IVictoza iyi-analogue ye-glucagon-peptide. Le nto ifana ne-GLP yomuntu. Umuthi ucasulula ukuhlanganiswa kwe-insulin yizakhi ezikhethekile zamaselula uma i-glucose iqala ukwedlula izinga elijwayelekile. Lo muthi usetshenziswa ngabanesifo sikashukela neziguli ezifuna ukukhipha amaphawundi angeziwe.
Igama Lezwe elingafanele
ILiraglutide
I-ATX
A10BX07
Khipha amafomu nokwakheka
Umuthi uyatholakala ngesimo sesisombululo, okuhloswe ngaso ukuphathwa ngaphansi kwesikhumba bese ufakwa kwisirinji ekhethekile engu-3 ml.
Ipeni lesirinji liqukethe ama-18 mg wezinto ezisebenzayo (liraglutide).
Izinto ezengeziwe:
- i-sodium hydrogen phosphate dihydrate;
- i-hydrochloric acid;
- phenol;
- digoxin;
- propylene glycol;
- amanzi okujova.
Umuthi i-Viktoza utholakala ngendlela yesisombululo esibekwe kwisirinji yedigri.
Isenzo se-Pharmacological
Isithako esisebenzayo somuthi sibangela ukwakheka kwe-insulin namanyikwe. Ngaphezu kwalokho, kunciphisa ukukhiqizwa kwe-glucagon. Lokhu kukuvumela ukuthi wehlise izinga lakho ushukela ngokugwema i-hypoglycemia. Umuthi usiza ukwehlisa isifiso sokudla, wehlise ijubane lokudla kokudla okuqediwe ungene emathunjini kusuka esiswini.
Izilingo zemitholampilo zifakazele ukuphumelela kwalo muthi ngokuncipha kwesisindo. Lokhu kungenxa yokuvinjwa kokukhipha esiswini.
Umuthi weVictoza ungehlisa ushukela wegazi.
I-Pharmacokinetics
I-maximum maximum yento esebenzayo ku-plasma ifinyelelwa ngemuva kwamahora angama-8 ukuya kwengu-12 ngemuva kokusebenzisa umuthi. I-Lysinopril isetshenziswa ngendlela engafani kahle.
Le nqubo ihamba kancane, ngakho-ke umuthi ubonakala ngokuvezwa isikhathi eside.
Izinkomba zokusetshenziswa
Imvamisa, umuthi ubekelwe iziguli ezinesifo sikashukela sohlobo II. Isenzo saso sisebenza ngempumelelo ngokuhlanganiswa nokuzivocavoca umzimba njalo nokudla okukhethekile. Kunezimo ezi-3 okungenzeka ukuthi umuthi ubekiwe kuzo:
- I-Monotherapy. Yisidakamizwa kuphela lesi esisetshenziselwa ukuguqula isimo seziguli ezinesifo sikashukela sohlobo 2 futhi sizinzise isisindo somzimba ngesikhathi sokwehluleka kokudla okwe-carbohydrate metabolism ngenxa yokwanda kwesifiso sokudla.
- Ukwelashwa okuhlanganisiwe ngama-ejenti we-hypoglycemic (urea sulfinyl derivatives kanye ne-metformin). Le ndlela yokwelapha isebenza kahle ezimweni lapho i-monotherapy nomuthi ingazange iholele enkambisweni enhle.
- Ukwelashwa okuhlanganisiwe nge-insal insulin ezigulini ezingasizanga ezinye izinhlobo zokwelashwa.
IVictoza imvamisa kakhulu ichazwa isifo sikashukela sohlobo II.
Contraindication
Imiyalo yokusebenzisa umuthi ikhombisa imikhawulo enjalo:
- ukulimala okulimazayo kwe-yegilo yegilo;
- thayipha i-1 isifo sikashukela;
- ukungabekezelelani ngakunye kwezinto ekwakhiweni kwomuthi;
- ukwehluleka okukhulu / okukhulu kwe-hepatic / renal;
- ukuhluleka kwenhliziyo.
Ngokunakekela
Umuthi unqunywe ngokucophelela:
- nge-lactation nokukhulelwa;
- nge-pathologies ye-gland yegilo;
- phambi kwe-pancreatitis eyingozi;
- ngokuvuvukala mucosa esiswini;
- nge-diabetesic gastroparesis;
- esemncane;
- ngesifo sikashukela sikashukela.
Umuthi i-Victoza ubekwe ngokuqapha lapho kukhona ukuvuvukala kwe-mucosa esiswini.
Ungamthatha kanjani uVictoza
Umuthi ufakwa ngaphansi kwesikhumba endaweni yesisu, ehlombe noma ethangeni usebenzisa ipeni lesirinji elikhethekile. Ukufakwa komuthi akuhlanganisiwe ekudleni futhi kwenziwa isikhathi esingu-1 ngosuku ngasikhathi sinye. Kodwa-ke, ochwepheshe batusa ukwenza lokhu kukhwabanisa esiswini esingenalutho. Kulokhu, kusetshenziswa izinaliti ezikhethekile zokulahlwa kwe-Novo-Twist noma i-NovoFayn, okumele ilahlwe ngemuva kokusetshenziswa.
