Phakathi kwama-ejenti ahlukile kwesenzo se-hypoglycemic, isidakamizwa Maninil kukhulunywa ngaso ku-radar. Ukuze iziguli ziqonde umongo wokwelashwa futhi ziqaphele ubungozi obukhona, kuyadingeka ukuthi ucabangele umphumela wazo emzimbeni, ufunde ngendlela yokusebenzisa, imithamo nemiphumela emibi engenzeka.
Imininingwane ejwayelekile, ukwakheka, indlela yokukhululwa
Kumakhemisi, umuthi uyathengiswa ngaphansi kwegama lokuhweba elithi Maninil. Bayayikhipha eJalimane. I-INN (igama elingabambeki kwamanye amazwe) lisho iGlibenclamide (elivela egameni lezinto ezisebenzayo).
Yakhelwe ukusetshenziswa kwangaphakathi. Inomphumela we-hypoglycemic, ngakho-ke iqembu eliyinhloko leziguli ezilungiselelwe lona likashukela.
Ukuhanjiswa kweManinil kusimo samathebulethi. Anombala opinki kanye nomumo we-cylindrical. Olunye uhlangothi lwephilisi ngalinye lusengozini.
Isisekelo somuthi yiGlibenclamide, inani laso esigunjini singu-3.5 no-5 mg.
Ngaphezu kwalokho, izithako ezilandelayo ezisizayo zengezwa kulo muthi:
- isitashi samazambane;
- i-magnesium stereate;
- i-lactose monohydrate;
- i-gelatin;
- i-talc;
- udayi.
Umkhiqizo uthengiswa emabhodleleni engilazi angenawo umbala. Iphakheji liqukethe amaphilisi ayi-120.
I-Pharmacology ne-pharmacokinetics
Umuthi osebenzayo wesidakamizwa ungokwesigaba sokuphuma kwe-sulfonylurea. Inomphumela we-hypoglycemic, okwenza kube lula ukuyisebenzisa ekwelapheni isifo sikashukela. I-Glibenclamide ihlotshaniswa namaseli we-beta we-pancreas, ngenxa yokuthi umzimba ukhulisa ukukhiqizwa kwe-insulin.
Ngaphezu kwalokho, lapho uthatha la maphilisi, umuzwa we-insulin uyakhuphuka. Lokhu kunomthelela wokufakwa ngokushesha kweglucose izicubu zemisipha. Isici esibaluleke kakhulu se-Glibenclamide yikhono laso lokunciphisa i-lipolysis, esivimbela ukukhula kwe-atherossteosis. Futhi, lesi sidakamizwa sivimbela ukwakheka kwezigaba zegazi.
Ukufakwa kwe-glibenclamide kuvela emgodini wokugaya ukudla. Le nto iqala ukusebenza ngemuva kwamahora angaba ngu-2. Umuthi ungena ngokuxhumana namaphrotheni aqukethe kwi-plasma yegazi. I-Metabolism yenzeka esibindini, ngokwakhiwa kwama-metabolites amabili athathwa njengongasebenzi. Enye yazo isusa izinso, enye iqedwe nge-bile.
Ukususa uhhafu wezinto eziqukethwe emzimbeni, kuthatha amahora amathathu kuya kwayi-16 (lokhu kuya ngezimpawu zomuntu ngamunye). Isikhathi sokuchayeka kulo muthi okungenani amahora angama-20, ngenkathi ukusebenza kwawo kubonakaliswa ukuthamba kanye ne-physiology.
Izinkomba kanye ne-contraindication
Ekusetshenzisweni kwemithi kubaluleke kakhulu ukulandela imiyalo hhayi ukuyisebenzisa ngokungadingekile. Okuhle kunakho konke ukuthi lapho umuthi unqunywe ngudokotela, khona-ke ungaqiniseka ukuthi umuthi okhethiwe ulungele isiguli esithile.
Kuyadingeka ukwazisa uchwepheshe wazo zonke izinto ezisolisayo, ngoba zingaba yizimpawu zokuphambana okungatholakali.
I-Maninil inconyelwe ukusetshenziswa kuhlobo lwesibili sikashukela. Kuvunyelwe ukuyisebenzisa ngesimo se-monotherapy, ngaphezu kwalokho, ingasetshenziswa ekwelapheni ngokuhlanganiswa. Imvamisa, ezinye izidakamizwa ezinemiphumela ye-hypoglycemic zisetshenziswa nayo.
Ubuye abe nemibuso lapho ukusetshenziswa kungavunyelwe noma kudinga ukuqapha okukhulu.
