Isidakamizwa se-Glimepiride sokunciphisa ushukela kushukela

I-Glimepiride (eresiphi yesiLatin - Glimepiride) - Lona umuthi ukhohliwe ngokungafanele namuhla. Kuzo zonke izidakamizwa ze-antidiabetic ezimele isigaba sezidakamizwa ze-sulfonylurea, lo umuthi ulula kakhulu. Ngenkathi amaphilisi eqala ukubonakala kunethiwekhi yamakhemisi, ayengomunye wemithi ethandwa kakhulu. Kepha ngemuva kokutholwa kwesigaba esisha sezidakamizwa (ama -retretin), baqala ukukukhohlwa ngokungafanele.

Umuthi futhi unamathuba okungeziwe kwe-pancreatic: ukwandisa ukuzwela kwezicubu ukungena kuma-insulin asezindlini, kunciphisa ukukhiqizwa kwe-glucose esibindini, ukuvimbela ukwakheka kwezigaxa zegazi, futhi kunciphise izinga lama-radicals mahhala.

Ifomu lomthamo

Umkhiqizi wasekhaya ophethe i-PHARMSTANDART ukhiqiza i-Glimepiride ngesimo samathebhulethi ayi-4:

• Umbala opinki okhanyayo - 1 mg ngamunye;
• I-hue ekhanyayo eluhlaza - 2 mg ngayinye;
• Uphuzi okhanyayo - 3 mg;
• Umbala oluhlaza okwesibhakabhaka - 4 mg ngamunye.

Amaphilisi ahlanganiswa emalungeni e-aluminium ama-pc ayi-10., Amapuleti afakwa emaphaketheni ephepha. Gcina lo muthi ebhokisini lawo lasekuqaleni emazingeni okushisa asemakamelweni isikhathi esingaphansi kweminyaka emithathu. Kwa-Glimepiride, inani lentengo emakhemisi online lisuka kuma-ruble ayi-153. kufika ku-355 rub. kuya ngomthamo. Isigaba sokusabalalisa sinikezwa umuthi.

I-Glimepiride - izithonjana kanye namagama womqondo

Umuthi wokuqala, owokuqala, ofundwe kakhulu, ngu-Amaril ovela enkampanini iSanofi Aventis. Zonke ezinye izidakamizwa, kufaka phakathi i-glimepiride, ziyi-analogues, izinkampani zemithi zizikhiqiza ngokuya nge-patent. Phakathi kokudume kakhulu:

• I-Glimepiride (iRussia);
• I-Diamerid (Russia);
• I-Diapyrid (Ukraine);
• I-Glimepirid Teva (eCroatia);
• UGlemaz (Argentina);
• UGlianov (Jordan);
• UGlibetik (ePoland);
• I-Amaril M (Korea);
• IGlairi (India).

Ukuqanjwa kwesidakamizwa i-Glimepiride

I-Glimepiride yi-ejenti yomlomo ye-antidiabetic ngomqondo onamandla. Umuthi ungowesigaba se-sulfonamides, esivela ku-urea.

Isakhi esisebenzayo somuthi yi-glimepiride. Kuthebhulethi eyodwa, isisindo sayo ngu-1 kuya ku-4 mg. Into esebenzayo ihlanganiswe nezinto ezisizayo: isitashi se-sodium, i-povidone, i-polysorbate, i-microcrystalline cellulose, i-lactose, i-magnesium stearate, i-indigo aluminium varnish.

Ikhemisi

I-Glimepiride iyisidakamizwa esichitha isifo sikashukela eqenjini le-sulfonylurea elisebenzayo uma lithathwa ngomlomo. Kuklanyelwe ukulawula isifo sikashukela sohlobo 2. Indlela yokusebenza yesidakamizwa isuselwe ekuvuseleleni kwama-β-cell abhekene nokukhiqizwa kwe-insulin endulin. Umuthi ubopha iprotheni yelungu lale maseli ngokushesha okukhulu.

