Iziguli ezihlushwa ukuphazamiseka kwe-lipid metabolism zivame ukuba nokukhetha, okungcono - i-Atorvastatin noma iRosuvastatin? Yize i-Rosuvastatin isetshenziswe kakhulu muva nje, akunakwenzeka ukuthi unikeze impendulo eqondile kulo mbuzo, ngoba umuthi ngamunye unobuhle nobubi bawo.
Zombili lezi zidakamizwa kumele zithathwe kuma-pathologies anjenge -xube noma i-homozygous hypercholesterolemia (ikhuphukile i-LDL), i-hypertriglyceridemia (i-triglycerol eyeqile) kanye ne-atherosulinosis (enciphisa i-lumen yemithambo yegazi ngenxa yokuncipha kwama-cholesterol plaques). Zisetshenziselwa futhi ukuvikela izinkinga ze-atherossteosis - umfutho wegazi, isifo senhliziyo esijwayelekile, unhlangothi kanye nokuhlaselwa yisifo senhliziyo.
Njengoba kunomehluko phakathi kokuphikisana, ukusabela okuphambene, i-pharmacokinetics ne-pharmacodynamics, kuyadingeka ukuthola ukuthi yisiphi isidakamizwa esisebenza kakhulu futhi esiphephile.
Ayini ama-statins?
Izimo zifaka iqembu elikhulu lezidakamizwa ezisetshenziselwa ukwehlisa ukugcwala kwe-LDL ne-VLDL egazini.
Ezimweni zesimanje zokwelapha, ama-statin awakwazi ukwabiwa ukuvimbela nokwelashwa kwe-atherossteosis, hypercholisterinemia (okuxubile noma kwe-homozygous), kanye nezifo zenhliziyo.
Ngokuvamile, izidakamizwa zaleli qembu zinomphumela ofanayo wokulapha, i.e. yehlisa amazinga we-LDL ne-VLDL. Kodwa-ke, ngenxa yezinhlobonhlobo zezinto ezisebenzayo nezisizayo, kukhona umehluko okufanele ubhekwe ukuze kugwemeke ukusabela okungekuhle.
Ama-Statins ahlala ahlukaniswe ngo-I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) kanye nesizukulwane se-IV (Pitavastatin, Rosuvastatin).
Izimo zingaba zemvelo noma zokwenziwa. Kwingcweti, ukukhethwa kwezidakamizwa ezisezingeni eliphansi, eliphakathi nendawo, noma eliphakeme ezigulini kuyinto ebalulekile.
I-Rosuvastatin ne-Atorvastatin zivame ukusetshenziselwa ukwehlisa i-cholesterol. Umuthi ngamunye unezici:
I-Rosuvastatin isho ama-statins wesizukulwane sesine. Umenzeli wokunciphisa i-lipid wenziwe ngokuphelele ngomthamo ophakathi wesithako esisebenzayo. Ikhiqizwa ngaphansi kwezimpawu zokuthengisa ezahlukahlukene, ngokwesibonelo, iKrestor, Mertenil, Rosucard, Rosart, njll.
I-Atorvastatin isho ama-statins wesizukulwane sesithathu. Njenge-analogue yayo, inemvelaphi yokwenziwa, kepha iqukethe umthamo omkhulu wento esebenzayo.
Kukhona ukuqondanisa okunjalo kwesidakamizwa njenge-Atoris, Liprimar, Toovacard, Vazator, njll.
Ukwakheka kwamakhemikhali kwezidakamizwa
Zombili lezi zidakamizwa ziyatholakala kwifomu lethebhulethi. I-Rosuvastatin ikhiqizwa kumithamo eminingana - 5, 10 no-20 mg wengxenye efanayo esebenzayo. I-Atorvastatin ikhishwa kumthamo we-10,20,40 no-80 mg wezithako ezisebenzayo. Ngezansi kwetafula eliqhathanisa izingxenye ezisizayo zabameli abaziwayo bama-statin.
| Rosuvastatin | I-Atorvastatin (Atorvastatin) |
| I-Hypromellose, isitashi, i-titanium dioksidi, i-crospovidone, i-microcrystalline cellulose, i-triacetin, i-magnesium stearate, i-silicon dioxide, udayi we-titanium, udayi we-carmine. | I-Lactose monohydrate, i-croscarmellose sodium, titanium dioksidi, hypromellose 2910, hypromellose 2910, talc, calcium stearate, polysorbate 80, cellulose ye-microcrystalline, |
Umehluko omkhulu phakathi kweRosuvastatin ne-Atorvastatin yizakhiwo zabo ze-physicochemical. Inzuzo ye-rosuvastatin ukuthi yephuka kalula ku-plasma yegazi nakulunye uketshezi, i.e. yi-hydrophilic. I-Atorvastatin inesinye isici: inyibilika emafutheni, i.e. yi-lipophilic.