Ukuphulwa okuqinile kufaka phakathi:
- ukungabekezelelani ngakunye ekwakhekeni;
- uhlobo lokuqala lwesifo sikashukela;
- i-coma noma i-precoma yemvelaphi yesifo sikashukela;
- isifo sikashukela sikashukela;
- ukuhlinzwa kwe-pancreatic kwakamuva (resection);
- ukwehluleka kwesibindi okunzima;
- ukwehluleka okunzima kwezinso;
- ukuvinjwa kwamathumbu;
- ukuzala ingane;
- ukuncelisa;
- iminyaka yesiguli ingaphansi kweminyaka engu-18.
Ukuqapha kuyadingeka maqondana neziguli ezinezici ezilandelayo:
- isifo se-febrile;
- uphuzo oludakayo;
- isifo se-yegilo;
- ubuthi botshwala;
- iminyaka engaphezu kwengu-70.
Kulezi zimo, ukwelashwa ngeManinil kuvunyelwe, kepha kudinga ukwandiswa kokuhlolwa kwezokwelapha.
Ividiyo ezimpawu zesifo sikashukela sohlobo 2:
Imiyalo yokusebenzisa
Uhlobo lokuphuza umuthi iManinil 5 lukhethiwe ngokuhlukile ngokuya nge-glucose egazini, iminyaka yesiguli, izifo ezihambisana nezinye izici. Imvamisa, umthamo wokuqala wesidakamizwa ungama-2,5-5 mg ngosuku (isigamu sethebhulethi noma ithebhulethi yonke). Uma inkambo enjalo ingalethi umphumela oyifunayo, umthamo ungandiswa. Ukukhishwa okuphezulu okuvunyelwe kulo muthi ngu-15 mg.
Thatha umuthi ngaphakathi ngaphambi kokudla. Awudingi ukuhlafuna amaphilisi, kufanele agezwe ngamanzi. Uma umthamo omncane, usetshenziswa ngesikhathi (kaningi ekuseni). Izingxenye ezinkulu zomuthi kufanele zihlukaniswe ngemithamo emi-2.
Kungcono ukuphuza amaphilisi ngasikhathi sinye, lokhu kuzogcina iphrofayili engapheli yomuthi. Uma ukwamukela bekuphuthelwe, ukwengeza umthamo akunconywa.
Iziguli Ezikhethekile Nezinkomba
Kwezinye iziguli, ukuqapha kuyadingeka lapho usebenzisa iManinil.
Lokhu kufaka phakathi:
- Abesifazane abakhulelwe. Ngesikhathi sokuzala kwengane, lesi sidakamizwa siyaphulwa. Ngakho-ke, abesifazane abakhulelwe banikezwa enye impatho.
- Omama abahlengikazi. Akukho mininingwane ngomphumela wezakhi ezisebenzayo zomuthi esekhwalisini yobisi lwebele, ngakho odokotela abalubeki ngesikhathi sokuqunjelwa.
- Izingane nentsha. Ukuphepha kanye nokusebenza kahle kwezidakamizwa zalo mkhakha weziguli akukaphenywa. Ngokuqondene nalokhu, abanesifo sikashukela abangaphansi kweminyaka yobuningi, iManinil ayinconywa.
- Abantu abadala. Ngenxa yezinguquko ezihlobene nobudala emzimbeni walezi ziguli, ukusabela okunamandla kungenzeka kulo muthi, yingakho izinkinga zingaba khona. Ukusetshenziswa kwezidakamizwa ukubelapha kuvunyelwe, kepha badinga umthamo ophansi.
Ukuhambisana nezindlela zokuqapha kuqinisekisa ukusebenza kahle kwezokwelapha nokuphepha kweziguli.
Ama-pathologies ahlobene nesifo sikashukela nawo anomthelela ekukhetheni izidakamizwa. Ezinye izifo ziyisizathu sokwenqaba ikhambi elikhethiwe.
Ngokuqondene neManinil, izifo ezinjalo yilezi:
- Ukwehluleka kwesibindi. Uma ikhona, umphumela we-glibenclamide uyathuthukiswa, ngenxa yokuthi umuntu ukhulisa i-hypoglycemia.
- Ukwehluleka kwangempela. Ngenxa yalokho, i-excretion yento esebenzayo evela emzimbeni ihamba kancane, okunyusa amathuba okuba ne-hypoglycemia. Noma kunjalo, ngale ndlela yokugula, udokotela angabeka iManinil ngethamo elincishisiwe (uma lesi sifo singaqhubeki ngendlela enzima).