Njengayo yonke imishanguzo kuleli qembu, isidakamizwa sandisa ukuzwela kwezicubu ekuvuseleleni ushukela. Inomuthi kanye nomphumela owengeziwe we-pancreatic. Ukukhiqizwa kwe-insulin ngaphansi kwethonya lomuthi kwenzeka ngenxa yokufinyelela okuthuthukile kwiziteshi ze-calcium: ukwanda kwethonya le-calcium kukhuthaza ukukhishwa kwe-insulin.

Phakathi kwemiphumela eyingqayizivele, ukuncipha kokumelana kwamangqamuzana kuma-hormone nokuncipha kwezinga lokusetshenziswa kwawo esibindini kungabonakala. Eziswini nasemafutheni omzimba, ushukela ushiswa ngosizo lwamaprotheni okuhambisa, umsebenzi wawo owanda kakhulu ngemuva kokuthatha umuthi.

I-Pharmacokinetics

I-bioavailability ye-glimepiride ingu-100%. Ukudla ngokulinganayo kwezakhamzimba kubambezela ukumuncwa kancane. Okuqukethwe kwe-plasma okuphezulu kugcinwa amahora angama-2,5 ngemuva kokuba umuthi wamukelwe endaweni yokugaya ukudla. Umthamo wokusabalalisa wesidakamizwa uphansi (8.8 L), ubopha amaprotheni we-serum ngangokunokwenzeka (99%), ukucaciswa kwesidakamizwa kungama-48 ml / min.

Ngohlobo lwe-dosing oluphindaphindwe kabili, isilinganiso sempilo-samahora ngamahora angama-5-8. Ngokukhula komthamo wokwelapha, kulokhu kuyanda. Ama-Metabolites aqedwa ngokwemvelo: I-58% yomthamo owodwa omakwe yi-isotope yomsakazo yatholakala kumchamo kanye nama-35% ezindundwini. Ukuphila kwesigamu kwemikhiqizo yokubola kungamahora angama-3-6.

Akukho mehluko osisekelo kuma-pharmacokinetics we-glimepiride kuma-diabetesics asemncane noma avuthiwe, owesifazana noma owesilisa. Kwizazi zesifo sikashukela esine-creatinine imvume ephansi, akukho bungozi bokukhishwa komuthi. Amapharamitha we-pharmacokinetic ezigulini ezi-5 ngemuva kokuba i-cholecystectomy ifana nalezi ezinesifo sikashukela esinempilo kulokhu.

Ezinganeni ezingama-26 zintsha ezineminyaka eyi-12 kuya kwengu-12 ubudala, kanye nezingane ezi-4 ezineminyaka eyi-10,5 ubudala, iziguli ezinesifo sikashukela sohlobo 2, isilinganiso esisodwa somuthi omncane (1 mg) wesidakamizwa sakhombisa imiphumela efana neyabantu abadala.

Ubekwa ubani umuthi

Amacwecwe amiselwe uhlobo 2 sikashukela uma ukulawulwa kwe-glycemic ngokuguqulwa kwempilo kunganele. Kungenzeka ukunquma umuthi njengowengeziwe, ekwelashweni okuyinkimbinkimbi namanye ama-hypoglycemic agents.

Ngubani ongakhonjisiwe i-glimepiride

Umuthi awulungele abanesifo sikashukela abanesifo sohlobo 1; asisetshenziselwa isifo sikashukela sikashukela, ukoma kanye nethambo, kanye nokungasebenzi kahle kwezinso nezinso.

Njenganoma yisiphi isidakamizwa, i-glimepiride ayinqunyelwe abanesifo sikashukela abanokuzwela okuphezulu kuzithako zefomula, neminye eminye imithi ye-sulfonylamide.

I-Glimepiride icutshaniswe nokukhulelwa nokukhipha isisu.

Ungayisebenzisa kanjani kahle i-Glimepiride

Ukuqinisekisa ukulawulwa kwe-glycemic eyi-100%, ukwelashwa kwezidakamizwa akwanele.

Uhlelo olukhombisa imithwalo yemisipha kushukela sikashukela sohlobo lwe-2 lokwenza okukhanyayo noluphakathi kungaba ngale ndlela elandelayo:

• Ukuzivocavoca amandla - 2-3 p. / Isonto;
• Ukuhamba ngamandla - ama-ruble ama-3 / isonto .;
• Ukubhukuda, ukuhamba ngebhayisikile, ithenisi noma umdanso;
• Ukuhamba ngezitebhisi, ukuhamba okuthulile - nsuku zonke.

