I-Nateglinide iyisidakamizwa sokwenziwa esinezakhiwo ze-hypoglycemic, ukusetshenziswa kwayo okuvumela ukuthi ulawule ngempumelelo izinga le-glycemia egazini enohlobo 2 sikashukela.
I-Nateglinide itholakala ku-amino acid ephethe impahla ye-hypoglycemic.
Ukusetshenziswa kwalesi sidakamizwa kukuvumela ukuthi ulawule i-glycemia emzimbeni wesiguli esinesifo sikashukela.
Ukulawulwa kwezinga likashukela emzimbeni wesiguli kwenzeka ngenxa yokuvuswa kokuhlanganiswa kwe-insulin yama-hormone kumaseli we-beta kumaphaphu yiwo umuthi.
Umuthi uyimpuphu emhlophe ethambisa kalula i-methyl kanye ne-ethyl alcohol ne-chloroform. Ibuye inyibilike ku-ether, kunzima ukuncibilika ku-acetonitrile ne-octanol. Umuthi awusebenzi ngokuphelele emanzini. Isisindo se-molecule ye-complication singama-317.45.
I-Pharmacodynamics yesidakamizwa
Umuthi yi-ejenti yomlomo ye-hypoglycemic, lo muthi utholakala ku-phenylalanine.
Ezimweni zayo zamakhemikhali kanye nesenzo se-pharmacological, umuthi unokwehluka okubalulekile kweminye imithi ye-hypoglycemic.
Ukusetshenziswa kwesidakamizwa kukuvumela ukuthi ubuyisele ukukhululeka kokuqala kwe-insulin ye-hormone, okunciphisa ukucwaswa kwe-glucose kwe-plasma yegazi kanye nezinga le-glycemic hemoglobin HbA1c.
Inqubo yokutholwa kokuqala kwe-insulin njengempendulo yokwanda kokuhlungwa kweglucose yiyona ndlela ebaluleke kakhulu yokulawula inkomba ye-glycemic, eqinisekisa ukusebenza okujwayelekile komzimba.
Endabeni yokuthuthuka kwesifo sikashukela esinga-insulin esincike emzimbeni, ukuvela kwe-insulin ye-hormone kuyaphazamiseka. Ngaphezu kwalokho, isigaba sokuqala senqubo yokuqamba singanyamalala ngokuphelele. I-Nateglinide, ethathwe ngaphambi kokudla, yenza ngendlela yokuthi umzimba ubuyisele lesi sigaba senqubo yokwakheka kwe-hormone.
Indlela yokusebenza yesidakamizwa umphumela osheshayo noshintshayo wesakhi esisebenzayo somuthi eziteshini ezincike ku-potassium ezisuselwa kulwelwesi lwama-membrane wamaseli we-beta wezicubu ze-pancreatic. I-Nateglinide isebenza ku-insulin synthesis emizuzwini yokuqala eyi-15 ngemuva kokudla. Lesi senzo somuthi sisiza ukwehlisa iziqongo ekushintshashintsheni kwe-glucose ku-plasma yegazi.
Emahoreni alandelayo, inkomba yokuhlushwa i-insulin ibuyela kokujwayelekile, okugwema ukwenzeka kwe-hyperinsulinemia, okucasulayo ukuthuthukiswa kwesimo esibambezelekile se-hypoglycemia.
Izinkomba kanye ne-contraindication ukuze zisetshenziswe, i-overdose
I-Nateglenide iyasetshenziswa uma isiguli sinenhlobo 2 yesifo sikashukela esingaxhamli ku-insulin ngokungabikho koshintsho oluhle lapho sisebenzisa ukwelashwa kokudla nokwenza imisebenzi yomzimba ekhethiwe.
Umuthi ungasetshenziswa zombili ngesikhathi se-monotherapy nanjengengxenye yokwelashwa okuyinkimbinkimbi ekwelashweni kwesifo sikashukela sohlobo II.
Imvamisa, umuthi usetshenziswa ngokuhlanganiswa neMetformin.
Uma usebenzisa umuthi, kunezindlela eziningi zokuphikisana ngokusetshenziswa kwaso. Okusemqoka phakathi kokuphikisana nokusetshenziswa kweNateglinide yile elandelayo:
- ukuba khona kwesiguli esinohlobo lwe-1 mellitus yesifo sikashukela;
- ukuba khona kwesiguli esinesifo sikashukela i-mellitus izimpawu zokuthuthuka kwe-ketoacidosis yesifo sikashukela;
- ukutholwa kokuphazamiseka okusebenzayo kwesibindi;
- isikhathi sokukhulelwa nesikhathi sokuncelisa;
- iminyaka yezingane yesiguli esinesifo sikashukela;
- ukuba khona kokuzwela kokuzwa kwezakhi ezifakiwe ekwakhiweni komuthi.
Ngokusekelwe kumshini womphumela womuthi emzimbeni, kungacatshangelwa ukuthi umphumela oyinhloko wokwephulwa komthamo ophakanyisiwe ekwelashweni kwesifo sikashukela ukukhula kwe-hypoglycemia esigulini, okungavela ngokwenzeka kokwehlukahluka kobunzima ngokuya ngobukhulu be-overdose ngesikhathi sokwelashwa.
Ukukhethwa kwendlela yokwelapha izimpawu ze-overdose kuya ngesilinganiso sokuboniswa.
