URoxera ungummeleli weqembu lezidakamizwa ezithinta i-lipid metabolism. Isithako esikhulu esisebenzayo seRoxers yi-rosuvastatin, esivimbela i-enzyme eguqula i-cholesterol.
Iphuzu lokusebenzisa i-rosuvastatin ngama-hepatocytes, lapho i-cholesterol yenziwe khona futhi izingxenyana ze-atherogenic ze-lipoproteins zidiliza. Indlela yokusebenza yokwandisa inani lama-receptor endings kuma-hepatocytes e-LDL, ngaleyo ndlela inikeze ukuzwela okukhulayo nokuqhekeka kwe-LDL, ngaleyo ndlela kuvimbele ukuhlanganiswa kwe-lipoproteins ye-atherogenic.
Ngenxa yeRoxer, i-cholesterol, i-atherogenic complexes, ama-triglycerides (TAGs), kanye nokuqothuka kwezingxenyana ze-anti-atherogenic ze-lipoproteins ziyanda.
Umphumela okhulunywayo wokwelapha kwenzeka isonto ngemuva kokuqala kokuphatha. Kungakapheli amasonto amane elashwa, umphumela omkhulu wezidakamizwa utholakala, inqobo nje uma umuthi uthathwa ngokomthetho.
Umuthi kufanele unqunywe ngudokotela ohambelayo ebheka izimfanelo zesiguli ngasinye.
Ukuzelapha okwenziwe nguRoxeroy kungaholela emiphumeleni emibi emibi, kufaka phakathi i-rhabdomyolysis kanye nokwehluleka kwezinso.
I-Pharmacokinetics ne-pharmacodynamics
Umuthi une-bioavailability engamaphesenti amabili. Ukuguqulwa kanye nokusetshenziswa kwesidakamizwa kwenziwa ngamaseli wesibindi.
Cishe ama-90% amaRoxers ahlanganiswe namaprotheni e-plasma, ikakhulukazi nge-albhamuin. I-Pharmacokinetics ayiguquki lapho ithathwa njalo.
Cishe i-90% ye-rosuvastatin ilahlwa ngohlobo lwayo lwangempela ngomgudu wokugaya ukudla. Ingxenye encane yesidakamizwa isetshenziswa kuma -bucbu be-renal.
Izinkomba zokuqokwa kweRoxers yilezi:
- i-hypercholesterolemia eyinhloko;
- ukungalingani kwe-lipids;
- i-gener hypercholesterolemia;
- i-hypertriglyceridemia;
- isifo sokuqina kwemizwa;
- njengesidakamizwa ekuvinjelweni okuyinhloko kwenhlekelele eyenzeka enhliziyweni nasezigulini ngaphandle kwezimpawu zomtholampilo zesifo senhliziyo, kodwa ezisengozini enkulu.
Umuthi uyatholakala ngesimo samathebulethi ngegobolondo elivikelayo.
Ithebhulethi eyodwa ingaqukatha umthamo olandelayo: ama-milligram angama-5, ama-milligram angama-10, ama-milligram ayi-15, ama-milligram angama-20, ama-milligram angama-30, ama-milligram angama-40.
Umthamo ukhethiwe ngokuya ngesimo nangobunzima besifo. Umphumela wokwelapha uncike kumthamo nemvamisa yemithi.
Izici zobuzwe kanye nezofuzo zomuthi ziyahlukaniswa. Ekuvivinyweni kwemitholampilo, umjaho wamaMongoloid, uma uqhathaniswa neCaucasoid, ukhombise ukukhuphuka kwezinga le-plosma le-rosuvastatin.
Amathebhulethi e-Roxer aqukethe i-lactose carbohydrate, ngenxa yalokhu umuthi uvunyelwe ezigulini ezinesifo se-lactase, kanye ne-carbohydrate malabsorption syndrome.
Ngenxa yesiyezi, ikhanda kanye nokunye ukusabela okubi, ukuqapha nokuqapha kuyadingeka lapho ushayela umshini futhi ulawula izindlela eziqondile.
Ukuphathwa njalo nangendlela efanelekile kwalesi sidakamizwa kuvimbela ukuthuthukiswa kokungaphenduki okubi. Kubalulekile ukuthatha umuthi ku-dosage efanele ukuze ugweme ukucindezela kwesibindi nezinso, ngoba kulezi zitho lapho kwenzeka khona i-rosuvastatin metabolism.
