I-Humalog Mix yiqembu labenzeli be-hypoglycemic. Kunikezwa ngefomu le-ketshezi, kunqunyelwe izinhlobo zesifo sikashukela esincike ku-insulin. Izindleko zomuthi zingaphezulu kwesilinganiso. Kusetshenziselwa ukuguqula amazinga kashukela. Umuthi ubonakala yindawo emincane yokusetshenziswa. Izinzuzo zifaka inani lemikhawulo elisetshenzisiwe.
Igama Lezwe elingafanele
ILyspro insulin iyi-biphasic.
I-drug Humalog Mix iyatholakala ngesimo sesixazululo esenzelwe ukuphathwa kwe-subcutaneous.
I-ATX
A10AD04.
Khipha amafomu nokwakheka
Umuthi unikezwa ngesimo soketshezi. Isixazululo senzelwe ukuphatha ngokweqile. Njengomuthi osebenzayo, i-insulin lyspro iyasetshenziswa. Kuqukethe ukuhlukahluka okungu-2, okuhle kakhulu ngejubane lokuboniswa kwezakhiwo: i-insulin solution lyspro (ekuqoqweni okungama-25 no-50%), kunikeza umphumela wokwelapha ngaso leso sikhathi; Ukumiswa kwe-Lyspro protamine kwe-insulin (75 no-70%, ngokulandelana) - umphumela wayo unwetshwe isikhathi esithile. Ukuvumelana okudingekayo kwento yezidakamizwa kunikezwa ngamakhompiyutha alandelayo angakhombisi umsebenzi we-hypoglycemic:
- metacresol;
- i-phenol liquid;
- glycerol;
- protamine sulfate;
- sodium hydrogen phosphate heptahydrate;
- i-zinc oxide qs ukukhiqiza ama-zinc ion;
- amanzi wokujova;
- I-10% isisombululo se-hydrochloric acid kanye / noma i-sodium hydroxide ku-pH ye-7.0-7.8.
Ungathenga umkhiqizo kwiphakeji equkethe i-1 blister (ama-cartridge ama-5, ama-3 ml wokumiswa ngakunye). Ama-Cartridges afakwe esibayeni se-syringe se-QuickPen. Iphakheji ingaqukatha imikhiqizo engu-5.
Isenzo se-Pharmacological
Ukwakheka kwalesi sidakamizwa kufaka i-esikhundleni sokuphindaphindwa kwe-DNA esikhundleni se-insulin yomuntu. Isimiso sokusebenza sincike ekuhlelweni kwenqubo yokwakheka kweglucose.
Umgomo wesidakamizwa usekelwe ekuhlelweni kwenqubo yokwenziwa kweglucose.
Ngaphezu kwalokho, umuthi ubonakala ngempahla ye-anabolic (inegalelo ekwandeni kokukhula kwemisipha), ngakho-ke uHumalog angasetshenziswa kwezemidlalo.
Umuthi futhi ukhombisa umphumela wokulwa ne-catabolic. Ngakho-ke, ngaphansi kwethonya lazo, ukubonwa kwenqubo yokuqhekeka kwamaprotheni kuyaphawulwa. Izici ze-Anabolic kanye ne-anti-catabolic ziyaxhuma.
Umphumela walezi zinqubo ukwanda kokuqoqwa kwamafutha acid, glycogen, glycerol.
Ngesikhathi esifanayo, ukwanda kokuqina kokuhlanganiswa kwamaprotheni kuyaphawuleka, isidingo somzimba sama-amino acid siyakhula. Ngesikhathi esifanayo, izinga lokuqhekeka kwamafutha, ukukhiqizwa kwezidumbu ze-ketone, kanye nezinqubo ezinjenge-gluconeogeneis, i-glycogenolysis, ziyancishiswa.
I-lyspro ebambekayo ilingana ne-insulin equkethwe emzimbeni womuntu, ihlukaniswa ngamandla aphezulu esenzo. Kodwa-ke, into inomdwebo oguqukayo: umphumela otholakele awuhlali isikhathi eside.