Ngokusekelwe kulezi zici, umphumela weRosuvastatin ubhekiswa ikakhulukazi kumaseli we-parenchyma yesibindi, ne-Atorvastatin - ekwakhiweni kobuchopho.
I-Pharmacokinetics ne-pharmacodynamics - umehluko
Kakade esiteji sokuthatha amaphilisi, kunomehluko ngokufakwa kwawo. Ngakho-ke, ukusetshenziswa kweRosuvastatin akuxhomekile esikhathini sosuku noma sokudla. I-Atorvastatin akufanele idliwe kanyekanye ngokudla, njengoba lokhu kuthinta kabi ukufakwa kwengxenye esebenzayo. Okuqukethwe okuphezulu kwe-Atorvastatin kutholakala ngemuva kwamahora we-1-2, neRosuvastatin - ngemuva kwamahora angama-5.
Omunye umehluko phakathi kwama-statins umzimba wawo. Emzimbeni womuntu, i-Atorvastatin iguqulwa ifomu elingasebenzi lisebenzisa ama-enzyme wesibindi. Ngakho-ke, umsebenzi wesidakamizwa uhlobene ngqo nokusebenza kwesibindi.
Kuyathinteka nezidakamizwa ezisetshenziswa ngasikhathi sinye ne-atorvastatin. I-analogue yayo, kunalokho, ngenxa yomthamo ophansi, empeleni ayisebenzi nezinye izidakamizwa. Yize lokhu kungamsindisi ekubeni khona kokubi okungahambi kahle.
I-Atorvastatin ivezwa ikakhulu nge-bile.
Ngokungafani nama-statins amaningi, iRosuvastatin icishe ingafakwa emzimbeni wesibindi: ngaphezu kwe-90% yento isuswa ingashintshiwe yisisu futhi yi-5-10% kuphela yezinso.
Contraindication kanye nemiphumela emibi
Ukuba khona kwe-contraindication nezenzo ezingezinhle yizici ezibalulekile lapho ukhetha umuthi omuhle kakhulu. Lokhu okulandelayo izifo eziphambili nezimo lapho ukusetshenziswa kwezidakamizwa kwenqatshelwe, kanye nemiphumela emibi engenzeka.
| Contraindication | |
| Rosuvastatin | Atorvastatin |
| Ukuzwela komuntu ngamunye. Ukukhulelwa nokukhulelwa. Ukulimala kuma-hepatocytes nama-enzyme aphezulu wesibindi. Izingane nentsha engaphansi kweminyaka eyi-18. I-Myopathy noma isiphetho sayo. Ukwelashwa okuphelele nge-cyclosporine nama-fibrate. Ukungasebenzi kahle Uphuzo oludakayo I-Myotoxicity ngenkathi uthatha ezinye i-HMG-CoA reductase inhibitors. Ukusetshenziswa kwe-HIV proteinase blockers. Abamele umjaho wamaMongoloid (kuphela umthamo omncane uvunyelwe). | Hypersensitivity kuzakhi. Ukwanda komsebenzi wama-enzyme wesibindi. Ukuzala nezingane nesikhathi sokuzala. Izingane nentsha engaphansi kweminyaka engu-18 ubudala, ngaphandle kwekhambi le-heterozygous hereditary hypercholesterolemia. Ukuntuleka kokuvimbela inzalo okwanele. Ukusetshenziswa kwe-HIV proteinase blockers. Isifo sesibindi esisebenzayo. |
| Ukuphendula okungafani | |
