Njengoba icala ngalinye lesifo sikashukela lingumuntu ngamunye (njengoba abanye abakholelwa ku-endocrinologists besho, kunezinhlobo eziningi zesifo sikashukela njengoba iziguli zona ngokwazo), ukusabela ekuphathweni okwengeziwe kwe-insulin ye-hormone emzimbeni akunangqondo ngokuphelele. Omunye wemiphumela emibi yokwelashwa kwe-insulin yi-lipodystrophy.
Kuyini lipodystrophy (imininingwane ejwayelekile)
Kwezinye izimo, ukwanda kwezicubu ze-adipose kumuntu ophethwe yilesi sifo akunakwenzeka ngisho nangemva kokushintsha uhlobo lokudla (engeza ukudla okunamafutha, ama-carbohydrate “asheshe” ekudleni).Umehluko omkhulu phakathi kwe-lipodystrophy ne-classical dystrophy: ngokuwohloka kwamafutha, izicubu zemisipha nezinye izimpawu zokuwohloka okujwayelekile komzimba azincishisiwe. Imvamisa kuba nomphumela ophikisayo - isisindo semisipha (ngokudla okufanele namandla okuzivocavoca) siyakhula, esinomphumela omuhle esizalweni.
Izinhlobo, izimpawu nemiphumela engenzeka ye-lipodystrophy
Ngokujwayelekile, i-lipodystrophy engalingani futhi emnene ayibeki ingozi enkulu empilweni: lokhu kuyiphutha nje lokuhlobisa. Kodwa-ke, kwesinye isikhathi kuthinta kabi isimo sengqondo seziguli, ikakhulukazi abesifazane.
Ukwesaba kubangelwa yizimo ze-lipodystrophy ezinzima ezingxenyeni ezihlukene zomzimba, futhi ikakhulukazi, kwakungekho imijovo ye-insulin. Ngokomtholampilo, i-lipodystrophy ibonakala ngokungabikho ngokuphelele kwamafutha ngaphansi kwesikhumba. Esizeni se-lipoatrophy, kuba khona ukwanda kwe-vascularization (isimo sohlelo lwe-vascular), esenza ubunzima bokufakwa kwe-insulin. Lokhu, futhi, kuvimbela ukunxephezelwa kwalesi sifo futhi kuvimbela ukubalwa kwenhloso kwesikhathi sokwenza kwamalungiselelo we-insulin. Isimo sakamuva siyiqiniso ikakhulukazi kwizidakamizwa ezinomphumela owude.
Ngokuqondene ne-hypertrophy (ukubekwa ngokweqile) kwezicubu ze-adipose ezindaweni zomjovo, lokhu kusabela nakho kuthinta kabi ukungena kwezinto kwezinto ezisebenzayo zemithi ye-insulin emithanjeni yegazi. Ngaphezu kwalokho, i-lipomas (i-adipose) iyisici esibonakalayo sezimonyo.
Amacala okukhula kwe-lipodystrophy ngaphandle kwethonya lemijovo ye-insulin ayaziwa: izimo ezinjalo ziphakama ngemuva kwesizinda se-heneral metabolic pathologies. I-lipodystrophy engalimi kungenzeka ibe ngumphumela wokumelana ne-insulin futhi uvame ukuhlanganiswa nokuba khona kwe-metabolic syndrome. Lesi sifo sibonisa ukwephulwa okuqhubekayo kwe-lipid ne-carbohydrate metabolism.
Izimbangela ze-lipodystrophy
- Ukuphathwa okungalungile kwe-insulin (inqubo yokujova engafanele eholela ebuhlungwini);
- Kwehla izinga lokushisa lekhambi lezidakamizwa;
- Ukulimala kwethishu endaweni yomjovo we-insulin;
- Isenzo se-insulin njengento ekhulisa i-lipolysis;
- Ukusabela okungafanele komzimba.
Iningi labaphenyi balesi sifo linombono wokuthi i-atrophy yongqimba lwamafutha emzimbeni wesiguli esinesifo sikashukela ngemijovo ye-insulin kungenxa yokuphendula kwesistimu evikela umzimba. Umzimba womuntu ubheka lojovo njengosongo empilweni yawo futhi ngendlela ethile uphendula umjovo.
Kunombono wokuthi umphumela wamahomoni "angaphandle" emzimbeni uvezwa "ngokuqala kabusha" kwezindlela ze-metabolic. Ngenxa yalokhu, izinqubo ze-metabolic ziqala ukwenzeka ngendlela engajwayelekile - ikakhulukazi, i-metabolism yamafutha iyaphazamiseka: izicubu ze-lipoid ziqala ukuguqula amandla.