I-Pharmacokinetics
Izinga lokufakwa kwe-insulin liphezulu. Ngemuva kwemizuzu engu-15, kwenziwa ngcono isimo sesiguli. Izinga eliphakeme lomsebenzi wento alifinyelelwa kungakadluli amahora angama-2,5.
Izinga lokufakwa kwe-insulin liphezulu. Ngemuva kwemizuzu engu-15, kwenziwa ngcono isimo sesiguli.
Izinkomba zokusetshenziswa
Ithuluzi okukhulunywa ngalo libonakala yindawo emincane yokusetshenziswa. Kunqunyelwe ushukela kwifomu lokuya nge-insulin.
Contraindication
Umuthi awusetshenziselwa ukungabekezelelani kwengxenye esebenzayo. Enye i-contraindication yisimo esidalwa njenge-hypoglycemia. Kulokhu, ukwehla okwengeziwe kwe-glucose kuphawulwa ngaphansi kwethonya le-insulin lyspro. Lokhu kungaholela ekwehlisweni okubucayi kokuhlushwa kwayo egazini.
Umuthi usetshenziswa ngokuqapha ekwehlulekeni kwesibindi. Kulokhu, isilinganiso sokufakwa kwengxenye esebenzayo siyakhuphuka, futhi umphumela ugcinwa isikhathi esifushane. Uma kwenzeka umsebenzi we-renal ophazamisekile, umuthi futhi ungasetshenziswa, kodwa kuyadingeka ukuthi ngaso sonke isikhathi kuqashelwe isimo sesiguli. Ngaphezu kwalokho, ngokuqapha, umuthi okukhulunywa ngawo unqunywe emacaleni amaningi:
- ukucindezela
- ukukhuphuka kwamandla omzimba;
- shintsha ikhwalithi yokudla, yokudla.
Kufanele kukhunjulwe ukuthi ukusetshenziswa isikhathi eside kuvame ukukhuthaza ukuqala kwezimpawu ezingaphambili kwe-hypoglycemia.
Umphumela ofanayo uyatholakala lapho kunesimo se-pathological esifana nesifo sikashukela se-neuropathy.
I-Hypoglycemia yisimo se-pathological lapho kusetshenziswa khona umuthi we-Humalog Mix.
Ungayithatha kanjani i-Humalog Mix
Umuthi unqunywe ngaphambi kokudla. Isixazululo kufanele sisetshenziswe imizuzu eyi-15 ngaphambi kokudla. Lokhu kungenzeka kungenxa yokungena ngokushesha kwento. Kwezinye izimo, umuthi uphathwa ngokushesha ngaphambi kokudla, ikhefu aligcinwa. I-Lyspro insulin isetshenziswa kuphela. Ukuphathwa okuphathelene nomuthi kungavunyelwe. Ijubane lokusebenza kwento yezidakamizwa lincike ekutheni isikhumba sihlatshwa kuphi: ithanga, ihlombe, amabhuzu, isisu.
Ngaphezu kwalokho, kubalulekile ukuguqula njalo indawo yokujova umuthi. Imvamisa enconywayo yokulethwa kwezidakamizwa ngephuzu elingu-1 ayikho ngaphezulu kwesikhathi esingu-1 ngenyanga. Umuthi akufanele ungene emgodini wegazi ngokuphathwa kobuhlakani. Ukumiswa kungasetshenziswa kuphela uma izinga lokushisa lakhona lihambisana lokushisa kwekamelo. Imiyalo yokusebenzisa ipeni lesirinji:
- kuyadingeka ukufezekisa ukufana kokufana kwekhambi, okunconyelwa ngalo ukuvumisa isirinji phakathi kwezintende kaninginingi, useliguqula ngokushintshana, kodwa ungeke ukwazi ukusinyakazisa, ngoba kuvela ama-bubble, okwenza kube nzima ukucacisa ngokunembile umthamo owuthandayo womuthi;
- I-Lyspro insulin ivunyelwe ukuyisebenzisa ngemuva kokufana ngokungaguquguquki, lapho kukhona ama-flakes, ngisho nangemva kokuxubana, ukumiswa ngeke kusetshenziswe;
- Isirinji eli-1 liqukethe i-3 ml yesidakamizwa noma i-300 IU yento esebenzayo, uma sekuvumelekile ukungena kusuka kumayunithi angama-1 kuye kwangama-60, futhi inzuzo yepeni yikhono lokunquma ngokunembile umthamo womuthi;
- ngaphambi kokwethula inalithi ku-engilgoritik yangaphandle, izandla nesikhumba endaweni yokubamba okusolwa kufanele iphathwe nesixazululo se-antiseptic.