Okunye okuvelayo ngomuthi ukuthi kungathinta amandla okushayela. Lapho isimo se-hypoglycemic senzeka, isilinganiso sokuphendula nokunaka siyancipha, okungathinta ukuphepha.
Imiphumela emibi kanye ne-overdose
Eminye yemiphumela emibi eyenzeka ngenxa yalama pilisi ibizwa ngokuthi:
- hypoglycemia
; - ushintsho kwesisindo somzimba;
- isicanucanu
- imivimbo yesikhumba;
- ukwethuka kwe-anaphylactic;
- ukuphazamiseka okubukwayo;
- urticaria.
;Nge-overdose yesidakamizwa, ukuthuthukiswa kwe-hypoglycemia kungenzeka kakhulu. Awuthathi hlangothi ngezindlela ezihlukile - ngokuya ngamandla. Kwenziwa into efanayo nokwenziwa kwemiphumela emibi. Kwezinye izimo, ukusetshenziswa kweManinil kufanele kuyekwe.
Ukusebenzisana kwezidakamizwa kanye nama-analog
Ukusebenza ngempumelelo kokwelashwa kubuye kufundwe nokuhlanganiswa kwezidakamizwa.
UManilin ucindezelwe izidakamizwa ezifana:
- ama-barbiturates;
- okokugcobisa;
- i-sympathomimetics;
- ama-estrogens
- izindlela zokuvimbela inzalo ze-hormonal.
Lokhu kusho ukuthi uma udinga ukuthatha umthamo weManinil ngasikhathi sinye, udinga ukuwandisa.
Ukusebenza kwayo kuthuthukiswa ngu:
- izidakamizwa ze-hypoglycemic;
- ama-antifungal agents;
- ama-beta-blockers;
- Ama-inhibitors e-ACE;
- ama-salicylates;
- tetracyclines.
Ngomthelela ojwayelekile wokuhlanganiswa okunjalo, amaphilisi okukhulunywa ngawo kufanele athathwe kumthamo oncishisiwe.
Isidingo sezidakamizwa zesenzo esifanayo singenzeka kunoma yisiphi isiguli.
Kulezi zimo kuyasetshenziswa
:
- Glyformin;
- UBenjamini;
- I-Amaryl;
- Siofor et al.
Isiguli akufanele sishintshe umuthi sisodwa, ngoba udinga ukuthola ukuthi umuthi okhethiwe ufanelekile yini.
Imibono yongoti neziguli
Ukubuyekezwa kweziguli nodokotela mayelana nomuthi iManinil kuyaphikisana impela. Ayilungele abaningi ngenxa yemiphumela emibi eminingi. Lokhu kuphinde kufakazele ukuthi kuyadingeka ukusondela ekudleni izidakamizwa ngokucophelela nangokucophelela, unake inhlala-kahle kanye nokulinganisa ushukela egazini.
Akuvamile ukuba nginikeze iManinil iziguli zami. Kaningi kube nezimo ze-hypoglycemia ngenxa yalokho, ngakho-ke ngithanda ukusebenzisa ezinye izindlela. Yize ngizwe izinto eziningi ezinhle ngala maphilisi kusuka kozakwabo nakwabazana naye anconywe yena.
U-Lidia Mikhailovna, udokotela we-endocrinologist
Sekukaningi kufanele ngisebenzise lo muthi ukwelapha isifo sikashukela. Zilungele abanye, abanye bakhala ngemiphumela emibi. Kuyadingeka ukubheka izimfanelo zesiguli ngasinye ukuze ukhethe umuthi ofanele.
UDmitry Sergeevich, udokotela wobuchopho
Angimthandi uManinil. Vele, wayigcina ushukela ejwayelekile, kepha ngenxa yalokho ngaba namafutha kakhulu, ngaphandle kwalokho, ngangangihlushwa njalo ngenxa yezinkinga zesisu. Ngacela udokotela ukuthi athathe isikhundla.
UJulia, oneminyaka engama-32
Sekuphele iminyaka emibili ngisebenzisa iManinil. Ungifanela ngaphezu kweminye imishanguzo okwadingeka ngiyiphuze. Ayikho imiphumela emibi, ushukela awukhuphuki. Konke kuhamba kahle.
U-Andrey, oneminyaka engama-41
Izindleko zomuthi zincike kumthamo wento esebenzayo kuwo. Ngokwesilinganiso, iManinil 5 ibiza ama-ruble ayi-150, noma kungaba khona umehluko omncane entweni.
