I-Ultrashort insulin ngokubukeka iyinto ebonakalayo eketshezi futhi inomphumela osheshayo. Imvamisa, i-insulin esebenza ngokubambelela emfushane iqala ukusebenza emzimbeni womuntu onesifo sikashukela imizuzu eyi-1 - 20 ngemuva komjovo.
Umphumela omkhulu wesenzo sezidakamizwa utholwa ihora ngemuva kokuphathwa, futhi umphumela womuthi uhlala amahora ama-3 kuye kwangama-5. Ama-insulin asebenzisa i-Ultra-iDemo-asetshenziswa ngokushesha ngemuva kokudla futhi enzelwe ukwehlisa i-hyperglycemia eyenzeka emzimbeni wesiguli onesifo sikashukela ngemuva kokudla.
Ama-insulin alandelayo we-ultrashort akhona njengamanje kwiziguli:
- I-Apidra (insulin glulisin);
- I-NovoRapid (i-insulin aspart);
- I-Humalog (insulin lyspro).
Zonke izinhlobo ze-insulin ezisebenza ngokushesha zenzelwe ukuphatha ngokungahambi kahle, ngaphandle kwe-aspart ne-lispro, ezinethuba elengeziwe lokungeniswa emzimbeni ngomjovo we-intravenous.
I-insulin esheshayo i-insulin ingenye yezimpumelelo zakamuva zomkhakha wezemithi. Isikhathi saso sifushane kakhulu. I-insulin yemvelo ekhiqizwa ngabantu ihlelwe njenge-analogue ye-ultrashort insulin. Lesi sidakamizwa kwasekuqaleni sasisetshenziswa ezimweni lapho kungalindelwa khona ukuqhekeka kokudla ezigulini.
Izidakamizwa zalolu hlobo zingasetshenziswa ekwelashweni kwazo zombili izinhlobo zesifo sikashukela. Ekuqhubekeni kwesenzo salo, i-insulini ye-ultrafast yehlisa izinga loshukela osegazini le-plasma ukuya esimisweni sokuphila.
Isici se-insulin yesenzo se-Ultrafast
I-insulin ye-Ultrafast ingabonakala ngezimpawu ezilandelayo. Ukwethulwa kwalesi sidakamizwa emzimbeni wesiguli kwenziwa ngendlela yokujova okungaphakathi esiswini. Le ndlela yifushane kakhulu yokulethwa kwezidakamizwa esigulini.
I-insulin eshesha kakhulu kufanele ifakwe emzimbeni ngokushesha ngaphambi kokudla. Isikhathi sokuphumula esiphakathi komjovo nokudla akufanele singeqi imizuzu engama-30.
I-Ultrashort insulin ilawulwa kuphela ngokuya ngesidlo. Ngemuva kokwethulwa kwayo, ukudla kuyadingeka. Uma weqa ukudla okwenziwe ngomuthi owethulwe emzimbeni wesiguli, i-hypoglycemia ingakhula, okuye kwehle kakhulu inani leshukela kuplasma wegazi.
Ukuhlanganiswa kokuqala kwe-insulin ngezindlela zokwenziwa kwenziwa ngo-1921. Ngokuthuthuka okuqhubekayo embonini yezemithi, izinhlobo ezahlukene zezidakamizwa zitholakele, isisekelo sazo yi-insulin.
I-insulin ye-Ultrafast isetshenziselwa ukwenza bushelelezi ukuguquguquka kwesilinganiso se-plasma ushukela ngemuva kokudla.
Ukubalwa kwenani le-insulin esetshenziswayo kwenziwa kuphela yi-endocrinologist eye khona. Ngokuya ngezimpawu zomzimba wesiguli ngamunye. Kungani ukusetshenziswa kwesidakamizwa esisebenza ngokushesha kufaneleka?
Uhlobo olusebenza ngokushesha lwe-insulin emzimbeni womuntu lwenzelwe ukulingisa ukwakheka kwe-insulin yayo lapho ukudla okugcwele ama-carbohydrate asheshayo kungena emzimbeni.
Kwisisetshenziswa sethu ungafunda kabanzi ukuthi kungani i-insulin idingeka emzimbeni.
