Umuthi i-Finlepsin Retard: imiyalo esetshenzisiwe

Isidakamizwa i-Finlepsin Retard sisiza ukuguqula isimo ngokubandakanyeka komzimba, siqede izinhlungu, izimpawu ezingezinhle uma kwenzeka kuphazamiseka uhlelo lwezinzwa. Inethonya ezinqubweni eziningi ze-biochemical emzimbeni, ngakho-ke, lo muthi kufanele usetshenziswe ngaphansi kokuqondisa uchwepheshe. Izinzuzo zifaka inani eliphansi.

Igama Lezwe elingafanele

Carbamazepine. Igama ngesiLatini yiCarbamazepine.

Isidakamizwa i-Finlepsin Retard sisiza ukuguqula isimo ngokubandakanyeka kokuxineka, sisuse izinhlungu, izimpawu ezingezinhle ekuphazamisekeni kohlelo lwezinzwa.

I-ATX

I-N03AF01 Carbamazepine

Khipha amafomu nokwakheka

Ungathenga umuthi kuphela ngesimo samathebulethi. Umehluko phakathi kwe-Finlepsin Retard ubukhona begobolondo elibonakaliswa yizinto ezikhethekile. Inikeza umphumela wesikhathi eside wezidakamizwa. Lokhu kusho ukuthi into esebenzayo ikhishwa kancane. Umuthi uyingxenye eyodwa. Into esemqoka yi-carbamazepine. Inani layo ngokwakhiwa kwethebhulethi engu-1: 200 no-400 mg. Ezinye izinto:

• ikopolymer ye-ethyl acrylate, trimethylammonioethyl methacrylate, methylryacacetlate;
• unxantin;
• i-Copolymer ye-methaconic acid ne-ethyl acrylate;
• i-talc;
• i-crospovidone;
• i-microcrystalline cellulose;
• i-magnesium stearate;
• i-silicon dioxide colloidal.

Ungawuthenga lo muthi emaphaketheni aqukethe 3, 4 noma ama-5 amanxeba (ngalinye linamaphilisi ayi-10).

Ungawuthenga lo muthi emaphaketheni aqukethe 3, 4 noma ama-5 amanxeba (ngalinye linamaphilisi ayi-10).

IFinlepsin Retard ingathengwa kuphela ngefomu lepilisi.

I-Carbamazepine isebenza njengento esemqoka, inani layo ngokwakhiwa kwethebhulethi le-1: 200 no-400 mg.

Kusebenza kanjani

Izici eziyinhloko:

• antiepileptic;
• i-painkiller;
• antidiuretic;
• antipsychotic.

Umphumela we-pharmacological walomenzeli usekelwe ekuvinjeni iziteshi ze-sodium. Umphumela oyifunayo ungatholakala kuphela uma ancike ku-voltage. Ngenxa yalokhu, ukuqedwa kwe-excitability ekhuphukayo yama-neurons kuyaphawulwa, ngenxa yokuzinza kolwelwesi lwayo. Futhi, ngaphansi kwethonya lomuthi, ukuqina kwe-synaptic conduction ye-impulses kuyehla.

Isisekelo sokwelashwa kwe-antiepileptic ukwanda komkhawulo ophansi wokulungela ukweyisa.

Kukhona ukwehla kobukhulu bokukhiqizwa kwe-glutamate - i-amino acid efaka isandla ekwandeni kokukhishwa kwama-neurotransmitters. Ngenxa yalezi zakhiwo, amathuba okuqanjwa kokuwa kwesithuthwane ancishisiwe. Ingxenye eyinhloko ibandakanyeka ekuthuthweni kwe-potassium, i-calcium ion.

Uma i-negegia ye-trigeminal ikhula, ngenxa ye-Finlepsin Retard, ubukhulu bokuhlaselwa izinhlungu buyancipha.

