele ukhanseliwe.
Isicelo sokusebenza kokulimala kwezinso
Akunconyelwe ukusetshenziswa kubantu abanenkinga yokwehluleka okukhulu.
Sebenzisa umsebenzi wesibindi okhubazekile
Kubantu abanokwehluleka kwesibindi, umuthi ubekwa ngokuqapha ngokweqile.
I-Glucovans overdose
Uma uthathwa ngemithamo ephezulu, i-hypoglycemia ingavela. Ukweqisa okwenziwe isikhathi eside kungaholela ku-lactic acidosis, ukuphefumula okungajulile nezinye izinkomba ezingezinhle.
Izimpawu ezinesizotha / ezithambile ze-hypoglycemia ngenkathi kugcinwa ukwazi iziguli kungalungiswa ngoshukela. Ezimweni ezinjalo, isiguli sidinga ukulungiswa komthamo nokudla okunempilo.
Ukuvela kwezinkinga ezinzima ze-hypoglycemic kuma-diabetesics kubandakanya ukunikezwa okuphuthumayo kokunakekelwa kwempilo.
Uma kwenzeka kuba nezinkinga ezinzima uma kunokweqisa kwemithi ye-Glucovans, kudingeka usizo lwezokwelapha oluphuthumayo.
Umuthi awususwa ngesikhathi senqubo yokudayela.
Ukuxhumana nezinye izidakamizwa
Inhlanganisela ehlanganisiwe
Lapho uhlanganisa umuthi okubuzwa ngawo nge-miconazole, kunobungozi be-hypoglycemia, okungaholela ekhefeni.
Ukusetshenziswa kwe-iodine kufanele kunikezwe amahora angama-48 ngaphambi kokuthatha umuthi, noma ngabe kungukuphi isidlo.
Akuhlanganisiwe ukuhlanganisa
I-Phenylbutazone inyusa umphumela we-hypoglycemic we-sulfonylurea. Kungcono ukuthi unikeze izintandokazi kwezinye izidakamizwa ezilwa nokuvuvukala ezinomphumela omncane kakhulu.
Ukuhlanganiswa kwe-glibenclamide, utshwala ne-bosentan kukhulisa amathuba okuba nemiphumela ye-hepatotoxic. Kuyelulekwa ukuthi ungahlanganisi lezi zinto ezisebenzayo.
Inhlanganisela edinga ukuqashelwa
Imithamo ephezulu ye-chlorpromazine ne-danazol inyusa i-glycemia, inciphisa ukukhiqizwa kwe-insulin. Lapho uhlanganisa umuthi kanye namatafula okukhulunywa ngawo, isiguli kufanele sixwayiswe ngesidingo sokulawula ukugcwala kwe-plasma ye-glucose.
I-Tetracosactide ne-glucocorticosteroids zivusa ukugcwala kwe-plasma ye-glucose futhi kungaholela ketetosis. Ngale nhlanganisela, isiguli kufanele silawule izinga le-glucose egazini. Ama-diuretics kanye nokutholwa kwe-coumarin kungenzeka kube nomphumela ofanayo.
Ngokuhlanganiswa kwesidakamizwa i-Glucovans ene-glucocorticosteroids, isiguli kufanele siqaphe izinga le-glucose egazini.
Ukusetshenziswa okufanayo kwesidakamizwa nge-fluconazole ne-ACE inhibitors kukhulisa impilo yengxenye ye-glibenclamide ngengozi yezimpawu ze-hypoglycemic.
Ukuhambisana notshwala
Ngesikhathi sokusebenzisa umuthi, ukusetshenziswa kwama-ethanol aqukethe ama-ethanol notshwala kufanele kugwenywe.
Ama-Analog
- I-Glybophor;
- I-Glibomet;
- IDuotrol;
- I-Douglimax;
- I-Amaryl;
- Dibizide M;
- Avandamet;
- IVokanamet.
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela
Ayikwazi ukutholwa ngaphandle kwemvume kadokotela.
Malini
Intengo emakhemisi aseRussia iqala kusuka kuma-ruble angama-270. iphakethe ngalinye lamathebulethi angama-30 we-2,5 + 500 mg.
I-Amaril ingesinye sezichasiso zesidakamizwa i-Glucovans.
Izimo zokugcina zomuthi
Imiyalo ithi kuyadingeka ukugcina umuthi ngaphansi kwezimo ezishisayo ngaphakathi kuka + 15 ° ... 26 ° C. Gwema kude nezilwane ezifuywayo nezingane.
Isikhathi sokuphelelwa yisikhathi
Kufika eminyakeni emi-3.
Umkhiqizi
Inkampani yaseNorway-French Merck Sante.
Ukubuyekezwa kwe-Glucovans
Odokotela
U-Alevtina Stepanova (owelaphi), oneminyaka engama-43 ubudala, eSt
Umuthi ophephile futhi osebenzayo. Lolu khetho oluhle kakhulu uma i-monotherapy nezinye izidakamizwa, ukusebenza ngokomzimba nokudla kunganikeli umphumela oyifunayo.
UValery Torov (owelaphi), oneminyaka engama-35, u-Ufa
Imiphumela emibi lapho uthatha lo muthi uvame ukubonwa, kepha inesimo esifushane futhi idlulisa yodwa ezinsukwini zokuqala emva kokuqala kokwelashwa. Ngithanda intengo esebenza kahle futhi engabizi emthini.
I-Glucovans yezidakamizwa isatshalaliswa kuphela ngokuya ngomuthi, umuthi kufanele ugcinwe emazingeni okushisa angaba ngu-+ 15 ° C kuya ku- + 26 ° C.
Iziguli
ULyudmila Korovina, oneminyaka engama-44, uVologda
Ngiqale ukuphuza i-1 i-tablet yemithi njalo ekuseni. Ukugxila kweshukela ku-serum kwehle kusuka ku-12 kuye ku-8. Izinkomba eziseduze zizinza ngokuphelele. Ngaphambi kwalokhu, awuzange usize amakhambi okwelapha noma umuthi. Kwangimangaza ukuthi netheyithimenti encane yokuqala “iyasebenza” futhi inika amandla amahle. Manje ngithanda ukwenza izinqubo ezivela ezinhlamvwini zempilo, bese impilo yami izofana nasebusheni bami.
UValentina Sverdlova, oneminyaka engama-39 ubudala, eMoscow
Umyeni wami wayejwayele ukusebenzisa iBagomet, noma kunjalo, wanyamalala emakhemisi asendaweni yakithi, futhi asisekho isikhathi noma umzamo wokuya esikhungweni kusihlwa ngemuva komsebenzi. Isimo somlingani saqala ukuwohloka. Ushukela wawuphakeme njalo, amanyikwe aqala ukungasebenzi kahle, ngisho nezindebe zajika zaba luhlaza okwesibhakabhaka. Udokotela weluleke ukusebenzisa lesi sidakamizwa. Ezinsukwini ezimbalwa zokuqala, lowo oshade naye wayeba nesiyezi esincane, kodwa ngokushesha ukungajabuli kwaphela, futhi ushukela wehla waya ku-8.