Udokotela ohambelayo akufanele akhethe umthamo ofanele kuphela, kodwa futhi nenhlanganisela enengqondo yezidakamizwa phakathi kwabo. Lokhu kungenxa yokuthi iningi leziguli ezine-atherossteosis nazo zinezindlela ezihlobene nethambo lesifo sokuqina kwenhliziyo.
Imiyalo yokusebenzisa umuthi
I-Roxer ithathwa ngokuya ngezincomo zemiyalelo yepheshana ukuze isetshenziswe.
Umuthi uhloselwe ukusetshenziswa komlomo. Kwenqatshelwe ukuhlafuna nokugaya umuthi. Ithebhulethi kumele ithathwe inhlobo yayo yasekuqaleni, igezwe ngenani elikhulu loketshezi. Ukwemukelwa nganoma isiphi isikhathi, kungakhathaleki ukuthi ukudla kudla kangakanani.
Umphumela wesidakamizwa ubonwa kuphela uma kulandelwa ukudla okukhethekile. Ekuqaleni kokwelashwa, amamayela ama-milligram ayi-5 anqunywa ngosuku. Lapho ukhetha uhlobo lwedosi, amazinga e-cholesterol ayabhekelwa futhi acabangele ubungozi obunokwenzeka bezinhlekelele zenhliziyo. Ngaphezu kwalokho, lalela ubungozi engcupheni yemiphumela emibi.
Ungangeza umthamo ngemuva kwenyanga kusukela ekuqaleni ukwelashwa. Umthamo we-40 mg ugcwala inani elikhulu lemiphumela ngokuqhathaniswa nemithamo ephansi yento. Ukunyuswa okunjalo komthamo wokuhlushwa kuvunyelwe inyanga futhi kwenziwa kuphela ezigulini ezinezinga le-hypercholesterolemia futhi nengozi enkulu yokuba nezinhlekelele zenhliziyo. Ukwelashwa kwenziwa ngaphansi kokuqondisa udokotela.
Ngemuva kwenyanga yokwelashwa noma uma kwenzeka ushintsho kumthamo womuthi, kufanele kuthathwe iphrofayili ye-lipid. Ezigulini ezinokwehluleka okukhulu kwe-renal (ukucaciswa kwe-creatinine kungaphansi kwamamililitha angama-30 ngomzuzu), ukusetshenziswa kwento yokwelapha akuvumelekile.
I-Rosuvastatin ayikwazi ukubekelwa iziguli ezinesifo sesibindi esikhathini esibuhlungu. Iziguli ezingaphezu kweminyaka engama-65 ubudala kufanele nakanjani ziqale ukuthatha okungenani umthamo wansuku zonke.
Ukuphendula Okubi Nemikhawulo Roxers
Ukuphendula okuhlukile kuncike ngqo kwithamo lomuthi nasezimpawu zomuntu ngamunye.
Imiphumela emibi ihlukaniswa ngokuya ngokuvama kokuvela nezimpawu zokubonakaliswa.
Ukuphendula okuvame kakhulu kufaka phakathi ukusabela kwe-hypersensitivity (edema kaQuincke, i-urticaria, i-anaphylactic shock); ikhanda Isiyezi i-polyneuropathy; ukwephulwa kwemisebenzi yememori. Ukwephulwa komgudu wesisu ngendlela yokuqunjelwa, kulandelwa yisifo sohudo, isicanucanu kanye nokuhlanza, izinhlungu nokungaphatheki kahle esiswini akuhlanganisiwe; i-dystrophy yesibindi, i-hepatitis ene-icteric syndrome enzima; I-Stevens-Johnson syndrome; ukuqaqamba kwemisipha; i-myopathy kanye nokubhujiswa kwezicubu zemisipha; izinhlungu ezihlangene ukulahleka kwamaprotheni emchameni; ukulahleka kwamangqamuzana egazi abomvu kumchamo; isimo se-asthenic; ukungasebenzi kwehomoni yegilo.
Ngenxa yobuthi obuphezulu bomuthi, umenzi ukhombisa imingcele eminingana ekusetshenzisweni kweRoxers. Imikhawulo eyinhloko yile:
- Uhlobo olusebenzayo lwe-hepatitis noma enye i-hepatic pathology.