Ukusetshenziswa kwezidakamizwa ze-insulin ngesenzo se-ultrashort
Imiyalo ejwayelekile yokusetshenziswa kwamalungiselelo we-insulin okusheshayo ibandakanya ukwethulwa komkhiqizo wezokwelapha ngesikhathi esithile ngaphambi kokuqala kokudla. Ngokuyalela imiyalo esetshenzisiwe, isikhathi esiphakathi komjovo nokusetshenziswa kokudla kufanele kube kuncane.
Isikhathi sokuphumula phakathi komjovo nokudla kuya kakhulu ezicini zomzimba ngamunye. Isikhathi sokusetshenziswa kwesidakamizwa esiqukethe i-insulin ngaphambi kokudla senziwa yi-endocrinologist eye khona.
Lapho kubalwa irejimeni yemithi, kufanele kuthathelwe zonke izici zomzimba womuntu on uhlobo 1 lwesifo sikashukela.
Lapho usebenzisa amalungiselelo e-ultrashort, imiyalo yokusebenzisa nezincomo ezitholwe ku-endocrinologist kumele ibhekwe ngokuqinile. Iphuzu elibaluleke kakhulu ukuhlangana kweziqalo zesenzo somuthi osetshenziselwa ukujova nokudla ukudla.
Ukuhlangana kweziqongo zesenzo somuthi emzimbeni ngethanga lokungena kweglucose kuplasma kwegazi kugwema isimo somzimba, esiseduze kwe-hyperglycemia. Ukwehluleka ukulandela izincomo lapho uthatha umuthi wesenzo se-ultrashort kungavusa ukukhula kwe-hypoglycemia emzimbeni. Lesi simo senzeka ngemuva kokufakwa komuthi ngaphandle kokudla ukudla. Umthamo womuthi ubalwa ngendlela yokuthi ushukela ongena emzimbeni usetshenziswe ngokushesha.
Lapho usebenzisa i-insulini ye-ultrafast, kubalulekile ukulandela umthetho - ukudla kufanele kuthathwe kumthamo okwenzelwe kuwo umthamo womuthi.
Esimweni lapho inani lokudla linganele emzimbeni wesiguli, kungavela isimo se-hypoglycemia, futhi esimweni esiphambene, isimo se-hyperglycemia siyakhula. Izinketho ezinjalo zokukhula kwalesi sifo zigcwele nemiphumela emibi emzimbeni wesiguli.
Ukusetshenziswa kwe-insulin ye-ultrafast kunqunywe kuphela kulezo zimo lapho ukukhula kwe-glucose emzimbeni kubhekwa kuphela ngesikhathi sokudla.
Ngalesi sikhathi, ukuthatha lolu hlobo lwezidakamizwa kukuvumela ukuthi usebenzise kahle ushukela omningi emzimbeni.
Uhlobo lwe-insulin ye-Ultrafast ngokuphelele
Lapho usebenzisa lolu hlobo lwedivaysi yezokwelapha, izidingo ezithile nemiyalo kufanele kulandelwe, okulandelayo:
- Umjovo womuthi kufanele wenziwe kuphela ngaphambi kokudla okuyinhloko, noma ngabe uluhlobo luni lwe-insulin esebenza ngokushesha.
- Ngomjovo, sebenzisa kuphela isirinji ekhethekile ye-insulin.
- Indawo yomjovo oyintandokazi yisisu.
- Ngaphambi komjovo, indawo yomjovo akufanele ihlanjululwe, lokhu kuqinisekisa ukuhamba komuthi egazini.
- Ukubalwa komthamo osetshenziswa kwinqubo yokwelapha umuthi kufanele wenziwe ngawodwana. Udokotela kufanele afundise isiguli ngenani lemithi edingekayo lomjovo.
Esezinhlelweni zokusebenzisa lolu hlobo lwemithi, umuntu kufanele acabangele iqiniso lokuthi ukubalwa kwamthamo nesikhathi lapho i-insulin ifakwe emzimbeni, imali kufanele ibe njalo, nendawo yokulawulwa kwezidakamizwa kufanele iguquke.
