Ngaphandle kwezimpawu ezinhle zomuthi, i-Glucophage, imiphumela emibi okumele wonke umuntu ayazi, inezici ezithile zokusebenzisa.
Ngaphezu kwalokho, umenzi ukhiqiza iGlucophage Long, isidakamizwa somlomo esisetshenziselwa ukwandisa ukusabela kwama-receptors kuma-hormone anciphisa ushukela, kanye nokusetshenziswa kweglucose ngamaseli.
Le ndatshana izosiza ekuqondeni izingqinamba ezibalulekile njengezici zokusetshenziswa, imiphumela emibi kusuka ku-glucophage, contraindication, ukubuyekezwa, izintengo kanye nama-analogues.
Izici ze-Pharmacological
I-Glucophage yezidakamizwa ikhonjiswa sikashukela esincike ku-insulin, lapho umsebenzi womzimba kanye nokudla okhethekile kungasizi amazinga aphansi eglucose Imiyalo ithi i-ejenti yokuphambana nesifo sikashukela isebenza ngokukhuluphala lapho kukhula ukumelana kwesibili. Ekusebenzeni, kuhlanganiswa nakho konke ukwelashwa kwe-insulin nezidakamizwa ezahlukahlukene zokunciphisa ushukela.
Umenzi ukhiqiza i-Glucophage antidiabetesic ejenti ngendlela ye-tablet yemithamo ehlukene: 500, 850 no-1000 mg. Isakhi esiyinhloko salo muthi yi-metformin hydrochloride - ummeleli wesigaba se-Biguanide. Ithebhulethi ngayinye yesidakamizwa ifaka izinto ezifana ne-povidone, i-macrogol (4000, 8000), i-hypromellose ne-magnesium stearate.
Indlela ekhethekile yokukhululwa umuthi osebenza isikhathi eside. Amacwecwe akhiqizwa ngemithamo ehlukene (i-Glucofage Long 500 ne-Glucofage Long 750).
IGlucophage ayiholeli ekwakhiweni kwe-hypoglycemia, futhi futhi akukho ukweqa okubukhali kwizinkomba zeglucose yegazi. Lapho uthatha i-Glucofage kubantu abaphilile, akukho ukwehla kwe-glycemia ngaphansi komkhawulo we-3.3-5.5 mmol / L. Ukuhlelwa ngokwejwayelekile kokuqukethwe ushukela kutholakala ngenxa yezici ezilandelayo zomuthi:
- Ukukhiqizwa kwe-Beta insulin ngamaseli e-beta.
- Ukwanda kokucabanga kwe "cell cell" yeprotheni ne-adipose izicubu ze-insulin.
- Ukusheshisa kokusebenza koshukela yizakhi zomsipha.
- Ukugaya okwehlisiwe kwama-carbohydrate ngohlelo lokugaya ukudla.
- Kwehlisela ukubekeka phansi koshukela esibindini.
- Ukwenza ngcono imetabolism.
- Ukunciphisa ukugxila okuyingozi kwe-cholesterol, i-lipoproteins ephansi kanye ne-triglycerides.
- Ukwehla kwesisindo ezigulini ezinokukhuluphala kakhulu (i-Glucofage acidives fatty acids).
Ngokusetshenziswa komlomo kwe-Glucofage metformin, i-hydrochloride igxila ngokushesha emgodini wesisu, futhi okuqukethwe kwayo okuphezulu kuyabonakala ngemuva kwamahora amabili nesigamu. IGlucophage Long, kunalokho, igxila isikhathi eside, ngakho-ke ithathwa kuphela izikhathi ezi-1-2 ngosuku.
Ingxenye esebenzayo ayihlangani namaphrotheni, asakazeka ngokushesha kuzo zonke izakhiwo zomzimba. I-Metformin ikhishwa kanye nomchamo.
Abantu abahlushwa ukungasebenzi kahle kwezinso kufanele bazi ukuthi kungenzeka ukuthi imithi ivimbele izicubu ezithweni.
Imiyalo yokusebenzisa amaphilisi
Zombili lezi zidakamizwa (i-Glucophage ne-Glucophage Long) zithengwa ekhemisi, zinomyalezo we-endocrinologist nazo. Udokotela ubeka umthamo osuselwa enanini le-glucose nezimpawu kwisifo sikashukela.
