Ngesifo sikashukela, kubalulekile hhayi ukukala ushukela wegazi, kodwa futhi nokuvivinya njalo i-cholesterol. Uma ngabe le nkomba idluliwe, udokotela unquma indlela ekhethekile yokudla kanye nokwelashwa kwezidakamizwa.
Umuthi owaziwa kakhulu nge-hypercholesterolemia yi-Simvagexal, usho izidakamizwa ezokwehlisa i-lipid nge-intovvatinatin esebenzayo.
Amacwecwe afanele ukwelashwa kweziguli ezingaphezulu kweminyaka engu-18. Ungawathenga kunoma yiliphi ikhemisi lapho wethula incwadi kadokotela. Umthamo unqunywa udokotela ngawodwana, ugxile emlandweni wezokwelapha, ukuba khona kwe-contraindication kanye nezifo ezincane.
Ngabe usebenza kanjani umuthi?
Ukulungiselela okutholwe synthetical kumkhiqizo we-enzymatic Aspergillus terreus kwehlisa okuqukethwe kwe-plasma ye-triglycerides, lipoprotein ephansi kakhulu futhi ephansi, futhi futhi kukhulisa okuqukethwe kwe-lipoprotein ephezulu kwabantu.
Imiphumela emihle yokuqala ingabonakala ezinsukwini eziyi-14 ngemuva kokuqala kokwelashwa. Umphumela omkhulu wokwelapha utholakala kancane kancane, ngemuva kwenyanga nesigamu.
Kubalulekile ukuqeda inkambo ebekiwe yokwelashwa ukuze ulondoloze amanani ajwayelekile isikhathi eside.
Udokotela ubeka umuthi uma isiguli sinoku:
- I-Hypercholesterolemia;
- I-Hypertriglyceridemia;
- I-hypercholesterolemia ehlanganisiwe.
Imithi isetshenziswa uma ukudla okhethekile kungasizanga. Futhi, ukusetshenziswa kwamathebhulethi kuvunyelwe ngezinhloso zokuvimbela uma kunengozi yokufakelwa kwe-myocardial nge-index ye-cholesterol engaphezu kwe-5.5 mmol / lit.
Ngaphezu kwe-simvastatin ye-Into esetshenziswayo, amaphilisi we-oval omhlophe, ophuzi noma opinki aqukethe i-ascorbic acid, i-iron oxide, i-lactose monohydrate, isitashi sommbila, i-magnesium stearate, i-hypromellose, i-titanium dioxide.
Imiyalo yokusebenzisa umuthi
Ngokusho kwencwajana enamathiselwe, udinga ukuthatha i-Simvagexal kusihlwa kanye ngosuku, uphuze amanzi amaningi. Isikhathi sokwelashwa sinqunywa ngudokotela ohambelayo, ngokuguqula uzimele umthamo futhi nohlobo aluvunyelwe.
Uma umthamo wamanje uphuthelwe, umuthi uthathwa nganoma yisiphi esinye isikhathi, kuyilapho umthamo uhlala unjalo. Ngemuva kokuhlola isiguli, ukufunda umlando wezokwelapha nokuhlaziywa, udokotela unquma ukuthi mangaki amaphilisi adingekayo esigabeni sokuqala sokwelashwa.
I-dosi enkulu isungulwa, igxile ezingeni le-cholesterol, elatholakala esikhathini sokuthatha amasonto amane.
- Ngomthamo ojwayelekile, isiguli sithatha ama-40 mg ngosuku. Leli nani linganyuswa laya ku-80 mg ngosuku lapho kuba nengozi yokuhlaselwa yisifo senhliziyo lapho ukwelashwa kungasebenzi.
- Iziguli ezinesifo senhliziyo ezithatha i-20 mg ngosuku. Ngemuva kwenyanga, umthamo uma kunesidingo ukhuphukela ku-40 mg. Endabeni yokwehla kwenani eliphelele le-cholesterol liye ku-3.6 mmol / litre nangaphansi, isibalo samaphilisi sinciphile.