Umuthi uyasebenza futhi wehlisa ukuqina kwezimpawu ezingezinhle uma kwenzeka kuhlaselwa uhlobo oluhlukile. Ngesikhathi sokwelashwa kweziguli ezinesifo sokuwa, kukhona ukuthuthuka kwezimo zempilo ezinjengokukhathazeka, ukudangala, ukuba nolaka, ukungabekezeleleki.

Umphumela we-antipsychotic ubangelwa ukuvimbela izinqubo ze-metabolic ze-norepinephrine, dopamine. Ngobuthi botshwala, ubukhulu bokuthuthuka kokufiphala buyancipha. Lokhu kungenxa yokwanda komkhawulo ophansi wokulungela ukweyisa. Uma i-negegia ye-trigeminal ikhula, ngenxa ye-Finlepsin Retard, ubukhulu bokuhlaselwa izinhlungu buyancipha. Ngaphezu kwalokho, ukwelashwa okufika ngesikhathi nalesi sidakamizwa kusiza ukuvimbela ukuqala kobuhlungu ngokuxilongwa okunjalo.

I-Pharmacokinetics

Isikhathi sokukhishwa kwento esebenzayo singamahora ayi-12. Ekupheleni kwalesi sikhathi, kuyezwakala ukwanda kwezinga lokusebenza kahle kakhulu. Umuthi udonswa ngokuphelele yizindonga zendlela yokugaya.

Umuthi osebenzayo ubopha amaprotheni e-plasma anamandla ahlukahlukene: aze afike ku-60% ezinganeni, angama-70-80% ezigulini zabantu abadala.

Inqubo ye-metabolism ye-carbamazepine yenzeka esibindini, ngenxa yalokho, kukhiqizwa isakhi esisebenzayo esingu-1. Le nqubo iyafezeka ngokubamba iqhaza kweCYP3A4 isoenzyme.

Iningi le-carbamazepine eliguquliwe lifakwa ngesikhathi sokuchama, okuyingxenye encane enezinduku ngesikhathi sokwehla. Kuleli nani, 2% kuphela yento esebenzayo esuswa ingashintshiwe. Ezinganeni, i-carbamazepine metabolism isheshe. Ngalesi sizathu, kusetshenziswa imithamo ephezulu.

Isikhathi sokukhishwa kwento esebenzayo singamahora ayi-12.

Okunqunyelwe

Indawo esemqoka yokufaka isicelo isithuthwane. Ngaphezu kwalokho, umuthi uyasebenza ezimeni ezinjalo zezimpawu kanye nezimpawu:

• ukuthathwa kwemvelo ehlukile: ngokwengxenye, ngokuphoxayo;
• izindlela ezixubile zesifo sokuwa;
• i-neuralgia yemvelo ehlukile: i-trigeminal nerve, i-idiopathic glossopharyngeal neuralgia;
• i-pain syndrome ebangelwa i-peripheral neuritis, engahle ibe ngumphumela wesifo sikashukela;
• izimo ezethusayo ezenzeka ngemijikelezo yemisipha ebushelelezi, i-sclerosis eminingi;
• ukukhuluma okungahambi kahle, ukunyakaza okulinganiselwe (i-pathology yemvelo ye-neurological);
• ukuphefumula kobuhlungu nokungasebenzi kohlelo lwezinzwa oluzimele;
• ubuthi botshwala;
• ukuphazamiseka kwengqondo.

IFinlepsin Retard imiselwe ubuthi obunobuthi.

Amacwecwe amiselwe ukuphazamiseka kokukhuluma.

Umuthi uyasebenza ngezindlela ezixubile zesifo sokuwa.

Contraindication

Umuthi awunemikhawulo eminingi yokusetshenziswa, phakathi kwabo inothi:

• ukwephulwa kohlelo lwe-hematopoietic, oluhambisana nezimo ze-pathological ezinjenge-leukopenia, anemia;
• I-AV block
• isifo sofuzo se-porphyria, esihambisana nokuphulwa kwe-pigment metabolism;
• ukusabela okuhlukile komuntu noma i-hypersensitivity.

