I-Metformin ende ibekelwe iziguli ukuze kuncishiswe amazinga e-plasma glucose. Ngaphezu kwalokho, ithuluzi linconyelwa abantu abafuna ukunciphisa umzimba.
Umuthi weqembu le-Biguanide ubangela imiphumela eminingi engathandeki yomzimba, ngakho-ke kubalulekile ukubonana nodokotela ngaphambi kokuqala ukwelashwa.
Igama Lezwe elingafanele
I-Metformin (igama lesiLatini) - igama lezinto ezisebenzayo.
I-Metformin ende ibekelwe iziguli ukuze kuncishiswe amazinga e-plasma glucose.
I-ATX
I-A10BA02 - ikhodi yokuhlukaniswa kwamakhemikhali okwelashwa nokwelashwa.
Khipha amafomu nokwakheka
Amacwecwe ama-retard (obamba isikhathi eside) ayatholakala kumathini wamapoll wama-30 ama-pcs. kulinye lazo, kanye nama-5 noma ama-10 ama-PC. ekufakweni kweseli.
Ithebhulethi ngayinye iqukethe ama-850 mg noma ama-1000 mg wezinto ezisebenzayo.
Ithebhulethi ngayinye iqukethe ama-850 mg noma ama-1000 mg wezinto ezisebenzayo.
Isenzo se-Pharmacological
I-Metformin inethonya le-hypoglycemic, inciphisa ukukhululeka koshukela amaseli wesibindi futhi ibambezele ukungena kwayo emathunjini.
Ngesikhathi sokusetshenziswa kweMetformin, ukwehla kwesisindo somzimba wesiguli kuyabonakala, njengoba isakhi esisebenzayo somuthi sinomphumela omuhle ku-metabolism yezakhi ze-organic, kufaka phakathi amafutha (lipids).
I-Pharmacokinetics
I-Metformin idonswa kusuka ku-rectum iye ekujikelezeni kwe-systemic. Uma uphuza amaphilisi ngokudla, khona-ke kunenqubo ende yokufaka i-element esebenzayo.
Imikhiqizo yokubola yento esebenzayo idonswa izinso kumchamo futhi inani elincane lama-metabolites atholakala ezindundwini.
Uma uphuza amaphilisi ngokudla, khona-ke kunenqubo ende yokufaka i-element esebenzayo.
Izinkomba zokusetshenziswa
Umenzeli we-hypoglycemic ubekelwe:
- thayipha 1 bese uthayipha isifo sikashukela 2;
- ukukhuluphala, uma kunesidingo sokulawula ukugcwala kweglucose egazini, okungatholakali ngokubheka imigomo yokudla nokuzivocavoca;
- i-polycystic ovary, kepha ngaphansi kokuhlolwa ngudokotela.
Contraindication
Ithuluzi lihlaselwe ukusetshenziswa ne:
- ukungabekezelelani komuntu nomuntu nge-metformin;
- umsebenzi wokulimala wezinso (i-creatinine imvume 45-59 ml / min.);
- ukugabha okuphikelelayo kanye nohudo;
- izilonda ezithambile zezicubu;
- i-infarction ye-myocardial eyingozi kakhulu;
- ukwephulwa kwemali esele ye-electrolyte;
- Ukudla kwe-hypocaloric;
- amazinga akhuphukayo e-lactic acid egazini (lactic acidosis);
- uphuzo oludakayo.
Umuthi uphulwe ukuze usetshenziswe uma kwenzeka umsebenzi wokulimala we-renal (clearinine clearance 45-59 ml / min.).
Ngokunakekela
Iziguli ezinokwehluleka kwesibindi okunamandla azinconywa ukuthatha amaphilisi okukhishwa isikhathi eside.
Ungayithatha kanjani i-Metformin Long
Kubalulekile ukulandela imiyalo yokusetshenziswa komuthi ukufeza izinguquko ezinhle zezimpawu zomtholampilo.
Kunezici eziningi ezinjalo:
- Ithebhulethi akufanele ihlafunwe. Uma kunzima kwisiguli ukugwinya ithebhulethi engu-0,85 g, kunconywa ukulihlukanisa libe izingxenye ezimbili, ezithathwa ngokulandelana, kungagcini isikhathi sokuphumula.
- Kubalulekile ukuphuza umuthi ngamanzi amaningi ukuze ugweme izinkinga ngomgudu wokugaya ukudla.