- Ukwehluleka okukhulu kwezinso.
- I-Myopathy
- Ukwamukela nge-cytostatic cyclosporin.
- Ukusetshenziswa kanyekanye ngemicu.
- Isikhathi sokukhulelwa nokukhulelwa.
- Ukungabekezelelani kwe-lactose.
- Iminyaka yezingane.
- Ukungabekezelelani komuntu ngamunye kulo muthi.
Ukuthatha umuthi ngesikhathi sokukhulelwa nokuqunjelwa kuhlobene ngokuphelele. I-Contraindication ihlotshaniswa nomsebenzi ophezulu wento.
I-Rosuvastatin i-contraindicated kubantu abangaphansi kweminyaka engu-18 ubudala. Ngokuqapha, umuthi kufanele unqunywe kwabadala.
Ukukhetha okukodwa komthamo wento esebenzayo kusetshenziselwa ukungasebenzi kahle kwezinso, ngoba i-rosuvastatin inomphumela we-nephrotoxic. Lapho uthatha okungaphezu kwama-30 mg ngosuku kwento, ukuhlolwa okujwayelekile kokusebenza kwezinso kuyadingeka.
Umuthi yi-myotoxic. Ukuqhekeka kwe-Myalgia kanye nemisipha kwaqapheleka lapho kuhlanganiswa neminye izidakamizwa esehlisa i-lipid. Uma isiguli sinobuhlungu bemisipha, ubuthakathaka, ukuminyanisa kuhlangene ne-general ukuphuza udokotela, udokotela oholayo kufanele aziwe ngokushesha. Kubalulekile futhi ukunquma ngokuphuthumayo ukuqoqwa kwe-creatine phosphokinase egazini.
Ukwelashwa kumiswa ngokukhuphuka okukhulu kwe-creatine phosphokinase noma ngokuqhubeka kwesibonakaliso sobuhlungu bemisipha, ukuminyanisa nobuthakathaka.
Ukusebenzisana kweRoxers nezinye izidakamizwa
Ama-Roxers abonakala ngokuhlangana kwezidakamizwa neminye imithi.
Lapho usebenzisa umuthi nabanye ama-ejenti, ukusebenzisana okungenzeka phakathi kwabo kufanele kucatshangwe.
Ngezidakamizwa ezilandelayo, into inomphumela othile we-pharmacokinetic:
- I-Antimetabolite "Tsisklosporin". Ngokusetshenziswa kwezidakamizwa okuhlanganisiwe, kukhuphuka kakhulu inani le-rosuvastatin ku-plasma.
- I-Warfarin. Ukuphathwa kanyekanye kwezidakamizwa nakho kudala ingozi ethile esigulini. Ukuphathwa okuhlanganisiwe ngama-anticoagulants angaqondile kukhulisa ukugcwala kwe-rosuvastatin futhi iphindwe kabili isilinganiso esilinganisiwe somhlaba jikelele.
- Ezetimibe. Ukusetshenziswa ngasikhathi sinye kwale mishanguzo akukukhulisi ukugcwala kwegazi lakho lonke. Kodwa i-ezetimibe ingandisa ingozi yokuphendula kwe-myotoxic.
- Ezinye izidakamizwa ezokwehlisa i-lipid. Ngokuphathwa kanyekanye, ukuphawulwa kokuphindaphindwa kweRosuvastatin ku-plasma kuyaphawulwa. Ukuhlanganiswa okunjalo kukhulisa ubungozi obukhona bokuthuthukisa izicubu zomzimba.
- Imishanguzo yokwelapha i-antiretroviral: i-human immunodefasure virus proteinase inhibitors. Inhlanganisela enjalo inyusa izinga le-plasma le-rosuvastatin.
- Ama-antacid. Ukuhlanganiswa kwe-rosuvastatin ngama-antacid, afaka i-aluminium ne-magnesium hydroxide, kuholela ekwehleni kwezinga le-plasma le-rosuvastatin ngesigamu esingaphezu kwesigamu. Ukunciphisa umphumela ofanayo, ama-antacid akhishwa amahora amabili ngemuva komthamo wokugcina we-rosuvastatin.
