I-LIPODYSTROPHY KUSHUKELA - IZINDLELA NEZINDLELA ZOKWELASHWA

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Ukwelashwa kwe-insulin, noma ngabe kwenziwa ngokuhambisana nezincomo zezokwelapha, igcwele imiphumela engalindeleki (bheka i-athikili mayelana nama-insulin therapy regimens).

Njengoba icala ngalinye lesifo sikashukela lingumuntu ngamunye (njengoba abanye abakholelwa ku-endocrinologists besho, kunezinhlobo eziningi zesifo sikashukela njengoba iziguli zona ngokwazo), ukusabela ekuphathweni okwengeziwe kwe-insulin ye-hormone emzimbeni akunangqondo ngokuphelele. Omunye wemiphumela emibi yokwelashwa kwe-insulin yi-lipodystrophy.

Cabanga ukuthi uyini lo mlingisi, ubonakala kanjani, ungaqedwa kanjani nokuthi yiziphi izindlela okufanele zithathwe ukuvimba ukuthuthukiswa kwe-lipodystrophy.

Kuyini lipodystrophy (imininingwane ejwayelekile)

Ngomqondo obanzi waleli gama lipodystrophy yinto eyenzeka yokungabi bikho kwe-pathological of izicubu ze-adipose emzimbeni.

Kwezinye izimo, ukwanda kwezicubu ze-adipose kumuntu ophethwe yilesi sifo akunakwenzeka ngisho nangemva kokushintsha uhlobo lokudla (engeza ukudla okunamafutha, ama-carbohydrate “asheshe” ekudleni).

Umehluko omkhulu phakathi kwe-lipodystrophy ne-classical dystrophy: ngokuwohloka kwamafutha, izicubu zemisipha nezinye izimpawu zokuwohloka okujwayelekile komzimba azincishisiwe. Imvamisa kuba nomphumela ophikisayo - isisindo semisipha (ngokudla okufanele namandla okuzivocavoca) siyakhula, esinomphumela omuhle esizalweni.

I-Lipodystrophy kushukela ikhula ngenxa yokulimala kwe-insulin.

I-anomaly ihlala yendawo ngokwemvelo futhi ikhula ngokukhethekile kulezo zindawo lapho kwenziwa khona umjovo wokwelapha. I-Atrophy of adipose izicubu zivame ukwenzeka kwabesifazane nasezinganeni.

Kukhona inketho yokubuyela emuva kwengqondo: hypertrophy izicubu ze-adipose - ukwakheka kwesixha samafutha amnyama (lipoma) endaweni yomjovo we-insulin.

Ngokuvamile, i-lipodystrophy enokusebenzisa i-insulin therapy ibonwa engxenyeni yazo zonke iziguli ezinqunywe ama-hormone entravenous. Kulokhu, i-pathology ibonakaliswa ngaphandle kokuxhunyaniswa nomthamo nohlobo lomuthi olungiselelwe. Akuthinti ukuba khona kwe-lipodystrophy kanye nobunzima besi sifo, kanye nezinga lesinxephezelo.

Izinhlobo, izimpawu nemiphumela engenzeka ye-lipodystrophy

Ngokujwayelekile, i-lipodystrophy engalingani futhi emnene ayibeki ingozi enkulu empilweni: lokhu kuyiphutha nje lokuhlobisa. Kodwa-ke, kwesinye isikhathi kuthinta kabi isimo sengqondo seziguli, ikakhulukazi abesifazane.

Ukwesaba kubangelwa yizimo ze-lipodystrophy ezinzima ezingxenyeni ezihlukene zomzimba, futhi ikakhulukazi, kwakungekho imijovo ye-insulin. Ngokomtholampilo, i-lipodystrophy ibonakala ngokungabikho ngokuphelele kwamafutha ngaphansi kwesikhumba. Esizeni se-lipoatrophy, kuba khona ukwanda kwe-vascularization (isimo sohlelo lwe-vascular), esenza ubunzima bokufakwa kwe-insulin. Lokhu, futhi, kuvimbela ukunxephezelwa kwalesi sifo futhi kuvimbela ukubalwa kwenhloso kwesikhathi sokwenza kwamalungiselelo we-insulin. Isimo sakamuva siyiqiniso ikakhulukazi kwizidakamizwa ezinomphumela owude.

