Umuthi uSiofor 1000, imiyalo yokusetshenziswa kwawo ebaluleke kakhulu ekwelashweni ngempumelelo kwalesi sifo, ingeqembu le-Biguanides. Isifo sikashukela i-mellitus ukugula okungathi sína ezimeni eziningi kungalapheki kalula.
Ukuqinisekisa umphumela ofanele wokwelashwa, isiguli kufanele sishintshe kakhulu indlela yaso yokuphila. Kepha ngesifo sikashukela sohlobo II (esingathembela ku-insulin), izinguquko kuphela ekudleni nasekuzivocavoca asanele. Ukwenza ngcono lesi simo, kunikezwa imishanguzo ekhethekile esigulini, esinye saso okunguSiofor 1000.
Umuthi ubekelwe abantu abadala nezingane kusuka eminyakeni eyi-10. Njengoba kuphawuliwe kuzibuyekezo, umuthi uvame ukubekelwa iziguli ezinokukhuluphala, inqobo nje uma izindlela ezijwayelekile zokunciphisa umzimba zisebenza kahle (ukungondleki okufanele, ukusebenza komzimba). Kulokhu, umuthi uzosiza kakhulu ukunciphisa ingozi yokulimala kwesitho sikashukela.
Ukwelashwa kwesifo sikashukela kubantu abadala, umuthi weSiofor unqunywe ngokuhambisana nezinye izidakamizwa okuhloswe ngazo ukwehlisa amazinga kashukela egazini. Izidakamizwa ezinjalo zibandakanya noma imuphi umuthi wokulawulwa komlomo, kanye nemijovo ye-insulin. Ngaphezu kwalokho, iSiofor inqunywe ngaphandle kwezidakamizwa ezingezekile. Ezinganeni, yiSiofor kuphela ebekelwa ikakhulukazi ngaphandle kwemithi eyengeziwe (ngaphandle uma kuwukuthi imijovo ye-insulin)
I-Pharmacodynamics ne-pharmacokinetics yesidakamizwa
Umuthi iSiofor 1000 ungowama-biguanides - iqembu lezidakamizwa ze-hypoglycemic elibekelwe ushukela onganciki i-insulin. Isenzo se-pharmacological sikaSiofor sihlose ukwehlisa izinga likashukela egazini, okungukuthi, sinomphumela we-antidiabetes.
Umuthi unomphumela oyinkimbinkimbi ezinkomba ezahlukahlukene. Okokuqala, inqubo yokukhiqiza nokufakwa kweglucose emgodini we-gastrointestinal ihamba kancane. Ngesikhathi esifanayo, ukumelana ne-insulin (ukumelana ne-insulin) kuyancipha.
Ngaphezu kwalokho, ngaphansi kwethonya leSiofor 1000, ukusetshenziswa koshukela kuyathuthuka, i-lipid metabolism iyasheshiswa. Ngenxa yalokhu, akwenzeki kuphela ukuthi uthuthukise kahle inhlala-kahle yesiguli, kodwa futhi, uma kunesidingo, usize ekunciphiseni isisindo. Ngaphezu kwalokho, umuthi uyakwazi ukwehlisa isifiso sokudla, esiza futhi ekwelapheni ukukhuluphala ngokweqile.
Kungakhathalekile ukuthi izinga likashukela egazini, umuthi uyasiza ekwehliseni izinga le-triglycerides, cholesterol - okubili nokujwayelekile kwabantu.
Umuthi utholakala kuphela ngendlela yamathebulethi, kepha ukuhlukahluka okuhlukahlukene kungenzeka:
- amaphilisi ejwayelekile
- amaphilisi wokukhulula asekelwe
- ifilimu elihlanganisiwe
- ngenhlanganisela ye-enteric.
Wonke amaphilisi anenothi yokuhlukanisa, kanye ne-snap-tab recess.
Isakhi esisebenzayo seSiofor yi-metformin hydrochloride. Ukuqanjwa kubandakanya futhi i-titanium dioxide, i-magnesium stearate, i-povidone K-25, njll. Ithebhulethi elilodwa liqukethe i-1000 mg yento esebenzayo.
Iphakheji ingaqukatha amaphilisi ayi-10, 30, 60, 90 noma ayi-120, kepha akuwona wonke amakhemisi athenga zonke izindlela zomuthi, ngakho-ke amaphakheji anenombolo efanele amaphilisi kungenzeka angatholakali.