Ekuqaleni kokwelashwa, kunconywa ukuthi udle ama-500 mg kabili kathathu ngosuku. Ngemuva kwamaviki amabili, kuvunyelwe ukukhulisa umthamo. Kumele kuqashelwe ukuthi ngemuva kokuthatha i-Glucofage izinsuku zokuqala eziyi-10-14 kunemiphumela emibi ehambisana nokuthathelwa komzimba kwengxenye esebenzayo. Iziguli zikhala ngokwephulwa komgudu wokugaya ukudla, okungukuthi, ukuhlaselwa isicanucanu noma ukugabha, ukuqunjelwa noma, ngakolunye uhlangothi, isifo sohudo, ukunambitheka kwensimbi emgodleni womlomo.
Umthamo wokulondolozwa ngu-1500-2000 mg ngosuku. Ukuze unciphise imiphumela emibi ekuphuzeni umuthi, udinga ukuhlukanisa umthamo wansuku zonke izikhathi ezingama-2-3. Ubuningi ngosuku buvunyelwe ukudla kuze kufike ku-3000 mg.
Uma isiguli sisebenzisa omunye umuthi we-hypoglycemic, lapho-ke kufanele sikhansele ukuphuza kwakhe bese siqala ukwelashwa nge-Glucofage. Lapho uhlanganisa umuthi nomuthi we-insulin, kufanele uhambisane nomthamo wama-500 noma ama-850 mg kabili noma kathathu ngosuku, kanye no-1000 mg kanye ngosuku. Abantu abahlushwa ukwehluleka kwe-renal noma ezinye izifo ze-renal, kungakuhle ukuthi bakhethe umthamo womuthi ngamunye. Ezimweni ezinjalo, abanesifo sikashukela balinganisa i-creatinine kanye ezinyangeni ezingama-3-6.
Sebenzisa i-Glucofage Long 500 iyadingeka kanye ngosuku kusihlwa. Ukulungiswa kwezidakamizwa kwenzeka kanye njalo emavikini amabili. IGlucophage Long 500 ayivunyelwe ukusebenzisa ngaphezu kokuphindwe kabili ngosuku. Ngokuphathelene nomthamo we-750 mg, kufanele kuqashelwe ukuthi umthamo omkhulu uphindwe kabili ngosuku.
Ezigulini zobuntwana nobusha (iminyaka engaphezu kwe-10) kuvunyelwe ukudla kufika ku-2000 mg ngosuku. Ezigulini ezineminyaka engaphezu kwengama-60 ubudala, udokotela ukhetha umthamo ngenxa yokuncipha kokuncipha komsebenzi wezinso.
Izibhebhe ziyageza phansi ngengilazi yamanzi, ngaphandle kokuluma noma ukuhlafuna. Uma weqa ukuthatha umuthi, awukwazi ukuwuphinda kabili umthamo. Ukuze wenze lokhu, kufanele uthathe ngokushesha umthamo odingekayo we-Glucofage.
Kulezo ziguli eziphuza ngaphezu kwe-2000 mg we-glucophage, asikho isidingo sokuthatha umuthi okhipha isikhathi eside.
Lapho uthenga i-ejenti yesifo sokulwa nesifo sikashukela, hlola usuku lokuphelelwa yisikhathi, okuyiminyaka engama-500 no-500 mg weGlucofage, kanye neminyaka emihlanu ye-Glucofage 1000 mg - iminyaka emithathu. Umbuso wokushisa lapho kuhlanganiswa khona izinto zokupakisha akufanele wedlule i-25 ° C.
Ngakho-ke, ingabe i-Glucophage ingadala imiphumela emibi, futhi ingabe inokuphikisana? Ake sizame ukuthola lokhu.
I-Contraindication hypoglycemic drug
Isidakamizwa esijwayelekile kanye nesenzo isikhathi eside sine-contraindication ekhethekile nemiphumela emibi.
Ukuze ugweme ukusabela okungekuhle okwenzeka ngemuva kokuthatha i-Glucofage, abanesifo sikashukela badinga ukuxoxa nazo zonke izifo ezihambisana nodokotela wabo.
Iphakethe ngalinye lomuthi lihambisana nepheshana lokufaka eliqukethe konke ukuphikisana okungenzeka ngomuthi weGlucophage.