Enye yezinketho zokusebenzisa iVictoza ukungeniswa kwesirinji ngaphansi kwesikhumba esiswini.
Ngoshukela
Ukwelashwa kufanele kuqale ngomuthi ka-0.6 mg. Kancane kancane kufanele ikhule iye ku-1.8 mg ngosuku. Lokhu kwenziwa kungakapheli amasonto ayi-1-2.
Ukusetshenziswa kwomuthi akusho ukuthi ukuqedwa kwemithi ekwehlisa ushukela.
Ukwehla kwesisindo
Ukwehlisa isisindo somzimba, umuthi usetshenziswa cishe kumthamo ofanayo. Lapho kungekho khona amandla amahle, umthamo ulungiswa phezulu udokotela.
Imiphumela emibi
Lapho usebenzisa umuthi, imiphumela emibi ingabonakala. Lapho zivela, kufanele uthintane nodokotela njalo.
Amapheshana wesisu
Kubonwe:
- isifo sohudo
- isicanucanu
- i-gastritis;
- ukwanda kwegesi;
- ukuhlanza
- belching;
- ukushaya kwenhliziyo.
Isifo senhliziyo singeminye yemiphumela emibi yesidakamizwa iVictoza.
Izitho zeHematopoietic
Kubonwe:
- leukocytopenia;
- i-anemia
- i-thrombocytopenia;
- indlela ye-hemolytic ye-anemia.
Isistimu yezinzwa ephakathi
Iziguli zingakhalaza:
- kubuhlungu bekhanda;
- ngesiyezi (kuyaqabukela).
Ubuhlungu bekhanda bungumphumela ongemuhle wesidakamizwa iViktoza ovela ohlelweni lwezinzwa oluphakathi.
Kusuka ohlelweni lomchamo
Okulandelayo kuyaphawulwa:
- izinso ezingasebenzi kahle;
- ukukhuphula ukwehluleka kwezinso.
Engxenyeni yesikhumba
Kungenzeka:
- isikhumba esikhanyayo;
- imishayo.
Kusuka ohlelweni lwezitho zofuzo
Ukuboniswa:
- kwehla i-libido;
- ukungabi namandla.
Kusuka ohlelweni lwezinhliziyo
Okulandelayo kuyaphawulwa:
- i-tachycardia (kuyaqabukela);
- ukwehluleka kwenhliziyo.
I-Tachycardia ingumphumela ongemihle owenzeka lapho usebenzisa umuthi i-Victoza.
Uhlelo lwe-Endocrine
Kubonwe:
- ukukhuphuka kwamazinga e-calcitonin;
- goiter;
- i-pathology ye-gland yegilo.
Engxenyeni yesibindi ne-biliary
Ukweqisa kokwehluleka kwesibindi kungaba yindlela yokusabela engemihle.
Allergies
Ukuvela komzimba kuyenzeka:
- I-edema kaQuincke (kuyaqabukela);
- ukuvuvukala endaweni yomjovo;
- ubunzima bokuphefumula.
Ukuphefumula kuyindlela yokuphambanisa engezwani nomuthi i-Viktoza.
Imiyalo ekhethekile
Lapho kukhona ukwehluleka kwenhliziyo (ikilasi I noma II), umsebenzi wezinso olinganiselayo ngokulingana futhi usegugile, sebenzisa lesi sidakamizwa ngokucophelela ngangokunokwenzeka.
Ngezimpawu ze-pancreatitis, umuthi kufanele uyekwe.
Ukuhambisana notshwala
Ngaphandle kokungabikho kwemiyalo emiyalweni yomuthi maqondana nokuhambisana kwawo notshwala, akufanele uphuze utshwala. I-Ethanol ikhulisa amathuba okukhula kwe-pancreatitis ne-hypoglycemia.
Umthelela ekhonweni lokulawula izindlela
Iziguli ezisebenzisa umuthi kufanele zixwayiswe nge-hypoglycemia engenzeka. Ngakho-ke, lapho usebenza nezinqubo eziyinkimbinkimbi nokushayela, udinga ukubheka isimo sakho.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Nge-lactation kanye nokusebenzisa umuthi, ukuncelisa ibele kufanele kumiswe. Ngesikhathi sokukhulelwa, umuthi uvunyelwe ukusetshenziswa.
Ukuqokwa kweVictoza ezinganeni
Kwenqatshelwe ukusebenzisa lesi sidakamizwa ezinganeni ezingaphansi kweminyaka engu-18.
Sebenzisa ebudaleni
Iziguli ezineminyaka engaphezu kwengu-75 ubudala kufanele zisebenzise umuthi ngokuqapha ngokweqile nangaphansi kokubhekwa eduze kukadokotela.
Isicelo sokusebenza kokulimala kwezinso
Kwenqatshelwe ukusebenzisa umuthi ezigulini ezihluleka ngokweqile kwe-renal.