Izimo eziningana ze-pathological ziyaphawulwa lapho kulawulwa khona i-carbamazepine ku-plasma:

• ukwephulwa kwe-hematopoiesis yamathambo;
• ama-neoplasms ku-prostate;
• ukukhuphuka kwengcindezi ye-intraocular;
• ukwehluleka kwenhliziyo;
• i-hyponatremia;
• utshwala.

Ngokucindezela okwandayo kwe-intraocular, ukulawulwa kwe-carbamazepine ku-plasma kuyadingeka.

I-anemia kuwukuphikisana nokunikezwa umuthi.

Umuthi ubekwa ngokuqapha uma kungaphelelwa umsebenzi wenhliziyo.

Ungayithatha kanjani i-Finlepsin Retard

Umuthi usebenza ngempumelelo ngokulinganayo lapho usetshenziswa ngaphambi nangemva kokudla. Ithebhulethi ayikwazi ukuhlafunwa, kepha ingahlakazwa kunoma yiluphi uketshezi. Isikimu sehluka ngokuya ngohlobo lwesimo se-pathological. Imvamisa kunqunywa kungabi ngaphezu kwe-1200 mg yento ngosuku. Umthamo uhlukaniswe ngemithamo emibili, kepha ungasebenzisa umuthi kanye. Inani eliphezulu elivumelekile lansuku zonke yi-1600 mg. Imiyalo esetshenzisiwe kuma-pathologies ahlukahlukene:

• isithuthwane: inani lokuqala lomuthi liyahluka phakathi kwe-0-0-0,4 g ngosuku, bese lenyuswa laya ku-0,8-1.2 g;
• i-trigeminal neuralgia: qala inkambo yokwelapha kusuka ku-0-0-0.4 g ngosuku, kancane kancane umthamo unyuka uye ku-0,4-0.8 g;
• ubuthi botshwala: 0,2 g ekuseni, u-0,4 g kusihlwa, ezimweni ezibucayi, umthamo unyuswa waba ngu-1,2 g ngosuku futhi uhlukaniswe ngemithamo emibili;
• ukwelashwa kokuphazamiseka kwengqondo, izimo ezethusayo ku-multiple sclerosis: 0.2-0.4 g izikhathi ezi-2 ngosuku.

Umuthi usebenza ngempumelelo ngokulinganayo lapho usetshenziswa ngaphambi nangemva kokudla.

Ubuhlungu ku-neuropathy yesifo sikashukela

Uhlobo lokwenza okujwayelekile: i-0,2 g yento ekuseni kanye nomthamo ophindwe kabili (0.4 g) kusihlwa. Ezimweni ezihlukile, u-0,6 g unqunywa amahlandla ama-2 ngosuku.

Kuthatha isikhathi esingakanani

Inani eliphakeme lokusebenza libonakala emahoreni angama-4 ukuya kwe-12 ngemuva kokuqala kokwelashwa.

Khansela

Kwenqatshelwe ukumisa ngokushesha inkambo yokwelashwa, ngoba lokhu kungavusa ukukhula kokuhlaselwa. Kunconywe ukunciphisa umthamo kancane kancane - kungakapheli izinyanga eziyisithupha. Uma kunesidingo esiphuthumayo sokukhansela i-Finlepsin Retard, ukwelashwa ngezidakamizwa ezifanele kwenziwa. Lokhu kunciphisa amathuba okuba nemiphumela emibi.

Imiphumela emibi yeFinlepsin Retard

Ububi bomuthi ubungozi obukhulu bokuthuthukisa ukusabela komuntu kwesimo esehlukile ekuphenduleni ekwelashweni. Lokhu kungenxa yokuthi into esebenzayo ekwakhiweni kwayo ibandakanyeka ezinqubweni ze-biochemical zomzimba. Babona ubungozi bokuba nesiyezi, ukozela, ukuncipha okukhulu kwezicubu, ikhanda. Ukunyakaza okuzenzakalelayo, ama-nystagmus, ama-hallucinations, ukucindezela kanye nokunye ukuphazamiseka kwengqondo akuvamile ukwenzeka.

