I-Gluconorm iyadingeka ekwelapheni ukulwa nesifo sikashukela. Kuyasiza ukwenza amazinga e-glucose abe ngokwejwayelekile.
Igama Lezwe elingafanele
I-Glibenclamide + Metformin.
I-ATX
A10BD02.
Khipha amafomu nokwakheka
Umuthi ukhiqizwa ngendlela yamathebulethi. Ithebhulethi eyi-1 iqukethe i-2.5 mg ye-glibenclamide ne-400 mg ye-metformin hydrochloride njengezinto ezisebenzayo. Ziyindilinga ngesimo. Umbala - ukusuka kokumhlophe ucishe ube mhlophe.
I-Gluconorm iyadingeka ekwelapheni ukulwa nesifo sikashukela.
Isenzo se-Pharmacological
I-Metformin ingeqembu lezinto ezibizwa ngokuthi ama-Biguanides. Izinga likashukela egazini lapho lithathwa liyancipha ngenxa yokwanda kokuthikamezeka kwezicubu zepherishi emsebenzini we-insulin. Ukuthathwa kwe-glucose kusebenza ngokwengeziwe. Ama-carbohydrate awangenwa ngokushesha kangako ohlelweni lokugaya ukudla. Ukwakheka kweglucose esibindini kwehle kancane. Iqoqo le-cholesterol egazini liyancipha. I-Hypoglycemia ayikwazi ukubangela.
Ngokuphathelene ne-glibenclamide, kuyaphawuleka ukuthi itholakala kwesulfonylurea yesizukulwane sesibili. Isebenzisa ukukhiqizwa kwe-insulin, ukuphuma kwayo, kubambezela inqubo ye-lipolysis kwezicubu ze-adipose.
Izinga likashukela wegazi lapho lithatha i-Gluconorm lehla ngenxa yokuthi ukuzwela kwezicubu zomzimba ezithintekayo emisebenzini ye-insulin kuyakhuphuka.
I-Pharmacokinetics
Iqoqo eliphakeme kakhulu le-glibenclamide egazini liqoshwa ngemuva kwamahora angu-1-2 ngemuva kokuthatha iphilisi. Ama-95% ahlanganiswe namaprotheni e-plasma egazi. Ukubola kucishe kwenzeke i-100% esibindini. Ubuncane besigamu sempilo ngamahora ama-3, esiphezulu singafinyelela amahora ayi-16.
I-Metformin itholakala ngo-50-60%. Ukuxhumana namaprotheni e-plasma egazi mancane, ukusatshalaliswa ngaphezulu kwezicubu kungachazwa njengokufaniswa. Ziqhuma buthaka, zidlulwa ngokusebenzisa izinso. Ukuqedwa kwesigamu sempilo kungamahora ayi-9 ukuya kwele-12.
Iqoqo eliphakeme kakhulu le-glibenclamide egazini liqoshwa ngemuva kwamahora angu-1-2 ngemuva kokuthatha iphilisi.
Izinkomba zokusetshenziswa
Lesi sidakamizwa, esihlobene nama-hypoglycemic agents, sinqunyelwe ikakhulukazi uhlobo 2 sikashukela ezigulini. Imvamisa, ikhambi liyadingeka lapho isiguli selashwa ngesinye sezakhi esikhonjisiwe ekwakhiweni noma lapho kungekho ukusebenza kahle kokuzivocavoca umzimba nokudla.
Contraindication
Ukwelashwa ngomuthi akukwazi ukwenziwa lapho isiguli sinale mibandela elandelayo:
- i-hypoglycemia;
- ama-pathologies ahambisana ne-tishu hypoxia: i-myocardial infarction, ukungaphatheki kahle kwentliziyo kanye nokuphazamiseka kokuphefumula, ukushaqeka;
- isifo sikashukela sikashukela;
- thayipha i-1 isifo sikashukela;
- i-lactic acidosis ne-porphyria;
- ukushiswa okukhulu noma izinqubo zokutheleleka ezidinga ukwelashwa kwe-insulin okuphuthumayo;
- ukwanda kokuthola izithako ezisebenzayo eziyinhloko zomuthi.
