I-Lorista ND yisidakamizwa esisebenzayo esisetshenziswa emkhakheni wezokwelapha ukuze kuzinze umfutho wegazi futhi welaphe i-pathologies yesistimu yehliziyo nenhliziyo. Ingasetshenziswa njengesidakamizwa esizimele futhi njengengxenye yokwelapha ngezidakamizwa ze-antihypertensive.
Igama Lezwe elingafanele
IVenfaxx.
I-Lorista ND umuthi ophumelelayo osetshenziselwa ukuqinisa umfutho wegazi futhi welaphe i-pathologies yesistimu yenhliziyo.
I-ATX
Ayikho i-C09DA01.
I-Losartan kuhlangene ne-diuretics.
Khipha amafomu nokwakheka
Kuyatholakala ngesimo sethebhulethi. Kuhloswe ukusetshenziswa komlomo. Amacwecwe aqukethe izithako ezilandelayo ezisebenzayo:
- isithako esikhulu esisebenzayo yi-losartan, 100 mg;
- hydrochlorothiazide - 25 mg.
Umuthi uyatholakala kumthamo ka-12, 25, 50 no-100 mg.
ILorista ND iyatholakala ngesimo sethebhulethi.
Isenzo se-Pharmacological
I-Lorista ingeqembu le-pharmacological lezidakamizwa ezihlangene ze-antihypertensive. Inezici ze-diuretic.
Umuthi unomphumela olandelayo:
- Kwandisa ukuzivumelanisa nemithwalo yomzimba ezigulini ezihlushwa ukuhluleka kwenhliziyo okwenzeka ngendlela engapheli.
- Isiza ukuvimba i-angiotensin 2, inciphise ukugcwala kwe-aldosterone ku-plasma yegazi.
- Kwandisa umsebenzi we-plasma creatinine.
- Isiza ukwandisa umsebenzi wesibindi nama-enzymes wesibindi.
Ngenxa yenhlanganisela efanelekile yezithako ezisebenzayo ezifakwayo, ubungozi bokuqhamuka ne-hyperuricemia (ukwanda kwe-uric acid egazini), okujwayelekile ukusetshenziswa kwezidakamizwa ze-diuretic, kuyancishiswa. Ngenxa yomphumela we-diuretic, ususa ngempumelelo ukuvuvukala ebusweni, imikhawulo ephezulu nangaphansi.
I-Pharmacokinetics
Iqoqo eliphezulu lezinto ezisebenzayo livela ihora elilodwa ngemuva kokuthatha amaphilisi. Umphumela wokwelapha uhlala amahora angama-3-4. Cishe i-14% ye-losartan, ethathwe ngomlomo, ifakwa emzimbeni wayo kwi-metabolite yayo esebenzayo. Ukuphila kwesigamu kwe-losartan kungamahora ama-2. IHydrochlorothiazide ayikhiqizwanga umzimba futhi isheshe idululwe ngezinso.
Yini esiza?
Umuthi unqunywe ezimweni ezinjalo:
- Umfutho wegazi ophezulu we-Arterial.
- Njengendlela yokwelapha yokusekela yokunciphisa ukushona kwabantu abahlushwa i-hypertrophic yasesandleni noma i-hypertension enzima.
- Ukuvimbela ebungozini bokushaywa yimizwa, ukushaya kwenhliziyo, ukulimala kwe-myocardial ku-pathologies yesistimu yenhliziyo.
- Hypersensitivity nokungabekezelelani ngakunye kuma-inhibitors e-isoenzyme.
- I-hypertension ye-arterial, ikhula ngokumelene nesizinda sikashukela i-mellitus, ukwehluleka kwezinso.
- Ukwehluleka okukhulu kwenhliziyo.
- I-Myocardial infarction kwifomu elibi.
- Ukwehluleka kwenhliziyo kuyinkimbinkimbi ngezinqubo ezihambisanayo ezishubile.
Isidakamizwa sinconywa njengengxenye ebalulekile yokwelashwa okuhloswe ngayo ukulungiselela iziguli umsebenzi wokulimala we-renal we-hemodialysis.
