Ama-basal, noma njengoba ebizwa nangokuthi, ama-insulin asemuva adlala indima ebalulekile ekwelapheni isifo sikashukela. Basiza ukugcina amazinga kashukela egazini phakathi kokudla, akhuthaza ukumuncwa kwe-glycogen etholakala kumaseli wesibindi.
Kuze kube manje, sekufakwa insulin yanamuhla, isikhathi esingapheli ngaphezu kwamahora angama-42.
Enye yalezi zidakamizwa iRyzodeg, insulin yakamuva esebenza isikhathi eside.
Ukwakheka nezakhiwo
I-Ryzodeg yisizukulwane esisha se-insal insulin engasetshenziswa ngempumelelo ekwelapheni isifo sikashukela sohlobo 1 nohlobo 2. Ukuhluka kweRyzodega kulele ekutheni ngesikhathi esifanayo kuqukethe i-insulin aspart e-ultra-iDemo-insulin kanye ne-insulin yezenzo zesikhathi eside ze-degludec.
Yonke insulin esetshenziselwa ukulungisa iRyzodeg ilungiselelo le-insulin yomuntu. Zitholakala yi-biombektri ye-DNA ephindaphindayo isebenzisa isikhunta semvubelo unicellular ye-genus Saccharomyces cerevisiae.
Ngenxa yalokhu, babopha kalula i-receptor ye-insulin yabo yomuntu futhi, ekuhambeni kokusebenzisana nayo, banegalelo ekufakweni kweglucose okusebenzayo. Ngakho-ke, i-Ryzodegum isebenza ngokuphelele njenge-insulin endulin.
I-Ryzodeg inomphumela ophindwe kabili: ngakolunye uhlangothi, isiza izicubu zangaphakathi zomzimba ukuthola kangcono ushukela egazini, ngakolunye uhlangothi, inciphisa kakhulu ukukhiqizwa kwe-glycogen ngamaseli wesibindi. Lezi zakhiwo zenza iRyzodeg ibe ngenye ye-insal insulin esebenza ngempumelelo kakhulu.
I-Insulin degludec, okungenye yezingxenye zokulungiswa kweRyzodeg, inesenzo eside esengeziwe. Ngemuva kokwethulwa kwezicubu ezingaphansi, kancane kancane futhi ngokuqhubekayo kungena egazini, okuvumela isiguli ukuvimba ukwanda koshukela wegazi ngaphezulu kwezinga elijwayelekile.
Ngakho-ke, iRyzodegum inomphumela obizwa ngokuthi yi-hypoglycemic, naphezu kokuhlanganiswa kwe-degludec ne-aspart. Le miphumela emibili ibonakala ngokungafani ne-insulin kulo muthi idala inhlanganisela enhle lapho i-insulin ende ingahambisani khona nokufinyelwa okufushane.
Isenzo se-aspart siqala ngokushesha ngemuva komjovo weRyzodegum. Ingena ngokushesha egazini lesiguli futhi isiza ukwehlisa ngempumelelo ushukela wegazi.
Ngaphezu kwalokho, i-degludec iqala ukuthinta umzimba wesiguli, esimunca kancane futhi ihlangabezana ngokuphelele nesidingo sesiguli se-insal insulin amahora angama-24.
Imiyalo yokusebenzisa umuthi
I-Rysodeg kufanele ihanjiswe kuphela ezicutshini ezingasasebenzi, uma kungenjalo isiguli singaba nemiphumela eyingozi esidinga ukunakekelwa ngokushesha kwezokwelapha.
Ukujova neRyzodegum kuyadingeka izikhathi ezi-1 noma ezi-2 ngosuku ngaphambi kokudla kwasekuseni, isidlo sakusihlwa noma isidlo sasemini. Uma kufiswa, isiguli singashintsha ngokuzimela isikhathi somjovo, kodwa inqobo nje uma umuthi ungena emzimbeni ngaphambi kokunye kokudla okuyinhloko.
Ekwelashweni kweziguli ezitholakala ngohlobo lwe-2 mellitus yesifo sikashukela, i-Ryzodeg ingasetjenziswa zombili njengommeli ophambili wezokwelapha futhi kuhlangene namaphilisi anciphisa ushukela noma ama-insulin amafushane.
Ekwelashweni okwelashwa kweziguli ezinesifo sikashukela sohlobo lwe-1, i-Ryzodeg isetshenziswa ngokubambisana namalungiselelo amafushane we-insulin noma we-ultrashort. Kuleli qembu leziguli, kubalulekile ukuphatha umuthi ngaphambi nje kokudla, hhayi ngemuva kokudla.
Umthamo wesidakamizwa weRyzodeg kufanele ukhethwe ngokuqinile, ngokunaka isimo sesiguli kanye nezidingo zakhe. Ukuthola umthamo ofanele we-insal insulin kuzosiza ukukala njalo ushukela wegazi. Uma lenyuka, khona-ke umthamo udinga ukulungiswa ngokushesha.
