Umuthi ungasetshenziswa njengesilinganiso esiyinhloko sokwelashwa noma, kanye nezinye izindlela zokuphazamiseka kwenhliziyo. Lesi sidakamizwa se-antihypertensive, kepha ngasikhathi sinye ezinye izimo ze-pathological ziqedwa ngosizo lwayo. Ikhiqizwa ngendlela yamathebulethi. Umuthi ubonakala yindawo emincane yokusetshenziswa.
Igama Lezwe elingafanele
Losartan.
I-ATX
C09CA01 Losartan.
Umuthi ungasetshenziswa njengesilinganiso esiyinhloko sokwelashwa noma, kanye nezinye izindlela zokuphazamiseka kwenhliziyo.
Khipha amafomu nokwakheka
Umuthi wenziwa ngesimo esiqinile. I-Potassium losartan isebenza njengengxenye esemqoka esebenzayo. Ukuhlushwa kwethebhulethi engu-1 ngu-50 mg. Ezinye izinto ezingasebenzi:
- i-lactose monohydrate;
- i-microcrystalline cellulose;
- isitashi samazambane;
- i-povidone;
- i-magnesium stearate;
- isitashi se-sodium carboxymethyl;
- i-silicon dioxide colloidal.
Umuthi wenziwa ngesimo esiqinile.
Isenzo se-Pharmacological
Umsebenzi oyinhloko wesidakamizwa yikhono lokwenza ngokwejwayelekile izinga lomfutho wegazi. Lokhu kungenzeka kuhlinzekwa ngokuvimbela ukuvela kwemiphumela yomzimba okubangelwa ukubopha kwama-agonists nama-angiotensin II receptors. Into esebenzayo eBlocktran ayithinti i-enzyme kinase II, enomthelela ekubhujisweni kwe-bradykinin (i-peptide ngenxa yokuthi imithambo ikhulisa, kwehla umfutho wegazi).
Ngaphezu kwalokho, le ngxenye ayithinti ama-receptor amaningi (ama-hormone, iziteshi ze-ion) ezinegalelo ekwakheni ukuvuvukala neminye imiphumela. Ngaphansi kwethonya le-losartan, kuye kwashintsha ushintsho ekugxambeni kwe-adrenaline, i-aldosterone egazini. Ngaphezu kwalokho, le nto imele iqembu lama-diuretics - ikhuthaza ukuphuma komzimba. Ngenxa yesidakamizwa, amathuba okuthuthuka kwe-myocardial hypertrophy ayancishiswa, iziguli ezingenele ukusebenza kwenhliziyo zibekezelela kangcono ukusebenza komzimba okwandayo.
Umsebenzi oyinhloko wesidakamizwa yikhono lokwenza ngokwejwayelekile izinga lomfutho wegazi.
I-Pharmacokinetics
Izinzuzo zaleli thuluzi zifaka ukumuncwa ngokushesha. Kodwa-ke, i-bioavailability yayo iphansi impela - ama-33%. Izinga eliphakeme lokusebenza lutholakala ngemuva kwehora eli-1. Ngesikhathi sokuguqulwa kwento esemqoka esebenzayo, kukhululwa i-metabolite esebenzayo. Inani eliphakeme kakhulu lokwenza kahle ukwelashwa litholakala ngemuva kwamahora ama-3-4. Umuthi ungena kwi-plasma yegazi, okuyisibonakaliso sokubopha kwamaprotheni - 99%.
ILosartan ayiguquki ngemuva kwamahora angu-1-2. I-metabolite ishiya umzimba ngemuva kwamahora angama-6-9. Iningi lomuthi (60%) likhishwa ngamathumbu, amanye - ngokuchama. Ngezifundo zemitholampilo, kwatholakala ukuthi ukuqoqwa kwengxenye eyinhloko ku-plasma kukhula kancane kancane. Umphumela omkhulu we-antihypertensive unikezwa ngemuva kwamasonto angu-3-6.
