ILisinopril 10 iyi-inhibitor ye-ACE equkethe iqembu le-carboxyl, eliqinisekisa umphumela wayo wesikhathi eside nokubekezelelana okukhulu. Umuthi uvimbela unhlangothi, i-angina pectoris, ukwehluleka kwenhliziyo.
Igama Lezwe elingafanele
Lisinopril.
I-ATX
СО9АА03.
Khipha amafomu nokwakheka
Umuthi ukhiqizwa ngendlela yamathebulethi anesimo esiyindilinga. Into esebenzayo eyingxenye yayo yi-lisinopril dihydrate; Izithako ezengeziwe ziyadingeka ukunikeza amaphilisi ngesimo esiyindilinga.
ILisinopril 10 iyi-inhibitor ye-ACE equkethe iqembu le-carboxyl, eliqinisekisa umphumela wayo wesikhathi eside nokubekezelelana okukhulu.
Ababizi yilezi:
- calcium dihydrogen phosphate;
- isitashi;
- ukweba.
Izakhi ezingeziwe zihlangana nezitho nezicubu, kepha ungashintshi umuthi we-bioavailability womuthi.
Isenzo se-Pharmacological
Umuthi ukhulisa isikhathi sokuphila, uvimbela ukuthuthukiswa kwe-hypertrophy engakwesobunxele, wehlise inani lamaprotheni kumchamo, awubangeli i-hypoglycemia.
I-Pharmacokinetics
Izici zokwelapha zomuthi zibaluleke kakhulu emtholampilo:
- bioavailability ephezulu;
- isenzo esizimele, ngoba umuthi uyinto esebenzayo;
- isikhathi sokuvinjwa kwe-ACE;
- ukuqedwa.
Ngaphezu kwalokho, umuthi awubandakanyeki ku-metabolism, ngoba i-lipophilicity yayo iphansi, igqugquzela ukunwetshwa kwemithambo yemithambo, okukhishwe emchameni. I-Bioavailability ingu-50% futhi ayiguquki ngaphansi kwethonya lokudla.
Umuthi ukhiqizwa ngendlela yamathebulethi anesimo esiyindilinga.
Umuthi awuboli esibindini, ngokungafani namanye ama-vasodilators. Ukuhlushwa okuphakeme kakhulu kwe-serum kubonwa amahora angama-7 ngemuva kokuhoxiswa komuthi.
Ukungabikho kwe-metabolism esibindini kuvumela ukusetshenziswa kwento esebenzayo ezigulini ezine-pathology yohlelo lwe-hepatobiliary.
Okuphilisayo
Amathebulethi e-antihypertensive awumuthi womugqa wokuqala ekwelapheni ukungalingani okungapheliyo kwe-myocardial, kuhambisana nokungasebenzi kahle kwelejistra yomoya.
Umuthi unemiphumela elandelayo emzimbeni:
- isekela i-homeostasis;
- ine-antioxidant ne-cardioprotective effect;
- iphazamisa i-myocardial ischemia.
Izinkomba zokuqokwa kwalo muthi yilezi:
- isigaba se-hypertension II-III;
- infarction ebabazekayo ye-myocardial esigabeni sokuzinza kwe-hemodynamics;
- ukuvimba kwamagatsha esigaxa Sakhe;
- ukwephulwa kokusebenza kwe-systolic ye-ventricle yangakwesobunxele;
- angina pectoris;
- okuqukethwe okuphezulu kwe-lipid;
- isifo sikashukela mellitus;
- ukuvimbela ukunamathela kwe-platelet kanye nokuqhekeka kwegazi.
Isidakamizwa sisetshenziswa njengengxenye yokwelashwa okuhlanganiswa ngokuhlanganiswa ne-diuretics. Ithebhulethi limiselwe ukungasebenzi kahle kwe-asymptomatic kwesokunxele.
Ngokuvimbela kwesibili kwezifo zenhliziyo nezemithambo, umuthi ubekelwe iziguli ezinomlando wokufakelwa kwe-myocardial, ehlushwa ukuhlukaniswa kwemithambo yenhliziyo, ehambisana nokungasebenzi kahle kwe-systolic.
Ezigulini ezinomfutho wegazi ophakeme ongaphezulu kweminyaka engama-65, into esebenzayo ithinta ukusebenza kwezinso.