- Uma umuntu engezwa ngokwengeziwe ngeCyclosporine, i-Nicotinamide noma i-fibrate, umthamo wansuku zonke kanye nomkhawulo ophakeme wehliswa ube ngu-5-10 mg. Izenzo ezifanayo zithathwa uma kukhona ukwehluleka okungapheli kwe-renal.
Ngokulashwa kwe-immunosuppress, umthamo omkhulu awukhuphuki ngaphezulu kwe-5 mg ngosuku.
Ngubani ophikisana nokwelashwa kwezidakamizwa
Kubalulekile ukucabanga ukuthi amaphilisi ane-contraindication amaningi, ngakho-ke ukuzelapha ngokwakho akumele kwenziwe. Ngaphambi kokuthatha i-Simvagexal, udinga ukufunda imiyalo yokusebenzisa.
Intengo yesidakamizwa enezibuyekezo ezinhle ama-ruble ayi-140-600, ngokuya ngokufakwa. Ekhemisi ungathola amaphakethe we-5, 10, 20, 30, 40 mg. Ukubhekana nenkambo ejwayelekile yokwelashwa, kunconywa ukuthenga amaphilisi we-Hexal Simvagexal 20mg ngenani lama-30 ama-pcs.
Umuthi uyaphulwa uma isiguli sinoku:
- ukwehluleka kwesibindi;
- hypersensitivity kuzakhi zomuthi;
- ukuzwela kuma-statins;
- myopathy
- ukwephula ukwakheka kwamangqamuzana abomvu egazi (i-porphyria).
Awukwazi ukufeza ukwelashwa uma umuntu ephuza i-Itraconazole, iKetoconazole, izidakamizwa zokwelapha izifo ze-HIV. Futhi, amaphilisi ayaphikisana kwabesifazane abakhulelwe nababambisayo.
Ukuqapha kufanele kusetshenziswe lapho isiguli sisebenzisa kabi uphuzo oludakayo, siphathwa nge-immunosuppressants, sinesisindo esikhulayo noma esinciphile samathambo emithambo, sinezinkinga zokuqaqamba kwamalunga, ukugula okuthe xaxa, ukuqina komfutho we-arterial, i-endocrine enzima kanye nokuphazamiseka kwe-metabolic. Ukwelashwa kwenziwa ezigulini ezingaphezu kweminyaka engu-18.
Ngesikhathi sokukhulelwa, kungcono ukwenqaba umuthi, ngoba ezimweni zokuvivinya kwezokwelapha amacala okuthuthukiswa kokungafani kwengane ngemuva kokuqotshwa kwamathebulethi ejwayelekile kuyaqoshwa.
Ngesikhathi sokwelashwa, kuhle ukugwema ukukhulelwa ukuze kungalimazi ingane.
Imiphumela emibi
Lapho enquma ukwelashwa ngamaphilisi, udokotela kufanele aqiniseke ukuthi isiguli asiziphuzi ezinye izidakamizwa. Isiguli, naso, kufanele sazise udokotela ngokuthi imiphi imishanguzo aseyiphuza kakade. Lokhu kuyadingeka ukuze ugweme ukusebenzisana okungafuneki nezidakamizwa ezithile.
Ikakhulu, ngokusebenzisa i-fibrate, i-cytostatics, imithamo ephezulu ye-nicotinic acid, i-Erythromycin, i-proteinase inhibitors, ama-antifungal agents, ama-immunosuppressants, ama-Clarithromycin, ama-rhabdomyolysis angakhula.
Ngenxa yemiphumela ekhulayo yama-anticoagulants omlomo, ukopha kungakhula, ngakho-ke udinga ukubhekisisa isimo segazi ngesikhathi sokwelashwa. I-Simvagexal iphinde inyuse okuqukethwe kwe-plasma kwe-digoxin. Uma isiguli sisebenzise i-cholestyramine ne-colestipol phambilini, amaphilisi avunyelwe ukuthathwa kuphela ngemuva kwamahora amane.