Okuqukethwe okuphezulu kakhulu kwezidakamizwa emzimbeni kutholakala emahoreni angama-2,5 ngemuva kokuthatha iphilisi. I-Bioavailability (kumuntu onempilo) - ifinyelela kuma-60%. Ukusebenza komuthi ikakhulukazi kunqunywa yisikhathi sokudla kokugcina: ngakho-ke, uma uthatha umuthi ngokudla, lapho ukusebenza kwawo kuzonakala kakhulu.
I-Metformin hydrochloride cishe ayikwazi ukubopha kumaprotheni egazi. Okwembiwa kokuthile okuvela emzimbeni, okujwayelekile amahora angama-5 nomsebenzi wezinso ojwayelekile.
Uma ukusebenza kwabo kukhubazekile, ukuhlangana kwe-metformin egazini kuyakhuphuka, ngoba isikhathi sokukhishwa siyanda.
Contraindication
Naphezu kweqiniso lokuthi umuthi ubekezelelwa kahle yiziguli eziningi, kukhona ukungqubuzana kokuthatha amaphilisi weSiofor ayi-1000. I-contraindication enkulu uhlobo lwesifo sikashukela sohlobo lwe-I.
Umuthi awunqunyelwe uma ungalungisi engxenyeni esebenzayo yesidakamizwa - i-metformin hydrochloride - noma enye ingxenye yesidakamizwa.
Noma yiziphi izinkinga ezivelayo ngenxa yesifo sikashukela esincike ku-insulin kungaba ukweqa umthetho. Lokhu kufaka, ngokwesibonelo, kukhulu kakhulu kunokugxila okujwayelekile kwe-glucose ku-plasma yegazi, i-oxidation yegazi ngenxa yokuqukethwe okuphezulu kwemikhiqizo yokubola (imizimba ye-ketone) ebangelwa izimila nezinye izinto. Lesi simo singanqunywa wubuhlungu obukhulu esiswini, iphunga lezithelo elivela emlonyeni, ukozela, nobunzima bokuphefumula.
Imiyalo esemthethweni yokuthatha lo muthi ibuye ikhombise ezinye izimo nezifo lapho kunganconywa ukuthi uthathe iSiofor 1000:
- Ngokukhula kwesimo esibuhlungu, ngenxa yalokho kuvela kokuphulwa kokusebenza kwezinso, lapho kukhona ukutheleleka, ngokulahleka kwenani elikhulu loketshezi ngenxa yokuhlanza, isifo sohudo, ukuphazamiseka kokujikeleza kwegazi,
- Isingeniso ngesikhathi sokufunda umehluko ngokusekelwe ku-iodine. Into enjalo isetshenziswa, isibonelo, ocwaningweni lwe-X-ray.
- Izifo nezimo ezidale ukuthi kube nokushoda komoya-mpilo obalulekile - umsebenzi okhubazekile wenhliziyo, wahlaselwa yisifo senhliziyo ngaphambi nje kokuba kudalulwe umuthi, kwangena ukugula kwegazi, isifo sezinso, izinso, ukwehluleka kwesibindi,
- I-Alcoholism / ukudakwa kotshwala.
Futhi contraindication zifaka:
- isifo sikashukela sesifo sikashukela (noma isimo sokukhathazeka esedlule);
- ketoacidosis;
- indlala yokudla indlala (ngaphansi kuka-1000 kcal / ngosuku);
- iminyaka yezingane (kuze kube iminyaka eyi-10);
- ukuhlinzwa noma ukulimala kwakamuva;
- ukuzila ukudla okwelapha ngohlobo 2 sikashukela;
- ukunqamuka kokukhiqizwa kwe-insulin.
Uma kwenzeka enye yalezi zimo, kufanele uthintane nodokotela ukuze anikeze omunye umuthi.
Ukweqiwa okuqinile kokuphuza umuthi isikhathi sokukhulelwa nokukhishwa komzimba.
Ukwelashwa kulokhu, kusetshenziswa izidakamizwa ezahlukahlukene ezenzelwe i-insulin.
Imiyalo yokusebenzisa umuthi
Ukufeza umphumela owufunayo, kuyadingeka ngesikhathi sokulashwa nge-Siofor 1000, imiyalo yokusebenzisa ukunamathela ngokunemba ngangokunokwenzeka.