Ukonakala kwamafutha kukhula ngezikhathi ezahlukahlukene zokwelashwa kwe-insulin - kusuka enyangeni kuye eminyakeni eminingana. Ubukhulu buhlukahluka kusuka kufossa elincane endaweni yokujova kuya ekupheleleni kwesisekelo samafutha angaphansi kwendawo ebanzi. Imijovo iba buhlungu ikakhulukazi, okunzima kuyo iziguli ezingane.

Ngokuqondene ne-hypertrophy (ukubekwa ngokweqile) kwezicubu ze-adipose ezindaweni zomjovo, lokhu kusabela nakho kuthinta kabi ukungena kwezinto kwezinto ezisebenzayo zemithi ye-insulin emithanjeni yegazi. Ngaphezu kwalokho, i-lipomas (i-adipose) iyisici esibonakalayo sezimonyo.

Amacala okukhula kwe-lipodystrophy ngaphandle kwethonya lemijovo ye-insulin ayaziwa: izimo ezinjalo ziphakama ngemuva kwesizinda se-heneral metabolic pathologies. I-lipodystrophy engalimi kungenzeka ibe ngumphumela wokumelana ne-insulin futhi uvame ukuhlanganiswa nokuba khona kwe-metabolic syndrome. Lesi sifo sibonisa ukwephulwa okuqhubekayo kwe-lipid ne-carbohydrate metabolism.

Izimbangela ze-lipodystrophy

Imbangela eqondile yokuziphatha okungahambi kahle kwezicubu ze-adipose ukwelashwa kwe-insulin.

Kodwa-ke, indlela yokuthuthuka ne-pathogenesis yokuvela kwe-lipodystrophy ezigulini ezinesifo sikashukela akuqondakali ngokuphelele ngomuthi. Kukholelwa ukuthi ukuthuthukiswa kokuphendula kwe-pathological kucasulwa yimvelo ye-acid yokulungiselela kwe-insulin.

Ezinye izimbangela nezizathu ezivusa amadlingozi ze-lipodystrophy:

Ukuphathwa okungalungile kwe-insulin (inqubo yokujova engafanele eholela ebuhlungwini);
Kwehla izinga lokushisa lekhambi lezidakamizwa;
Ukulimala kwethishu endaweni yomjovo we-insulin;
Isenzo se-insulin njengento ekhulisa i-lipolysis;
Ukusabela okungafanele komzimba.

Iningi labaphenyi balesi sifo linombono wokuthi i-atrophy yongqimba lwamafutha emzimbeni wesiguli esinesifo sikashukela ngemijovo ye-insulin kungenxa yokuphendula kwesistimu evikela umzimba. Umzimba womuntu ubheka lojovo njengosongo empilweni yawo futhi ngendlela ethile uphendula umjovo.

Kunombono wokuthi umphumela wamahomoni "angaphandle" emzimbeni uvezwa "ngokuqala kabusha" kwezindlela ze-metabolic. Ngenxa yalokhu, izinqubo ze-metabolic ziqala ukwenzeka ngendlela engajwayelekile - ikakhulukazi, i-metabolism yamafutha iyaphazamiseka: izicubu ze-lipoid ziqala ukuguqula amandla.

Muva nje, kuye kwashiwo imibono eminingi ngokwengeziwe ngomsebenzi we-insulin. Le nto ibhekwa njengembangela enkulu kakhulu ye-lipodystrophy enzima. Kulokhu, i-insulin isebenza njenge-antigen ehlasela ukuvikela umzimba, ngasikhathi sinye ibulale ungqimba lwamafutha.

Izakhiwo ezishiwo kakhulu i-antigenic kuthiwa zenzelwe amalungiselelo e-insulin atholwe ezinkomeni. Ngalesi sizathu, iziguli ezithambekele kwi-lipodystrophy azinconywa ukusebenzisa izidakamizwa zokuhlanzeka okuphansi. Okunconyelwayo yi-insulin yomuntu.

Ukwelashwa Nokuvimbela

Ukwelashwa kwe-pathology kuhloswe ukunciphisa noma ukuqeda ngokuphelele izinto ezifaka isandla ekuthuthukisweni kokuwohloka kwamafutha. Ukuze uvikele ukungahambi kahle kwemishini, izinga lokushisa kanye nokufakelwa kwamakhemikhali, inqubo efanelekile yokwelapha ye-insulin kufanele ilandelwe.

