I-Metformin Zentiva 1000: ama-analogues nokubuyekezwa kulo muthi

I-Metformin zentiva isetshenziswa ngokoqobo kwezokwelapha, njengenye yezidakamizwa zohlobo 2 sikashukela.

Namuhla, imboni yamakhemikhali ikhiqiza inani elikhulu lemithi ehlukahlukene yokunciphisa ushukela, futhi i-metformin zentiva ingenye yazo.

Izinkomba zokusebenzisa umuthi

Umuthi wokwelapha iMetformin zentiva kudala wasetshenziswa ukwelapha isifo sikashukela sohlobo 2 ngokuhlangana nokudla okunqunywe ngudokotela.

Umuthi awuvumeli ukuletha kuphela izinga likashukela wegazi inani eliseduze nenkomba yokuzimisela ngokomzimba, kodwa futhi lenza ukuthi wehlise isisindo futhi ulilawule kuzilungiselelo ezijwayelekile, okuyinto ebalulekile kubantu abanalesi sifo.

Namuhla, ngenxa yocwaningo oluqhubekayo, izakhiwo ezintsha zalesi zinto ziyatholakala, futhi ukusetshenziswa kwaso kuyanda, okuvumela ukusetshenziswa kwalesi sidakamizwa hhayi kuphela ekulweni ne-pathology.

I-Metformin zentiva ingasetshenziswa ukuqeda nokwelapha izifo ezilandelayo:

1. Isiza ukuvikela ubuchopho ekuguga, okukuvumela ukuthi kusetshenziselwe izinjongo ze-prophylactic emelana nesifo i-Alzheimer's.
2. Sithinta kahle isimo semithambo yegazi nemithambo yegazi. Ngakho-ke, ngosizo lwe-metformin, ukuthuthukiswa kwe-vasherticosis yemithambo yegazi, ukwehluleka kwenhliziyo, umfutho wegazi ophakeme, kanye nokubalwa kwemithambo kungavinjelwa.
3. Yehlisa amathuba womdlavuza.
4. Ithinta kakhulu ukuthuthukiswa kwe-potency emadodeni, okwakhubazeka ngenxa yezifo ezihlukahlukene ze-senile.
5. Ikunciphisa ukuthuthukiswa kwamathambo kwabanesifo sikashukela. Ikakhulu kaningi, abesifazane bahlushwa amathambo ama-brittle ngemuva kokunqamuka kokuya esikhathini, ngoba kukhona ukwehla okukhulu kwama-hormone - estrogen.
6. Kuthinta kahle ukusebenza kwe-gland yegilo.
7. Inomsebenzi wokuzivikela maqondana nohlelo lokuphefumula.

Ngaphandle kokuthi umuthi unezinzuzo eziningi kangaka, akunakwenzeka ukusho ukuthi uphilile futhi ungalapha izifo eziningi.

Njengayo yonke eminye imithi, i-metformin ingasetshenziswa kuphela njengoba kuchazwe udokotela oholayo, uma kungenzeka amathuba ayo yonke imiphumela yayo emibi.

Izici zamakhemikhali zomuthi wethebhulethi

Umuthi ungowesigaba se-Biguanides, esetshenziswa ngomlomo.

Lo muthi we-hypoglycemic usiza amazinga aphansi kashukela.

Enye yezinzuzo eziphambili zesidakamizwa ukuthi, ngokungafani nezidakamizwa ezithathwe kuma-sulfonylureas, akubangeli i-hypoglycemia. Le mpahla ichazwa yiqiniso lokuthi iMetformin ayisona isisusa sokuvikeleka kwe-insulin ngamaseli e-beta wamanyikwe.

Lapho uthathwa kahle, umuthi ukhulisa umuzwa wokutholwa kwezicubu zomzimba kune-insulin, okuholela ekwandiseni ukusetshenziswa kweglucose amaseli ancike ku-insulin. Kuyasiza ukunciphisa ukukhiqizwa koshukela yizakhi zamaselula kwesibindi ngenxa yokuvinjwa kwezinqubo ze-gluconeogeneis kanye ne-glycogenolysis. Phakathi kwezakhiwo ezinhle kungabuye kubangelwe amandla ayo okunciphisa izinga lokufakwa kweglucose emathunjini.

Imiphumela enenzuzo ye-metformin ku-lipid metabolism nayo ibaliwe:

• ukwehla kwe-cholesterol ephelele;
• neqhaza ekuthuthukiseni izakhiwo zegazi;
• ukwehla kwe-LDL ne-triglycerides.

Isici esibalulekile futhi ukuthi ukugcinwa kokudla okufanele, kanye nokusetshenziswa kwe-metformin, kunomthelela ekwehliseni kancane kancane kwesisindo somzimba wesiguli.