Contraindication
Umuthi awunqunyelwe uma isiguli sithuthukise izinqubo ezilandelayo ze-pathological:
- i-hypertension ye-arterial;
- ukwethuka kwe-anaphylactic;
- i-potassium ephezulu egazini;
- izifo ezithinta izicubu;
- i-pathology yesibindi nezinso (kufaka nokugula okungapheli kwe-adrenal);
- gout
- ukulimala kwamathambo;
- i-renal artery stenosis;
- ukunciphisa ukusebenza kwe-thyroid;
- urticaria.
Ngama-pathologies wesibindi, isidakamizwa asinqunyelwe.
Kumuntu osekhulile, ngemuva kokusebenzisa umthamo omkhulu womuthi, ukuqubuka komqondo kuqubuka, isimo sezempilo siba sibi, futhi amathuba okuba nemiphumela ebulalayo ayanda.
Futhi, umuthi awubekelwe iziguli ezine-tachycardia, edema nezifo zohlelo lwe-bronchopulmonary. Isiguli esiphuze isilinganiso esikhulu somuthi sikhononda ngempilo engeyinhle, isiyezi, ubuthakathaka, ukozela, nokuqina.
Uma isiguli sinezinkinga ngama-valves enhliziyo noma ukulimala ebuchosheni nasentanjeni yomgogodla, khona-ke umfutho wegazi wehla kakhulu ngemuva kokuthatha i-vasodilator.
Ungayithatha kanjani iLisinopril 10
Umthamo wesidakamizwa unqunywe udokotela. I-vasodilator isetshenziselwa i-monotherapy, futhi futhi ichazwe njengengxenye yokwelashwa okuphelele nezinye izidakamizwa.
I-antihypertensive ithathwa ngasikhathi sinye.
Umthamo wesidakamizwa unqunywe udokotela.
NgeRenovascular Hypertension
Umuthi uyasebenza emsebenzini ophansi we-plasma renin. Ezigulini ezineminyaka engaphezu kwengama-60 ubudala, kunconywa umuthi okwenziwa ngomuthi wansuku zonke we-2,5-40 mg. Ezimweni eziningi, udokotela unquma ukuthatha amaphilisi ngethamo lika-5 mg / ngosuku.
Uhlobo lokwelashwa lwe-hypertension luyinto eyodwa, ngokuya ngobukhulu begazi. Ngokungabikho komphumela, umthamo wesidakamizwa ukhuphukela ku-10-15 mg. Ukwelashwa nge-antihypertensive kwenziwa ngenhloso yokulungisa umfutho wegazi, kufinyelele ezingeni eliphezulu le-140/90 mm RT. Ubuciko. (kubantu abanesifo sikashukela).
Amacwecwe anqunywe ngokuhlangana ne-beta blocker ne-diuretic.
Ngokuhluleka kwezinso
Ekusebenzeni kwemitholampilo, umuthi ubekelwe ukunciphisa ukwehla kwama-capillaries ku-glomeruli, ukunciphisa ingcindezi kanye nokuphuma kweprotheni ngomchamo. Ukwehluleka kwangempela kuyisisekelo sokukhetha umthamo ngamunye womuthi.
Ukwehluleka kwangempela kuyisisekelo sokukhetha umthamo ngamunye womuthi.
Eenkambisweni ezingekho lula zesifo, inani lomenzeli wezokwelapha li-5-10 mg 1 isikhathi ngosuku. Ezigulini ezine-creatinine imvume engaphansi kwama-80 ml / umzuzu, inhlanganisela ye-ejenti ye-hypotensive ne-diuretic isetshenziswa ngenani le-10 mg / 125 mg kanye ngosuku.
I-infraction ye-myocardial esebenzayo
Umuthi unqunywe ngosuku lokuqala lokukhula kwenqubo ye-pathological acute. Umthamo wesidakamizwa ngu-5-10 mg. Isiguli sithatha umuthi amasonto ama-3. Ngemuva kokwelashwa, umsebenzi we-ventricle yangakwesokunxele uyathuthuka.
Ukwelashwa kwe-myocardial infarction, umenzeli we-angiopertgency ubekwa njengengxenye yokwelapha ngokuhlanganiswa ne-acetylsalicylic acid.
Ukuthatha umuthi wesifo sikashukela
Isidakamizwa sinconyelwa iziguli ezinohlobo lwe-insulin oludinga i-insulin II. Amathebulethi agcina ithoni evamile yemithambo, umfutho wegazi ophansi. Isiguli sinqunywe amaphilisi ayi-10 mg.
