Ngokusho kwezifundo ezintsha, i-estrogen isiza ukulawula izinga likashukela emzimbeni, futhi ivikele nakwisifo sikashukela sohlobo 2 esikhathini se-postmenopausal.
Efunda izidalwa zabantu nezamagundane kwabesifazane base-postmenopausal, uJacques Philippe, uchwepheshe wesifo sikashukela eYunivesithi yaseGeneva eSwitzerland, nozakwabo bathole ukuthi i-estrogen isebenza emangqamuzaneni athile kumanyikwe namathumbu, yathuthukisa ukuthathwa koshukela emzimbeni.
Phambilini kutholakale ukuthi ngemuva kokuya esikhathini abesifazane babe nengozi enkulu yesifo sikashukela sohlobo 2, esibangelwa ushintsho lwamahomoni, kubandakanya ukwehla komkhiqizo we-estrogen. Ngokusekelwe kule mininingwane, ososayensi banqume ukuthola ukuthi ngabe i-estrogen replacement therapy ingasiza yini ukuvikela lokhu kuthuthukiswa kwemicimbi, futhi bathola impendulo evumayo.
I-estrogen namathumbu
Ocwaningweni, uPhilip nozakwabo bajova i-estrogen emgundweni we-postmenopausal. Okuhlangenwe nakho kwangaphambilini kugxile ekutheni i-estrogen isebenza kanjani kumaseli we-pancreatic akhiqiza insulin. Manje, ososayensi bagxile ekutheni i-estrogen ixhumana kanjani namaseli akhiqiza i-glucagon, i-hormone ekhulisa amazinga kashukela egazini.
Ngokusho kocwaningo olusha, amaseli we-pancreatic alpha akhiqiza i-glucagon azwela kakhulu i-estrogen. Kubangela ukuthi la maseli akhulule i-glucagon encane, kepha ama-hormone amaningi abizwa ngokuthi yi-glucagon-like peptide 1 (HLP1).
I-GLP1 ivuselela ukukhiqizwa kwe-insulin, ivimba ukukhululeka kweglucagon, inikeze umuzwa wokugcwala, futhi ikhiqizwa emathunjini.
"Ngempela, kunamaseli we-L emathunjini afana kakhulu namaseli we-pancreatic alpha, kanti umsebenzi wawo omkhulu ukukhiqiza i-GP1," kuchaza uSandra Handgraaf, omunye wababhali balolu cwaningo. "Ukuthi sabona ukwanda okukhulu ekukhiqizweni kwe-GLP1 emathunjini kwembula ukuthi kubaluleke kanjani ukuthi lesi sitho sidlale ukulawula i-carbohydrate futhi mkhulu kangakanani umphumela we-estrogen kuyo yonke imetabolism," kunezela uSandra.
Kumaseli womuntu, imiphumela yalolu cwaningo iqinisekisiwe.
Ukwelashwa kweHormone esikhundleni njengethuluzi lokulwa nesifo sikashukela
Ukwelashwa kweHormone phambilini bekuhlotshaniswa nobungozi obuhlukahlukene empilweni yabesifazane be-postmenopausal, ngokwesibonelo, ukuthuthukiswa kwesifo senhliziyo.
UPhilip uthi: “Uma uthatha ama-hormone isikhathi esingaphezu kweminyaka eyi-10 emva kokuyeka ukuya esikhathini, impela le ngozi iyanda kakhulu. Uyanezela, "Kodwa-ke, uma ukwelashwa kwama-hormone kwenziwa iminyaka embalwa nje ngemuva kokuqala kokuya esikhathini, ngeke kube khona ukulimala ohlelweni lwezinhliziyo, futhi uhlobo lwesifo sikashukela 2 lungavinjelwa. Ngakho-ke, ukuphathwa ngendlela efanele kwe-estrogen kuzoletha. izinzuzo ezinkulu zempilo yabesifazane, ikakhulukazi maqondana nokuvimbela isifo sikashukela, ”kuphetha usosayensi.