Ngeke kube yinto ephezulu ukubakhumbula:

I-insulin kufanele isetshenziswe kuphela emazingeni okushisa asekamelweni, futhi mhlawumbe izinga lokushisa lomzimba (kwenqatshelwe ukusebenzisa umuthi ngokushesha esiqandisini);
Kuyadingeka ukushintsha iphuzu lokulawulwa kwezidakamizwa - umjovo endaweni efanayo awenziwa ngaphezulu kwezinsuku ezingama-60 (udokotela wakho uzokutshela ngokuningiliziwe ngokujikeleza okulungile kwemijovo ye-insulin);
Ukufakwa kwenziwa ngemijovo yepulasitiki elahlekayo (enenalithi ezacile) noma amapeni wesirinji, anciphisa amathuba okulimala kwezicubu;
Massage yendawo yomjovo ngokushesha ngemuva komjovo ongasoze waphazamisa;
Uma ukuhlikihla isikhumba ngekhambi lotshwala ngaphambi kokuba kwenziwe umjovo (okuyinto enqabile kakhulu namuhla), kubalulekile ukulinda kuze kube yilapho utshwala buqhamuka ebusweni besikhumba.

Abanye odokotela batusa ukusebenzisa amaphampu e-insulin, anciphisa amathuba okuba nemiphumela emibi ngemuva kwemijovo. Abanye abaphenyi be-lipodystrophy baphawula ukuthi uma usebenzisa i-insulin noma i-porcine monocomponent insulin (ephendula ngokungathathi hlangothi), cishe awekho amacala okuwohloka kwezicubu ezinamafutha.

Uma i-lipodystrophy enzima isivele ikhona, ngaphambi kokuqeda imiphumela yayo, kuyadingeka ukuthi sihlaziye ukuthi yiziphi izinto ezaholela ekutholakaleni kwalesi sifo. Okokuqala, ukwethulwa kwezidakamizwa ze-hormonal ezindaweni lapho kubonwa khona izicubu ze-adipose izicubu kufanele kususwe ngokuphelele. Kwezinye, ukuphathwa kwe-insulin kusiza nge-Novocaine yezidakamizwa.

Ukuqeda imiphumela ye-lipodystrophy, izinqubo ezilandelayo zingabekwa:

I-Electrophoresis yezindawo ezithintekile (ukuphathwa kweNovocaine noma iLidase ngokushukunyiswa kukagesi);
Izicelo zikaphalafini ezindaweni ezithintekile;
I-Inductometry iyindlela yokuzivocavoca umzimba esekelwe ekuchayweni kazibuthe wamandla kazibuthe aphezulu;
Ukushintsha ukulungiswa kwe-insulin (kuhlangene ne-massage endaweni yomjovo);
Ukwelashwa kwe-Ultrasound - i-ultrasound icasulisa ukuhanjiswa kwemishini kuzicubu ekujuleni okukhulu, okusiza ukukhuthaza ukujikeleza kwegazi nemetabolism: umphumela we-ultrasound uhlanganiswe nokwelashwa kwendawo ethintekile ngamafutha e-hydrocortisone;
Ukwethulwa kwezidakamizwa ze-hormonal zeqembu le-anabolic ukukhuthaza ukwakheka kwamafutha.

Umphumela omuhle kakhulu wokwelapha utholakala lapho kuhlanganiswa izindlela eziningana zokwelapha - ukukhuthaza kagesi, ukubonakaliswa kwezidakamizwa, i-massage (i-hardware noma i-manual).

Inhlanganisela ye-inductometry ne-phaphonophoresis nayo iyasetshenziswa. Noma imaphi amacala okuvela kwe-lipodystrophy angawomuntu ngamunye, ngakho-ke, isu lamaqhinga okwelapha lakhiwa udokotela ohambayo ngenxa yesithombe samanje somtholampilo asibonayo. Imizamo yokuzimela yeziguli yokuqeda i-atrophy enamafutha ngokuvamile ayiholeli emiphumeleni emihle ehlala njalo, futhi kwezinye izimo ingasibhebhethekisa lesi simo.

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