Umuthi unganconywa njengengxenye yokwelashwa okuyinkimbinkimbi okuhloswe ngayo ukulungiselela iziguli umsebenzi wokuphazamiseka wezinso okhubazekile we-hemodialysis.
Kukuziphi izingcindezi zokucindezela?
Umuthi usebenza ngempumelelo emfucweni wegazi ophakeme, unomthelela ekuqineni kwawo ngokushesha.
Contraindication
Kunqatshelwe ngokuphelele ukusebenzisa i-Lorista uma:
- I-Pathology yezinso, iqhubeka ngendlela enzima.
- Umsebenzi wesibindi ongasebenzi kahle.
- Anuria.
- Ukungabekezelelani komuntu ngamunye noma i-hypersensitivity kuzakhi ezisebenzayo zomuthi.
- Ukwanda kokuhlushwa kwe-urea.
- Ukwephulwa kokusebenza kwepheshana elisebenzayo.
- Ukwanda kokuthambekela kokusabela komzimba.
- Ukwehla komzimba.
- I-Hypersensitivity ye-lactose, ukungabukeli kwayo komzimba.
- Ukubonakaliswa kwe-hypotension ye-arterial, kuqhubeka ngendlela enzima, enamandla.
- Gout.
- I-Cholestasis.
Ukusetshenziswa kwesidakamizwa nge-gout akuvunyelwe ngokuphelele.
Ukusetshenziswa kwomuthi ngesikhathi sokwelashwa kwe-diuretic akunconywa.
Ngokunakekela
Ngokuqapha okwandayo, uLorista ubekelwe iziguli ezinalezi zifo ezilandelayo:
- isifo sikashukela mellitus;
- isifuba somoya;
- izifo ezingapheli zegazi;
- ukwephula ibhalansi elenziwa ngamanzi-emzimbeni;
- i-stenosis yemithambo yemithambo yezinzwa;
- ukwephulwa kokujikeleza kwegazi kanye ne-microcirculation;
- isifo se-coronary artery;
- i-cardiomyopathy;
- I-arrhythmia evela ngesimo esibi ngokumelene nesizinda sokuhluleka kwenhliziyo.
Kuzo zonke lezi zimo, umuthi unqunyelwe imithamo emincane, futhi inkambo yokwelashwa ingaphansi kokuqashwa okuqinile kwezokwelapha.
Ungayithatha kanjani iLorista ND?
Yakhelwe ukusetshenziswa kwasendlini. Kudliwa amaphilisi ngemuva kokudla, kugezwe ngamanzi amaningi ahlanzekile. Umthamo ofanele uqokwa ngokuya ngohlelo olulodwa olubheka isigaba seminyaka seziguli kanye nesifo esitholakala kuye.
Umthamo omkhulu wezinsuku zonke weLorista akufanele udlule i-50 mg.
Kwezinye izimo, umthamo unganyuswa ngudokotela uye ku-100 mg umuthi ngosuku. Isikhathi esiphakathi sokwelashwa sisuka kumaviki amathathu kuya ezinyangeni eziyi-1.5.
Kudliwa amaphilisi ngemuva kokudla, kugezwe ngamanzi amaningi ahlanzekile.
Ukwelashwa kuqala ngemithamo emincane - ukusuka kuma-12-13 mg uLorista ngosuku. Ngemuva kwesonto, umthamo wansuku zonke uyanda ube ngu-25 mg. Ngemuva kwalokho amaphilisi athathwa ngemthamo ka-50 mg.
Nge-hypertension ye-arterial, umthamo wansuku zonke ungasukela ku-25 uye ku-100 mg. Lapho unquma imithamo emikhulu, nsuku zonke kufanele ihlukaniswe kabili. Ngesikhathi sesifundo sokwelashwa ngethamo elinyukayo lezidakamizwa ze-diuretic, i-Lorista inqunywe inani lama-25 mg.