Isidakamizwa sinconyelwa iziguli ezinohlobo lwe-insulin oludinga i-insulin II.
Umuthi unomphumela ohlala njalo. Ngokuphikisana nesizinda sesifo sikashukela, kunciphisa ubungozi bokuthola i-microvascular pathology, kubambezela ukuguquka kwesimo sangaphambi kwesifo sikashukela sikashukela. Umthamo wansuku zonke wezidakamizwa ungahlukaniswa ngemithamo emi-2: ekuseni nakusihlwa, ithebhulethi ½.
Imiphumela emibi
I-vasodilator ibangela imiphumela engafuneki engaba mnene futhi ihlale isikhashana.
Amapheshana wesisu
Ukuphuza amaphilisi okucindezela iminyaka eminingana esigulini esinemikhuba emibi kuyinto ebaluleke kakhulu ekwakhiweni kwe-gastritis. Izinkinga zibonakaliswa isicanucanu, ukugabha, ukungaphatheki kahle kwesisu, isifo sohudo, kanye nokushintsha ukunambitheka.
Ngokuvamile kuthuthukiswa:
- i-pancreatitis
- i-hepatitis;
- jaundice.
Isiguli sikhononda ngokubonakala kosizi ngemuva kokudla, ukushaya kwenhliziyo.
Kusukela epheshaneni lesisu, imiphumela emibi eminingana ingavela, ngokwesibonelo, ukushisa kwenhliziyo.
Izitho zeHematopoietic
Imvamisa ngemuva kokuthatha umuthi, isiguli sibona ukuvela kwezimpawu ezithile.
Umphumela omubi wesidakamizwa egazini uhambisana nalokhu:
- i-leukopenia;
- i-thrombocytopenia;
- ukwehla okubucayi kwama-agranulocytes ne-hemoglobin.
Isistimu yezinzwa ephakathi
Izimpawu ezilandelayo zihambisana nokuphazamiseka kwe-neurotic esigulini:
- ukunciphisa isikhathi sokunakwa;
- ukudideka kokwazi;
- ukozela
- ikhanda
- ukuswelana okukhanyayo kwezindebe nezingalo;
- ukuguquguquka kwengcindezi yegazi;
- i-paresthesia.
Ukomela kungenye yemiphumela emibi yokuphuza umuthi ohlelweni lwezinzwa oluphakathi.
Ukuphuza ngokweqile, ukusebenza ngokweqile, ukugcwala ngokweqile kuholela ekuwohlisweni kwesistimu yezinzwa, futhi ukwelashwa nge-vasodilator kubhebhethekisa isimo sesiguli.
Kusuka ohlelweni lokuphefumula
I-Bronchospasm inkinga enkulu eyenzeka ngemuva kokuphuza amaphilisi omuthi wegazi ophezulu. Isiguli sinenkinga yokuntuleka komoya, ukwesaba ukufa, ukuthamba, ukukhwehlela komile. Epheshaneni lokuphefumula, i-mucus iyaqongelela, amathuba okukhula kwe-edema ye-laryngeal ayanda.
Isiguli sikhononda ngokugcwala owomile, umoya wakhe uyanwebeka, nemithambo yentamo ivuvukala ku-exhale.
Engxenyeni yesikhumba
Ngemuva kokuthatha umuthi, ukuvela kwesikhumba okulandelayo kungavela:
- i-urticaria;
- i-angioedema;
- ukuqhuma kwesikhumba;
- ukulunywa
- umkhuhlane.
Ngemuva kokuphuza umuthi, ukubonakaliswa kwe-allergic kungenzeka: ukulunywa, ukuqubuka esikhunjeni.
Isikhumba esihlanganisiwe singambozwa ngamabhamuza amancane. Izilonda zenzeka kunoma iyiphi ingxenye yomzimba: ingemuva lekhanda, intamo, ingaphambili lamathanga, izindololondo ze-elbow.
Kusuka ohlelweni lwezitho zofuzo
Umuthi uthinta inkambo yenqubo yokuvuvukala esitho somchamo.
Isiguli sithuthukisa lezi zimo ezilandelayo zokugula:
- cystitis
- i-pyelonephritis;
- ukwehluleka kwezinso okulimazayo.
Ukungasebenzi kwezinso okubukhali kuholela ekuzenziseni ubuthi emzimbeni.