Uma inkimbinkimbi enjalo ingalungile, ungakwenza ukwelashwa nsuku zonke. Esikhundleni sokuhlala, umuntu onesifo sikashukela angaba ngaphandle kwekhefu imizuzu engekho ngaphezulu kwe-30.

Umthamo ofanele wokwelapha ukhethwa ngudokotela, kucatshangelwa isigaba salesi sifo, i-concomitant pathologies, isimo esivamile, ubudala besiguli, ukusabela komzimba wakhe kulo muthi.

Imiyalo ye-Glimepiride yokusetshenziswa itusa ukusetshenziswa kwe-1 mg / ngosuku. (ngomuthi wokuqala). Ngokuvama kwamasonto ayi-1-2, lapho sekuvele kungenzeka ukuthi kuhlolwe umphumela, kungathunyelwa nge-titithe uma irejimeni lokwelashwa langaphambili belingasebenzi ngokwanele. Okujwayelekile kungaphezu kwe-4 mg / ngosuku. isetshenziswa ezimweni ezikhethekile. Inani elikhulu lemithi lifinyelela ku-6 mg / ngosuku.

Uma umthamo omkhulu we-metformin unganikeli i-100% glycemic control, i-glimepiride ingathathwa njengendlela yokwelapha esekelayo ngasikhathi sinye, ihlanganiswe kahle nalo muthi, kuhlanganiswe nezidakamizwa ezihlanganiswa nalezi zinto ezimbili ezisebenzayo. Ukwelashwa okuphelele kuqala ngethamo elincane le-glimepiride (1 g), ukuqapha nsuku zonke izinkomba ze-glucometer kuzosiza ukulungisa okujwayelekile. Zonke izinguquko ku-algorithm zenziwa kuphela ngaphansi kokuqashwa kwezokwelapha.

Mhlawumbe inhlanganisela ye-glimepiride nangamalungiselelo we-insulin. Imithamo yamathebulethi, kulokhu, kufanele iqale ibe mincane. Ngokusekelwe emiphumeleni yezivivinyo, njalo emavikini amabili isilinganiso somuthi singalungiswa.

Imvamisa, umthamo owodwa wemithi. Hlanganisa nesidlo sasekuseni esiqinile noma isidlo emva kwaso, uma ibhulakufesi kwisifo sikashukela kungokomfanekiso.

Kungcono ukuthatha iphilisi imizuzu embalwa ngaphambi kokudla, ngoba kuthatha isikhathi ukuthatha isinyathelo. Uma uphuthelwe isikhathi sokuthatha i-Glimepiride, umuthi kufanele uphuzwe ngethuba lokuqala, ngaphandle kokushintsha umthamo.

Uma umthamo omncane we-Glimepiride ubangela izimpawu ze-hypoglycemia, umuthi ukhanseliwe, ngoba kwanele ukuthi isiguli silawule ushukela wakhe ngokudla okufanele, imizwa enhle, ukulandela ukulala nokuphumula, umsebenzi owanele womzimba.

Lapho ukulawulwa ngokuphelele kwesifo sikashukela kutholakala, ukumelana nama-hormone kungancipha, okusho ukuthi ngokuhamba kwesikhathi, isidingo somuthi sizoncipha. Kuyadingeka futhi ukuthi uvuselele umthamo ngokuncipha kwesisindo ngokushesha, ushintsho esimweni sokuzivocavoca umzimba, isizinda sokucindezela okwandisiwe nezinye izinto ezidala ubunzima be-glycemic.