Umthamo womuthi ubekwa ngawodwana esigulini ngasinye, kuye ngezinga likashukela wegazi, khona-ke lizolungiswa.
Ekuqaleni kokwelashwa, hhayi ngaphezu kwe-1 g yeSiofor (500 noma 850) kuvame ukubekwa. Ngemuva kwalokho, umthamo weviki wonke uyanda njalo isonto ngalinye uye ku-1.5 g, ohambelana namatafula ama-3 e-Siofor 500 noma ama-2 amaphilisi e-Siofor 850.
Kwisidakamizwa i-Siofor, i-1000 mg ngokwesilinganiso kubhekwa ukuthi isuka kumaphilisi ama-2 g (i.e. 2 amaphilisi), kepha hhayi ngaphezu kwe-3 g (amaphilisi ama-3) ngokwesilinganiso njengethamo elijwayelekile.
Ukuze amaphilisi asebenze kakhulu, kubalulekile ukulandela ngokuqinile imiyalo enikezwe emiyalweni yomuthi.
Kuyadingeka ukuthatha uSiofor ngokudla. Amacwecwe akufanele alunywe noma ahlafunwe. Esikhundleni salokho, phuza amanzi amaningi.
Uma udinga ukuthatha ngaphezu kwe-1 i-tablet ye-Siofor ngosuku, khona-ke kunconywa ukuyihlukanisa kube izingxenye ezi-2 noma ezi-3 ezilinganayo bese uthatha ngakunye nokudla. Umuthi ophuthelwe ngengozi akufanele uphinde usebenze kulokhu okulandelayo, uthathe isilinganiso esiphindwe kabili somuthi.
Isikhathi senkambo yokwelashwa usebenzisa ukulungiswa kweSiofor sinqunywa ngudokotela oya khona.
Njengoba sekushiwo, iSiofor icutshaniswe ngokungqongqo ngesikhathi sokukhulelwa, ukukhipha isisu. Njengoba kungekho datha emitholampilo enembile, umuthi awubekelwe ukwelashwa kwesifo sikashukela esincike ezinsaneni.
Ngaphezu kwesifo sikashukela, iSiofor ikuvumela ukuba ulahlekelwe isisindo ngokushesha. Kepha ekungabikhona kwesifo sikashukela sohlobo lwe-I, uma umuthi kufanele usetshenziselwe ukunciphisa umzimba kuphela, kufanele ube nomqondo omuhle ukuthi ungamthatha kanjani uSiofor kuleli cala. Akunakusho ukuthi kufanele weqe umthamo okungenani we-0,5 amaphilisi iSiofor 1000.
Ngesikhathi sokulahlekelwa isisindo, kubalulekile ukulandela ukudla futhi ukhuphule ukusebenza komzimba. Uma kwenzeka kuba nemiphumela emibi, kunconywa ukuthi uyeke ukuthatha lo muthi.
Qhubeka nenkambo yokuthatha uSiofor yokunciphisa isisindo ayidluli izinyanga ezi-3.
Imiphumela emibi engenzeka
Njenganoma yisiphi esinye isidakamizwa, kwezinye izimo, iSiofor 1000 ingadala imiphumela emibi ehlukahlukene, yize iyivelakancane futhi kungewona wonke umuntu othatha lesi sidakamizwa.
Imvamisa, kwenzeka ngenxa yokweqa umthamo ovumelekile womuthi.
Phakathi kokuvama kakhulu, imiphumela elandelayo elandelayo ihlukaniswa - isicanucanu, ukonakala okuthe xaxa noma ukuntuleka kokudla, isifo sohudo, ushintsho kwemizwa yokunambitha.
Imiphumela emibi yeSiofor imvamisa yenzeka kuphela ekuqaleni kokwelashwa ngalo muthi. Imvamisa badlula ngaphandle kokwelashwa okukhethekile ngemuva kwesikhashana. Ukuze ugweme ukubonakaliswa kwezimpawu ezinjalo, kuyadingeka ukuthi uqaphele ngokuqinile umthamo okhonjiswe kwimiyalo esemthethweni yomuthi.
Inani elinconyiwe lomuthi kufanele lihlukaniswe ngemithamo engama-2-3. Uma, kulandela zonke izidingo, izimpawu zingashabalali, kufanele uthintane nodokotela ngokushesha.