Ngokwehlukana, kunikezwa imiyalo yokulungiselela isirinji yokusebenzisa:
- Udinga ukudonsa isicephu ukuze usisuse, akufanele usijikeleze.
- Lungiselela inaliti entsha. Ukuze wenze lokhu, susa ilebuli ekugcineni kwayo kwangaphandle. Ophethe inaliti uphathwa ngesisombululo se-antiseptic futhi abekwe esibayeni sesirinji.
- Kwenziwa isheke sokuba khona kwe-insulin, futhi kubalulekile ukulinda kuze kube kuvela into encane lapho kuthathwa inkinobho.
- Ingxenye yesembozo sangaphandle isilungisiwe, khona-ke inaliti ifakwa bese inkinobho icindezelwa, ngemuva kokuyibeka esimweni esifunayo.
- Inaliti isuswa kwikhava elingaphandle. Ithiphu yayo inconywa ukuthi ivalwe nge-cap, futhi indawo yokujova kwe-insulin imbozwe nge-swab yekotini, ngokucindezela okuncane esikhunjeni. Ukuhlikihla isembozo esingaphandle kule ndawo akunakwenzeka. Ngemuva kokubambelela imizuzwana eminingana, kususwa ikotoni.
- Ngemuva kokufakwa kovalo inaliti, kufanele ivalwe futhi ilahlwe.
Ngaphambi kokulawulwa ngakunye kwalomuthi, kufakwa inaliti entsha. Ngaphezu kwalokho, kufanele uhlole njalo usuku lokuphela kwe-insulin (kwelebula yesirinji).
Ngoshukela
Umthamo wabantu abadala nezingane unqunywa ngokuhlukile. Uhlobo lokwelashwa lukhethiwe ngokuya ngezinga le-glucose emzimbeni.
Kwezemidlalo
Umuthi okukhulunywa ngawo ukhombisa umphumela ongemuhle we-anabolic, anti-catabolic. Kodwa-ke, ukusetshenziswa kwe-insulin ngemuva kokuzivocavoca kunomthelela ekuvinjelweni kokuguqulwa kwama-amino acid kube ushukela. Ngenxa yalokhu, amaprotheni awasetshenziswa ngumzimba ukwanelisa izidingo zamandla, kepha ukuvuselela izicubu zomzimba. Ngaphambi kokusebenzisa umuthi, bonana nodokotela wakho, njengoba Ukusetshenziswa okungalawulwa kwe-insulin kungaba yingozi empilweni.
Ukusetshenziswa kwe-Humalog Mix yezidakamizwa ngemuva kokuqeqeshwa kwezemidlalo kudinga ukubonisana nodokotela.
Mangaki amahora avumelekile
Umphumela wokwelapha uphikelela emahoreni angama-3-4 alandelayo. Ngaphansi kwezimo ezithile, i-insulin ihlala amahora angama-5.
Imiphumela emibi
Ngesikhathi sokulashwa, ukungezwani okuhle kungahle kube nokukhula kwe-hypoglycemia, ikakhulukazi, isimo sokwehla. Ezinye izinkomba yilezi:
- indlala enkulu;
- ukungazi kahle;
- Isiyezi
- ukuqina kokujuluka;
- isilinganiso senhliziyo siyaphazamiseka (tachycardia);
- ukushuba kwemilenze;
- coma.
