Izivuseleli ze-pancreatic zokukhiqizwa kwabo kwe-insulin zithatha indawo yokuqala ekulinganisweni kwemithi ye-antidiabetes. Kuleli qembu - amalungiselelo we-sulfonylurea chungechunge (Maninil, Diabetes, Amaryl) nobumba.
Umuthi wesimanjemanje uNovoNorm, umenzeli we-hypoglycemic onamandla okushesha okwenza izinto, nawo ungowesigaba sokugcina. Kufanele isetshenziswe ngokucophelela, futhi amaphilisi awalungile kubo bonke abantu abanesifo sikashukela ngohlobo lwe-2 lwesifo, ngakho-ke kuyadingeka ukuthi ujwayelane nemiyalo (okungenani kanye nenguqulo yayo ehunyushiwe).
Ukwakheka nokwelashwa
Ukuqanjwa kweNovoNorm, isithombe sayo esivezwe kulesi sigaba, siyisakhi esisebenzayo se-repaglinide, esenezelwe nge-cellulose, isitashi sommbila, i-potassium polacryline, i-glycerin, i-povidone, i-calcium hydrogen phosphate, i-magnesium stearate, i-iron oxide, i-poloxamer, i-meglumine, i-dyes.
Umuthi ungakhonjwa ngesimo sawo (amaphilisi we-convex ayindilinga), umbala (ophuzi ku-1 mg no-brown, ngombala opinki ku-2 mg) ne-logo eqoshwe yinkampani - uNovo Nordisk. Ithebhulele amaphakethe emabhulashini ama-15 ama-pcs.
Ebhokisini lamapuleti anjalo kungaba kusuka kwababili kuya kwabayisithupha. KuNovonorm, intengo ingenye yesabelomali kunazo zonke sezidakamizwa zesifo sikashukela: ama-ruble ayi-177. ezibhebheni ezingama-30. Uyakhishwa umuthi onikezwa umuthi. Umenzi waseDenmark unqume impilo yeshelufu ye-repaglinide kungakapheli iminyaka emi-5. Umuthi awudingi izimo ezikhethekile zokugcinwa.
Ikhemisi
Isizinda se-repaglinide eyisisekelo siyisisusa esinamandla sokukhiqizwa kwe-insulin. Ukuqinisa umsebenzi wamanyikwe, ngokushesha umuthi uvamisa i-glycemia. Amandla ayo ahlobene ngqo nenombolo yama-b-cell asebenzayo abhekele ukuhlanganiswa kwamahomoni.
Ngemuva kokuthatha ithebhulethi, phindisela kabusha ku-plasma kushukela likashukela kuqongelela engxenyeni yehora. Lokhu kukuvumela ukuthi ulawule i-glycemia ngesikhathi sokudla kanye nokufakwa kokudla okulandelayo. Lapho nje umthwalo wepheshana lesisu uncipha, ukuqina komuthi kunciphe, izinga eliphansi liqondiswa amahora ama-4 ngemuva kokuba umuthi ungene emgodini wokugaya ukudla.
Ukuphepha komuthi kuhlolwe endaweni yomtholampilo. Ukwehla okuncike kumthamo kwe-glycemic indices kwabhalwa ngokusetshenziswa kwe-0.5-4 mg NovoNorm. Imiphumela iqinisekisa ukutholakala kokudla kuqala (imizuzu eyi-15-30 ngaphambi kokudla) isidakamizwa.
I-Pharmacokinetics
I-Repaglinide idonswa ngentshiseko kusuka emgudwini wesisu. Amanani aphezulu egazi abonwa ngehora elilodwa ngemuva kokungenela bese ancipha ngokushesha nje nge-bioavailability ephelele ka-63% ngenhlanganisela yokuhlukahluka okungu-11%.
INovoNorm isuswa emahoreni angama-4-6 nempilo enesigamu sehora. Umuthi wenziwe umzimba ngokuphelele, kepha ama-metabolites awo awasebenzi. Ingxenye engasho lutho yento esetshenzisiwe yatholakala kumchamo nasezindlini - ifinyelela ku-8% no-2%, ngokulandelana. Umthamo oyinhloko wama-metabolites uqedwa nge-bile.