Uhlelo lwe-Endocrine
Izilonda ezilandelayo ze-yegilo zivame kakhulu:
- ukuncipha komsebenzi wesitho se-endocrine;
- ukuvuvukala yegilo.
Isiguli sikhononda ngezimpawu ezimbi:
- ukukhathala
- ukulahlekelwa amandla;
- ukozela
- ubumsulwa;
- ukuvuvukala
- ukuqunjelwa.
Ngemuva kokuphuza umuthi, isiguli singakhalaza ngokuqunjelwa.
Isifo sikashukela sohlobo II singakhula. Lesi sifo siqhubeka ngokushesha okukhulu.
Emadodeni, i-potency igcwele.
Imiyalo ekhethekile
Kuyadingeka ukulawula ukusebenza kwezinso, uphuze uketshezi olwanele ngaphambi kokuthatha umuthi.
Umthelela ekhonweni lokulawula izindlela
Lapho uthatha amaphilisi ngesimo sezulu esishisayo, ukuvimbela kungakhula, kuyilapho ukugxilisa ukunaka kuya ngokuya kukhula. Ngakho-ke, lo muthi awunconywa kwiziguli ezenza umsebenzi onobungozi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ithuluzi linomphumela ongemuhle enkambisweni nasemiphumeleni yokukhulelwa.
Ithuluzi linomphumela ongemuhle enkambisweni nasemiphumeleni yokukhulelwa.
Azikho izifundo ezenziwayo zokuthola isilinganiso sobungozi ngesikhathi sokuncelisa ibele.
Ukuyalela uLisinopril ezinganeni eziyi-10
Umuthi ubekiwe uma kungekho okuphikisanayo futhi kucatshangelwa iminyaka yengane. Isiguli sinconywa umthamo okwehlisiwe wesidakamizwa se-antihypertensive, ukhetha izidakamizwa ngomphumela we-metabolic ongathathi hlangothi. Isiguli esinesifo se-pyelonephritis sikhethwa ngokuphathwa okwanele.
Sebenzisa ebudaleni
Ezigulini ezinomfutho we-hypertension obalulekile, umuthi unqunywe kumthamo we-10 mg / ngosuku. Ngomfutho wegazi ophakeme weganga lokuqala lobunzima, umuthi uvumela ukufeza ukufaniswa kwengcindezi ye-diastolic.
Umphumela womuthi uhlala amahora angama-24 lapho uthathwa isikhathi esingu-1 ngosuku. I-ACE inhibitor ibonakala ngokusebenza okuphezulu kwabadala.
I-ACE inhibitor ibonakala ngokusebenza okuphezulu kwabadala.
Isicelo sokusebenza kokulimala kwezinso
Umuthi uthathwa ngomlomo isikhathi esingu-1 ngosuku, kungakhathalelwa ukuthathwa kokudla. Uma kwenzeka umsebenzi we-renal ongasebenzi kahle, kuthathwa umthamo wokuqala ophansi: 2,5-5 mg / ngosuku. Ngesikhathi sokulashwa, kuyadingeka ukulawula ukusebenza kwesitho somchamo, ukuhlangana kwama-ion we-potassium ku-serum yegazi.
Umthamo wokuqala unqunywa ngokuya ngemvume ye-creatinine. Uma inani layo lingu-10-30 ml / umzuzu, khona-ke ama-2,5-5 mg wesidakamizwa esine-hypertgency anconyelwe ukwelashwa.
Sebenzisa umsebenzi wesibindi okhubazekile
Kwamukelwe ngokumelene nesizinda se-pathologies yesibindi. Umonakalo we-organ awuthinti ama-pharmacokinetics womuthi. Ukuthatha umuthi ngomuthi we-10 mg ngosuku kunciphisa umfutho wegazi ku-53% weziguli.
Iziguli ezine-steatosis ne-cirrhosis zisabela kabi ekwelashweni kwezidakamizwa ze-antihypertensive. Umthamo wesidakamizwa uphindwe kabili noma i-hypothiazide ingeziwe.
Iziguli ezine-steatosis ne-cirrhosis zisabela kabi ekwelashweni kwezidakamizwa ze-antihypertensive.
Ukweqisa
Ezigulini zeminyaka esezingeni eliphakeme nelingasho lutho, ekwelapheni ukwehluleka kwenhliziyo okungapheli, izimpawu zivame ukuvela, okubonisa ukweqisa komuthi we-antihypertensive.
