Ekwelapheni uhlobo 2 lwesifo sikashukela, kusetshenziswa ama-hypoglycemic agents noma ama-insulin akhethekile. Umenzeli omuhle we-hypoglycemic uthathwa njengoDiabetes.
Umuthi usebenza kakhulu futhi awubizi kakhulu. Izindleko zomuthi i-Diabeteson 60 mg zingama-ruble angama-250 ukuya kwangama-300. Umuthi kadokotela usatshalaliswa.
Futhi yini izifanekiselo ze-Diabeteson analogues? Ekwelapheni uhlobo lwesifo sikashukela sohlobo 2, ama-hypoglycemic agents angasetjenziswa, ahlanganisa izinto ezifana ne-glimepiride, glibenclamide noma glycvidone.
Kafushane nje ngesifo sikashukela nangemigomo yokusebenza kwayo
Isifo sikashukela siyikhambi sikashukela, isakhi esisebenzayo yi-gliclazide. Ngithanda ukuqaphela ukuthi umkhiqizo uyatholakala kumthamo ka-60 mg no-30 mg. Ngaphezu kwe-gliclazide, ukwakhiwa komuthi kufaka phakathi i-lactose, hypromellose, i-magnesium stearate, i-maltodextrin, i-silicon dioxide.
Ngakho-ke, ithini imiphumela ye-hypoglycemic yesidakamizwa esekelwe? I-Gliclazide inciphisa ushukela wegazi ngokuvuselela ukucasulwa kwe-insulin ngamaseli e-beta weziqithi ze-pancreatic zeLangerhans. Ngo-diabetes, kusetshenziswa i-Diabeteson, inani eliphakeme lokuqala le-insulin secretion liyabuyiselwa, futhi amathuba okuqhubeka kwe-thrombosis ancishisiwe.
Izinkomba zokusetshenziswa kweSifo sikashukela yizimo lapho ukwelashwa kokudla kungazinzile amazinga eglucose. Futhi, umuthi uyasetshenziswa uma kunethuba lokuba nezinkinga zesifo sikashukela sohlobo 2, ikakhulukazi i-hyperglycemic coma.
Imiyalo yokusetshenziswa kombuso yokuthi Diabeteson 60 mg noma 30 mg kufanele iphuzwe nokudla. Ngaphezu kwalokho, imvamisa yokusebenzisa amaphilisi isikhathi 1 ngosuku. Umthamo oqala nsuku zonke ngu-30-120 mg. Lapho uyikhetha, iminyaka, izici zomuntu ngamunye ogulayo noshukela wegazi kuyabhekwa.
Phakathi kokuphikisana kokusetshenziswa kweSifo sikashukela yilezi:
- Thayipha isifo sikashukela sokuqala.
- Isikhathi sokuzala.
- Idlozi likashukela noma ikoma.
- Isifo sikashukela sikashukela.
- Hypersensitivity kuzakhi zomuthi.
- Ukwehluleka kwe-Hepatic noma kwe-renal.
- Ukusetshenziswa kwama-quinolones noma i-miconazole.
Phakathi kwemiphumela emibi yesidakamizwa, ukwephulwa emsebenzini wegaya wokugaya ukudla, ukungasebenzi kahle kwesikhumba nezicubu ezingaphansi kungabonakala. Futhi, amathuba okuba nezinkinga ze-hematological, kufaka phakathi i-anemia, i-leukopenia, i-granulocytopenia, angeke kukhishwe. Ngenxa yezinguquko emazingeni kashukela egazi, ukuphazamiseka ekusebenzeni kwezitho zombono kungavela.
Imiphumela emibi ivame ukuzixazulula ngokushesha ngemuva kokuyeka umuthi.
I-Glimepiride
Ama-analogues amahle we-Diabeteson izidakamizwa ezibandakanya i-glimepiride. Njenge-analogue yeDiabeteson MV 30, ungasebenzisa i-Glimepiride 2 mg n 10. Intengo yomuthi ingama-ruble ayi-150-200. Ngale ndlela, i-Glimepiride 1 mg, 3 mg, 4 mg iyathengiswa. Zonke zihlukile kumthamo wento esebenzayo kwithebhulethi.
Lesi sidakamizwa sitholakala sulfonylurea. Isakhi esisebenzayo somuthi sisebenza ngokukhuthaza ukukhishwa kwe-insulin kumaseli we-pancreatic beta.
I-Glimepiride ingasetshenziswa ekwelapheni uhlobo lwesifo sikashukela sohlobo 2, uma izinga le-glucose esegazini lingenakulungiswa kuphela ngokwelashwa okudla nangokuzivocavoca umzimba.
Ungayithatha kanjani le-analogue yeDiabeteson MV? Imiyalo yokusetshenziswa ithi umthamo kufanele ukhethwe ngudokotela ohambelayo. Kulokhu, udokotela kufanele acabangele izinga le-glucose esegazini nomchamo.