Umphumela wesidakamizwa uvezwa kakhulu kubantu abanesifo sikashukela asebekhulile nakubo bonke abanezinkinga zezinso. Ngemuva kwezinsuku ezi-5 zokuthatha iNovoNorm ku-3 p / Usuku. I-2 mg ngezindlela ezinzima zokuphazamiseka kwe-renal kanye ne-TЅ iphindwe kabili.
Isifo sikashukela sezingane asizange sihlanganyele esivivinyweni. Izifundo zezilwane azivezwanga imiphumela ye-teratogenic ku-repaglinide, kepha zathola ubuthi bokuzala. Ngomthamo omkhulu wezidakamizwa, ukungafani kwezimpawu zamagundwane kwaqapheleka, umuthi nawo ungene obisini lukamama lwabesifazane.
Izinkomba
Umuthi uhlanganiswa nezidakamizwa ezi-antidiabetic nenye indlela yokusebenza - i-metformin, i-thiazolidinediones, ngakho-ke nayo ingasetshenziswa ekwelapheni okuyinkimbinkimbi.
Contraindication for Repaglinide
Ngokwengeziwe kwe-hypersensitivity kuzithako zefomula, ukuphindaphinda akuboniswa:
- Ngohlobo 1 sikashukela kanye ne-C-peptide sikashukela ongemuhle;
- Esimweni se-ketoacidosis yesifo sikashukela (ngisho nalapho kungekho khona ukoma);
- Omama abakhulelwe futhi abancelile;
- Isifo sikashukela nge-hepatic dysfunction;
- Ngokusebenzisa okufanayo kwe-gemfibrozil.
Iziphakamiso zokusetshenziswa
Udokotela ukhetha umthamo womuthi uqobo, ecabanga ngemiphumela yokuhlolwa, isigaba sesifo, i-pathologies esetshenzisanayo, ubudala, kanye nokuphendula komzimba kulo muthi. Njalo emavikini amabili, kuqapha ukusebenza kohlelo olukhethiwe lokucacisa umthamo, ukuhlolwa kwenhloso kunikezwa yi-glycated hemoglobin.
Ukuqapha kuyadingeka ukunciphisa i-glycemia ngesilinganiso esiphezulu esinconyiwe (ukwehluleka okuyinhloko) nokubona ukungabikho kokuphendula okwanele ngemuva kwesikhathi esithile sokuthatha umuthi (ukwehluleka kwesibili).
NgeNovoNorma, imiyalo yokusebenzisa incoma umthamo wokuqala we-0,5 mg. Kwisigamu senyanga sekuvele ukuthi kuhlolwe ukusabela komzimba nokwenza i-titration. Uma isifo sikashukela seNoNNorm sidluliselwa kwesinye isakhi se-hypoglycemic, khona-ke umthamo wokuqala kufanele ube ngaphakathi kwe-1 mg.
Ukwelashwa kwesondlo kubandakanya ukusetshenziswa kwe-repaglinide kuze kufike ku-4 mg / ngosuku. Imizuzu engu-15-30 ngaphambi kokudla. Udinga ukuphuza iphilisi ngaphambi kokudla ngakunye, ngoba umphumela wezidakamizwa ohlelweni lokugaya uhlala isikhathi esifushane. Umthamo ophelele wesidakamizwa yi-16 mg / ngosuku.Amathebulethi ahanjiswa kabili kathathu.
Ngokulashwa okuyinkimbinkimbi nge-metformin noma i-thiazolidinediones, umthamo wokuqala we-reaglinide awudluli ku-0,5 mg, umthamo wezinye izidakamizwa ushiywe ungashintshiwe.
Akukho datha ekuphepheni nasekusebenzeni kweNovoNorm yezingane.
Imiphumela yokusetshenziswa ngokweqile nemiphumela engathandeki
Ngenhloso yesayensi, amaviki ayi-6, i-repaglinide yanikezwa amavolontiya ngenani le-4-20 mg / ngosuku. lapho isetshenziswa amahlandla amane. I-Hypoglycemia ezimeni zokuhlolwa yayilawulwa okuqukethwe kwe-caloric ekudleni, ngakho-ke, akukho miphumela emibi eyalotshwa.