- I-antibiotic Erythromycin. Ukuphathwa kanyekanye kuholela ekunciphiseni kokuhlushwa kwe-rosuvastatin. ngenxa yokwanda kokuhamba kwamathumbu.
- Kuhlanganiswe izindlela zokuvimbela inzalo zomlomo kanye nezinye izinhlobo zokwelashwa kwehomoni. Ukusetshenziswa okuhambisanayo ne-rosuvastatin kukhulisa ukugcwala kwezinto ezisebenza ngokusebenza ngama-plasma egazi. Ukuqeda lokhu kusabela, kulungiswa idosi lokugcina.
- I-Cardiac glycosides.
Ukuvumelana nezidakamizwa ezingenhla kuphansi. Ukuqokwa ngasikhathi sinye kufanele kunconywe ngokusobala ngokuya ngezimpawu ngazinye zesiguli.
Umuthi emakethe yasekhaya
Lo muthi ungathengwa kunoma iyiphi ikhemisi eRussia nasemazweni e-CIS.
Umuthi uyatholakala emakethe yasekhaya ngaphandle kwemithi.
Izindleko zincike kumthamo womuthi.
Namuhla intengo iyahluka:
- amaphilisi ngomthamo ka-5 mg ngama-90 ama-pcs. - ama-ruble ayi-1056;
- amaphilisi ngomthamo we-10 mg ngama-30 ama-pcs. nama-90 ama-PC. - 461 rub. nama-ruble angama-999. ngokufanele;
- Izibhebhe ezinomthamo we-15 mg wama-30 nama-90 ama-PC. - 404 rub. nama-ruble ayi-1225. ngokufanele;
- amaphilisi anomthamo ka-20 mg ngama-30 ama-pcs. cishe i-690 rub.
Emakethe yamakhemikhali aseRussia kunezithombe eziningi zeRoxers. I-analogue yisidakamizwa esinezinto ezifanayo ezisebenzayo. Umuthi ojwayelekile owenziwa kwamanye amazwe iRosuvastatin yisithako esisebenzayo kwizidakamizwa eziningi emakethe yaseRussia. Igama lomkhiqizo lomuthi lingahluka kuphela.
Umuthi ukhiqizwa ukukhathazeka kweSlovenia "Krka". Kepha futhi abakhiqizi abaningi, kubandakanya nabasekhaya, babandakanyeka ekuphothulweni kwe-rosuvastatin. Ngaphezu kwalokho, kukhona nabanye abamele iqembu lama-statin.
Amalungiselelo wamaqembu ahlobene (Atorvastatin, Rosuvastatin Canon, Tevastor, njll.) Nawo angama-analogues kwizici zemishini yokusebenza. Ukukhethwa komuthi othile kuncike ezimfanelweni zesiguli.
URoxer unezibuyekezo eziningi zeziguli ezithatha lo muthi.
Ukubuyekezwa okuningi kuvame ukuba okuhle, ngaphandle kwezimo zokusabela ezingezinhle. Ukubuyekezwa kweRoxera akukubi ezimweni zesikhathi eside sokwelashwa.
Imvamisa imiphumela emibi emzimbeni yenzeka ngenxa yokuthi isiguli saphuza utshwala ngenkathi belashwa, sinikeze umuthi uqobo noma sidlule isilinganiso esinconyelwe isimo sakhe. Ukubuyekezwa okunjalo komuthi akuyona inhloso futhi akunakusebenza njengesizathu esithembekile sokwenqaba ukuphuza umuthi.
Ngokuphatha okunengqondo, umuthi kufanele usize isiguli. Yizindawo ezisetshenziselwa ukwehlisa i-lipid zomuthi ezinganciphisa i-cholesterol kanye nengozi ye-atherosulinosis kanye nezinkinga zayo. Imiphumela emibi yokuphuza umuthi incane kakhulu kunomphumela wezokwelapha obulindelekile.
Kubalulekile ukuhlanganisa ukubanjwa kwazo zonke izidakamizwa ezokwehlisa i-lipid nokudla okunengqondo kanye nendlela yokuphila ehambayo.
Indlela ehlanganisiwe yokulwa nesifo senhliziyo e-coronary nezinye izibonakaliso ze-atherosulinosis iyona ephumelela kakhulu futhi inesizathu.
Izimo zichaziwe kuvidiyo ekulesi sihloko.