- Umthamo wento esebenzayo ukhuphuka ngemuva kwezinsuku eziyi-10-14.
- Umthamo omkhulu wemihla ngemihla weMetformin ngu-3000 mg.
Ithebhulethi akufanele ihlafunwe. Uma kunzima ngesiguli ukugwinya ithebhulethi engu-0,85 g, kunconywa ukuyihlukanisa izingxenye ezimbili.
Ngaphambi noma ngemuva kokudla
Umuthi kufanele uphuzwe ngesikhathi sokudla isidlo sakusihlwa noma ngokushesha ngemuva kokudla.
Ngoshukela
I-Metformin isetshenziswa njengesijobelelo ekusebenziseni okuhlangene kwe-insulin.
Umthamo wokuqala wengxenye esebenzayo ngu-500 mg (Metformin MV-Teva), bese uyandiswa ube ngu-750 mg ngosuku.
Ukwehla kwesisindo
Ukukhetha kwe-dose kwenziwa ngakunye. Ezimweni eziningi, umthamo ophelele nsuku zonke weMetformin awudluli ku-2000 mg.
Ukuze ulahlekelwe isisindo, ukukhethwa kwamthamo kwenziwa ngokuhlukile.
Imiphumela emibi yeMetformin Long
Umuthi ubangela imiphumela emibi eminingi.
Amapheshana wesisu
Iziguli zivame ukukhononda ngohudo nokuhlanza. Kepha izimpawu ezifanayo ezimweni eziningi ziyanyamalala kungakapheli isonto lokuqala ukuphuza amaphilisi.
Ngasohlangothini lwe-metabolism
Akukapheli ukuthi kukhuliswe i-lactic acidosis.
Engxenyeni yesikhumba
Ubomvu besikhumba kungenzeka, okuhambisana nokulunywa kanzima.
Uhlelo lwe-Endocrine
I-Hypoglycemia akuvamile ukwenzeka.
Kusukela ohlelweni lwe-endocrine, i-hypoglycemia ayivelakancane.
Allergies
Uma kwenzeka kune-hypersensitivity kuMetformin, kuvela ukuqubuka esikhunjeni.
Umthelela ekhonweni lokulawula izindlela
Ithuluzi alithinti ukushayela.
Imiyalo ekhethekile
Kuyadingeka ukubheka izici ezimbalwa ngaphambi kokusebenzisa umuthi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ukuthatha amaphilisi kubhekwe kubesifazane abakhulelwe nangesikhathi sokuncelisa, njengoba ukwephula lo mthetho kungalimaza ingane.
Ukuthatha amaphilisi kubhekwe kubesifazane abakhulelwe nangesikhathi sokuncelisa, njengoba ukwephula lo mthetho kungalimaza ingane.
Ukunquma Imetformin Isikhathi Eside Enganeni
Izingane ezingaphansi kweminyaka engu-15 ubudala akufanele zisebenzise lesi sidakamizwa, ngoba ukuphepha kokusetshenziswa kwayo kulesi sigaba sobudala akukaze kufakazelwe.
Sebenzisa ebudaleni
Kubalulekile ukuqapha njalo amazinga eglucose egazini futhi ubheke nesimo sezinso ngesikhathi sokwelashwa.
Isicelo sokusebenza kokulimala kwezinso
Ngokuqapha, kubekwa izibhebhe ezigulini ezinenkinga yokuqina kwezinso.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukulungiswa komthamo kuyadingeka kwiziguli ezinenkinga yesibindi.
Ukulungiswa komthamo kuyadingeka kwiziguli ezinenkinga yesibindi.
I-overdose yeMetformin ende
Ngokusetshenziswa okungalawulwa kwesidakamizwa, i-lactic acidosis iyakhula, ehambisana nokuhlanza nobuhlungu esiswini esingezansi.
Uma kwenzeka kweqisa okwenziwe ngezinto ezisebenzayo, i-hemodialysis izosebenza.
Ukuxhumana nezinye izidakamizwa
Kubalulekile ukucubungula okulandelayo:
- I-Hypoglycemia kungenzeka ngokusetshenziswa kanyekanye kokutholwa kwe-sulfonylurea.
- Lapho kuhlanganiswa ne-cimetidine, inqubo yokuqedwa kweMetformin emzimbeni yehlisa ijubane.