Umuthi onqunywe kumthamo omkhulu ubangela izimpawu zokuntuleka kwezitho eziningi zomzimba, ukuphazamiseka kwesigqi senhliziyo.
Isiguli sakha lezi zimpawu ezilandelayo:
- ukuntuleka komoya;
- ukushesha komoya ngesikhathi sokuzivocavoca komzimba;
- ukukhwehlela;
- i-tachycardia;
- arrhythmia;
- ukukhathala
- Isiyezi
- tinnitus;
- ukuvuka
- ukuqwasha
- ukudangala
Njengomphumela we-overdose, isiyezi kungenzeka.
Ukuxhumana nezinye izidakamizwa
Umuthi kanye nama-diuretics asetshenziswa ngasikhathi sinye kubangela i-hypercalcemia, kuvela inkinga eyingozi - ukuboshwa kwenhliziyo.
Umphumela wokuthatha umuthi uyanda uma unqunywa ngabakwa-beta-blockers, ama-thiazides, ama-calcium blockers.
Izidakamizwa zokwelashwa kwezilonda zinciphisa ukumunca i-ACE inhibitor esiswini.
Ukuhambisana notshwala
Ukusetshenziswa okuhambisanayo neziphuzo eziqukethe utshwala kuholela ekuphuzweni ngokweqile kwento esebenzayo kanye nokuthuthukiswa kwezimpawu eziyingozi empilweni yesiguli.
Ama-Analog
I-Hypertension ukugula okungathi sína. Ama-genetic ajwayele ukusetshenziselwa ukwelapha:
- Diroton;
- Dapril;
- ISinopril;
- I-Lizonorm;
- ILisinotone;
- I-Captopril;
- UCorffar.
UDiroton ungenye yezimpawu zesidakamizwa.
Izidakamizwa zinomphumela we-antihypertensive.
Izimo zeholide zeLisinopril 10 ezivela emakhemisi
Ukuthenga umuthi, udinga umuthi kadokotela wakho.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ezimweni ezihlukile, ungathenga lo muthi kusokhemisi, echaza isizathu sokuntuleka kwencwadi kadokotela.
Malini
Izindleko ziyehluka ngokuya ngomkhiqizi.
Umuthi wenkampani ye-ALSI-Pharma ubiza ama-ruble ayi-17. iphakethe ngalinye lama-30 ama-pcs. Intengo evela kumenzi Ratiopharm - ama-ruble angama-330. ama-30 ama-PC.
Izimo zokugcina zomuthi
Esitokisini esitokisini egumbini lokushisa endaweni emnyama.
Gcina kwiphakethe yeseli endaweni yokushisa yasekamelweni endaweni emnyama.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-4
Umkhiqizi uLisinopril 10
Umuthi ukhiqizwa abakhiqizi abaningana:
- Teva
- Izinkanyezi;
- I-Ratiopharm nabanye
Ukubuyekezwa mayelana neLisinopril 10
Odokotela nabathengi baphendula kahle ngomuthi.
Odokotela
U-Irina, udokotela wenhliziyo, uNovorossiysk
Ngincoma umuthi ekwelapheni umfutho wegazi ophakeme. Ngaphambi kokuqala ukwelashwa, nginquma ukusebenza kwezinso. Ngibeka i-10 mg kanye ngosuku njengengxenye yokwelashwa okuphelele.
UValentin, udokotela wenhliziyo, eMoscow
Nginikeza umuthi ekwelapheni umfutho wegazi ophezulu. Lapho uyithatha, kubalulekile ukulandela zonke izincomo, njengoba Izidakamizwa zingadala imiphumela emibi.
Iziguli
U-Olga, 62 g, eMoscow
Ngihlushwa umfutho wegazi ophakeme we-III degree, ukuvuvukala okuhlukumezekile, ukuphefumula komoya, ukuqina kwemizwa. Udokotela unikeze umuthi wokucindezela ngokuhlanganiswa ne-Indapamide.Ngiphuza amaphilisi ngemuva kokudla i-5 mg ekuseni nakusihlwa. Isimo sesingcono.
U-Igor, oneminyaka engama-56, u-Omsk
Udokotela unikeze lesi sidakamizwa ukuthothisa ukuphefumula. Isimo sesingcono, engakayiboni imiphumela emibi.