Umuthi ungadala ukubonwa kwezimpawu zamehlo.

Ngemuva kokuthatha umuthi, ubungozi besiyezi buyabonakala.

Ukusabela okubi kulo muthi kukhonjiswa ngobuhlungu besisu.

Ngemuva kokuthatha i-Finlepsin, uRetard uyanyamalala.

Ngemuva kokuthatha amaphilisi, isicanucanu kwenzeka, futhi emva kwaso - ukuhlanza.

Amapheshana wesisu

Ukubonakala komile emgodini womlomo kuyaphawulwa, isifiso sokudla siyanyamalala. Kukhona isicanucanu, futhi emva kwaso - ukugabha, izinguquko zesisu, Ubuhlungu esiswini. Izimo ezinjalo ze-pathological zikhula: i-stomatitis, i-colitis, i-gingivitis, i-pancreatitis, njll.

Izitho zeHematopoietic

I-anemia, i-leukopenia, i-thrombocytopenia, i-agranulocytosis, i-porphyria yemvelo ehlukile.

Kusuka ohlelweni lomchamo

Ukwehluleka kwe-Renal, i-nephritis, izimo ezihlukahlukene ze-pathological ezidalwe ukwephulwa kokukhipha komchamo (ukugcinwa kwe-fluid, incontinence).

Kusuka ohlelweni lwezinhliziyo

Izinguquko ekushintsheni kwe-intracardiac, i-hypotension, izimo zokugula okubangelwa ukwanda kokubonakala kwegazi kanye nokwanda kokuqina kweplatelet, izinkinga zesifo se-coronary, ukuphazamiseka kwesigqi senhliziyo.

Ukusabela kokungezwani nomuthi kukhonjiswa i-urticaria.

Ukusuka ohlelweni lomchamo, ukwehluleka kwezinso, i-nephritis, kuvela izimo ezahlukahlukene ze-pathological.

Uhlelo lwe-endocrine kanye nemetabolism kungadala ukukhuluphala.

Kusuka ohlelweni lwe-endocrine kanye nemetabolism

Ukukhuluphala, ukuvuvukala, okuhambisana nokugcinwa kwamanzi emzimbeni wezicubu, umphumela emiphumeleni yokuhlolwa kwegazi, ushintsho kumetabolism yethambo, okuholela ezifweni zohlelo lwe-musculoskeletal.

Allergies

I-Urticaria. I-Erythroderma ingahle ikhule.

Umthelela ekhonweni lokulawula izindlela

Umuthi unomphumela omubi emsebenzini wezitho eziningi nezinhlelo, kuvuselela izimpawu eziyingozi: ukwazi ukungasebenzi kahle, ukuqunjelwa ingqondo, isiyezi, njll. Ngalesi sizathu, kufanele kuqashelwe lapho ushayela izimoto. Kungcono ukuyeka ukushayela isikhashana.

Ngesikhathi sokulashwa, kufanele kuqashelwe lapho ushayela.

Ukuqala ukwelashwa ngomuthi, kufanele kwenziwe i-electroencephalogram.

Ngaphambi kokuqala ukwelashwa, udinga ukuthatha ukuhlolwa kwegazi nomchamo.

Imiyalo ekhethekile

Qala ukwelashwa ngemithamo emincane. Kancane kancane, inani lemihla yonke leincenye main liyanda. Kubalulekile ukulawula izinga le-carbamazepine egazini.

Kumele kukhunjulwe ukuthi ukwelashwa kwe-antiepileptic kuvusa ukubukeka kwezinhloso zokuzibulala, ngakho-ke, isiguli kufanele sigadiwe kuze kube yilapho inkambo yokwelashwa isiqediwe.

Ngaphambi kokuqala ukwelashwa, kuhlolwa isimo sesibindi nezinso. Kuyadingeka ukuthatha ukuhlolwa kwegazi, ukuhlolwa komchamo, i-electroencephalogram.

