I-Glipizide iyinto eyingxenye yezidakamizwa eziningi ze-hypoglycemic ukulawula amazinga kashukela kuhlobo 2 sikashukela.
Ukusetshenziswa kwayo kunesizathu ezimweni lapho ukudla kanye nokuzivocavoca komzimba kungakwazi ukunikeza ukwehla kokuxineka ushukela, kanye nezinkinga ze-microangiopathy, okungukuthi, ukulimala kwemithambo yegazi emincane.
Ngaphambi kokuthatha umuthi, isiguli kufanele sijwayeze ukuthi singasisebenzisa kanjani lesi sidakamizwa futhi sivunyelwe kumaphi amacala? Ngaphezu kwalokho, kungakuhle ukutadisha ukubuyekezwa mayelana nomuthi weziguli nodokotela, futhi uma kunesidingo, futhi nokutadisha ukuthi yimaphi ama-analogues we-Glipizide akhona.
Imininingwane ejwayelekile mayelana nalokhu
Ingxenye le yi-ejenti yokwenziwa kwe-hypoglycemic.
I-Glipizide ayikwazi ukuncibilika emanzini noma kotshwala, noma kunjalo, isixazululo se-NaOH (i-0,1 mol / L okuhlushwa) ne-dimethylformamide ichaza lesi sakhi kahle. Le nto ikhiqizwa kumathebhulethi ajwayelekile kanye namaphilisi wokukhishwa aqhubekayo.
Lapho into ingena emzimbeni wesifo sikashukela, kugqugquzela ukukhishwa kwe-insulin kusuka ekusebenzeni kwamaseli we-beta we-islet Apparatus.
I-Glipizide isebenza kanjena:
- Yehlisa ushukela kanye ne-glycosylated hemoglobin esiswini esingenalutho.
- Kwandisa ukubekezelelwa kwe-glucose, kanye nezinga elincane - ukucaciswa koketshezi lwamahhala.
- Yehlisa amathuba okuba ne-hyperglycemia ngemuva kokudla.
Ingxenye esebenzayo ayithinti i-lipid metabolism. Ukwenza kusebenze kwawo kuqala ngemuva kwemizuzu engama-30 yokwamukelwa futhi kuyaqhubeka usuku lonke. Ukuqoqeka okuphezulu kwento kubonwa ngemuva kwamahora ama-1-3 wokusetshenziswa komlomo.
Kumele kuqashelwe ukuthi i-Glipizide kungcono ukungayisebenzisi ngesikhathi sokudla, ngoba ukumunca ngokuphelele kuyancipha. I-Biotransformation yento yenzeka esibindini.
Ingxenye leyo ivezwa njenge-metabolite kanye nezindunduma kanye nomchamo, kufaka phakathi okungashintshiwe - cishe i-10%.
Imiyalo yokusebenzisa
Ngaphambi kokusebenzisa amalungiselelo aqukethe i-glipizide, udinga ukubonana nodokotela noma i-endocrinologist. Udokotela kuphela ongabheka ngokufanelekile ukufaneleka kokusebenzisa ikhambi elilodwa noma elinye.
Ngemuva kokuthenga umuthi, udinga ukufunda ngokucophelela ipheshana lokufundisa. Umthamo wokuqala ngu-5 mg, okhishwa kanye ngosuku ngaphambi noma ngemuva kokudla. Ngokuhamba kwesikhathi, ngokuba nenempilo evamile yesifo sikashukela, umthamo ungakhuphuka kancane kancane ufike ku-15 mg, uhlukanise ukuphathwa komuthi kaningana.
Imiyalo ithi uma umuthi uphuthelwe, kepha sekudlule amahora ambalwa seluthathiwe umuthi ofanele, umuthi kufanele uphathwe ngokushesha. Kepha uma cishe usuku seludlulile, kumele kulandelwe indlela ejwayelekile yokwelashwa.
Iziguli zokuguga kanye nokuhlushwa i-pathology yesibindi kufanele zisebenzise umuthi okungenani ngemithamo - ama-2,5 mg ngosuku, namathebhulethi akhululwa isikhathi eside - kusuka ku-5 kuye ku-10 mg kanye, mhlawumbe ekuseni.
Njengayo yonke eminye imithi, i-Glipizide idinga ukugcinwa kude nezinsana endaweni evikelwe umswakama emazingeni okushisa asekamelweni.