Muva nje, kuye kwashiwo imibono eminingi ngokwengeziwe ngomsebenzi we-insulin. Le nto ibhekwa njengembangela enkulu kakhulu ye-lipodystrophy enzima. Kulokhu, i-insulin isebenza njenge-antigen ehlasela ukuvikela umzimba, ngasikhathi sinye ibulale ungqimba lwamafutha.
Izakhiwo ezishiwo kakhulu i-antigenic kuthiwa zenzelwe amalungiselelo e-insulin atholwe ezinkomeni. Ngalesi sizathu, iziguli ezithambekele kwi-lipodystrophy azinconywa ukusebenzisa izidakamizwa zokuhlanzeka okuphansi. Okunconyelwayo yi-insulin yomuntu.
Ukwelashwa Nokuvimbela
Ukwelashwa kwe-pathology kuhloswe ukunciphisa noma ukuqeda ngokuphelele izinto ezifaka isandla ekuthuthukisweni kokuwohloka kwamafutha. Ukuze uvikele ukungahambi kahle kwemishini, izinga lokushisa kanye nokufakelwa kwamakhemikhali, inqubo efanelekile yokwelapha ye-insulin kufanele ilandelwe.
- I-insulin kufanele isetshenziswe kuphela emazingeni okushisa asekamelweni, futhi mhlawumbe izinga lokushisa lomzimba (kwenqatshelwe ukusebenzisa umuthi ngokushesha esiqandisini);
- Kuyadingeka ukushintsha iphuzu lokulawulwa kwezidakamizwa - umjovo endaweni efanayo awenziwa ngaphezulu kwezinsuku ezingama-60 (udokotela wakho uzokutshela ngokuningiliziwe ngokujikeleza okulungile kwemijovo ye-insulin);
- Ukufakwa kwenziwa ngemijovo yepulasitiki elahlekayo (enenalithi ezacile) noma amapeni wesirinji, anciphisa amathuba okulimala kwezicubu;
- Massage yendawo yomjovo ngokushesha ngemuva komjovo ongasoze waphazamisa;
- Uma ukuhlikihla isikhumba ngekhambi lotshwala ngaphambi kokuba kwenziwe umjovo (okuyinto enqabile kakhulu namuhla), kubalulekile ukulinda kuze kube yilapho utshwala buqhamuka ebusweni besikhumba.
Abanye odokotela batusa ukusebenzisa amaphampu e-insulin, anciphisa amathuba okuba nemiphumela emibi ngemuva kwemijovo. Abanye abaphenyi be-lipodystrophy baphawula ukuthi uma usebenzisa i-insulin noma i-porcine monocomponent insulin (ephendula ngokungathathi hlangothi), cishe awekho amacala okuwohloka kwezicubu ezinamafutha.
Uma i-lipodystrophy enzima isivele ikhona, ngaphambi kokuqeda imiphumela yayo, kuyadingeka ukuthi sihlaziye ukuthi yiziphi izinto ezaholela ekutholakaleni kwalesi sifo. Okokuqala, ukwethulwa kwezidakamizwa ze-hormonal ezindaweni lapho kubonwa khona izicubu ze-adipose izicubu kufanele kususwe ngokuphelele. Kwezinye, ukuphathwa kwe-insulin kusiza nge-Novocaine yezidakamizwa.
- I-Electrophoresis yezindawo ezithintekile (ukuphathwa kweNovocaine noma iLidase ngokushukunyiswa kukagesi);
- Izicelo zikaphalafini ezindaweni ezithintekile;
- I-Inductometry iyindlela yokuzivocavoca umzimba esekelwe ekuchayweni kazibuthe wamandla kazibuthe aphezulu;
- Ukushintsha ukulungiswa kwe-insulin (kuhlangene ne-massage endaweni yomjovo);
- Ukwelashwa kwe-Ultrasound - i-ultrasound icasulisa ukuhanjiswa kwemishini kuzicubu ekujuleni okukhulu, okusiza ukukhuthaza ukujikeleza kwegazi nemetabolism: umphumela we-ultrasound uhlanganiswe nokwelashwa kwendawo ethintekile ngamafutha e-hydrocortisone;
- Ukwethulwa kwezidakamizwa ze-hormonal zeqembu le-anabolic ukukhuthaza ukwakheka kwamafutha.