Ungayithatha kanjani i-gluconorm?
Ngoshukela
Ngaphambi kokuthatha amaphilisi, isiguli ngasinye kufanele sifunde imiyalo ukuze ingalimazi impilo yayo. Umthamo kufanele unqunywe ngudokotela onquma umuthi. Unquma umthamo ofanele ngokusekelwe kuliphi izinga le-glucose egazini elibhalwe esigulini ngesikhathi esithile. Ngokuvamile, ukudla kubhekwa.
Umthamo ophakeme kakhulu ngosuku awukwazi ukuba ngaphezu kwamaphilisi ayi-5. Ngokuyisisekelo, yithebhulethi eli-1 ngosuku (400 mg / 2.5 mg). Kusukela ekuqaleni kokwelashwa, njalo emavikini angu-1-2 inkambo yokwelashwa ingalungiswa, njengoba udokotela eqapha ushintsho emazingeni kashukela egazini. Uma iwa, khona-ke, ngokufanele, umthamo kufanele wehliswe.
Umthamo kufanele unqunywe ngudokotela onquma umuthi.
Imiphumela Emibi ye-Gluconorm
Ukuphuza umuthi kungavusa ukubukeka kokungaphenduki kahle kwezitho ezahlukahlukene.
Amapheshana wesisu
Kungahle kube nokuncipha kwesifiso sokudla, isicanucanu, umuzwa wensimbi emlonyeni.
Amanye amacala aqopha ukuvela kwe-cholestatic jaundice, hepatitis kanye nokwanda kokukhiqizwa kokusebenza kwama-enzyme wesibindi.
Izitho zeHematopoietic
Njengokusabela okungathandeki kokubi kusuka ohlelweni lwe-hematopoietic, ukuthuthukiswa kwe-leukopenia, i-thrombocytopenia kwenzeka. Ngokuvamile, ukwehla kwenani lamangqamuzana amhlophe egazi, i-megaloblastic anemia eba.
Njengokusabela okungathandeki kokubi kusuka ohlelweni lwe-hematopoietic, ukuthuthukiswa kwe-leukopenia kwenzeka.
Isistimu yezinzwa ephakathi
Isiguli singaba nesifo sohlelo lwezinzwa oluyinhloko lapho sisebenzisa lo muthi. Isiguli singathola ikhanda, ubuthakathaka nesiyezi, ukukhathala okukhulu nokuphendula kokungabekezeleli.
I-carbohydrate metabolism
I-Hypoglycemia kungenzeka.
Ngasohlangothini lwe-metabolism
Ukubonakaliswa okuphakeme kakhulu kwezinkinga ze-metabolic yi-lactic acidosis.
I-Hypoglycemia kungenzeka.
Engxenyeni yesikhumba
Into eyivelakancane kakhulu ukwanda kokutholwa kokukhanya kwe-ultraviolet.
Allergies
I-Proteinuria, umkhuhlane, ukulunywa i-urticaria - lokhu kusabela okungalungile kungenzeka esigulini eselashwa ngalo muthi.
Umthelela ekhonweni lokulawula izindlela
Ngenxa yezimpawu zohlelo oluphambili lwezinzwa, kungcono ukwenqaba ukulawula izindlela.
Ngenxa yezimpawu zohlelo oluphambili lwezinzwa, kungcono ukwenqaba ukulawula izindlela.
Imiyalo ekhethekile
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi akufanele uphuzwe ngesikhathi sokukhulelwa. Uma kunesidingo sesifo sikashukela, lokhu kufanele kwenziwe ngokwelashwa kwe-insulin.
I-Metformin iqoqwa obisini lwebele. Lokhu kusho ukuthi ngesikhathi sokwelashwa, kufanele uyeke ukwelashwa nomuthi noma uyeke ukuncelisa ibele bese udlulisela ingane kokufakelwa.
Ukuyalela i-Gluconorm ezinganeni
Ukusetshenziswa kokwelashwa ebuntwaneni akunconywa.
Ukusetshenziswa kokwelashwa ebuntwaneni akunconywa.