Ngenkathi ugcina ukwazi kwesiguli nokungabikho kokubonakaliswa kwemizwa, kunconywa ukuthatha isixazululo se-glucose noma ushukela ngaphakathi bese ulungisa ukudla okwedliwayo.
Ngokuthuthukiswa kwendlela enzima yesimo se-hypoglycemic, lapho kunokuthuthuka kwethenda kanye nokuquleka, kuyanconywa ukuba kwenziwe isisombululo se-glucose esangaphakathi.
Inqubo ye-hemodialysis inqubo engasebenzi, ngoba iNateglitin inezinga eliphakeme lokubopha amaprotheni e-plasma.
Imiyalo yokusebenzisa umuthi
Ukuthatha umuthi wesifo sikashukela kungaphakathi.
Endabeni ye-monotherapy, kuthathwa umthamo ka-120-180 mg kathathu ngosuku.
Uma i-Nateglinide isetshenziswa njengengxenye yezakhi eziyinkimbinkimbi yokwelapha, umthamo ophakanyisiwe ngesikhathi sokwelashwa uvela ku-60 uye ku-120 mg kathathu ngosuku.
Lapho usebenzisa umuthi, isiguli singaba nemiphumela emibi emzimbeni.
Imiphumela emibi lapho uphuza umuthi ubonakala ekusebenzeni okungaphazamiseki kwalezi zinhlelo nezitho zomzimba zomuntu ogulayo:
- Ukwephulwa kohlelo lwezinzwa nezitho zomzimba.
- Ukuphazamiseka ekusebenzeni kohlelo lokuphefumula.
- Ukwehluleka kuphephabhuku lesisu.
- Ukuphazamiseka kwemetabolic.
Ngaphezu kwalokho, kungaba nemiphumela emibi ethinta isimo somzimba jikelele.
Uma kunokuphazamiseka ohlelweni lwezinzwa, isiguli sizwa umuzwa wesiyezi.
Ukungasebenzi kahle ohlelweni lokuphefumula kuboniswa ngokubonakala kwezifo zokuphefumula esigulini, ukuthuthukiswa kwezimpawu ze-bronchitis, kanye nokubonakala kokhwehlela.
Uma kwenzeka imiphumela emibi ethinta ukusebenza kwamapheshana emathunjini, isiguli sivele ngokuvela komhudo nomuzwa wokucanuzelelwa kwenhliziyo.
Umphumela oyinhloko wokuphazamiseka kwe-metabolic ukukhiqizwa kwesimo se-hypoglycemic emzimbeni wesiguli, nakuzimo ezinzima ze-glycemic coma.
Ukuthuthukiswa kwesimo se-hypoglycemic nokusetshenziswa kweNateglinide ngesikhathi sokwelashwa akuvamile kakhulu.
Isicanucanu nesifo sohudo njengemiphumela emibi yokuphuza umuthi nayo ivela kakhulu, imvamisa lemiphumela emibi iba kumuntu lapho esebenzisa ukwelashwa okunesifo sikashukela sohlobo 2 uma iMetformin ingenye yezingxenye zokwelapha.
Kwesinye isikhathi lapho uthatha iNetelinid esigulini esinesifo sikashukela, njengesimo esibuhlungu, ukubonakala kobuhlungu emgogodleni kuyaphawulwa.
Ngaphezu kwalokho, izimo ezinjengomkhuhlane zingakhula emzimbeni wesiguli.
Ukufana kwezidakamizwa, ukugcinwa kanye nezindleko zomuthi
Umuthi kufanele ugcinwe endaweni emnyama. Izinga lokushisa lomuthi kufanele libe ku-15 kuya ku-30 degrees Celsius.
Impilo yeshalofu yesidakamizwa yiminyaka emibili. Ngemuva kokuphela kwesikhathi sokulondolozwa, umuthi uvunyelwe ukusetshenziselwa ukwelashwa. Umkhiqizo ophelelwe isikhathi kufanele uvuselelwe.
Indawo yokubeka umuthi akufanele ifinyeleleke ezinganeni.
Kuze kube manje, imboni yezemithi ikhiqiza inqwaba yezidakamizwa ezinomphumela ofanayo emzimbeni wesiguli onesifo sikashukela sohlobo 2.
Izidakamizwa ezivame kakhulu ezinomphumela ofanayo yilezi ezilandelayo:
- I-Guarem;
- I-Amaryl;
- IVictoza;
- I-Berlition;
- UGalvus Met;
- I-Metformin Teva;
- ILangerine;
- Siofor850 nabanye.
Iziguli eziningi ezisebenzise i-Natelitid enkambeni yokwelapha zishiya ukubuyekeza okuhle mayelana nomuthi.
Ukuba khona kwezibuyekezo ezingezinhle mayelana nomuthi uvame ukuhlotshaniswa nokuphazamiseka komthamo.
Umuthi ungathengwa emakhemisi ngokunikezwa umuthi.
Izindleko zesidakamizwa eRussia Federation ikakhulukazi zincike esifundeni lapho isidakamizwa sithengiswa khona.
Intengo yesidakamizwa eRussia Federation, ngokuya ngesifunda, ingasukela kuma-ruble angama-6300 kuya kwangama-10500 ngephakeji ngalinye.
Yiziphi izidakamizwa ezingasetshenziswa ekwelapheni isifo sikashukela ezizotshela ividiyo ekulesi sihloko.