Amandla okushintsha kusuka kwamanye ama-antidiabetesic agents abe glimepiride

Lapho ushintsha ukusuka kwezinye izindlela zokwelashwa zohlobo 2 lwesifo sikashukela ezinomlomo, i-Half-life yezidakamizwa ezedlule iyabhekwa. Uma umuthi unalesi sikhathi eside kakhulu (njenge-chlorpropamide), ikhefu lezinsuku ezimbalwa kufanele ligcinwe ngaphambi kokushintshela ku-glimepiride. Lokhu kuzonciphisa amathuba okukhula kwe-hypoglycemia ngenxa yomphumela wokungezelela wama-ejenti ama-2. Lapho uthatha indawo yezidakamizwa, umthamo wokuqala unconywa okungenani i-1 mg / ngosuku. I-Titration yenziwa ngaphansi kwezimo ezifanayo.

Ukubuyiselwa kwe-insulin esikhundleni se-diabetes sinesifo sohlobo 2 kwenziwa ezimweni ezimbi kakhulu nangaphansi kokuqashwa njalo kwezokwelapha.

Imiphumela emibi

Kwi-glimepiride, kanye nezinye izidakamizwa ze-sulfa, isisekelo sobufakazi obuqinile busetshenzisiwe. Izifundo zemitholampilo sezibuye zahlola nokuphepha kwazo. Ngokuhambisana nezincomo ze-WHO, ubungozi bokuqhamuka nemiphumela engafuneki ihlolwe kulesilinganiso esilandelayo:

• Imvamisa kakhulu ≥ 0.1;
• Imvamisa: kusuka ku-0.1 kuye ku-0,01;
• Ngokujwayelekile: kusuka ku-0.01 kuya ku-0.001;
• Kuyaqabukela: kusuka ku-0.001 kuya ku-0.0001;
• Akuvamile kakhulu <0, 00001;
• Akukaziwa ukuthi, ngokwezibalo ezitholakalayo, akunakwenzeka ukuhlola izinga lobungozi.

Imiphumela yokuphendula komzimba kusuka ezinhlotsheni nasezinhlelweni ezahlukahlukene ivezwa etafuleni. Iningi lazo azihlali unomphela futhi zidlulela zodwa ngemuva kokufaka umuthi.

Siza ngokweqile

Ingozi eyinhloko ye-overdose ye-Glimepiride yi-hypoglycemia ehlala amahora angama-72, ngemuva kokujwayelekile, ukubuyela emuva kungenzeka. Izimpawu zokuqala ze-overdose zingavela kuphela ngosuku ngemuva kokufakwa umuthi. Ngezimpawu ezinjalo (ukuphazamiseka kwe-dyspeptic, ubuhlungu besifuba), isisulu sidinga ukuqashwa esikhungweni sezokwelapha. Nge-hypoglycemia, ukuphazamiseka kwemizwa kungenzeka futhi: ukungaboni kahle nokuxhumana, ukwethuka kwesandla, ukukhathazeka, isomnia, imisipha yemisipha, ukoma.

Usizo lokuqala uma kwenzeka kune-overdose ukuvimbela ukumuncwa kwezidakamizwa ezingezelelweyo ngokugeza isisu. Udinga ukudala i-gag Reflex nganoma iyiphi indlela, bese uphuza namalahle ocushiwe noma enye i-adsorbent ne-laxative ethile (ngokwesibonelo, i-sodium sulfate). Ngasikhathi sinye, kumele kubizelwe i-ambulensi ukuze iphuthunyiswe esibhedlela ngokushesha.

Isisulu sizongenwa nge-glucose kahle ngaphakathi: okokuqala, i-50 ml yesisombululo esingu-50%, bese - 10%. Kaningi ngangokunokwenzeka, udinga ukubheka izinga loshukela ku-plasma. Ngokungeziwe ekwelashweni okuthile, isibonakaliso siyasetshenziswa futhi.

Uma ingane ithathe ngengozi i-glimepiride, kukhethwa umthamo we-glucose kucatshangelwa amathuba okukhula kwe-hypoglycemia. Izinga lobungozi lihlolwa ngezikhathi ezithile nge-glucometer.

I-Glimepiride ngesikhathi sokukhulelwa

Ukuphambuka kokujwayelekile ekwakhiweni kwegazi ngesikhathi sokukhulelwa kungadala ukungalunganga kwengane ngisho nokufa kwe-perinatal, futhi nemingcele ye-glycemic kulokhu ayifani. Ukunciphisa ubungozi be-teratogenic, owesifazane kufanele aqaphele iphrofayili yakhe ye-glycemic njalo.