- Imiphumela emibi ibonakaliswa ngendlela yokuqina kwemisipha, i-asthenic syndrome, isiyezi, umbono ofiphele, i-paresthesia, ukunambitheka kokukhamba, ikhanda, ukuqwasha, i-peropheral neuropathy.
- Kunezimo zokuphazamiseka kwesistimu yokugaya ukudla, ukuqunjelwa, isicanucanu, idyspepsia, ukugabha, izinhlungu esiswini, i-flatulence, i-pancreatitis, uhudo, i-hepatitis.
- Ezimweni ezingavamile, ukusabela komzimba kubonwa ngendlela yokulunywa kwesikhumba nokuqhaqha, i-polymyalgia rheumatism, i-thrombocytopenia, umkhuhlane, ukukhuphuka kwesilinganiso se-erythrocyte sedimentation, urticaria, ukuphefumula komoya, i-eosinophilia, i-angioedema, isikhumba se-hyperemia, vasculitis, i-arus, eustheusus.
- Umuntu angathola i-myalgia, myopathy, ubuthakathaka jikelele, i-rhabdomyolysis. Ngenxa yalokho, i-potency iyancipha, i-palpitations iyashesha, ukukhula kwe-anemia, kanye nokwehluleka kwesibindi okukhanyayo.
Uma kwenzeka kweqa ngokweqile, njengomthetho, izimpawu ezithile aziveli, kodwa kubalulekile ukususa into esebenzayo ngokwengeziwe emzimbeni. Ukuze wenze lokhu, isiguli siyahlanzwa, sinikeze namalahle ocushiwe. Ngesikhathi sokwelashwa, kuyadingeka ukuqapha izinga le-serum le-creatine phosphokinase, imisebenzi ye-renal kanye ne-hepatic.
Uma uthatha ama-statin isikhathi eside, esimweni esingajwayelekile kuba khona isifo samaphaphu esijwayelekile, esihambisana nokukhwehlela okungokomile, ukwanda kwesimo esijwayelekile, ukukhathala okwandayo, ukwehla kwesisindo, kanye nokubanda.
Lapho kuvela lezi zimpawu, ukwelashwa ngamathebulethi kufanele kumiswe.
Izincomo Zodokotela
Uma umuntu ngesikhathi senqubo yokwelashwa enyusa umsebenzi we-creatine phosphokinase kanye nokuvela kwemisipha, kuyadingeka ukushiya ukuzikhandla okukhulu ngokomzimba.
Kuyadingeka futhi ukuqeda izimbangela zomsebenzi owandayo we-enzyme, okubandakanya ukuba khona komkhuhlane, ukulimala, ukulimala, i-hypothyroidism, izifo, ubuthi bekhabhoni diokshini, i-polymyositis, i-dermatomyositis, utshwala nezidakamizwa. Uma ngemuva kwalokhu umsebenzi we-enzyme uqhubeka ukwanda, amaphilisi we-Simvagexal kufanele ashiywe ngokuphelele. Esikhundleni salokho, ungasebenzisa ama-analogues avela kwabanye abakhiqizi.
Ngaphambi kokuqala ukwelashwa, udokotela kufanele enze ukuhlolwa kwegazi komsebenzi we-KFK. Le nqubo kufanele iphindwe ngemuva kwezinyanga ezintathu. Ukuqapha ama-pinephosinases e-creatine asebekhulile nasezigulini ngokuxilongwa kwe-insulin kuncike kushukela, i-hypothyroidism, ukungasebenzi kahle kwezinso kwenziwa phakathi nonyaka.
Kunoma yiluphi uhlobo lwesifo sikashukela, kuyadingeka ukuthi ngaso sonke isikhathi kwenziwe isivivinyo sikashukela wegazi, ngoba umuthi usiza ukwandisa ukugcwala koshukela ku-plasma.
Ezinye iziguli ziba ne-hyperglycemia, edinga umuthi okhethekile.
Kodwa odokotela abancomi ukuthi kumiswe ukwelashwa ngama-statins, ngoba i-cholesterol ephakeme ingadala izinkinga ezinkulu kubashukela lapho kungekho ukwelashwa okufanele.