Kuyenqatshelwa ukusebenzisa umuthi i-Victoza ukwehluleka okukhulu kwe-renal.
Sebenzisa umsebenzi wesibindi okhubazekile
Ngokuhluleka kwesibindi (okulinganiselayo), ukusebenza kahle komuthi kuncishiswa ngo-15-30%. Ezimweni ezinzima, ukusetshenziswa kwayo kwenqatshelwe.
Ukweqisa
Kuqoshwe icala elilodwa kuphela lesidakamizwa. Inani laso laliphakeme izikhathi ezingama-40 kunokujwayelekile okuvumelekile. Ngenxa yalokhu, isiguli sathola ukuhlanza kanye nenausea.
Uma izimpawu ezinjalo zivela, kuyadingeka ukusebenzisa ukwelashwa okubonakalayo futhi ulandele imiyalo kadokotela.
Ukuxhumana nezinye izidakamizwa
Ngesikhathi sokuvivinywa kwemitholampilo, kwatholakala ukuthi into esebenzayo yesidakamizwa ingaphenduka nezinye izakhi ezithile.
Inhlanganisela ehlanganisiwe
Kwenqatshelwe ukuhlanganisa imijovo yesidakamizwa nezinto ezikwazi ukudambisa ukonakala kwengxenye yayo esebenzayo.
Akuhlanganisiwe ukuhlanganisa
Njengoba kunikezwe ukuntuleka kwemininingwane yemitholampilo ekuhambisaneni nomuthi ne-Insulin nezidakamizwa eziqukethe okususelwa ku-coumarin, kufanele kuhlanganiswe nokuqapha ngokweqile.
Ayikho imininingwane emtholampilo ekuhambisaneni nomuthi i-Victoza ne-Insulin.
Inhlanganisela edinga ukuqashelwa
Lapho kuhlanganiswa ne-warfarin kanye ne-sulfonylurea derivatives, isiguli sidinga ukulawulwa kwe-INR. Ngaphezu kwalokho, umuthi kufanele uhlanganiswe ngokucophelela neGriseofulvin, Atorvastin, Paracetamol kanye necala le-Insulin.
Ama-Analog
Izithonjana zezidakamizwa ezitholakalayo:
- UJardins (amaphilisi);
- Atorvastatin (amaphilisi);
- I-Thiazolidinedione (amaphilisi);
- I-Attokana (amaphilisi);
- I-Baeta (ikhambi lokujova);
- I-Digoxin (ikhambi lokujova);
- I-Trulicity (isixazululo somjovo), njll.
Imibandela yekhefu lekhemisi
Umuthi ukhishwa ngomuthi kuphela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi awunakuthengwa ngaphandle kwemithi kadokotela.
Malini uViktoza
Intengo yomuthi iqala kusuka kuma-ruble ayizinkulungwane eziyi-8,8 ngepakethe eli-1 lamapeni wesirinji.
Izimo zokugcina zomuthi
Kunconywa ukugcina umuthi esiqandisini at lokushisa lika + 2 ... + 8 ° C.
Isikhathi sokuphelelwa yisikhathi
Impilo yeshelufu yepeni yesirinji evuliwe ayidluli inyanga e-1.
Umkhiqizi
Inkampani yezokwelapha "NOVO NORDISK A / S" (eDenmark).
Ukubuyekezwa mayelana neVictoza
Mayelana nomuthi, baphendula kahle. Ukubuyekezwa okungalungile kuhlangene nezindleko eziphakeme zomuthi nokusetshenziswa kwawo okungalungile.
Odokotela
U-Albert Gorbunkov (i-endocrinologist), oneminyaka engama-50, iMayini
Umuthi omuhle owamisa ngokushesha amazinga kashukela. Ngithanda indlela esezingeni eliphezulu yokuyisebenzisa. Kwanele ukuthi isiguli sikhombise kanye, ngemuva kwalokho ingazifaka ngokwakhe.
UVictoria Shlykova (owelaphi), oneminyaka engama-45 ubudala, uNovorossiysk
Nginikeza umuthi wesifo sikashukela kanye nokunciphisa umzimba. Ithuluzi elinethezekile, livumela ngokuphelele inani laso.
Iziguli
U-Albina Alpatova, oneminyaka engama-47, eMoscow
Isifo sikashukela sasiba yizinkinga eziningi. Kodwa-ke, lapho udokotela ebeka lo muthi, konke kwashintsha kwaba ngcono. Kusuka "emiphumeleni" engihlangabezana nayo kuphela ikhanda.
USemen Boshkov, oneminyaka engama-50 ubudala, eSt
Ngiphethwe ushukela ophezulu. Ukuxazulula le nkinga, udokotela uncome ukusebenzisa imijovo yeVictoza. Ngisithandile isidakamizwa saseDenmark, ngabona umphumela omuhle ngaso leso sikhathi, umuthi uxazulula inkinga. Kukhathaza nje ukuthi akubizi kakhulu, kepha izindleko eziphakeme zinesizathu.