Sebenzisa ebudaleni

Kuvunyelwe ukusebenzisa umuthi ezigulini ezingaphezulu kweminyaka engu-65. Kodwa-ke, umthamo onconywayo ngu-0,2 g ngosuku kanye.

Kuvunyelwe ukusebenzisa umuthi ezigulini ezingaphezulu kweminyaka engu-65.

Ngesikhathi sokukhulelwa, uvunyelwe ukusebenzisa umuthi, kepha lokhu kufanele kwenziwe kuphela ngokuya izinkomba eziqinile.

Ukuqokwa kweFinlepsin Retard ezinganeni kuvunyelwe kusuka eminyakeni engu-6.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Umuthi ungangena nge-placenta ubisi lwebele, kanti ukuqoqwa kwe-carbamazepine kuleli cala kungu-40-60% wesamba sonke esisegazini. Ngesikhathi sokukhulelwa, kunobungozi bokukhula kwama-pathologies esibelethweni ngenkathi uthatha umuthi okukhulunywa ngawo. Kodwa-ke, isavunyelwe ukusebenzisa umuthi, kepha kufanele wenziwe kuphela izinkomba eziqinile, uma imiphumela emihle yokwelashwa idlula ukulimala okungenzeka.

Ukunquma uFinlepsin Buyisela Ezinganeni

Vumela ukwelashwa kweziguli kusuka eminyakeni engu-6. Umthamo onconyiwe ngu-0,2 g ngosuku. Ngemuva kwalokho yandiswa nge-0,1 g kuze kube yilapho umphumela oyifunayo ufinyelelwa.

Isicelo sokusebenza kokulimala kwezinso

Umuthi uvunyelwe ukusetshenziswa kuma-pathologies alesi sitho, noma kunjalo, kuyadingeka ukuqapha isimo sesiguli.

Sebenzisa umsebenzi wesibindi okhubazekile

Kuvunyelwe ukunquma ikhambi kuleli cala. Uma umsebenzi wesibindi ongasebenzi kahle uqina, udinga ukuphazamisa inkambo.

Ukusetshenziswa kwesidakamizwa kuvunyelwe uma kwenzeka umsebenzi wesibindi ongasebenzi kahle.

Ukuthi wenzeni ngokweqile kwe-Finlepsin Retard

Ukubonakaliswa okumbalwa okungekuhle kuyabonakala ukuthi kwenzeka ngokwenyuka okujwayelekile nokubalulekile kwenani elivumelekile le-carbamazepine:

• coma
• ukwephulwa kohlelo lwezinzwa: ukweqiwa, ukugwinya, ukunyakaza okungahleliwe, ukungasebenzi kahle kwamehlo;
• hypotension;
• ukuphazamiseka kwesigqi senhliziyo;
• ukuvimbela umsebenzi wohlelo lokuphefumula;
• ukugabha kanye nenausea;
• kuguqulwa imiphumela yokuhlolwa kwelebhu.

Yenza ukwelashwa okuhlose ukuqeda imiphumela. Ngasikhathi sinye, babheka umsebenzi wenhliziyo, balawula izinga lokushisa lomzimba. Ukulungiswa kokungalingani kwamanzi-electrolyte kuyenziwa. Izinga lezinto ezisebenzayo egazini linqunywa. Gastric lavage kwenziwa. Thatha umuthi. Esikhundleni sekhabhoni eyenziwe yasebenza, noma iyiphi i-ejenti yaleli qembu ingabekwa: iSmecta, i-Enterosgel, njll.

Ngokweqile kwe-Finlepsin Retard, isiguli singawela ekhefini.

Uma kwenzeka okweqa isidakamizwa, kuqubuka i-gastric.

Ngemuva kokudonswa esiswini, kufanele kuthathwe iSmecta.

Ukuxhumana nezinye izidakamizwa

Ngaphambi kokuqala ukwelashwa, naka ubungozi bezinkinga, ezingabangelwa ukusetshenziswa kwezinye izidakamizwa.