Ngaphezu kwalokho, okunye ukusabela kuyaphawulwa:
- ukungezwani komzimba, okuvame ukubonakaliswa yizimpawu zasendaweni: ukucasuka, ubomvu kwesikhumba, ukuvuvukala, okungabangelwa ukuthambekela kabi kwesisombululo se-antiseptic ngumzimba noma ukwephulwa kwemithetho yokusebenzisa umuthi (ukusetshenziswa okungafanele kwesirinji);
- ukuhleleka komzimba okwenzeka ohlelweni lokukhula okuvame ukwanda kakhulu, kulokhu izimpawu zibonakaliswa ukulunywa okukhulu, i-edema ebanzi, ukwehluleka kokuphefumula, i-hypotension, ukufushane komoya, i-hyperhidrosis.
Umthelela ekhonweni lokulawula izindlela
Inhloso efanelekile, kanye nokusetshenziswa kwesidakamizwa okukhulunywa ngaso, akunagalelo ekunciphiseni kwezinga lokunakwa, akuholeli ekuphulweni kwemisebenzi ebalulekile. Ngakho-ke, ingasetshenziselwa isifo sikashukela. Kodwa-ke, kufanele kuqashelwe, ngoba ukusetshenziswa isikhathi eside kwalesi sidakamizwa kungadala i-hypoglycemia.
Imiyalo ekhethekile
Ipeni lesirinji kufanele ligcinwe ngokwahlukile ngenaliti. Uma ithiphu ingasuswa, umuthi ungoma noma uvuze ngokuphelele.
Isirinji sigcinwa ngaphansi kwezimo ezifanele. Uma usigcina ngaphandle kwesiqandisi, umuthi uzolahlekelwa yizinto zawo.
Akunconyelwe ukuthi ushintshe uhlobo, uhlobo noma izinhlobo ze-insulin ngesikhathi sokwelashwa.
Ngasikhathi sinye, ukulungiswa kwenani lezinto ezisebenzayo kanye nokulawulwa kukadokotela kwesinye isikhathi kuyadingeka.
Ezigulini ezinesifo sohlobo lwe-1 isifo sikashukela esixilongiwe, ukwephula uhlobo lokudla kwe-insulin, ukunqanyulwa okubukhali kwezokwelapha yizimbangela ze-hyperglycemia, ketoacetosis yesifo sikashukela.
Ukusebenza kwezinso nezinso kusiza ukunciphisa ukufunwa kwe-insulin kushukela.
Isidakamizwa esinenqwaba yokuqedwa kwe-lyspro high-speed 25% singabekelwa izingane ezingaphezulu kweminyaka engu-12. Lapho kudingekile ukwelapha iziguli ezingaphansi kwalesi sikhathi, kusetshenziswa i-insulin uma imiphumela emihle idlula ukulimala okungenzeka ngamandla.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ngokucatshangelwa ukuthi ucwaningo lwesenzo se-insulin emzimbeni womuntu noma wesikazi ngesikhathi sokukhulelwa nokuncelisa lungakaze lwenziwe, umuthi kufanele unqunywe uma imiphumela emihle idlula ukulimala okungenzeka. Kwi-trimester yokuqala, isidingo se-insulin sivame ukwehla. Kuma-trimesters we-2 ne-3, kunalokho, ayanda.
I-Humalog Mix yomuthi inqunywa ngesikhathi sokukhulelwa uma imiphumela yayo emihle idlula ukulimala okungenzeka.
Ukuhambisana notshwala
Lapho usebenzisa iziphuzo eziqukethe utshwala, umenzeli osembuzweni ukhombisa ukusebenza kahle okuphezulu.