Uma ukhulelwe - isifo sikashukela esinesifo sohlobo 2, sidluliselwa okwesikhashana ku-insulin. Abesifazane asesigabeni sokuhlela kwengane kufanele baxwayise i-endocrinologist yabo ngezinguquko ezizayo zokulungisa irejimeni yokwelashwa.

Akukho mininingwane ngemiphumela ku-fetus yomuntu we-glimepiride. Uma sigxila emiphumeleni yocwaningo lwezilwane ezikhulelwe, umuthi unobuthi bokuzala obuhlobene nomphumela we-hypoglycemic glimepiride.

Akutholakali ukuthi umuthi ungena yini ebisini lukamama, kepha umuthi ungeniselwe ubisi lukamama ngamagundane, ngakho-ke amaphilisi nawo akhanselwa ngesikhathi sokuqunjelwa. Njengoba eminye imithi yochungechunge lwe-sulfonylomide idlula iye obisini lwebele, ingozi ye-hypoglycemia enganeni ingokoqobo impela.

Izingane

Akunamininingwane ngokusetshenziswa kwalesi sidakamizwa ezinganeni ezinesifo sikashukela ezingaphansi kweminyaka engu-8. Okwabantu abadala (kuze kube iminyaka eyi-17), kukhona izincomo zokusebenzisa umuthi njenge-monotherapy. Ulwazi olushicilelwe alwanele ukusetshenziswa kabanzi kwesidakamizwa ngalesi sigaba sabanesifo sikashukela

Izici Zokwelashwa kwe-Glimepiride

Baphuza amaphilisi imizuzu embalwa ngaphambi kokudla ukuze umuthi udakwe bese uqala ukusebenza. Ngokunxeshezelwa okunganele kwamakhono omuthi ngama-carbohydrate, kungavusa izimo ze-hypoglycemic. Ukuhlasela kungaqashelwa ngokuhlanganiswa kwalezi zimpawu ezilandelayo: ikhanda, isifiso se-wolfish, ukuphazamiseka komzimba, isomnia, ukululama okungavamile, ukubonakaliswa kokuhlukumezeka, ukusabela okuvinjelwe, ukukhathazeka okwandayo, ukuphazamiseka, umbono okhubazekile kanye nenkulumo, ukwazi ukungadideki, ukulahlekelwa ukuzwela nokulawula, imisipha yokuqina kwenhliziyo, ukwehluleka , i-precom ne-coma. Ukuphikiswa kwe-Adrenergic kuboniswa ukukhuphuka kokujuluka, izintende zezimvula, ukukhathazeka okukhulayo, ukuphazamiseka kwesigqi senhliziyo, umfutho wegazi ophezulu, isifo senhliziyo.

Ukuhlangenwe nakho ekwelashweni kwabanesifo sikashukela nge-analogues yochungechunge lwe-sulfonylomide kukhombisa ukuthi, ngaphandle kokusebenza okusobala kwezinyathelo zokumisa ukuhlaselwa, kunobungozi bokuvela kabusha. Isimo se-hypoglycemic esinzima futhi isikhathi eside, esivame ukwenzeka ngaphansi kwethonya ushukela ojwayelekile, sifaka ukwelashwa okuphuthumayo, kubandakanya izimo ezimile. Izici ezilandelayo zikhulisa ubungozi be-hypoglycemic:

• Ukunganaki izeluleko zezokwelashwa, ukungakwazi ukubambisana;
• Ukudla okulambile, ukudla okungakaze kwenzeke, ukudla okunganele ngenxa yezimo zomphakathi ezingezinhle;
• Ukungahambisani nemigomo yokudla okuphansi kwe-carb;
• Ukuntuleka kokulinganisela phakathi kwenani lemithwalo yemisipha nenani lama-carbohydrate asetshenzisiwe;
• Ukusebenzisa kabi utshwala, ikakhulukazi ukungondleki;
• Ukungasebenzi kahle kwe-Renal ne-hepatic;
• I-overdose ye-glimepiride;
• Ama-pathologies we-endocrine ancishisiwe athinta izinqubo ze-metabolic (ukungasebenzi kahle kwe-pituitary noma adrenal, ukungasebenzi kahle kwe-thyroid);
• Ukusetshenziswa okufanayo kweminye imithi.