Imiyalo yokusebenzisa umuthi

Imithi Metformin Zentiva ikhiqizwa ifomu lethebhulethi emithanjeni ehlukahlukene.

Umkhiqizi womuthi onjalo utholakala eRiphabhlikhi yaseSlovakia, kuyilapho iCzech Republic isebenza njengomnikazi wesitifiketi sokubhalisa.

Umuthi ungathengwa cishe kunoma yisiphi isikhungo sokhemisi kule mithamo elandelayo:

• I-500 mg yesithako esisebenzayo kwithebhulethi eyodwa;
• I-850 mg yento esebenzayo;
• I-1000 mg ye-metformin.

Kuya ngomthamo, imithetho yokuphuza umuthi ingahluka kakhulu. Kumele kuqashelwe ukuthi udokotela oholayo kuphela ongancomela ukusetshenziswa kwalesi sidakamizwa, kufaka nokufaka okunye esikhundleni somuthi owaphuzwa ngaphambili.

Inkambo yokwelashwa ichazwa kumithamo, enqunywa yimiphumela yokuhlaziya kanye nezifundo zomzimba kanye nezimpawu zomuntu ngamunye zesiguli. Isikhombisi esiyinhloko okudingeka unake ngaso lapho unquma umthamo izinga le-glucose ku-plasma yegazi kanye nesigaba sesisindo sesiguli.

Umthamo omncane lapho ukwelashwa kuqala khona kungu-500 mg wesidakamizwa ngokwanda okulandelayo okulandelayo. Ngaphezu kwalokho, umthamo owodwa futhi awukwazi ukudlula isibalo esingenhla. Ukuze ukwazi ukubekezelela kangcono umuthi, kanye nasendabeni yemithamo ephezulu, inani lemithamo lingahlukaniswa kabili noma kathathu ngosuku. Ngakho-ke, kuzokwazi ukuvimbela ukuthuthukiswa kwemiphumela emibi.

Umthamo omkhulu kakhulu wesidakamizwa akufanele wedlule i-3000 mg yento esebenzayo.

Umuthi uthathwa ngomlomo, emva kwalokho, ngemuva kwamahora amabili kuya amathathu, umsebenzi wawo omkhulu uqala ukuvela. Cishe amahora ayisithupha ngemuva kokuthatha umuthi, i-plasma concentration ye-metformin iyancipha, ngoba ukufakwa kwengxenye esebenzayo kuyaphela.

Kwezinye izimo, kuvunyelwe ukuthatha umuthi ngezinhloso ze-prophylactic, futhi umthamo kumele wehliswe amahlandla amabili kuya kwamathathu.

Umphumela omkhulu wokuphuza umuthi utholakala ngemuva kwesikhathi sokulashwa esithatha amasonto amabili.

Uma, ngenxa yezimo ezithile, umuthi ulahlekile, asikho isidingo sokuwunxephezela ngokwandisa umthamo olandelayo.

Lapho uthatha umuthi, kuyadingeka ukuthi ucabangele inkambo ejwayelekile yezinqubo ze-metabolic nempilo enhle, ngoba kunengozi enkulu ye-lactic acidosis.

Izindlela zokuvikela ukusetshenziswa komuthi

Ukusetshenziswa okungalungile kweMetformin kungadala imiphumela emibi eminingi, izakhiwo eziyingozi zomuthi womzimba womuntu zizovuleka. Yingakho umuthi kufanele unqunywe kuphela ngudokotela ohamba naye, ebheka zonke izici zesiguli, ubukhulu bokuthuthuka kwe-pathology nezifo ezihambisanayo.

Ukubonakaliswa okungekuhle kwesidakamizwa kubandakanya lokhu okulandelayo:

1. Ukuthuthukiswa kwezinkinga ngezitho zomgudu wesisu, ukuphazamiseka kokugaya ukudla, okungahle kuhambisane nokwanda kwegesi, izinhlungu esiswini noma isifo sohudo.
2. Imvamisa yensimbi engathandeki emlonyeni ingavela ngemuva kokungenisa.
3. Isicanucanu nokuhlanza.
4. Ukuntuleka kwamaqembu athile wamavithamini, ikakhulukazi i-B12. Kungakho kunconyelwa ukuthi ukungena okungeziwe kwezakhiwo ezikhethekile zemithi ekwaziyo ukwenza ngokwejwayelekile izinga lazo zonke izinto ezidingekayo emzimbeni.
5. Ukuthuthukiswa kokuphendula okungezwani nezinto ezakhiwayo zomkhiqizo obhebheni.
6. Ukwehla kweshukela egazini ngaphansi kwamanani ajwayelekile.
7. Ukubonakaliswa kwe-lactic acidosis.
8. I-anemopablastic anemia.