Ngokunakekela

Le mishanguzo elandelayo ivusa ukwanda kwezinga lezinto eziyinhloko kwiplasma yegazi: iVerapamil, i-Felodipine, iNicotinamide, i-Viloxazine, i-Diltiazem, i-Fluvoxamine, i-Cimetidine, ne-Danazole, i-Acetazolamide, i-Desipramine kanye nenani lemithi ye-macrolide. Ngalesi sizathu, ukulungiswa komthamo kwenziwa ukunciphisa ukujabhiswa kwe-carbamazepine.

Kukhona ukwanda kokusebenza kwe-folic acid, praziquantel. Ngaphezu kwalokho, ukuqedwa kwama-hormone e-thyroid kuyathuthukiswa.

Kukhona ukwanda kokusebenza kweFinlepsin Retard lapho kuhlangene neDepakine.

Inhlanganisela ayinconywa

Ukuqokwa kukaFinlepsin Retard, kanye nezinye izidakamizwa ezivimbela i-CYP3A4 kuthuthukisa ukuthuthukiswa kwemiphumela emibi. Ngakolunye uhlangothi, ama-CYP3A4 ama-inducers asiza ukusheshisa izinqubo ze-metabolic kanye ne-excretion yento esebenzayo, okuholela ekuncipheni kokusebenza kwomuthi.

Ukuhambisana notshwala

Kwenqatshelwe ukusebenzisa iziphuzo eziqukethe utshwala ngesikhathi sokwelapha ne-Finlepsin. Izinto zisebenza ngesisekelo semigomo ephikisanayo, ngenkathi kunokuncipha kokusebenza kwomuthi.Ngaphezu kwalokho, utshwala bandisa umthwalo esibindini.

Ama-Analog

Ukufakwa esikhundleni okusebenzayo:

• Carbamazepine;
• I-Finlepsin;
• Tegretol;
• Tegretol CO.

I-Tegretol iyisikhundla esisebenzayo seFinlepsin Retard.

Njengokubambela lo muthi, kusetshenziswa umuthi i-Finlepsin.

ICarbamazepine iyi-analogue ephumelelayo yeFinlepsin Retard.

Kwenqatshelwe ukusebenzisa iziphuzo eziqukethe utshwala ngesikhathi sokwelapha ne-Finlepsin.

Imibandela yekhefu lekhemisi

Kutholakala kuphela ngencwadi kadokotela.

Ngingakwazi ukuthenga ngaphandle kadokotela

Cha.

I-Finlepsin Buyisela Intengo

Izindleko ezijwayelekile ziyehluka kusuka kuma-ruble ayi-195-310.

Izimo zokugcina zomuthi

Ukushisa komoya akufanele kudlule + 30 ° С.

Isikhathi sokuphelelwa yisikhathi

Ngemuva kweminyaka emithathu kusukela ngosuku lokukhiqizwa, awukwazi ukusebenzisa umuthi.

Umkhiqizi

I-Teva Operations Poland, ePoland.

Ukushisa komoya ngesikhathi sokulondolozwa umuthi akufanele kudlule + 30 ° C.

Umuthi unikezwa ngomuthi kuphela.

Intengo yeFinlepsin Retard iyahlukahluka kusuka kuma-ruble ayi-195-310.

Ukubuyekezwa kuFinlepsin Retard

UMarina, oneminyaka engama-36, u-Omsk

Umuthi unikezwe umyeni wakhe ngemuva kokushaywa unhlangothi. Ukululama kwenzeka ngaphandle kwezinkinga, ngokushesha okwanele. Umyeni uthathe lesi sidakamizwa ngemuva kwalokhu unyaka. Kwakungekho miphumela emibi.

UVeronika, oneminyaka engama-29 ubudala, uNizhny Novgorod

Ngangiquleka (hhayi ngesimo sokuwa). Ngemuva kwalokho ngaqala ukuphuza umuthi. Kepha akahambelani: isimo siyadakasa futhi kukhona ukubuyisa impendulo.