Lapho usebenzisa umuthi, imithetho yokugcina umuthi kufanele ibonwe kahle. Lokhu kuyadingeka ukuze umuthi oqukethe i-insulin ungazishintshi izakhiwo zawo futhi nomthamo wokuqondisa ukuya emzimbeni ubalwa kahle.
Isenzo se-insulin ye-ultrafast siqala ngaphambili kunokuba umzimba unesikhathi sokuthola ukudla kwamaprotheni futhi sikusebenzise kushukela. Ngomsoco ofanele, ukusetshenziswa kwe-insulin ene-ultra-iDemo-ayidingeki. Lo muthi kufanele uthathwe kuphela kulezo zimo lapho kudingekile ukuphuthumisa ngokweqile ukugcwala kwe-glucose kuplaya kwegazi lomuntu onesifo sikashukela mellitus.
Okuqukethwe isikhathi eside kwe-plasma glucose okuholela kuholela emiphumeleni emibi, ukwanda okubukhali koshukela wegazi kunomthelela ongemuhle emzimbeni, ukuze kuvikelwe ukuthuthuka okunjalo kwemicimbi, kusetshenziswa imithi equkethe i-insulin ye-ultrafast.
Ngenxa yesikhathi esifushane sokusebenza, lesi sidakamizwa masishintsha ngokwejwayelekile izinga leshukela emzimbeni, lisisondeze ezingeni elijwayelekile lomzimba.
Uma umuntu onesifo sikashukela ehambisana nayo yonke imfuneko yokudla kokudla, khona-ke i-insulin yokugcina ayidingeki kuye, isetshenziswa kuphela ezimweni zokwanda okuphuthumayo kwezinga likashukela emzimbeni ukuze kubuyiselwe kokujwayelekile.
Izinto ezingalungile zokusebenzisa amalungiselelo e-insulin e-ultrafast
I-insulin enesenzo se-ultrafast inesikhathi esifushane kakhulu somsebenzi wethanga futhi izinga layo esegazini lesiguli lehla ngokushesha okukhulu. Njengoba inani lesenzo somuthi libukhali kakhulu, ukubalwa komthamo womuthi ukuze usetshenziselwe kunobunzima bawo. Zonke izici zokusebenzisa i-insulin enjalo zikhonjisiwe kwimiyalo ehambisana nokusetshenziswa.
Umkhuba wokusebenzisa lolu hlobo lwesidakamizwa ukhombisa ukuthi umphumela we-insulin emzimbeni wesiguli onesifo sikashukela i-mellitus ngandlela-thile ungazinzi futhi uqine kakhulu ngokuqhathanisa nezinye izinhlobo zemithi equkethe i-insulin esetshenziselwa ukwelapha isifo sikashukela.
Ukusetshenziswa kwomuthi kuyadingeka kuphela ezimweni ezingejwayelekile. Isibonelo sezimo ezinjalo kungaba uhambo lokuya endaweni yokudlela noma uhambo lomoya.
Lapho kubalwa umthamo we-insulin ye-ultrafast, iziguli eziningi zidlulisela wonke umthwalo kudokotela oya khona Kepha ukuze kubuyiselwe impilo kokujwayelekile, kuyadingeka nokuthi isiguli sibe nesibopho ngokwengeziwe sokusebenzisa izincomo.
Akunzima ukubala umthamo odingekayo we-insulin esebenza ngokubamba okusheshayo. Ngale njongo, ukuqapha njalo okuqukethwe ushukela ku-plasma yegazi kuyadingeka. Kuyadingeka ukuthola isikhathi sokuqala kwe-gxuma kokuqukethwe koshukela egazini - ngalo mzuzu yisikhathi sokwethula umuthi wesenzo se-ultrafast.
Ukwenza ukubalwa okuzimele kwenani lomuthi osetshenzisiwe kudinga ukunakekelwa okukhethekile. Ngokubala okulungile, ukwelashwa kwesifo sikashukela kuyasebenza futhi akunikezeli izinkinga. Ividiyo ekulesi sihloko sendlela izinhlanga zikhuluma ngayo nge-ultrashort insulin.