Futhi yize iMetformin ifakiwe eqenjini lemithi ephephile, kufanele ufunde ngokucophelela konke ukubonakala okungalungile. Umuthi onjalo ungaba yingozi uma ungalandeli imithetho efanelekile yokuphathwa kwawo.

Eminye yemiphumela emibi ejwayelekile evela ekusetshenzisweni kwesidakamizwa yi-lactic acidosis ku-mellitus yesifo sikashukela. Lesi simo sihambisana nezimpawu ezinjengokwehla kokuqina, ukuqina kwemisipha, ukwehla kwezinga lokushisa lomzimba nomfutho wegazi, nobunzima bokuphefumula.

Ngokukhula kwesifo esinjalo, isiguli sidinga ukulashwa ngokuphuthumayo esibhedlela. I-Lactic acidosis ingenye yemiphumela emibi eyenzeka ngenxa yokuqina ngokweqile komuthi.

I-Metformin Zentiva ayivunyelwe ukuyisebenzisa phambi kwento eyodwa noma eziningana:

• i-metabolic acidosis ngamafomu asebusweni noma angapheli;
• isimo sokukhubazeka sikashukela noma ukhokho;
• ngezinkinga ezinkulu emsebenzini wezinso;
• ngenxa yokuphelelwa ngamanzi emzimbeni;
• lapho kuvela izifo ezinkulu ezithathelwanayo noma ngokushesha emva kwazo;
• ukwehluleka kwenhliziyo noma i-myocardial infarction;
• Izinkinga ngokusebenza okujwayelekile kwendlela yokuphefumula;
• uphuzo oludakayo.

Futhi kwenqatshelwe ukuphuza umuthi osukwini oluzayo nangemva kokungenelela kokuhlinzwa (okungenani izinsuku ezimbili ngaphambi kokuhlinzwa nezinsuku ezimbili emva kokuba kudlule).

Analogs of Metformin Zentiva

Ukuhlolwa kweziguli kubonisa umphumela omuhle owalethwa ukwelashwa kwe-metformin. Izindleko zayo eziphakathi nendawo e-Russian Federation zingasukela kuma-ruble ayi-100 kuye kwangama-150, ngokuya ngendawo ekhemisi.

Uma kunesidingo, udokotela ohambelayo angangena esikhundleni somunye umkhiqizo wezokwelapha ngokuqanjwa okufanayo noma izakhiwo ezifanayo. Kuze kube manje, imakethe yamakhemikhali inikezela ngezifanekiselo ezilandelayo zesidakamizwa iMetformin, okuthi ngokwezibuyekezo, futhi ibe nemiphumela emihle:

1. I-Glucophage - amaphilisi okwehlisa ushukela atholakala kwimithamo ehlukahlukene. Isithako esikhulu esisebenzayo yi-metformin hydrochloride. Isiza ngokwejwayelekile amazinga eglucose ngaphandle kokubangela i-hypoglycemia. Isigaba sentengo samathebhulethi anjalo, njengomthetho, awadluli kuma-ruble angama-200.
2. I-Glycon isidakamizwa, lapho kunezinto ezimbili ezisebenzayo ngasikhathi sinye - i-metformin ne-glibenclamide. Lokhu kulungiselelo elihlanganisiwe elihlanganisa izakhiwo ze-Biguanides ne-sulfonylurea derivatives. Ibuye isetshenziswe kaningi ukwelapha uhlobo lwe-II yesifo sikashukela mellitus. Intengo ephakathi yesidakamizwa ama-ruble angama-210-240.
3. I-Diasphor isidakamizwa esivela eqenjini le-Biguanide, okuyi-analogue ephelele yamathebulethi weMetformin. Intengo yayo ephakathi kumakhemisi asedolobheni ingahluka kusuka kuma-ruble angama-250 kuya kwangama-350.
4. I-Metadiene - amaphilisi aqhamuka ekilasini lama-dimethylbiguanides, atholakala kumithamo ehlukahlukene. Ngokuya ngenani lezinto ezisebenzayo, izindleko zomuthi ziyasungulwa. Njengomthetho, inani lentengo leSofamed kumakhemisi ehlukene aleli dolobha alidluli kuma-ruble ayi-130.
5. UNova Met.
6. I-Glibenclamide.

Kuze kube manje, inani le-analogues noma izichasazi impela. Zonke, njengomthetho, zinezindawo ezifanayo noma ezifanayo, kepha ziyehluka enkampanini yokukhiqiza, intengo, igama.

Ngaphezu kwalokho, ochwepheshe bezokwelapha batusa ukusetshenziswa kwaleyo mishini yezokwelapha equkethe, ngaphezu kwengxenye eyisebenzayo, inani elincane lamadivayisi asizayo.

Imininingwane ngesidakamizwa iMetformin ivezwe kuvidiyo ekulesi sihloko.