| Ubuhlungu bekhanda, izinkinga zokuxhumana, i-malaise ejwayelekile. Ukuthuthukiswa kwe-proteinuria kanye ne-hematuria. Isikhumba ukuqhuma, okhalweni, ukulunywa. Ukuphazamiseka kwesistimu ye-musculoskeletal. I-Dyspepsia, isihlalo sokuphazamiseka, ukuvuvukala kwepancreas (pancreatitis). I-mellitus engavikelekile nge-insulin. Ukukhula kwesifuba emadodeni. Ukuba khona kokhwehlela owomile, ukufushane komoya. Stevens-Johnson Syndrome. | Ukuthuthukiswa kwe-nasopharyngitis, izifo ezithinta umchamo. Ukuvela kwe-thrombocytopenia. I-Hypo- ne-hyperglycemia, i-anorexia. Ubuhlungu ekhanda, i-paresthesia, ukukhula kwe-peripheral neuropathy, i-hypesthesia, i-amnesia, isiyezi, i-dysgeusia. Ukuzwa kokukhubazeka, i-tinnitus, ukulimaza okubukwayo. Umphimbo obuhlungu, ekhaleni. I-dyspeptic disorder, i-belching, ubuhlungu be-epigastric, ukuthuthukiswa kwe-pancreatitis. I-Urticaria, imishayo yesikhumba, i-edema kaQuincke. Ukubonakala kwe-gynecomastia. Ukuphazamiseka okuhlukahlukene kohlelo lwe-musculoskeletal. IHepatitis, ukwehluleka kwesibindi, i-cholestasis. I-Hyperthermia, i-asthenia, i-malaise. Ukwanda komsebenzi wama-enzyme wesibindi, i-QC kanye nokuhlaziywa okuhle kwe-leukocytes kumchamo. |
Ukusebenza kahle nombono wabathengi
Umsebenzi oyinhloko wezidakamizwa ze-statin ukunciphisa ukwehla kwe-LDL egazini futhi kukwenyuse izinga le-HDL.
Ngakho-ke, ukukhetha phakathi kwe-Atorvastatin neRosuvastatin, kufanele siqhathanise ukuthi banciphisa kangakanani i-cholesterol.
Ucwaningo lwakamuva lwesayensi lufakazele ukuthi i-rosuvastatin isidakamizwa esisebenza kangcono.
Imiphumela yesivivinyo somtholampilo yethulwe ngezansi:
- Ngomthamo olinganayo wezidakamizwa, iRosuvastatin inciphisa i-cholesterol ye-LDL ngo-10% ngempumelelo ngaphezulu kwe-analogue yayo. Le nzuzo ivumela ukusetshenziswa komuthi ezigulini ezine-hypercholesterolemia enkulu.
- Imvamisa yokuthuthuka kwezinkinga zenhliziyo nokuqala komphumela obulalayo uphakeme e-Atorvastatin.
- Izehlakalo zokungaphenduki ngokubi ziyefana kuzo zombili lezi zidakamizwa.
Ukuqhathanisa ukusebenza ngempumelelo kokunciphisa ukuqoqwa kwe-cholesterol "embi" kufakazela iqiniso lokuthi iRosvvatin yisidakamizwa esisebenza kangcono. Kodwa-ke, umuntu akufanele akhohlwe ngezinto ezifana nokuba khona kwe-contraindication, imiphumela emibi nezindleko. Ukuqhathaniswa kwamanani alezi zidakamizwa zombili kuvezwe etafuleni.
| Umthamo, inani lamathebulethi | Rosuvastatin | Atorvastatin |
| 5mg No. 30 | 335 rub | - |
| I-10mg No. 30 | Ama-ruble angama-360 | 125 rub |
| 20mg No. 30 | 485 RUB | 150 rub |
| 40mg No. 30 | - | 245 RUB |
| I-80mg No. 30 | - | I-490 rub |
Ngakho-ke, i-atorvastatin iyi-analogue eshibhile engabanjiswa abantu abahola kancane.
Yilokho iziguli ezikucabangayo ngemithi - iRosuvastatin ibekezelelwa kahle futhi ngaphandle kwezinkinga. Lapho kuthathwa, i-cholesterol embi iyancishiswa
Ukuqhathaniswa kwezidakamizwa kusiza ekuphetheni ukuthi njengamanje esigabeni samanje sokuthuthukiswa kwezokwelapha, izikhundla zokuqala phakathi kwamathebhulethi amahle kakhulu we-cholesterol zithathwa ngama-statins wesizukulwane sesine, kufaka phakathi Rosuvastatin.
Mayelana nomuthi i-Rosuvastatin nezimpawu zayo zichazwa kuvidiyo kule ngxenye.