Amathebulethi kufanele athathwe ngokucophelela uma isiguli sisebenzisa kabi utshwala. Uma kunokwehla kokusebenza kwe-yegilo, isifo sezinso, lesi sifo sokuqala selashwa kuqala, kuphela ngemuva kwalapho ungaqala ukwehlisa ukuqina kwe-cholesterol egazini.
Izidakamizwa ezifanayo zibandakanya iZokor, Avestatin, Sinkard, Simgal, Vasilip, Aterostat, Zorstat, Ovenkor, Holvasim, Simplakor, Actalipid, Zovatin nabanye.
Gcina umuthi endaweni yokushisa engeqi ngama-30 degrees, kude nelanga kanye nezingane.
Ukudla ukwehlisa i-cholesterol
Ngaphezu kokuthatha imishanguzo, isiguli kufanele sinamathele ekudleni kwe-hypocholesterol, okubandakanya ekudleni ukudla okuphansi emafutheni ezilwane. Ukudla ngendlela efanele kungathuthukisa isimo semithambo yegazi futhi kuqede ama-atherosulinotic plaque.
Ukudla okuvinjelwe kufaka phakathi inyama yezilwane kanye namafutha okuphikisa, ibhotela lemvelo, imajarini, inyama enamafutha, amasoseji nososeji. Isiguli kufanele senqabe amaqanda amaqanda, amazambane athosiwe, ama-pancake, ama-khekhe kanye ne-confectionery yekhilimu.
Futhi, ukufakwa kososo, ubisi luphelele, ubisi oluhlanjululwe, ukhilimu, ukhilimu omuncu, ushizi we-cottage shizi kuyadingeka ekudleni.
Kunconyelwa ukuthi isiguli sixubeke izitsha nge-soya, i-canola, i-olive, i-sesame namanye uwoyela wezitshalo, aqukethe ama-asidi omega-amathathu.
Udinga ukudla njalo i-salmon, i-trout, i-mackerel kanye nezinye izinhlobo zezinhlanzi ezinamafutha, inyama enamafutha, inkukhu, ne-turkey. Ukudla okunjalo kungumthombo omuhle kakhulu wamaprotheni.
Imenyu iqukethe noma yiziphi okusanhlamvu okuphekwe emanzini, isinkwa esiphelele sokusanhlamvu, okuphekiwe okuningilizayo, imifino emisha nezithelo.
Njengoba unesifo sikashukela sanoma yiluphi uhlobo, awukwazi ukusebenzisa kabi amaswidi, ophaya, amabhisikidi.
Ukudla okwelapha nge-cholesterol ephezulu kunemithetho eminingana eyisisekelo okufanele ilandelwe. Iziphuzo ezidakayo, ikofi, itiye elinamandla zisetshenziselwa ukungqubuzana ngokuphelele, ukudla okumnandi futhi okunesitashi kusetshenziswa inani elilinganiselwe.
Ukudla kufaka imifino, izithelo, imikhiqizo yobisi enamafutha amancane. Ukudla okuthosiwe kufakwa esikhundleni sokudla okubilisiwe nokunamafutha. Umhluzi wenyama ophekisiwe udliwa ubandwe ngaphandle kongqimba lwamafutha. Inkukhu eyenziwe ngomumo ihanjiswa etafuleni ngaphandle kwesikhumba, amafutha awasetshenziswa ngenkathi kuphekwa. Amaqanda enkukhu adliwa ngaphandle kwama-yolks.
Ukudla izakhamzimba kuzodambisa i-cholesterol eyeqile, kuvikele imithambo yegazi nesibindi. Ezinsukwini eziyisikhombisa zokuqala, isiguli sizizwa singcono, ngoba uhlelo lokugaya aluveziwe ekucindezelekeni. Ukudla okunjalo akunazimpikiswano, ngoba kulinganiselwe, ngakho-ke kuhle kwabanesifo sikashukela.
Ungayilungisa kanjani i-lipid metabolism echazwe kuvidiyo kuleli vidiyo.