Kudingeka umthamo oncishisiwe kwiziguli ezinenkinga yokusebenza kwe-hepatic, ukwehluleka kwezinso.
Ngoshukela
Ukwelashwa kuqala ngomthamo we-50 mg. Amathebhulethi athathwa isikhathi esingu-1 ngosuku. Esikhathini esizayo, umthamo unyuswa waba ngu-80-100 mg, nawo uthathwa kanye ngosuku.
Esikhathini sikashukela i-mellitus, ukwelashwa kuqala ngomthamo we-50 mg.
Imiphumela emibi uLorista ND
Ukwemukelwa kweLorista kungavusa ukubukeka kokungathandeki okunjengokuthi:
- i-myalgia;
- ukulimala kohlelo lwe-musculoskeletal;
- ukwephulwa komsebenzi we-erectile;
- buthaka isifiso sobulili;
- ukuchama njalo;
- ukujuluka ngokweqile;
- ukwephulwa kwemisebenzi yokubonakalayo, yokunambitha kanye neye-olodoory;
- ukweqisa kwesikhumba;
- Ubuhlungu emhlane;
- isifo sekhwehlela;
- i-rhinitis;
- ubunzima bokuphefumula;
- izibonakaliso zesifo somoya (brunchial asthma).
Imiphumela emibi eminingi yenzeka lapho isiguli sine-contraindication noma ngenxa yesibalo sethamo esingalungile. Ucwaningo luye lwabonisa ukuthi ukusetshenziswa kweLorista kungavusa ukungasebenzi kwezindlala ze-parathyroid.
Amapheshana wesisu
Okungaba khona:
- ukuthopha;
- isicanucanu kanye nezikhathi zokuhlanza;
- ukuphazamiseka kwesitulo;
- i-gastritis
- Ubuhlungu esiswini.
Ukwemukelwa kweLorista kungavusa ukuphazamiseka kwesitulo.
Izitho zeHematopoietic
Isifo seShenlein Genoch, i-anemia, sinciphile i-hemoglobin egazini, i-bradycardia, ukuphazamiseka kwesigqi senhliziyo, izinhlungu esifubeni.
Isistimu yezinzwa ephakathi
Ukuhlaselwa ikhanda, ukudangala, ukuphazamiseka kokulala, ukwehluleka, i-fatigue syndrome, isiyezi, ukuncipha kwekhono lokukhumbula ulwazi olusha nokuhlushwa, ukuhlangana okungahambi kahle kokunyakaza.
Ukuhlaselwa kwekhanda kungenzeka lapho uthatha uLorista.
Allergies
Umuthi ungavusa ukuthuthuka kokungezwani komzimba, kuboniswe ngesimo se:
- i-rhinitis;
- ukukhwehlela
- imichilo yesikhumba njengamakhuba;
- isikhumba esikhanyayo.
Imiyalo ekhethekile
Ngenxa yomthelela omkhulu ohlelweni lwezinzwa oluphakathi nokwehla komfutho wegazi ngesikhathi sokwelashwa, uLorista kungcono ukwenqaba ukulawula imishini nezimoto.
Ngesikhathi sokulashwa, uLorista ungcono ukwenqaba ukushayela imishini nezimoto.
Ngesikhathi sokufunda, kunconywa ukubheka amazinga we-calcium ukuze ugweme ukuthuthukiswa kwe-hypercalcemia.
Sebenzisa ebudaleni
Abantu beminyaka yobudala obudala banqunywa kumithamo emincane. Inkambo yokwelashwa kufanele ibe ngaphansi kokuqashwa okuqinile kwezokwelapha.
Ukuqokwa kwezingane zeLorista ND
Ngenxa yomthelela ongafundwe kaLorista emzimbeni wezingane, lesi sidakamizwa asisetshenziselwa ukwelapha izingane ezingaphansi kweminyaka yobuningi.