Uma ekhaya kunezimpawu ze-overdose esimweni sokukhukhula okwandayo, ukuthuthumela, ukuqaqanjelwa nokulahleka kokuhlangana, kubalulekile ukunika isisulu ukudla okunokuqukethwe okuphezulu kwama-carbohydrate asheshayo. Uma isimo sishubile futhi isiguli siphelelwa amandla, sifakwa ngeglucose bese sithunyelwa esibhedlela.
I-Hypoglycemia ingenye yezinhlobo ezimbi kakhulu zezehlakalo ezingalindelekile. Imvamisa yokubonakaliswa kwayo kuhlotshaniswa nendlela yokuphila yesifo sikashukela: ukudla, izinga lokuxineka kwemisipha nokuthinteka ngokomzwelo, umthamo kanye nokuhambisana kwezidakamizwa. Izibalo zamacala anjalo wethulwa kahle etafuleni.
| Ama-Organs nezinhlelo | Izinhlobo zokuphendula ezingezinhle | Isigameko |
| Ukungavikeleki | ukungezwani komzimba | akuvamile |
| Izinqubo ze-Metabolic | hypoglycemia | Akukhonjwa |
| Umbono | ushintsho lokuphikisa | ngesinye isikhathi |
| Inhliziyo nemithambo yegazi | izimo zenhliziyo | kaningi |
| Amapheshana wesisu | Ubuhlungu be-epigastric, ukuphazamiseka kwesigqi se-defecation, ukuphazamiseka kwe-dyspeptic | kaningi akuvamile |
| Isikhumba | hypersensitivity | Akukhonjwa |
| Ukugaya | ukungasebenzi kwesibindi, ukukhula kwe-enzyme | akuvamile |
Gwema imiphumela engathandeki kuzovumela ukwanda kancane kancane komthamo, ukuthola izifo, ukutheleleka, ukuphuza utshwala, ukuphelelwa amandla, abanesifo sikashukela abakhuthele kumele banakwe.
Ngingangena kanjani esikhundleni seNovoNorm
KwaNovoNorm, ama-analogues akhethwa ngokuya ngohlelo lwamazwe omhlaba lokuhlukaniswa kwezidakamizwa i-ATS (i-anatomical, yezokwelapha kanye nesigaba samakhemikhali) I-Repaglinide ekwakhiweni kwayo inemithi eminye engu-2 - i-Repodiab ne-Insvada.
Ngokuya izinkomba kanye nendlela yokusebenzisa, repaglinides ziyefana:
- I-Guarem;
- I-Baeta;
- IVictoza;
- I-Lycosum;
- I-Forsyga;
- Saxenda;
- UJardins
- Attokana.
Amaril, Bagomet, Glibenclamide, Glibomet, Glyukofazh, Glurenorm, Glyclazid, Diabeteson, Diaformin, Metformin, Maninil, Ongliza, Siofor, Yanumet, Yanuviya nabanye abaningi kusondele kwekhodi 3 ATC code (ukwakheka kwehlukile, kepha izinkomba zivamile).
Ekwehlukanisweni kwezidakamizwa zesimanje ze-hypoglycemic, odokotela abajwayezayo abahlali bezithoba, futhi akwamukeleki ukuthi kwabanesifo sikashukela bahlolwe ngezidakamizwa ngaphandle kwemfundo yezokwelapha. Imininingwane eku-athikili yethulwe ireferensi ejwayelekile kuphela.
Ukubuyekezwa kwezidakamizwa
Mayelana nokubuyekezwa kwe-NovoNorm kodokotela nabanesifo sikashukela abahle kakhulu. Umuthi lo ukhiqizwa eDenmark enkampanini yeNovoNordisk, lapho kuqala ukuphepha kwezidakamizwa.
Iseluleko sezazi ngokuphathwa kukashukela wohlobo 2 - kumbukiso we-TV "Ithebhulethi" - kule vidiyo.