I-contraindication eyinhloko yile:
- ukwanda kokucabanga kwezinto eziqukethwe;
- isifo sikashukela sikashukela;
- ikhesa, i-precoma nesifo sikashukela;
- ukuthuthukiswa kwe-pathologies okuholela ekubonakala kwezicubu hypoxia (infyoction myocardial ,phefumula / inhliziyo ukuhluleka);
- ukungasebenzi kwesibindi noma ukwehluleka kwesibindi;
- umsebenzi wezinso ongasebenzi kahle noma ukwehluleka kwezinso (i-creatinine ngaphansi kwama-60 ml ngomzuzu);
- izimo ezimbi kakhulu ezandisa amathuba okuwohloka kwezinso (isifo sohudo, ukugabha), ukushaqeka, izifo ezithathelwanayo;
- ukulimala okubanzi, kanye nokungenelela kokuhlinzwa;
- isikhathi sokukhulelwa nokuqunjelwa;
- ukudakwa ngokweqile, kanye nophuzo oludakayo;
- ezinsukwini ezimbili ngaphambi nangemuva kokuhlolwa kwe-radioisotope ne-x-ray ngokwethulwa kwengxenye equkethe iodine equkethe okuthile;
- i-lactacidemia, ikakhulukazi emlandweni.
Ngaphezu kwalokho, kwenqatshelwe ukuthatha lesi sidakamizwa uma kusetshenziswa isidlo se-hypocaloric (esingaphansi kuka-1000 kcal ngosuku).
Imiphumela emibi kanye ne-overdose
Yini imiphumela emibi yomuthi?
Njengoba kushiwo ngaphambili, i-Glucophage ithinta ukusebenza kwamapheshana esiswini ekuqaleni kwezokwelapha.
Umlutha womzimba uhambisana nezimpawu ezinjengokucanuzelelwa kwenhliziyo, ukugabha, izitofu ezikhululekile, ukuqunjelwa, ukunambitheka kwensimbi, umlomo owomile, ukulahleka kokudla, i-bulimia.
Enye "imiphumela eseceleni" ihlotshaniswa nokuphazamiseka okuningana ekusebenzeni kwezinhlelo zezitho zangaphakathi.
Okokuqala, kuvela uhlangothi olubi:
- Ukuthuthukiswa kwe-lactic acidosis.
- Ukuvela kokuntuleka kwe-Vitamin B12, okumele kuthathwe ngokungathí sina nge-megaloblastic anemia.
- Isikhumba kanye nokushintshana okususelwa emuva njenge-pruritus, ukuqubuka, ne-erythema.
- Imiphumela emibi kwesibindi, ukuthuthukiswa kwe-hepatitis.
Nge-overdose, ukuthuthukiswa kwesimo se-hypoglycemic akubonwanga. Kodwa-ke, i-lactic acidosis kwesinye isikhathi ingenzeka. Izimpawu ezingenzeka zingafaka ukwazi okufiphele, ukufiphala, ukugabha, isicanucanu, isiyezi, ikhanda, nabanye.
Yini okufanele uyenze uma isiguli sikhombisa izimpawu ze-lactic acidosis? Kufanele ihanjiswe esibhedlela ngokushesha ukuze inqume ukugcwala kwe-lactate. Njengomthetho, udokotela unquma i-hemodialysis njengenqubo ephumelela kakhulu yokususa i-lactate ne-metformin hydrochloride emzimbeni. Ukwelashwa okubonakalayo kuyenziwa futhi.
Imiyalo ikhombisa izindlela ezinganconyelwanga nezinto, lapho zisetshenziswa ngasikhathi sinye neGlucofage, ezingavusa ukwanda noma ukwehla ngokushesha kwenqanaba loshukela. Awukwazi ukuhlanganisa ukwelashwa kwe-Glucofage ne:
- ama-antipsychotic;
- danazol;
- i-chlorpromazine;
- beta2-sympathomimetics
- ukwelashwa kwe-hormone;
- "loop" diuretics;
- ethanol.
Ngaphezu kwalokho, akunconywa ukuhlanganisa ukuphathwa kwe-Glucofage nezakhi zemihluko eziqukethe iodine.
Ukusetshenziswa kwesidakamizwa ukunciphisa umzimba kanye nempilo yabesifazane
Iziguli eziningi ziyazibuza ukuthi kungani i-glucophage ithinta ukwehla kwesisindo. Njengoba umuthi ukhuthaza ukwenziwa kwama-acid acid acid futhi unciphise ukusetshenziswa kwama-carbohydrate, kubangela ngqo ukwehla kwesisindo somzimba ngokweqile.