Njengomthetho, umthamo wokuqala we-glimepiride ngu-1 mg. Uma umthamo omncane ungasizi ukuqinisa izinga likashukela egazini, khona-ke umthamo wansuku zonke unyukela ku-2, 3 noma 4 mg, ngokulandelana. Kepha kufanele sikhumbule ukuthi umthamo ukhuphuka kancane kancane ngezikhathi ezithile zamasonto ama-1-2. Umthamo omkhulu wansuku zonke wesidakamizwa yi-6 mg.
Vele, i-Glimepiride, njenganoma yimuphi umenzeli we-hypoglycemic, inezinombolo eziningi zokuphikisana okufanele zisetshenziswe. Phakathi kwazo kukhona:
- Isifo sikashukela esincike ku-insulin (uhlobo 1).
- Isifo sikashukela sikashukela.
- Idlozi likashukela noma ikoma.
- Ukulimazeka okukhulu kwesibindi.
- Ukusebenza kahle ezinso, ikakhulukazi ukwehluleka kwezinso.
- Ukungezwani komzimba kwizakhi zomuthi. Ngaphezu kwalokho, awukwazi ukuthatha i-glimepiride noma umuntu enokungabekezeleleki kwezinye izinto eziphuma ku-sulfonylurea.
Ngesikhathi sokwelashwa, kufanele ulandele ngokuqinile isidlo. Kepha kumele sikhumbule ukuthi, akunakuphikwa ukuthi ungakwehlisa kakhulu ukudliwa kwekhalori. Ngaphandle kwalokho, i-hypoglycemic coma ingahle ikhule. Futhi, ngesikhathi sokwelashwa akuvunyelwe ngokuphelele ukuthi kudle noma ibuphi utshwala.
Imiphumela emibi ye-glimepiride:
- Ukuphazamiseka emsebenzini wesistimu yenhliziyo ne-hematopoietic. Zivela ngesimo sokunciphisa umfutho wegazi, i-thrombocytopenia, i-granulocytopenia, i-leukopenia, i-agranulocytosis, i-pancytopenia, i-erythropenia, i-anemia.
- Ukungasebenzi kahle kohlelo lwezinzwa nezitho zomqondo - isiyezi, i-migraine, ukuncipha okuphindayo ku-acuity ebonakalayo.
- Isicanucanu, ukuhlanza, ubuhlungu besisu, umuzwa wobunzima esifundeni se-epigastric, uhudo, i-cholestasis ye-intrahepatic.
- I-Hypoglycemic coma.
- I-Hyponatremia.
- Ukungezwani komzimba.
- Ukuphefumula.
- I-Hepatitis, umsebenzi owengeziwe wama-hepatic transaminases.
- I-photosensitivity.
Lapho kwenzeka imiphumela emibi kakhulu, umuthi uyakhanselwa, bese kukhethwa omunye umenzeli we-hypoglycemic.
I-Glibenclamide yesifo sikashukela
Uma iDiabeteson MV 30 ingalungile, ungathenga ithuluzi elinjenge-Glibenclamide. Umuthi uthandwa kakhulu phakathi kwabanesifo sikashukela, ngenxa yokusebenza kwawo okuphezulu nokubekezelela okuhle. Intengo yeGlibenclamide 5 mg n 100 ingama-ruble ayi-100-120 kuphela.
Lesi sikhundla se-Diabeteson siqukethe i-glibenclamide esetshenziswayo yezinto nezinto ezisizayo - i-lactose monohydrate, isitashi samazambane, i-povidone, i-E124, i-magnesium stearate.
I-Glibenclamide ivuselela amaseli we-pancreatic beta, ahambisana nokugqugquzela nokukhushulwa okwandisiwe kwe-insulin endulin. Umuthi uyasebenza lapho kukhona ama-pancreas amaseli e-beta esebenza kahle akhiqiza i-insulin endulin. Into esebenzayo ye-Glibenclamide isiza ukunciphisa ukuncipha kweplatelet.
Umenzi ukhombisa kwimiyalo ukuthi lo muthi kufanele usetshenziswe ekwelapheni isifo sikashukela sohlobo 2 lapho ukwelashwa kokudla kanye nezinye izindlela zokwelapha kungasizi ukuthi kuguqulwe amanani eglucose egazini.
Umthamo wokuqala we-glibenclamide ngu-2,5-5 mg. Kulokhu, isiguli sidinga ukubheka njalo izinga le-glycemia. Uma imithamo emincane okungenani umphumela we-hypoglycemic ungakhulunywa, khona-ke umthamo wansuku zonke uyaphakanyiswa.
Uma kunesidingo, i-glibenclamide ihlanganiswe namanye ama-hypoglycemic agents. Kulokhu, imvamisa imithamo iyancishiswa futhi ikhethwe ngendlela yokuthi inciphise ubungozi bokukhula kwe-hypoglycemic coma.
Contraindication ekusebenziseni umuthi:
- Ukungezwani komzimba kwizakhi zomuthi. Okwamanje akusanconywa ukuthi uthathe amaphilisi abantu abanesifo sikashukela abake baba nokuphendula kwe-hypersensitivity kwamanye ama-sulfonylurea derivatives.