Ngemuva komthamo owodwa, umphumela oyifunayo ngesikhathi sokwelashwa utholakala ngemuva kwamahora ambalwa. Iqoqo lama-losartan liyehla kancane kancane. Ukuqedwa ngokuphelele kwale nto kuthatha usuku olu-1. Ngenxa yalesi sizathu, ukuthola umphumela owuthandayo wokwelapha, kuyadingeka ukuthatha umuthi njalo, kulandela uhlelo.
Iningi lomuthi (60%) likhishwa ngamathumbu, amanye - ngokuchama.
Izinkomba zokusetshenziswa
Umenzeli unqunyelwe umfutho wegazi ophakeme. Ezinye izinkomba zokusebenzisa iBlocktran:
- ukungakwaneli kokusebenza kwenhliziyo ngesimo esingamahlalakhona, inqobo nje uma ukwelashwa kwangaphambili nge-ACE inhibitors kungazange kunikeze umphumela oyifunayo, kanye nasezimweni lapho i-ACE inhibitors inikela khona ekuthuthukiseni ukusabela okungekuhle futhi akunakwenzeka ukuyithatha;
- ukugcina umsebenzi wezinso kuhlobo lwesifo sikashukela sohlobo 2 esitholakele, kunciphisa ukuqina kokuthuthukiswa kokungapheleli kwalesi sitho.
Ngenxa yalomuthi, kukhona ukwehla kwamathuba okuba kwakheke kobuhlobo phakathi kwezifo zesistimu yenhliziyo nokufa kwabantu.
Contraindication
Imikhawulo ekusetshenzisweni kweBlocktran:
- hypersensitivity kunoma yiziphi izingxenye zomuthi;
- Izimo eziningana zesimo sokuzalwa sendalo eyindlalifa: ukungabekezelelani kwe-lactose, i-glucose-galactose malabsorption syndrome, ukuntuleka kwe-lactase.
Umenzeli unqunyelwe umfutho wegazi ophakeme.
Ngokunakekela
Uma isifo se-coronary, izinso, inhliziyo noma ukwehluleka kwesibindi (i-stenosis kwemithambo yezinso, i-hyperkalemia, njll.) Kutholakala, kubalulekile ukusebenzisa umuthi ngaphansi kokuhlolwa udokotela, uqaphela umzimba ngokucophelela. Uma kwenzeka ukuvela kokubi, inkambo yokwelashwa ingaphazamiseka. Lezi zincomo zisebenza kumacala lapho i-angioedema ithuthukile khona noma umthamo wegazi wehlisiwe.
Ungayithatha kanjani iBlocktran
Umthamo wansuku zonke yithebhulethi eyi-1 enokuhlunga kwento esebenzayo ka-50 mg. Ngomfutho wegazi ongalawulwa, kuvunyelwe ukwandisa leli nani liye ku-100 mg ngosuku. Ihlukaniswe ngemithamo emi-2 noma ithathwe kanye ngosuku. Ezimweni ezahlukahlukene zokugula, umthamo wokuqala wansuku zonke ungaphansi kakhulu:
- ukwehluleka kwenhliziyo - 0,0125 g;
- ngokwelashwa kanyekanye nge-diuretics, umuthi unqunywe kumthamo ongadluli ku-0,025 g.
Ngokwesilinganiso esinjalo, umuthi uthathwa isonto lonke, khona-ke umthamo unyuswa kancane. Lokhu kufanele kuqhutshwe kuze kufike umkhawulo wansuku zonke we-50 mg ofinyelela.
Umthamo wansuku zonke yithebhulethi eyi-1 enokuhlunga kwento esebenzayo ka-50 mg.
Ukuthatha umuthi wesifo sikashukela
Kunconywa ukuthi uqale ukwelashwa nge-0.05 g ngosuku. Kancane kancane, umthamo unyuka ufinyelele ku-0,1 g, kepha kufanele ubheke njalo izinga lomfutho wegazi.