- Ukuhambisana komuthi nemithi equkethe iodine kuqinisekisiwe. Izidakamizwa ezinjalo zisetshenziselwa izifundo ze-x-ray. Kunengozi enkulu yokuthola ukungasebenzi kwe-renal kuleli cala.
- I-Nifedipine yenza buthaka umphumela we-hypoglycemic weMetformin.
I-Nifedipine yenza buthaka umphumela we-hypoglycemic weMetformin.
Ukuhambisana notshwala
Kufanele uyeke ukusetshenziswa kweziphuzo eziqukethe i-ethanol ukuze ugweme izinkinga.
Ama-Analog
I-Glucophage ende ayisebenzi ngempumelelo ye-Metformin.
Uyini umehluko phakathi kweMetformin neMetformin ende
Umehluko oyinhloko umthamo wento esebenzayo.
Umehluko omkhulu kusuka kuMetformin umthamo wento esebenzayo.
Imibandela yekhefu lekhemisi
Umuthi lo uyatholakala cishe kuwo wonke amakhambi ekhemisi eRussia.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi ungathengwa ngaphandle kwemithi kadokotela.
Intengo yeMetformin Long
Izindleko zemithi eRussia zingama-ruble angama-270. amaphilisi angama-60.
Izimo zokugcina zomuthi
Kubalulekile ukukhawulela ukufinyelela kwezingane nomuthi.
Isikhathi sokuphelelwa yisikhathi
Umuthi ungasetjenziswa engakapheli iminyaka emi-3 ukusuka ngelanga lokwenziwa ngawo.
Umkhiqizi
Amathebulethi akhiqizwa yinkampani yaseRussia i-Biosynthesis.
Amathebulethi akhiqizwa yinkampani yaseRussia i-Biosynthesis.
Ukubuyekezwa mayelana neMetformin Long
Kunezimpendulo zombili ezinhle nezimbi mayelana nezindawo zokwelapha zomuthi.
Odokotela
U-Anatoly Petrovich, oneminyaka engama-34, eMoscow
Nginikeza lo muthi ezigulini zabantu abadala ukwelashwa kwesifo sikashukela. Emsebenzini wezokwelapha, angizange ngihlangane nemiphumela emibi ekuphuzeni amaphilisi okubuyisa. Ukuhlelwa ngokwejwayelekile kwamazinga kashukela egazini kuye kwabonwa izinsuku eziyi-14.
U-Yuri Alekseevich, oneminyaka engama-38, eSt
Ngokuya ngemithetho yokuphuza umuthi, akubanga khona ukusabela okungathandeki komzimba. Ezimweni ezingavamile, abesifazane babe nokuhlaselwa i-malaise kanye nokudla. Angincomi umuthi ezigulini ezinenkinga yokusebenza kwesibindi.
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Iziguli
U-Olga, oneminyaka engama-50, u-Omsk
Yaphathwa nge-Metformin isikhathi eside, okwaba yisizathu sokumuncwa kabi kwe-vithamini B12. Ngenxa yalokhu kwephula umthetho, i-anemopablastic anemia yathuthuka. Umuthi kufanele uphathwe ngokucophelela futhi kubalulekile ukuthi uhlolwe ngokuxilonga ngesikhathi esifanele.
UMikhail, oneminyaka engama-45, Perm
Wanelisekile ngomphumela wokwelashwa ngeMetformin. Ukuphuza amaphilisi akubeki umkhawulo ekukhetheni komsebenzi wobungcweti. Umuthi awuthinti ukuphathwa kwezindlela eziyinkimbinkimbi, ngakho-ke zingasetshenziswa uma umsebenzi uhlotshaniswa nokukhula kokunakwa okuningi.
Ukulahlekelwa isisindo
ULarisa, oneminyaka engama-34, u-Ufa
Awuzange uzuze umphumela oyifunayo. Ngilandele ukudla futhi angangeqi umthamo wento esebenzayo esungulwe udokotela. Ubhekene nokuhlanza okungapheli kanye nesitulo esidabukisayo ngosuku lwe-5 lokuthatha umuthi.
UJulia, oneminyaka engama-40, Izhevsk
Akukho ukusabela okungekuhle okwenzekile, kepha akubanga lula ukwehlisa isisindo ngemuva kwenyanga yokulawulwa okuhleliwe kwamathebulethi.