Ngokulashwa kwezidakamizwa, ukuqapha njalo i-glycemia kuyadingeka. Ukugwema izinkinga, kubalulekile ukuthi uhlale uvivinye njalo:

• Ihlola ukusebenza kwe-hemoglobin ye-glycated - isikhathi esingu-1 / izinyanga eziyi-3-4;
• Ukubonana nodokotela wamehlo, i-nephrologist, isifo sezinzwa, uma kudingekile;
• I-Microalbuminuria - amahlandla ama-2 / unyaka;
• Ukuhlolwa kwephrofayili ye-lipid + BH - isikhathi esingu-1 / unyaka;
• Ukuhlolwa kwemilenze - isikhathi esingu-1 / izinyanga ezi-3;
• HELL - Isikhathi esingu-1 / inyanga;
• ECG - isikhathi esingu-1 / unyaka;
• Ukuhlaziya okujwayelekile - isikhathi esingu-1 / unyaka.

Kubalulekile ukubheka ngezikhathi ezithile ukusebenza kwesibindi nokwakheka kwegazi, ikakhulukazi isilinganiso samaplatelet namaseli amhlophe egazi.

Uma umzimba ubhekana nengcindezi enkulu (ukulimala, ukushiswa, ukuhlinzwa, izifo ezingathi sína), ukumiselela amaphilisi nge-insulin kungenzeka.

Akukho okuhlangenwe nakho kokusebenzisa umuthi ekwelashweni kwabanesifo sikashukela nge-hepatic pathologies enzima, kanye neziguli ze-hemodialysis. Ekungasebenzi kahle kwe-renal noma hepatic, isifo sikashukela sidluliselwa ku-insulin.

I-Glimepiride iqukethe i-lactose. Uma umuntu onesifo sikashukela enokungabekezeleli kofuzo ku-galactose, ukuntuleka kwe-lactase, ukungasebenzi kahle kwe-galactose-glucose, unikezwa ukwelashwa okubuyisela esikhundleni.

Umphumela we-glimepiride ekhonweni lokulawula izindlela eziyinkimbinkimbi

Izifundo ezikhethekile ze-glimepiride zamandla okushayela izimoto noma ukusebenza ekukhiqizeni endaweni enobungozi obukhulu azenziwanga. Kepha, njengoba umuthi unemiphumela emibi ngendlela ye-hypoglycemia, kunengozi yokuncipha kwesivinini sokuphendula kanye nokunaka ukunaka ngenxa yombono ongalungile nezinye izimpawu ze-hypoglycemic.

Lapho unquma umuthi, onesifo sikashukela kufanele axwayiswe ngengozi yemiphumela emibi lapho elawula izindlela eziyinkimbinkimbi. Lokhu kuyiqiniso ikakhulukazi kulabo abavame ukuba nezimo ze-hypoglycemic, kanye nalabo abangakwazi ukubona izimpawu zenkinga ezayo.

Imiphumela yokusebenzisana neminye imithi

Ukusetshenziswa okufanayo kwezidakamizwa kungadala ukuthi umuntu onesifo sikashukela andise amandla e-hypoglycemic futhi akwazi ukuvimbela izakhiwo zawo. Eminye umuthi ayithathi hlangothi lapho isetshenziswa ndawonye. Isazi kuphela esinganikeza ukuhlolwa okulungile kokuhambisana, ngakho-ke, lapho udweba irekhodi lokwelashwa, kubalulekile ukuxwayisa i-endocrinologist ngayo yonke imishanguzo isifo sikashukela esivele siyithatha ukwelapha izifo ezihlangene.