Contraindication kanye nomonakalo ongaba khona
Eminye imikhakha yabanesifo sikashukela ayikwazi ukuthatha leli khambi.
Imiyalo enamathiselwe ine-contraindication ehlobene nokuzwela komuntu ngamunye entweni, isifo sikashukela, uhlobo oluncike ku-insulin sikashukela, iketoacidosis, umkhuhlane, ukuhlinzwa kwamuva, ukukhulelwa nesikhathi sokuncelisa ibele.
Ezimweni ezinzima kakhulu, ukusetshenziswa kwe-Glipizide kungenzeka ngesikhathi sokubeletha kwengane. Kepha ukusetshenziswa kwayo kuzodingeka kukhanseliwe ngenyanga eyi-1 ngaphambi kokuzalwa okulindelekile.
Ngesikhathi sokuncelisa, ukuphuza umuthi akuvunyelwe ngokuphelele.
Ukubonisana nodokotela ngaphambi kokusebenzisa i-Glipizide kuyadingeka, ngoba ukuphathwa kabi kwesidakamizwa kungaholela emiphumeleni eminingi engathandeki:
- ikhanda, ukudideka ukwazi, ukukhathala, ukuphefumula kwe-retinal, isiyezi, ukudangala, i-paresthesia, ukukhathazeka, ubuhlungu beso kanye ne-conjunctivitis;
- ukuthatheka, isicanucanu, ukugabha, ukungcola kwegazi ezinduneni, ukuqunjelwa, i-dyspepsia ne-anorexia;
- ukulunywa, ukuqhaqha, nezinqe;
- i-pharyngitis, i-rhinitis ne-dyspnea;
- ezihambisana nesistimu yenhliziyo nokwakheka kwegazi: i-arrhythmia, syncope, umuzwa wokukhanya okushisayo nomfutho wegazi ophezulu;
- futhi i-glycemia yohlobo 2 sikashukela mellitus kuze kufike ku-glycemic coma.
- okuhlobene nohlelo lwe-genitourinary: ukuncipha kwesifiso sobulili kanye ne-dysuria.
Ngaphezu kwalokho, kuneminye imiphumela emibi eminingana engahle ibe khona - ukuquleka, ukoma okungacimekiyo, i-myalgia, i-arthralgia, ukujuluka, ukuqaqamba komzimba.
Izindleko, ukubuyekezwa kanye nama-analogues
Njengoba i-glipizide iyisakhi esisebenzayo, izidakamizwa eziningi eziqukethe into enjalo zingatholakala emakethe yemithi yaseRussia. Isibonelo, iGlucotrol CL noGlibenez Retard. Kuya ngesimo sokukhishwa, intengo yesidakamizwa i-Glucotrol HL isukela kuma-ruble angama-280 kuya kwangama-360, kanye no-Glibenez Retard - kusuka kuma-ruble angama-80 kuye kwangama-300.
Ukubuyekezwa kwabashukela abaningi abathathe lelo khambi kuyanelisa. Kodwa-ke, abaningi baphawula ukuthi umphumela wokwelapha we-glipizide wehla ngokuhamba kwesikhathi, ngakho-ke uvame ukusetshenziswa lapho uhlangana neminye imishanguzo yesifo sikashukela. Phakathi kwezinzuzo zesidakamizwa kungahlukaniswa kalula kokusebenzisa kanye namanani athembekile wezidakamizwa aqukethe i-glipizide.
Esimweni lapho umuthi owodwa ungalungile ngenxa yokuphikisana noma ukusabela okungekuhle, udokotela unquma i-analogue. Le mithi ifaka phakathi:
- Movoglek.
- I-Antidiab.
- I-Glibenesis.
- UMinidiab.
Ngaphandle kwemvume kadokotela, ukuzelapha akusizi. Ukulungiselela okuqukethe i-glipizide kungaba nomthelela ongemuhle emzimbeni womuntu. Ngokusebenzisa umuthi ngendlela efanele, ungagcina izinga likashukela lijwayelekile futhi ususe izimpawu zesifo sikashukela. Kepha futhi akufanele sikhohlwe ngokwelashwa okuzivocavoca sikashukela nokudla okufanele.
Kuvidiyo ekulesi sihloko, udokotela uzokhuluma ngezidakamizwa zesifo sikashukela.