Imiphumela emibi yeBlocktran
Ezimweni eziningi, lesi sidakamizwa sibekezelelwa kahle. Uma kuvela izimpawu ezingezinhle, kuvame ukunyamalala zodwa, kanti asikho isidingo sokukhansela umuthi. Imiphumela emibi evela ezithweni zezinzwa ingakhula: umsebenzi wokubona ongaboni, i-tinnitus, amehlo avutha, i-vertigo.
Amapheshana wesisu
Ubuhlungu esiswini, isisu sobunzima, isihlalo soketshezi, ushintsho ekugayweni, isicanucanu nokuhlanza, ukwanda kwegesi, izinqubo ezigugayo esiswini, umlomo owomile.
Izitho zeHematopoietic
I-anemia, i-ecchymosis, i-Shenplein-Genoch nsomi.
Isistimu yezinzwa ephakathi
Ubuhlungu bekhanda, isiyezi, umuzwa wokukhathazeka, ohambisana nomuzwa ovuthayo. Ukweqa, ukuphambuka kwengqondo (ukudangala, ukuhlaselwa ukwethuka nokukhathazeka), ukuphazamiseka kokulala (ukozela noma ukuqwasha), ukwehluleka, ukwethuka kwezinto eziphelele, ukuncipha kokuxineka, ukukhubazeka kwenkumbulo, ukungazi kahle kanye nokuquleka kuyaphawulwa.
Ngemuva kokuphuza umuthi, kungahle kube nobuhlungu esiswini.
Kusuka ohlelweni lomchamo
Ukungasebenzi ngocansi emadodeni, ubunzima bokuchama, kunamandla kunabantu abanempilo, ukuthambekela kokukhula kwezifo ezithathelanayo.
Kusuka ohlelweni lokuphefumula
Ukukhwehlela, i-rhinitis, ukuqubuka kwamakhala, ukuphuma kwe-sinus. Izifo eziningana zokuvuvukala ziyaphawulwa futhi: i-bronchitis, pharyngitis, laryngitis.
Engxenyeni yesikhumba
Ukoma ngokweqile kwesikhumba, ukulunywa, i-erythema, ukuqunjelwa, ukuncipha kwezinwele okukhulu, okuholela ekuthempeni. I-Hyperhidrosis, imichilo, isikhumba, kanye nokuzwela okwengeziwe kokukhanya nakho kuyaphawulwa.
Kusuka ohlelweni lwe-musculoskeletal
I-Myalgia, izinhlungu emilenzeni, emuva, ukuvuvukala okuhlangene, ubuthakathaka bemisipha, isifo samathambo, i-arthralgia, i-fibromyalgia.
Kusuka ohlelweni lwezinhliziyo
I-AV block (ama-degree ama-2), i-myocardial infarction, i-hypotension yemvelo ehlukile (i-arterial or orthostatic), ubuhlungu esifubeni kanye ne-vasculitis. Izimo eziningana ze-pathological ziyabonakala, zihambisana nokuphulwa kwesigqi senhliziyo: angina pectoris, tachycardia, bradycardia.
Ukusuka ohlelweni lwenhliziyo, kungahle kube nokuqanjwa kwe-myocardial.
Allergies
I-Urticaria, ukufushane komoya ngenxa yokuthuthuka kokuphefumula kwephepha lokuphefumula, ukusabela kwe-anaphylactic.
Umthelela ekhonweni lokulawula izindlela
Akunemikhawulo eqinile yokushayela. Kodwa-ke, kucwayiswa kulokhu kuleli cala ngenxa yokuthola amathuba okuba nezimpawu eziyingozi (ukwazi ukungasebenzi kahle, isiyezi, ukufakwa kwe-myocardial, njll.).
Imiyalo ekhethekile
Ngaphambi kokuqala ukwelashwa, iziguli ziboniswa ukuphelelwa amanzi emzimbeni. Kubalulekile ukuhlola njalo ukugxila kwe-potassium.