Ukuqinisa umphumela we-hypoglycemic we-Glimepiride kucasukisa ukusetshenziswa okufanayo kwe-phenylbutazone, i-azapropazone ne-oxyphenbutazone, izidakamizwa ze-insulin nezomlomo ze-hypoglycemic, i-solfanilamides yesikhathi eside, i-metformin, i-tetracyclines, i-MAO inhibitors, i-salicylic aminocyclolleonollenonenolenonollenonenonenolenonollen futhi lelencyonololonephololonepholollenonenolollenonenollenonollenollenonlenollenonenollenonlenollenon futhiollenonolololon futhi. , i-miconazole, i-fenfluramine, i-disopyramide, i-pentoxifylline, i-fibrate, i-tritocvalian, i-ACE inhibitors, i-fluconazole , Fluoxetine, allopurinol, simpatolitikov, Cyclo, iThrojani kanye phosphamide.

Ukuvinjwa kwamandla we-hypoglycemic okungenzeka kwe-glimepiride kungenzeka ngokuhlinzwa okuhlanganyelanayo ngama-estrogens, ama-saluretics, ama-diuretics, ama-glucocorticoids, ama-thyroid stimulants, ama-phenothiazine derivatives, adrenaline, chlorpromazine, sympathomimetics; i-nicotinic acid (ikakhulukazi umthamo omkhulu), ama-laxatives (ukusetshenziswa isikhathi eside), i-phenytoin, i-diazoxide, i-glucagon, i-barbiturates, i-rifampicin, i-acetosolamide.

Umphumela ongalindelekile unikezwa ngokwelashwa okuyinkimbinkimbi ngama-β-blockers, i-clonidine ne-reserpine, kanye nokuphuza utshwala.

I-Glimepiride iyakwazi ukunciphisa noma ukwandisa umphumela emzimbeni we-coumarin derivatives.

Ukubuyekezwa kwe-Glimepiride

I-Glimepiride, ngokusho kodokotela neziguli, umuthi osebenza ngempumelelo kakhulu. Ukuphepha kwayo kuhlinzekwe ngemithamo emincane, futhi inezici ezingeziwe ezingeke zijabule kepha zijabule. Kepha, njengazo zonke izidakamizwa ezilwa nesifo sikashukela, i-analogue ye-Amaril isebenza kuphela uma umuntu onesifo sikashukela emsiza.

• I-Olga Grigoryevna, Isifunda saseMoscow. Ngiphuza i-tablet ye-Glimepiride (2 mg) ngaphambi kokudla kwasekuseni, nangemva kokudla - futhi iMetforminum eyinde ekuseni nakusihlwa ka-1000 mg. Uma ngingoni ngokudla, imishanguzo igcinwa ushukela. Angazi ukuthi obani ubuhle bakhona obukhulu, kepha ngamaholide, lapho kunzima ukugwema idili nokudla ngokweqile, ngiphuza u-3 mg we-Glimepiride. Ngibhalelwe umuthi e-polyclinic ngokuya ngomuthi oncishisiwe, yingakho yonke into ingifanele.
• U-Andrey Vitalievich, Yekaterinburg. Eminyakeni engaba mi-3 nganqunyelwa i-Amaril, ngaphuza i-4 mg ekuseni. Kwathi emtholampilo kwakungekho i-Amaril yamahhala, bayifaka esikhundleni sayo i-Glimepirid, generic yesabelomali. Ngizamile ukuyithatha ngethamo elifanayo - ushukela weqa waya ku-12 mmol / l (wawungelikhulu kune-8). Udokotela wandise umthamo waba ngu-6 mg, konke kwabonakala kuhamba kahle, kepha ngathenga i-Amaril. Futhi, i-4 mg ngosuku yayanele kimi. Kepha mhlawumbe kuzodingeka ngibuyele kwi-analogue yamahhala, ngoba ngisawathenga imithi yenhliziyo namaphilisi we-cholesterol. Kuyisihawu esinqamule i-Amaril yamahhala.
• Abelaphi bendabuko bakholelwa ukuthi isifo sikashukela sohlobo 2 asisona nje isifo esivela ekungondleki kanye nasendleleni yokuphila, kepha futhi sisuka ekungakwazi ukujabulela impilo, ekucindezelekeni. Ukuze ubaphendule ngokunembile, kufanele ube ngumuntu ovumelanayo, ohlose uthando.