Ukweqisa
Uma umuthi uthathwa isikhathi eside noma irejimeni yokwelashwa iphulwa (kuphakama imithamo emikhulu ye-insulin), ubungozi be-hypoglycemia buyanda. Uma kwenzeka ukubonakaliswa okungekuhle kuchazwe ngenhla, ukulungiswa komthamo kuyadingeka, ngaphezu kwalokho, izinga leshukela lifakwa ngokujwayelekile ngokuthatha umkhiqizo omnandi (ngokwesibonelo, ushukela).
Ngezimpawu ezibuthakathaka ze-hypoglycemia, isilinganiso esifana nokwehla komzimba siyasebenza.
Kulesi simo se-pathological sobunzima obulinganiselayo, izinga le-glucose lilungiswa ukuphathwa kwe-glucagon (subcutaneously). Emva kwalokhu, kunconywa ukudla okunama-carbohydrate amaningi. Izinyathelo ezifanayo zithathwa ukubonakaliswa okunamandla kwe-hypoglycemia, kepha kulokhu, i-glucagon nayo iphathwa nge-intramuscularly / intravenously.
Ukuxhumana nezinye izidakamizwa
Ukusebenza kweHumalog Mix kungancishiswa ngenkathi kusetshenziswa izindlela ezinjalo:
- glucocorticosteroids;
- izindlela zokuvimbela ukuphathwa komlomo;
- ama-hormone egilo aqukethe iodine;
- I-diuretics yeqembu le-thiazide;
- i-beta2-adrenergic agonists;
- ama-ejenti aqukethe i-phenothiazine derivatives;
- Isoniazid;
- i-nicotinic acid.
Lapho uxhumana nomuthi i-Isoniazid, ukusebenza kweHumalog Mix kuyancishiswa.
Izinga lokusebenza landa ngaphansi kwethonya lezidakamizwa ezinjalo:
- izidakamizwa ze-anabolic;
- ama-beta-blockers;
- izidakamizwa ze-tetracycline;
- amanye ama-ejenti we-hypoglycemic;
- izidakamizwa ze-antimicrobial zeqembu le-sulfanilamide;
- ama-salicylates;
- ama-ejenti we-angiotensin aguqula iqembu le-enzyme inhibitor.
Ama-Analog
Isikhundla esijwayelekile i-Insulin Lizpro ngezigaba ezimbili.
Izimo zokuphumula Humaloga Mix kusuka ekhemisi
Umuthi yiqembu lemithi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Cha.
Intengo Ye-Humalog Mix
Izindleko ezijwayelekile ama-ruble ayi-1800.
I-Humalog Mix itholakala kuphela ngokubhaliwe.
Izimo zokugcina zomuthi
Izinga lokushisa lingahluka phakathi kuka + 2 ... + 8 ° ะก. Ngemuva kokuvula ukufaka, isirinji ingagcinwa ngaphakathi uma izinga lokushisa lomoya lingadluli + 30 ° C.
Isikhathi sokuphelelwa yisikhathi
Umuthi osephaketheni eligciniwe awuphuthelwa yimpahla iminyaka emi-3 kusukela ngosuku okhiphe ngalo. Ngemuva kokuvula ingasetshenziswa zingakapheli izinsuku ezingama-28.
Umenzi weHumalog Mix
ILilly France, eFrance.
Ukubuyekezwa Komxube weHumalog
UVeronika, oneminyaka engama-38, uNizhny Novgorod
Isidakamizwa sisebenza ngokushesha, lokhu inzuzo yaso eyinhloko. Kepha angiyithandi indlela esebenza ngayo: iguqula ushukela ngokweqile ube amafutha, othinta isisindo. Ngenkathi i-analogue ingenakukhethwa, ngiyaqhubeka nokusebenzisa leli thuluzi.
U-Ana, oneminyaka engama-42, Perm
Umuthi kulula ukusisebenzisa: ungazifaka umjovo, ulawule impilo yeshelufu ye-insulin esitokisini. Kuyadabukisa ukuthi umphumela unyamalala ngokushesha. Ngaphandle kwalokho, lesi sidakamizwa singifanele. Intengo iphakeme kancane, kepha kwizimali zaleli qembu kubhekwa njengokujwayelekile.