Uma uthatha umuthi ngesikhathi sokukhulelwa (ku-2nd ne-3rd trimester), ubungozi bokushona kwengane kanye nezinsana buyanda. Ama-pathologies abukhali avame ukwenzeka ezinganeni.
Uma ibhalansi yama-electrolyte iphazamiseka, amathuba okuba ne-hypotension anda.
Uma uthatha umuthi ngesikhathi sokukhulelwa (ku-2nd ne-3rd trimester), ubungozi bokushona kwengane buyanda.
Ngokwesifo sikashukela sohlobo 2, i-hyperkalemia ingahle ivele.
Uma isiguli sitholakala sine-hyperaldosteronism eyisisekelo, umuthi okukhulunywa ngaso awunqunyelwe, ngoba kuleli cala umphumela omuhle awutholakali.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi uvunyelwe ukusetshenziswa.
Umuthi weBlocktran Wezingane
Uma unikezwe ukuthi ukusebenza kweBlocktran akuqinisekisiwe, futhi ukuphepha kwayo akukasungulwa, kufanele ugweme ukuthatha lesi sidakamizwa ekwelashweni kweziguli ezingakafinyeleli ebusheni.
Sebenzisa ebudaleni
Kulokhu, akudingekile ukunciphisa inani lomuthi.
Ekwaluphaleni, akudingekile ukunciphisa inani lomuthi.
Isicelo sokusebenza kokulimala kwezinso
Umthamo awulandiswa, ngoba isakhi esisebenzayo ezigulini ezinezifo ezitholakele zalesi sitho nabantu abanempilo sitholakala egazini ngesilinganiso esifanayo.
Sebenzisa umsebenzi wesibindi okhubazekile
Uma kunomlando wezokwelapha walesi sitho, umuthi kufanele uthathwe ngobuningi obuningi, ngoba unempahla yokuqongelela, okusho ukuthi amandla okusebenza azokwanda. Ngama-pathologies aqatha, akukho okuhlangenwe nakho ngokusetshenziswa, ngakho-ke kungcono ukwenqaba ukuthatha umuthi.
I-blocktran Overdose
Izimpawu zenzeka:
- ukwehla okunamandla komfutho wegazi;
- i-tachycardia;
- bradycardia.
I-overdose yeBlocktran ibangela i-tachycardia.
Izindlela zokwelashwa ezinconyiwe: i-diuresis, ukwelashwa okuhlose ukunciphisa ubukhulu noma ukuqedwa ngokuphelele kwezimpawu ezingezinhle. I-Hemodialysis kuleli cala ayisebenzi.
Ukuxhumana nezinye izidakamizwa
Kwenqatshelwe ukuthatha umuthi kanyekanye ne-aliskiren ye-izidakamizwa kanye nama-ejenti ngokusekelwe kuwo, uma isiguli sitholakala sine-mellitus yesifo sikashukela noma ukwehluleka kwe-renal.
Kwenqatshelwe ukuthatha amalungiselelo aqukethe i-potassium ngesikhathi sokwelashwa ngeBlocktran.
Akukho ukusabela okungekuhle ngokusetshenziswa kwesidakamizwa esifanayo kanyekanye ne-hydrochlorothiazide, warfarin, digoxin, cimetidine, phenobarbital.
Ngaphansi kwethonya leRifampicin, ukwehla kokuxakaniseka kwento esebenzayo ekwakhiweni kweBlocktran kuyaphawulwa. UFluconazole usebenza ngesimiso esifanayo.
Kwenqatshelwe ukuthatha amalungiselelo aqukethe i-potassium ngesikhathi sokwelashwa ngeBlocktran.
ILosartan inciphisa ukugcwala kwe-lithiamu.
Ngaphansi kwethonya lama-NSAIDs, ukusebenza kahle kwezidakamizwa okukhulunywa ngazo kuyancipha.