Eminye yemiphumela emibi, ukulahleka kokudla, abanesifo sikashukela abaningi bathola usizo, ngoba banciphisa ukudla kwabo kwansuku zonke. Kodwa-ke, ukusebenza kahle kwezidakamizwa kungancishiswa ngenxa yokwanda kwendawo ene-acid emzimbeni. Ngakho-ke, ngesikhathi sekwemukelwa i-Glucofage, akunconywa ukuba uzithwalise ngokweqile ngokuzivocavoca okhathala. Kepha akekho noyedwa ohoxise ukudla okunempilo. Kuyadingeka ukulahla ukudla okunamafutha kanye nama-carbohydrate angagaya kalula.
Isikhathi sokwelashwa kokuncipha kwesisindo akufanele singeqi amasonto angama-4-8. Ngaphambi kokuthatha umuthi, udinga ukubonisana nochwepheshe wakho wezempilo ukuze uvikele ukulimala okungenzeka kanye nokuthuthukiswa kwe-hypoglycemia ku-mellitus yesifo sikashukela.
Ucwaningo lwakamuva luveze ukuthi ukuphuza umuthi kusebenza kahle kokuzala. Ngaphezu kwalokho, kuthathwa i-polycystic, okubangele ukuthi ema-57% amacala ukungakwazi ukuba nezingane. Le pathology ingabangelwa yi-metabolic syndrome noma ukumelana ne-insulin.
Ekuqaleni, iziguli eziningi zithola izimpawu ezinjengokulibaziseka, isikhathi esingajwayelekile, ne-cystitis. Lezi zimpawu azihambi kahle futhi zidinga ukuxhumana ngokushesha nodokotela wezifo zabesifazane.
Ukuhlanganiswa kweGlucophage neDuphaston kusiza ukuqinisa amazinga e-hormone.
Izindleko, ukubuyekezwa nokunye
I-Glucophage isimangaza hhayi ngokusebenza kwayo, kodwa futhi ngamanani amnandi. Ngakho-ke, izindleko zephakethe elilodwa le-Glyukofage ziyahlukahluka kusuka kuma-ruble angamaRussia angama-31 kuya kwangama-310, kanye nesenzo eside - kusuka kuma-ruble angama-320 kuya kwangama-720, ngokuya ngesimo sokukhishwa.
Ukubuyekezwa kweziguli ezithatha lo muthi muhle kakhulu. I-Glucophage ayiholeli ku-hypoglycemia futhi iqinise izinga likashukela kwabanesifo sikashukela. Futhi, izibuyekezo eziningi zibonisa ukusebenza kwekhambi lokunciphisa umzimba. Nasi, ngokwesibonelo, ngenye yamazwana:
ULyudmila (iminyaka engama-59): "Ngabona iGlucofage kule minyaka emithathu edlule, ushukela awudluli ku-7 mmol / L. Yebo, ekuqaleni kwezokwelapha bengigula, kepha ngicabanga ukuthi uma uzizwa ugula, ungakunqoba. Uma uqhubeka nokuthatha umuthi, "Eminyakeni emithathu edlule, isisindo somzimba wami besingama-kg angama-71, ngosizo lwaleli thuluzi isisindo sami sehlile safinyelela kuma-64 kg. Vuma, kube nomphumela omuhle. Impela, awukwazi ukwenza ngaphandle kokudla nokushaja kwezokwelashwa."
Noma kunjalo, kunokubuyekezwa okungalungile mayelana nomuthi. Zihlotshaniswa nokugayeka kokunye nokuphendula okungalungile komzimba. Isibonelo, ingcindezi iyanda, umthelela omubi ezinso. Futhi, umuthi ungadala ukukhula kwe-cholecystitis, i-atraya fibrillation, izimpawu ezandayo ze-psoriasis kubantu abaphethwe yilesi sifo. Yize ubudlelwano obuqondile phakathi kwezifo nokuphuza umuthi bungakaze busungulwe ngokuphelele.
Njengoba i-Glucophage iqukethe into edumile emhlabeni wonke - i-metformin, ine-analogues eminingi. Isibonelo, iMetformin, iBagomet, iMetfogammam, iFommetin, iNovava, iGliformin, iSiofor 1000 nabanye.
IGlucophage (500, 850, 1000), kanye neGlucophage 500 no-750 izidakamizwa ezisebenzayo zesifo sikashukela sohlobo 2. Ngokuvamile, izidakamizwa ezibangela ukusabela okungekuhle zimane nje zisetshenziswe kabi. Uma isetshenziswa ngendlela efanele, ilungele impilo futhi iqeda i-glycemia ephezulu kushukela likashukela.
Imininingwane nge-Glucofage inikezwe kuvidiyo ekulesi sihloko.