Imiphumela emibi kakhulu ayivelakancane:
- Isikhumba ukuqubuka, ukulunywa, ukucasuka.
- Ngokuphikisana nesizinda sokuthatha umuthi, ukuntuleka kwe-vithamini B12 kungaqhamuka ngenxa ye-megaloblastic anemia (ukuntuleka kwamangqamuzana abomvu egazi),
- Ukuphazamiseka okuhlukahlukene kwe-metabolic, isibonelo, i-lactate acidosis - i-oxidation yegazi ngaphansi kwethonya le-lactic acid. Izimpawu ze-lactic acidosis ziyefana nemiphumela emibi ejwayelekile (isifo sohudo, ukugabha, ubuhlungu besisu). Kepha ngemuva kwamahora ambalwa, kuvela izimpawu ezibucayi zesifo (ukuphefumula ngokushesha, izinhlungu zemisipha kanye nokuqunjelwa, ukulahleka kwengqondo, okungenzeka kube ukukhohlisa).
Kuyaqabukela, ushintsho esimweni sesibindi lubonwa: umphumela ongajwayelekile wokuhlolwa kwesibindi, i-hepatitis, ehambisana ne-jaundice (noma ngaphandle kwayo). Ngokuvamile, ngokukhanselwa kukaSiofor, yonke imiphumela emibi inyamalala ngesikhathi esifushane.
Kunamacala ambalwa wemiphumela emibi yokuphuza umuthi ezinganeni, ngakho-ke izibalo kuleli cala azilungile. Zonke izibonakaliso nobukhali bazo ziyefana nakwabadala. Uma ingane ibe nemiphumela emibi ngemuva kokuthatha uSiofor engakhonjisiwe kwimiyalo yomuthi, kuyadingeka ukwazisa udokotela noma usokhemisi ngabo.
I-overdose ye-Siofor kwisifo sikashukela ayibangeli i-hypoglycemia (ukwehla okukhulu kwezinga loshukela). Kodwa ubungozi busengozini enkulu yokuqhamuka ne-lactic acidosis ngazo zonke izinkomba zokubonakaliswa. Ngakho-ke, kuyadingeka ukwazisa udokotela.
Njengoba i-overdose ithwala ingozi enkulu yezempilo, isiguli siyelashwa esibhedlela.
Amanani kanye nokubuyekezwa kwezidakamizwa
Ungasithenga lesi sidakamizwa kunoma yiliphi ikhemisi. Ngasikhathi sinye, inani lentengo leSiofor eRussia ezifundeni ezahlukahlukene lishintshashintsha ama-ruble angama-450 ngephakeji lomuthi ngamunye.
Ama-analogues ajwayelekile kakhulu omuthi yiFomumetin, iGlucofage, iMetformin 850.
Inethiwekhi ungathola ukubuyekezwa okuningi mayelana nomuthi, kubo bonke odokotela nakulabo abaye belashwa isifo sikashukela. Ochwepheshe bashiya ukubuyekezwa mayelana neSiofor emihle, njengoba kuphawulwe ukuthi umuthi ukuvumela ukuba wenze ngokwejwayelekile amazinga eglucose wegazi futhi unciphise isisindo, okubalulekile kwiziguli eziningi ezinesifo sikashukela. Kepha, ngokusho kodokotela, kufanelekile ukuthi uphuze umuthi kuphela onesifo sikashukela sohlobo II.
Ezigulini ezinesifo sikashukela, umuthi uthole ukwelashwa okuhle, ngoba uSiofor usiza ukulawula amazinga kashukela futhi enze lula impilo ethile inhlobo yesifo sikashukela II.
Labo abathathe iSiofor yokulahlekelwa isisindo abathi umuthi unikeza ngempela umphumela odingekayo, uyasiza ekunciphiseni isifiso sokudla, futhi ngaphandle kwalokho uthengiswa ngentengo enengqondo kakhulu. Kodwa-ke, ngemuva kokuphela kokwamukela, isisindo sibuyela ngokushesha. Ngaphezu kwalokho, imiphumela emibi njengokuwohloka kwendlela yokugaya ukudla ihlala ivela. Ividiyo ekulesi sihloko iqhubeka nengqikithi yeSiofor yesifo sikashukela.