Ngaphezu kwalokho, kungadingeka ukulungiswa lapho kuguqulwa isidlo noma ukudla okwenziwa yisiguli. Futhi, ukuthathwa kwemithi ethile kuvame ukuthinta izinga likashukela wegazi, okungadinga ukwanda komthamo weRysodeg.
Ungayikhetha kanjani imithamo ye-basal insulin Ryzodeg:
- Thayipha isifo sikashukela sokuqala. Ngalesi sifo, umthamo weRyzodeg kufanele ube cishe yi-65% yesidingo esigcwele sansulini sesiguli. Kuyadingeka ukuphatha umuthi isikhathi esisodwa ngosuku ngaphambi kokudla ngokuhlangana ne-insulin efushane. Uma kunesidingo, umthamo we-insal insulin kufanele ulungiswe;
- Thayipha isifo sikashukela sesi-2. Ezigulini ezinale ndlela yalesi sifo, njengethamo lokuqala lomuthi, kunconywa ukufaka amayunithi ayi-10 eRyzodeg nsuku zonke. Lomthamo ungashintshwa futhi kuya ngezidingo zomuntu ngamunye.
Ungayisebenzisa kanjani iRyzodeg:
- I-Basal insulin Risodeg ihloselwe ukuphathwa okufakwayo kuphela. Lesi sidakamizwa asiwulungele umjovo we-intravenous, ngoba ungadala ukuhlaselwa kanzima kwe-hypoglycemia;
- Isidakamizwa i-Ryzodeg akufanele futhi siphathwe ngokungemthetho, ngoba kuleli cala ukufakwa kwe-insulin egazini kuzoshesha kakhulu;
- I-Ryzodeg ayenzelwe ukusetshenziswa epompini le-insulin;
- Ukufakwa kwama-insulin Rizodeg kufanele kwenziwe emathangeni noma esiswini, kwesinye isikhathi kuvunyelwe ukubeka imijovo ezandleni;
- Ngemuva komjovo ngamunye, indawo yomjovo kufanele ishintshwe ukuze i-lipodystrophy ingenzeki ku-mellitus yesifo sikashukela.
Isidakamizwa iRyzodeg singasetshenziselwa ukwelapha iziguli eqenjini elikhethekile, okungukuthi ngaphezulu kweminyaka engama-65 noma sinenkinga yokwehluleka kwezinso noma kwesibindi. Kodwa-ke, kulokhu, kufanele ubheke ngokucophelela izinga le-glucose egazini futhi, uma kunesidingo, ulungisa umthamo we-insulin.
Le insulin ye-basal engasetshenziswa ngokulingene ekwelashweni kwesifo sikashukela ezinganeni nasentsheni engaphansi kweminyaka engu-18.
Kodwa akukho zifundo ezifakazele ukuphepha kweRyzodegum ezigulini ezingane.
Intengo yesidakamizwa
Izindleko ze-insal insulin Ryzodeg ngokuya ngesimo somuthi. Ngakho-ke ama-cartridge weglasi we-3 ml (ama-300 PIECES) angathengwa ngentengo yama-ruble angama-8150 kuya ku-9050. Kodwa-ke, kwamanye amakhemisi lo muthi unikezwa ngentengo ephakeme kakhulu, ngama-ruble angaphezu kuka-13,000.
Intengo yepeni yesirinji iqine kakhudlwana futhi, njengomthetho, isukela kuma-ruble angama-6150 kuya kwangama-6400. Ezimweni ezingavamile, ingafinyelela kuma-ruble ayi-7000.
Izindleko zomuthi i-Ryzodega cishe zifana kuzo zonke izifunda zaseRussia. Kodwa-ke, umuthi ongajwayelekile ezweni lethu, ngakho-ke awunakuthengwa kuwo wonke amakhithi aseRussia.
Imvamisa, labo abafuna ukuthenga iRyzodeg kufanele babeke phambili lesi sidakamizwa ekhemisi, ngoba yize kunentengo ephezulu, ithengiswa ngokushesha yiziguli ezinesifo sikashukela. Lokhu kungenxa yokuthi izibuyekezo mayelana nokusetshenziswa kwalesi sidakamizwa zinhle kakhulu.
Ama-Analog
Ezinye izinhlobo ze-insal insulin ziyizifanekisisi zomuthi weRyzodeg. Lokhu kufaka phakathi izidakamizwa ezifana ne-insulin Glargin neTujeo, ezakhiwe ngesisekelo se-insulin glargine neLevemir, efaka ne-Detemir insulin.
Le mishanguzo ifana kakhulu nomphumela wayo, onayo emzimbeni wesiguli. Ngakho-ke, lapho ushintsha usuka eLantus, eTujeo noma kuLevemir eRaizodeg, isiguli asidingi ukuguqula umthamo, ngoba uhunyushwa ngesilinganiso se-1: 1.
Ividiyo ekulesi sihloko ikhombisa ukuthi ungayifaka kanjani ngokufanele insulin.