Sebenzisa ebudaleni
Umuthi akufanele unikezwe iziguli ezingaphezulu kweminyaka engama-60 ezibonisa ukusebenza kakhulu kwezimoto. Lokhu kungaholela ekukhuleni kwe-lactic coma.
Isicelo sokusebenza kokulimala kwezinso
Ngokungasebenzi kahle kwezinso, ungasebenzisi umkhiqizo.
Sebenzisa umsebenzi wesibindi okhubazekile
Ekusebenzeni okukhulu kwesibindi, ukwelashwa kwezidakamizwa akukwazi ukwenziwa.
Ekusebenzeni okukhulu kwesibindi, ukwelashwa kwezidakamizwa akukwazi ukwenziwa.
I-Gluconorm overdose
Uma umthamo onconyiwe weqiwe kakhulu, isiguli singabhekana ne-lactacide, ukwelashwa okufanele kwenziwe esibhedlela nge-hemodialysis. I-Hypoglycemia kungenzeka, okuzobonakala ngokubonakala komzwa wokulamba, ukuthuthumela, izinkinga zokulala isikhashana nokuphazamiseka kwemizwa.
Ukuxhumana nezinye izidakamizwa
Akunconyelwe ukusetshenziswa kanyekanye ne-fenfluramine yezidakamizwa, i-cyclophosphamide, i-ACE inhibitors, izidakamizwa ze-antifungal, njengoba zithuthukisa umphumela womuthi.
I-Thiazide diuretics equkethe ama-iodine thyroidones angenza buthaka umsebenzi wayo.
Akunconyelwe ukusetshenziswa kwe-fenfluramine.
Ukuhambisana notshwala
Ngesikhathi sokulashwa, kufanele wenqabe ukuphuza utshwala.
Ama-Analog
Ungawususa umkhiqizo nge-Glibomet, Metglib, Gluconorm nge-blueberries (itiye le-herbal, isivuno esivela e-Altai).
Imibandela yekhefu lekhemisi
Ngingakwazi ukuthenga ngaphandle kadokotela?
Ukuphumula kusuka kumakhemisi kungenzeka kuphela ngokuthola umuthi.
Ukuphumula kusuka kumakhemisi kungenzeka kuphela ngokuthola umuthi.
Intengo ye-Gluconorm
Izindleko zomuthi ziqala kusuka kuma-ruble angama-250.
Izimo zokugcina zomuthi
Ukuze uqhube isitoreji emazingeni okushisa angeqi ku-25 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emithathu
Umkhiqizi
M.J. Biopharm (India).
Izindleko zomuthi ziqala kusuka kuma-ruble angama-250.
Ukubuyekezwa kwe-Gluconorm
Bobabili odokotela kanye neziguli abaye belashwa ngalo muthi bashiya izibuyekezo ezinhle.
Odokotela
D.E. UTikhonov, GP, uRyazan: "Umuthi ukhombisa imiphumela emihle ekwelashweni kwesifo sikashukela sohlobo lwe-2. Iziguli zingcono kakhulu."
O.D. U-Ivanova, udokotela obambelela e-endocrinologist, eMoscow: "Ngiwuthatha umuthi njengengcono kakhulu ekwelashweni kwesifo sikashukela sohlobo 2, ngoba sisiza ngokushesha nangendlela ebonakalayo ukuthi singavumeli ukuvela kokubi. Ngizoqala kaningi."
Iziguli
U-Alina, oneminyaka engama-29 ubudala, uBryansk: "Kwakudingeka ngilashelwe ukugula okungathi sikashukela. Ukwelashwa kwakukude, kepha isimo sathuthuka kakhulu. Ngakho-ke, ngiyawuncoma lo muthi."
U-Ivan, oneminyaka engama-49, u-Ufa: "Ngelashwa lesi sidakamizwa esibhedlela. Ngigculisekile ngakho konke, okubandakanya nokunakekelwa kodokotela kanye nomsebenzi wabo. Bangihlola futhi ngakubheka emiphumeleni ebekiwe umthamo walesi sidakamizwa. Ngingasibiza lesi sidakamizwa ngempumelelo futhi ngisincoma kuzo zonke iziguli ezinesifo sikashukela."