Umuthi awusetshenziselwa ukwelapha izingane ezingaphansi kweminyaka yobudala obuningi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngenxa yomthelela wayo onobuthi, umuthi ungathinta kabi ukwakheka kohlelo lwezinhliziyo nemithambo yezinzwa yengane ngesikhathi sokukhula kwengane, okugcwele ukufa. Ingozi ebusaneni ikhulu ikakhulukazi kuma-trimesters amabili okuqala okukhulelwa. Ngalesi sizathu, iLorista ayisetshenziselwa ukwelapha abesifazane abakhulelwe.
Musa ukusebenzisa uLorista ngesikhathi sokuncelisa. Uma kunesidingo, ukusetshenziswa kwalesi sidakamizwa se-antihypertensive kudluliselwa okwesikhashana kokuphakelayo okufakwayo.
Isicelo sokusebenza kokulimala kwezinso
Uma kwenzeka ukungasebenzi kahle kwe-renal okuqinile ukuya kobukhulu obulinganiselwe, umuthi unqunywe kwimithamo ejwayelekile. Ezimweni ezibucayi kakhulu, isinqumo sethamo elifanele nokwenzakala kokusebenzisa iLorista sithathwa ngudokotela ngawodwana.
Uma kwenzeka ukungasebenzi kahle kwe-renal okuqinile ukuya kobukhulu obulinganiselwe, umuthi unqunywe kwimithamo ejwayelekile.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukuba khona kokuphazamiseka kwe-hepatic function, i-cirrhosis yesibindi kuphakamisa ukunikezwa okucophelela komuthi kanye nokwehla komthamo wansuku zonke ojwayelekile.
I-Overdose Lorista ND
Ibonakala ngendlela yezimpawu ezilandelayo:
- Ukuvuvukala kobuso, imikhawulo ephezulu nangaphansi.
- Isifo sokuwa.
- Pallor ngokweqile kwesikhumba.
- Ukuvuvukala kwezindebe nolimi.
- Ukukhwehlela.
- Umsebenzi wokuphefumula okhubazekile.
- Umkhuhlane.
Uma kwenzeka kweqisa ngokweqile, isiguli sidinga ukunakekelwa okuphuthumayo kwezokwelapha, ukugcwala kwesisu, kanye nokudla izangoma.
Ngezimpawu ezinjalo, isiguli sidinga ukunakekelwa okuphuthumayo kwezokwelapha, ukugcwala kwesisu, nokusebenzisa izangoma. Ukwelashwa okuqhubekayo kuyimpawu. Ngaphandle kwalokho, ubungozi bokuphelelwa ngumzimba komzimba nokwanda kwe-hepatic coma, okugcwele ukufa kwesiguli.
Ukuxhumana nezinye izidakamizwa
Ngokusetshenziswa kanyekanye kweLorista nezinye izidakamizwa ze-antihypertensive, ukwehla okusheshayo nangokuphumelelayo kwezinkomba zokucindezela kwegazi kutholakala.
Ukuhlanganiswa kwama-antidepressants kanye nama-antipsychotic kungabangela ukukhula kokuwa.
AmaBarbiturates nama-inhliziyo glycosides ahlangana kahle neLorista, ngokungafani neRifampicin, ehlisa ukusebenza kwalesi sidakamizwa. I-Asparkum iyahambisana neLorista, kodwa ngokusetshenziswa kanyekanye kwale mishanguzo, kuyanda ukulawula amazinga e-calcium.
Ukuhambisana notshwala
Ngesikhathi sokwelashwa, uLorista ngokwezifiso waphula umthetho wokusetshenziswa kotshwala. I-ethyl alcohol iyandisa ingozi yesiguli yokuthola izinkinga eziyingozi njengokuhlaselwa yisifo senhliziyo nemivimbo.
Ngesikhathi sokwelashwa, uLorista ngokwezifiso waphula umthetho wokusetshenziswa kotshwala.
Ama-Analog
Umuntu obambele lesi sidakamizwa uLorista N. Izidakamizwa ezilandelayo zingaba enye indlela ye-losartan:
- IVasar;
- Cozaar;
- ILozal Plus;
- IGizaar.