Ngokuthola kwesifo sikashukela i-mellitus kanye nokwehluleka kwezinso, kuyenqatshelwa ukusebenzisa i-aliskiren nezidakamizwa ezisuselwa kuyo ngesikhathi sokwelashwa ngeBlocktran.
Ukuhambisana notshwala
Umuthi osebenzayo ekwakhiweni kwalesi sidakamizwa okukhulunywa ngaso uvusa izinkinga ezinzima uma zisetshenziswa ngasikhathi sinye neziphuzo eziqukethe utshwala.
Ama-Analog
Izithonjana:
- I-Losartan;
- ILosartan Canon;
- ULorista
- I-Lozarel;
- Presartan;
- I-blocktran GT.
Kwamukelekile ukuthi ucabangele izidakamizwa zaseRussia (iLosartan neLosartan Canon) kanye nama-analogues angaphandle. Abathengi abaningi bathanda izidakamizwa ezibhebheni, ngoba zilungele ukuyisebenzisa: asikho isidingo sokulandela imithetho yokuhlanzeka ekuphatheni umuthi, asikho isidingo sezimo ezikhethekile zokuphatha, njengoba kunjalo nangesixazululo. Amathebulethi angathathwa nawe, kepha umthamo uyalandelelwa uma umkhiqizo usetshenziswa ngolunye uhlobo.
Imibandela yekhefu lekhemisi
Kunikezwa umuthi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Alikho ithuba elinjalo.
Intengo yeBlocktran
Izindleko ngama-ruble ayi-110.
Izimo zokugcina zomuthi
Ukushisa okunconyelwayo kufinyelela ku- + 30 ° ะก.
Kunikezwa umuthi kadokotela.
Isikhathi sokuphelelwa yisikhathi
Kuyenqatshelwa ukusebenzisa leli thuluzi ngemuva kweminyaka engu-3 kusukela ngosuku lokukhiqizwa.
Umkhiqizi
I-Pharmstandard-Leksredstva, eRussia.
Ukubuyekezwa kweBlocktran
Ukuhlolwa kochwepheshe nabathengi kuyindlela ebaluleke kakhulu lapho ukhetha umuthi. Kuyabhekwa kanye nezakhiwo zomuthi.
Odokotela
U-Ivan Andreevich, udokotela wezifo zenhliziyo, uKirov
Umuthi uvimba ama-receptors athile kuphela, futhi awuthinti izinqubo ze-biochemical eziqinisekisa ukusebenza okujwayelekile komzimba. Lapho uqoka, isimo sesiguli kanye nokuba khona kwezifo ezibhekene nazo kuyabhekelelwa, ngoba iBlocktran ineziphambeko eziningi ezihlobene.
Iziguli
U-Ana, oneminyaka engama-39, uBarnaul
Nginomfutho wegazi ophakeme empilweni yami. Ngiyazisindisa ngaleli thuluzi. Futhi ezimweni ezibucayi, lesi sidakamizwa kuphela esisizayo. Ngemuva kokuqeda ukubonakaliswa obukhulu bokuqina komfutho wegazi, ngiyaqhubeka nokuthatha amaphilisi ukuze ngigcine ingcindezi ngezinga elijwayelekile. Umphumela walokhu kwelashwa muhle kakhulu.
UVictor, oneminyaka engama-51, Khabarovsk
Nginesifo sikashukela, ngakho-ke ngiwusebenzisa ngokucophelela lo muthi. Amathebulethi anganciphisa kakhulu umfutho wegazi uma uthatha umthamo odlula lowo unconyiwe. Kepha kuze kube manje angikaze ngithole enye indlela phakathi kwezidakamizwa ezinesilinganiso esiphakeme kangako sokwenza kahle, ngisebenzisa iBlocktran. Ngiphinde ngazama izithasiselo zokudla, kepha aziniki umphumela oyifunayo nakancane.