- Thayipha isifo sikashukela sokuqala.
- Idlozi likashukela noma ikoma.
- Ukwehluleka kwesibindi.
- Ukwehluleka kwangempela kanye nokunye ukuphazamiseka ukusebenza kwezinso.
- Isikhathi sokukhulelwa nokukhulelwa.
- Ukuncipha kwesifo sikashukela ngenxa yokuhlinzwa.
Kuhle ukukhumbula ukuthi umphumela we-hypoglycemic we-Glibenclamide uyathuthukiswa uma umuntu esebenzisa ama-sulfonamides, ama-painkillers, ama-coumarin derivatives, heparin. Izakhiwo ezinciphisa ushukela nazo zithuthukiswa kakhulu uma zihlanganiswa nama-inhibitors we-MAO, ama-hypocholesterolemic agents, amanye ama-antibhalthi nama-barbiturates.
Kodwa ukwehla kwezakhiwo ze-hypoglycemic kungenzeka uma i-Glibenclamide ihlanganiswe nama-antibiotic eqembu le-rifamycin noma i-thiazide diuretics.
Imiphumela emibi yomuthi:
- I-Hypoglycemia
- Ukuphazamiseka Kwesisu. Kuboniswe ngesimo sokuntuleka kwesifiso sokudla, ukubukeka kokunambitheka kwensimbi emlonyeni, ukugabha, isifo sohudo, ubuhlungu besisu, ukushaya kwenhliziyo.
- Ukungezwani komzimba.
- I-Cholestasis.
- Umsebenzi wesibindi ongasebenzi kahle.
- Ukungasebenzi kohlelo lwe-hematopoietic.
- Ukwephula uzwela.
Futhi, imiyalo yokusebenzisa ithi i-glibenclamide ingadala ukuthuthukiswa kwe-photosensitivity.
Glurenorm esikhundleni
I-Diabeteson ingathathelwa indawo ithuluzi elinjenge-Glyrenorm. Le ejenti ye-hypoglycemic ayisebenzi kangako. Intengo yeGlurenorm 30 mg n 60 cishe ama-ruble ayi-500-620.
Isakhi esisebenzayo somuthi yi-glycidone. Ngezinhloso ezisizayo, i-lactose, isitashi sommbila, i-magnesium stearate yengezwe ezibhebheni. Ngabe isisekelo sendlela yokusebenza kweGlurenorm isuselwe kuphi?
I-Glycvidone (into esebenzayo) ivuselela imfihlo yokuqalwa kwe-insulin yendawo ngamaseli e-beta pancreas. Okusho ukuthi, imigomo yokusebenza kwesidakamizwa iyafana nama-ejenti amaningi we-hypoglycemic.
Ngosizo lwe-Glyurenorm, kungenzeka ukwelapha isifo sikashukela sohlobo lwe-2, lapho ukudla kanye nokuzivocavoca komzimba kungasizi ukuqinisa izinga le-glucose egazini. Kwesinye isikhathi lo muthi usetshenziswa ngokuhlangana nezinye izidakamizwa ze-hypoglycemic.
Ungawaphuza kanjani amaphilisi? Imiyalo yokusetshenziswa ithi umthamo wokuqala kufanele ungabi ngaphezu kwe-15 mg. Udinga ukuphuza iphilisi ngokudla. Ngokungasebenzi kwezindlela zokwelapha, umthamo uyandiswa kancane kancane. Kepha kufanele sikhumbule ukuthi umthamo wansuku zonke ophezulu ngu-120 mg. Akunakwenzeka ukuwela lo mkhawulo.
Contraindication ukusetshenziselwa:
- Uhlobo lwesifo sikashukela esincike ku-Insulin.
- I-precomatose noma ikhefana.
- Isifo sikashukela siyinkimbinkimbi yi-acidosis noma i-ketosis.
- Ukuphinda usebenzise ama-pancreas.
- Isikhathi ngaphambi kokuhlinzwa.
- Ukuphazamiseka kwesibindi.
- I-Hepatic porphyria.
- Ukungezwani komzimba kwizakhi zomuthi.
Phakathi kwemiphumela emibi ye-Glenrenorm, i-agranulocytosis, i-leukopenia, i-thrombocytopenia, i-hypoglycemia ingahlukaniswa. Futhi, umuntu akakwazi ukukhipha inyumbana yokuthola ukuthamba, isiyezi, i-migraine, i-paresthesia, ukuphazamiseka kwendawo yokuhlala, ukusabela komzimba, i-cholestasis.
Kubikwe nokuthi ukuthatha i-Glurenorm kungadala i-angina pectoris, ukuhluleka kwenhliziyo, kanye nomfutho wegazi ophansi. Ekuqaleni kokwelashwa okwelashwa, ukuphazamiseka ekusebenzeni kwamgudu wokugaya ukudla kungenzeka, kuboniswe ngendlela yokuhlanza, ukuqunjelwa, nomlomo owomile. Ividiyo ekulesi sihloko izokhuluma ngoDiabetes.