Uyini umehluko phakathi kweLorista neLorista ND
Umehluko omkhulu ukuthi ukwakheka kweLorista ND kufaka i-hydrochlorothiazide, esiza ukunciphisa i-sodium reabsorption. Ngaphezu kwalokho, izindleko zeLorista ziphansi. Kepha zombili lezi zidakamizwa ziyizichazamazwi eziguqukayo ezinomphumela we-hypotensive.
Imibandela yekhefu lekhemisi
Kudingeka umuthi ukuthenga umuthi.
Kudingeka umuthi ukuthenga umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha.
Intengo yeLorista ND
Izindleko ziyahlukahluka kusuka kuma-ruble angama-230 kuye kwangama-450.
Izimo zokugcina zomuthi
Lesi sidakamizwa sinconywa ukuba sigcinwe endaweni emnyama, epholile ngaphandle kokutholwa yizingane. Isitoreji sokushisa esifanele sifinyelela ku- + 30 ° C.
Lesi sidakamizwa sinconywa ukuba sigcinwe endaweni emnyama, epholile ngaphandle kokutholwa yizingane.
Isikhathi sokuphelelwa yisikhathi
Akudlule iminyaka eyi-5, ngemuva kokuphela kwesikhathi kwethemu akuvunyelwe ngokuphelele ukwamukela.
Umkhiqizi
Inkampani yezokwelapha yaseSlovenia iKrka.
Ukubuyekezwa mayelana neLorista ND
Ngenxa yezakhiwo zayo eziningi ezizuzisayo nezenzo ezisheshayo, lo muthi uzuze inani elikhulu lokubuyekezwa okuhle okuvela kuzo zombili iziguli nodokotela.
Izazi zezenhliziyo
UValeria Nikitina, udokotela wezifo zenhliziyo, eMoscow
Ukusetshenziswa kweLorista ND kukuvumela ukuthi uyeke ukuthuthukiswa kwezinkinga eziyingozi ezinjalo ze-pathologies yesistimu yethambo lokubeletha njengokuhlaselwa yisifo sohlangothi kanye ne-myocardial infarction. Kwimithamo ekhethwe kahle, umuthi ubekezelelwa kahle yiziguli ngaphandle kokuthuthukiswa kwemiphumela emibi.
UValentin Kurtsev, uprofesa, isazi sezinhliziyo, Kazan
Ukusetshenziswa kweLorista kudlangile emkhakheni wenhliziyo. Ukuzivocavoca kwezokwelashwa kanye nemiphumela yokuhlolwa kwemitholampilo kufakazele ukuthi umuthi unciphisa kakhulu ukushona kweziguli ezinesifo senhliziyo nesifo somfutho wegazi ophakeme.
Umuthi uzuze inani elikhulu lokubuyekezwa okuhle okuvela kuzo zombili iziguli nodokotela.
Iziguli
UNina Sabashuk, oneminyaka engama-35, eMoscow
Sekuphele iminyaka eyi-10 ngihlushwa umfutho wegazi ophakeme. Ngemuva kokutholakala ukuthi ngine-hypertension, ngaphuza izidakamizwa eziningi, kepha ukusebenzisa iLorista ND kuphela kuyangivumela ukuthi ngisheshe ngiqinise isimo sami futhi ngibuyele empilweni yami ejwayelekile ezinsukwini ezimbalwa.
UNikolay Panasov, oneminyaka engama-56, Ukhozi
Ngamukela uLorista ND iminyaka eminingana. Umuthi ngokushesha uletha ukucindezela kokujwayelekile, unikeza umphumela omuhle wokugaya. Futhi intengo yomuthi iyabiza, nakho kubalulekile.
U-Alexander Panchikov, oneminyaka engama-47, eYekaterinburg
Nginokuhluleka kwenhliziyo ngenkambo engapheli. Ngokukhulisa lesi sifo, udokotela uyalela ukuthi bathathe amaphilisi eLorista ND. Ngenelisekile ngemiphumela. Yize kungaba nemiphumela emibi ebanzi ebanzi, lo muthi uqhamuke kahle.
